format-version: 1.2 subsetdef: anatomical_site_slim "" subsetdef: BrainName "" subsetdef: BrainName_Embargo "" subsetdef: cell_slim "" subsetdef: Cross-product_review "" subsetdef: Cross_product_review "" subsetdef: cumbo "CUMBO" subsetdef: cur "" subsetdef: cyclostome_subset "cyclostome structures" subsetdef: defined_by_cytoarchitecture "brain region defined by cyto-architecture" subsetdef: defined_by_ordinal_series "classes that are defined by relative position counting from first in a series of elements along an axis in an individual organism rather than by strict homology" subsetdef: deprecated "" subsetdef: developmental_classification "developmental_classification" subsetdef: dubious_grouping "Indicates that subclasses in AOs may be inappropriately linked" subsetdef: early_development "A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes." subsetdef: efo_slim "EFO slim" subsetdef: emapa_ehdaa2 "derived from the union of EHDAA2 and EMAPA - still to be checked" subsetdef: EmbDevSlim "" subsetdef: FB_gloss "" subsetdef: feed_aligned "subset of classes that have logical defs text defs and synonyms aligned with FEED" subsetdef: FlyTed "" subsetdef: frequent_anatomy_items "" subsetdef: FT_new "" subsetdef: functional_classification "functional_classification" subsetdef: goantislim_grouping "" subsetdef: gocheck_do_not_annotate "" subsetdef: gocheck_do_not_manually_annotate "" subsetdef: goslim_aspergillus "" subsetdef: goslim_candida "" subsetdef: goslim_generic "" subsetdef: goslim_goa "" subsetdef: goslim_metagenomics "" subsetdef: goslim_pir "" subsetdef: goslim_plant "" subsetdef: goslim_pombe "" subsetdef: goslim_synapse "" subsetdef: goslim_virus "" subsetdef: goslim_yeast "" subsetdef: gosubset_prok "" subsetdef: granular_stage "" subsetdef: granular_stage "Subset consisting of classes describing highly granular developmental stages (for instance, '23-year-old'). Such stages might be useful for annotation purpose, but might be folded into less granular parents for display purpose." subsetdef: grouping_class "Subset consisting of classes creating for grouping purposes" subsetdef: hidden_assertion "" subsetdef: high_level_annotation_qc "" subsetdef: homology_grouping "A grouping class that depends on an assumption of homology between subclasses" subsetdef: inconsistent_with_fma "classes that have some inconsistency with FMA" subsetdef: larval_OF "" subsetdef: major_organ "somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads" subsetdef: metazoa_core "core classes typically found across metazoa. one purpose is to create a rough set of terms that could be used to start a new metazoan AO. Note this subset is not yet fully fleshed out" subsetdef: mf_needs_review "" subsetdef: non_informative "abstract class brought in to group ontology classes but not informative" subsetdef: olfactory_system_draft "" subsetdef: organ_slim "organs, excluding individual muscles and skeletal elements" subsetdef: organism_views "" subsetdef: pheno_slim "Phenotype slim" subsetdef: phenotype_rcn "A subset specifically created for the 2012 Phenotype RCN meeting. Includes some human-specific terms that may eventually be removed when they are adequately represented with part of relationships in FMA" subsetdef: RD "" subsetdef: sectional_anatomy_items "" subsetdef: termgenie_unvetted "" subsetdef: TL_lineage_clone "" subsetdef: uberon_slim "Uberon slim - subset that excludes obscure terms and deep compositional terms" subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis" subsetdef: unverified_taxonomic_grouping "Indicates that the class encompasses classes from other AOs that have not been verified" subsetdef: upper_level "abstract upper-level terms not directly useful for analysis" subsetdef: vertebrate_core "core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO" subsetdef: virus_checked "" synonymtypedef: ABBREVIATION "abbreviation" synonymtypedef: acronym "" synonymtypedef: anamorph "" synonymtypedef: blast_name "" synonymtypedef: BRAIN_NAME_ABV "" synonymtypedef: BRAND_NAME "" synonymtypedef: common_name "" synonymtypedef: COMPARATIVE_PREFERRED "preferred term in the context of comparative anatomy" synonymtypedef: DEPRECATED "" synonymtypedef: DEPRECATED "A historic synonym, no longer encouraged" synonymtypedef: DEVELOPMENTAL "developmental term" synonymtypedef: DUBIOUS "dubious or contested synonym" synonymtypedef: equivalent_name "" synonymtypedef: FORMULA "" synonymtypedef: genbank_acronym "" synonymtypedef: genbank_anamorph "" synonymtypedef: genbank_common_name "" synonymtypedef: genbank_synonym "" synonymtypedef: HOMOLOGY "a synonym made on the basis of a possibly homologous structure in another species" synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens" synonymtypedef: in_part "" synonymtypedef: InChI "" synonymtypedef: InChIKey "" synonymtypedef: INCONSISTENT "indicates that a synonym is used in an inconsistent or confusing way, typically between species" synonymtypedef: INN "" synonymtypedef: IUPAC_NAME "" synonymtypedef: LATIN "latin term" synonymtypedef: misnomer "" synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded" synonymtypedef: misspelling "" synonymtypedef: NON_AMNIOTE "synonym that is inappropriate for amniotes" synonymtypedef: NON_MAMMAL "synonym that is inappropriate for mammals" synonymtypedef: octopoda "" synonymtypedef: PENDING_REVIEW "expert consultation and attribution required" synonymtypedef: PLURAL "" synonymtypedef: PLURAL "plural term" synonymtypedef: PLURAL "plurals" synonymtypedef: scientific_name "" synonymtypedef: SENSU "" synonymtypedef: SENSU "taxonomic disambiguation" synonymtypedef: SMILES "" synonymtypedef: squid "" synonymtypedef: synonym "" synonymtypedef: SYSTEMATIC "a systematic synonym used as the base name for design patterns" synonymtypedef: systematic_synonym "" synonymtypedef: teleomorph "" synonymtypedef: TRAIT "" remark: \nUberon ontologies with the prefix 'collected' are ontologies that\nimport the core Uberon ontology together with one or more external\ntypically species-centric ontologies plus *bridging* axioms that\nconnect Uberon to the species-centric ontology. Bridging axioms may be\ndirect equivalence axioms, taxonomic equivalence axioms, or subclass\naxioms. See the Uberon homepage for details.\n remark: Includes Ontology(OntologyID(Anonymous-18)) [Axioms: 1 Logical Axioms: 0] remark: Includes Ontology(OntologyID(Anonymous-39)) [Axioms: 778 Logical Axioms: 307] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 4508 Logical Axioms: 1463] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 349 Logical Axioms: 125] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 39823 Logical Axioms: 6633] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 32323 Logical Axioms: 5383] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 17898 Logical Axioms: 12108] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 64250 Logical Axioms: 28913] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 2262 Logical Axioms: 660] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 19156 Logical Axioms: 3677] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 11088 Logical Axioms: 4103] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 14827 Logical Axioms: 2467] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 3127 Logical Axioms: 517] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 3418 Logical Axioms: 1044] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 157 Logical Axioms: 11] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 166 Logical Axioms: 13] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 412 Logical Axioms: 62] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 3608 Logical Axioms: 700] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 144 Logical Axioms: 8] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 252 Logical Axioms: 30] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 147 Logical Axioms: 9] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 2182 Logical Axioms: 416] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 0 Logical Axioms: 0] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 0 Logical Axioms: 0] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 0 Logical Axioms: 0] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 0 Logical Axioms: 0] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 0 Logical Axioms: 0] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 0 Logical Axioms: 0] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 0 Logical Axioms: 0] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 3900 Logical Axioms: 762] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 1412 Logical Axioms: 262] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 7471 Logical Axioms: 1471] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 22009 Logical Axioms: 4371] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 1242 Logical Axioms: 227] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 179 Logical Axioms: 15] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 2978 Logical Axioms: 575] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 15474 Logical Axioms: 3076] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 2779 Logical Axioms: 535] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 597 Logical Axioms: 99] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 495 Logical Axioms: 79] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 178 Logical Axioms: 16] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 3144 Logical Axioms: 609] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 10463 Logical Axioms: 2071] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 267592 Logical Axioms: 58246] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 10143 Logical Axioms: 3193] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 36258 Logical Axioms: 12383] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 3399 Logical Axioms: 1345] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 10054 Logical Axioms: 5157] remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 22468 Logical Axioms: 11339] ontology: uberon/bridge/collected-metazoan property_value: dc-creator "Uberon editors" xsd:string property_value: dc-description "\nThis is an ontology that collects all of the core uberon, plus ALL\ngross anatomical ontologies for metazoans.\n " xsd:string property_value: dc-title "Uberon importer for metazoan structures" xsd:string property_value: foaf-homepage http://purl.obolibrary.org/obo/uberon/bridge/collected-metazoa xsd:anyURI property_value: foaf-homepage http://uberon.org xsd:anyURI property_value: http://purl.org/dc/elements/1.1/subject NCBITaxon:33208 property_value: seeAlso http://genomebiology.com/2012/13/1/R5 xsd:anyURI property_value: seeAlso http://purl.obolibrary.org/obo/uberon/references/reference_0000027 xsd:anyURI [Term] id: AEO:0000013 name: single-cell tissue def: "Anatomical structure composed of a single cell." [CARO:MAH] is_a: UBERON:0000479 ! simple tissue [Term] id: AEO:0000078 name: lumen of tube def: "The inner space within a tube." [AEO:JB] synonym: "tube lumen" RELATED [] is_a: AEO:0000221 ! open anatomical space [Term] id: AEO:0000079 name: lumen of epithelial sac def: "A small cavity bounded by an epithelium." [AEO:JB] synonym: "cavity of vesicle" RELATED [] is_a: AEO:0000222 ! enclosed anatomical space [Term] id: AEO:0000080 name: foramen def: "A hole in a tissue." [AEO:JB] is_a: UBERON:0000015 ! anatomical surface [Term] id: AEO:0000081 name: matrix-based tissue def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." [AEO:JB] is_a: UBERON:0000479 ! simple tissue [Term] id: AEO:0000082 name: bone def: "Ossified structure that is predominantly extracellular matrix and forms part of the support system of the body." [AEO:JB] is_a: UBERON:0000481 ! multi-tissue structure [Term] id: AEO:0000083 name: endochondral bone def: "Bone that is preformed in cartilage." [AEO:JB, VAO:0000145] is_a: AEO:0000082 ! bone is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part CL:0000058 ! chondroblast relationship: has_part CL:0000062 ! osteoblast relationship: has_part CL:0000138 ! chondrocyte relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000085 name: membrane bone def: "Bone that forms directly from mesenchyme." [AEO:JB, VAO:0000023] is_a: AEO:0000082 ! bone is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part CL:0000062 ! osteoblast relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000086 name: sesamoid bone def: "An endochondral bone that forms within tendenous or ligamentous matrix." [AEO:JB, VAO:0000137] is_a: AEO:0000083 ! endochondral bone [Term] id: AEO:0000087 name: cartilage def: "Dense connective tissue made primarily of type II collagen." [AEO:JB, VAO:0000040] is_a: AEO:0000081 ! matrix-based tissue relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000090 name: ligament def: "A strap of predominantly extracellular matrix connecting two bones." [AEO:JB] is_a: AEO:0000081 ! matrix-based tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000057 ! fibroblast relationship: has_part CL:0000327 ! extracellular matrix secreting cell relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000091 name: tendon def: "A strap of predominantly extracellular matrix connecting a muscle to a bone." [AEO:JB] is_a: AEO:0000081 ! matrix-based tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000057 ! fibroblast relationship: has_part CL:0000327 ! extracellular matrix secreting cell relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000092 name: aponeurosis def: "A sheet of extracellular matrix." [AEO:JB] is_a: AEO:0000081 ! matrix-based tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000327 ! extracellular matrix secreting cell [Term] id: AEO:0000093 name: non-connected functional system def: "An anatomical group whose component structures share a common function." [AEO:JB] is_a: UBERON:0000477 ! anatomical cluster [Term] id: AEO:0000094 name: sense organ def: "Multicellular anatomical structure with largely bona fide boundary that transduces some sensory stimulus to the nervous system." [AEO:JB] is_a: UBERON:0003103 ! compound organ [Term] id: AEO:0000095 name: fluid-based anatomical entity def: "Fluid anatomical entity containing cells." [AEO:JB] is_a: UBERON:0000481 ! multi-tissue structure [Term] id: AEO:0000096 name: gland def: "A multi-tissue structure that produces a secretion for use elsewhere in the body." [AEO:JB] is_a: UBERON:0000481 ! multi-tissue structure [Term] id: AEO:0000097 name: ducted gland def: "A gland that releases its secretion through a duct." [AEO:JB] synonym: "exocrine gland." RELATED [] is_a: AEO:0000096 ! gland [Term] id: AEO:0000098 name: ductless gland def: "A gland that releases its secretion directly into the bloodstream, or equivalent for an invertebrate." [AEO:JB] synonym: "endocrine gland." RELATED [AEO:JB] is_a: AEO:0000096 ! gland [Term] id: AEO:0000099 name: keratin-based structure def: "Acellular anatomical structure whose predominant constituent is keratin." [AEO:JB] is_a: UBERON:0000476 ! acellular anatomical structure [Term] id: AEO:0000100 name: chitin-based structure def: "Acellular anatomical structure whose predominant constituent is chitin." [AEO:JB] is_a: UBERON:0000476 ! acellular anatomical structure [Term] id: AEO:0000103 name: body def: "The region of the organism associated with the visceral organs." [AEO:JB] is_a: UBERON:0000475 ! organism subdivision [Term] id: AEO:0000106 name: head def: "The region of the body containing the brain and mouth." [AEO:JB] is_a: UBERON:0000475 ! organism subdivision [Term] id: AEO:0000108 name: neck def: "The region of the body connecting the head and the body." [AEO:JB] is_a: UBERON:0000475 ! organism subdivision [Term] id: AEO:0000109 name: tail def: "An external caudal extension of the body." [AEO:JB] is_a: AEO:0000193 ! appendage [Term] id: AEO:0000111 name: mesothelium def: "Epithelium derived from mesenchyme." [AEO:JB] is_a: UBERON:0000487 ! simple squamous epithelium relationship: surrounds UBERON:0000479 ! simple tissue [Term] id: AEO:0000114 name: epithelial tube def: "An epithelial structure capable of allowing fluid flow." [AEO:JB] is_a: UBERON:0000483 ! epithelium relationship: has_part CL:0000068 ! duct epithelial cell [Term] id: AEO:0000115 name: epithelial sac def: "An epithelial pouch with a single opening." [AEO:JB] is_a: UBERON:0000483 ! epithelium relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: AEO:0000117 name: arborising epithelial duct system def: "A group of connected epithelial tubes with a single portal." [AEO:JB] is_a: AEO:0000115 ! epithelial sac relationship: has_part CL:0000068 ! duct epithelial cell [Term] id: AEO:0000118 name: epithelial plexus def: "A network of interlinking epithelial tubes." [AEO:JB] is_a: AEO:0000114 ! epithelial tube [Term] id: AEO:0000119 name: epithelial vesicle is_a: UBERON:0000483 ! epithelium relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: AEO:0000119f name: epithelial vesicle def: "A closed epithelium with a lumen." [AEO:JB] is_obsolete: true [Term] id: AEO:0000122 name: muscle tissue def: "A tissue composed of myoblasts or muscle cells." [AEO:JB] is_a: UBERON:0000479 ! simple tissue [Term] id: AEO:0000123 name: neural tissue def: "Tissue composed predominantly of neurons." [AEO:JB] is_a: UBERON:0000479 ! simple tissue [Term] id: AEO:0000125 name: developing anatomical structure def: "A structure whose morphology or state of differentiation will change during normal development." [AEO:JB] is_a: UBERON:0000061 ! anatomical structure [Term] id: AEO:0000126 name: larva def: "A post-embryonic juvenile form which will undergo metamorphosis to become the adult." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure is_a: UBERON:0000468 ! multi-cellular organism [Term] id: AEO:0000127 name: apoptosing developing anatomical entity def: "An embryonic anatomical structure undergoing apoptosis." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure relationship: has_part CL:0000445 ! apoptosis fated cell [Term] id: AEO:0000129 name: functioning and developing structure def: "An embryonic entity that displays a physiological function but whose strucuture is not yet fully formed." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure [Term] id: AEO:0000131 name: developing structure with stem cells def: "Embronic structure that contains stem cellsr that may contribute to its future development or maintenance or to its future development or maintenance of another tissue." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure relationship: has_part CL:0000034 ! stem cell [Term] id: AEO:0000132 name: transitional anatomical structure def: "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure [Term] id: AEO:0000135 name: ganglion def: "A group of neurons, usually outside the CNS, which relay neuronal signals." [AEO:JB] is_a: AEO:0000123 ! neural tissue [Term] id: AEO:0000136 name: neuronal nucleus def: "A localised domain of predominantly neuronal tissue in the central nervous system." [AEO:JB] is_a: AEO:0001012 ! neuronal grey matter is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part CL:0000127 ! astrocyte relationship: has_part CL:0000129 ! microglial cell [Term] id: AEO:0000137 name: nerve def: "A group of neurons that provides a nervous supply." [AEO:JB] is_a: AEO:0000123 ! neural tissue [Term] id: AEO:0000138 name: nerve plexus def: "A complex of interconnecting nerves." [AEO:JB] is_a: AEO:0000123 ! neural tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000526 ! afferent neuron relationship: has_part CL:0000527 ! efferent neuron [Term] id: AEO:0000139 name: nerve fiber tract def: "A fasciculated bundle of neuron projections, largely or completely lacking synapses." [CARO:0001001, GO:0043005] synonym: "neuron projection bundle" RELATED [GO:0043005] is_a: AEO:0001011 ! neuronal white matter [Term] id: AEO:0000140 name: striated muscle tissue def: "A tissue composed of striated muscle cells." [AEO:JB] is_a: AEO:0000122 ! muscle tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000737 ! striated muscle cell [Term] id: AEO:0000141 name: smooth muscle tissue def: "A tissue composed of smooth muscle cells." [AEO:JB] is_a: AEO:0000122 ! muscle tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000192 ! smooth muscle cell [Term] id: AEO:0000142 name: cardiac muscle tissue def: "A tissue composed of cardiac muscle cells." [AEO:JB] is_a: AEO:0000122 ! muscle tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part CL:0000746 ! cardiac muscle cell [Term] id: AEO:0000143 name: smooth muscle sphincter def: "A ring of smooth muscle cells whose contraction closes the opening of the ring." [AEO:JB] is_a: AEO:0000141 ! smooth muscle tissue [Term] id: AEO:0000144 name: striated muscle sphincter def: "A ring of striated muscle cells whose contraction closes the opening of the ring." [AEO:JB] is_a: AEO:0000140 ! striated muscle tissue [Term] id: AEO:0000145 name: mesenchymal tissue def: "A group of not-yet-terminally-differentiatied cells that can pack in three dimensions." [AEO:JB] is_a: UBERON:0000479 ! simple tissue [Term] id: AEO:0000146 name: dense mesenchyme tissue def: "Mesenchyme with little extracellular matrix." [AEO:JB] is_a: AEO:0000145 ! mesenchymal tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000057 ! fibroblast [Term] id: AEO:0000147 name: cartilagenous condensation def: "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." [AEO:JB, GO:curator, VAO:0000092] is_a: AEO:0000148 ! developing mesenchymal condensation relationship: has_part CL:0000058 ! chondroblast relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000148 name: developing mesenchymal condensation def: "A delimited region of dense mesenchyme within looser mesenchyme." [AEO:JB] is_a: AEO:0000146 ! dense mesenchyme tissue is_a: AEO:0001016 ! developing mesenchymal structure relationship: has_part CL:0000335 ! mesenchyme condensation cell [Term] id: AEO:0000149 name: pre-muscle condensation def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become myoblasts." [AEO:JB] is_a: AEO:0000148 ! developing mesenchymal condensation relationship: has_part CL:0000680 ! muscle precursor cell [Term] id: AEO:0000150 name: pre-cartilage condensation def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." [AEO:JB] is_a: AEO:0000148 ! developing mesenchymal condensation relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000151 name: loose mesenchyme tissue def: "Mesenchyme whose cells are embedded in obvious amounts fo extracellular matrix." [AEO:JB] is_a: AEO:0000145 ! mesenchymal tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000057 ! fibroblast relationship: has_part CL:0000327 ! extracellular matrix secreting cell [Term] id: AEO:0000152 name: migrating mesenchyme population def: "Mesenchymal cells that are migrating." [AEO:JB] is_a: AEO:0000145 ! mesenchymal tissue is_a: AEO:0000217 ! migrating developing tissue relationship: has_part CL:0000134 ! mesenchymal cell [Term] id: AEO:0000153 name: mesenchymal tissue with stem cells def: "Multi-tissue mesenchymal structure one of whose parts contains stem cells that can replace other parts." [AEO:JB] is_a: AEO:0000187 ! multi-tissue structure with stem cells [Term] id: AEO:0000154 name: organism surfacef def: "The collection of structures that form the exxtenal covering of the organism." [AEO:JB] is_a: UBERON:0000475 ! organism subdivision [Term] id: AEO:0000161 name: groove def: "The exposed surface of a furrow or an incomplete tube." [AEO:JB] is_a: UBERON:0000015 ! anatomical surface [Term] id: AEO:0000162 name: ridge def: "A raised strip of tissue." [AEO:JB] is_a: UBERON:0000015 ! anatomical surface [Term] id: AEO:0000168 name: skeletal system def: "The rigid support system for the body." [AEO:JB, VAO:0000027] is_a: UBERON:0000467 ! anatomical system [Term] id: AEO:0000169 name: embryo def: "That part of the conceptus that will form the organism." [AEO:JB] is_a: UBERON:0000468 ! multi-cellular organism relationship: part_of AEO:0000194 ! conceptus [Term] id: AEO:0000170 name: anlage def: "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure [Term] id: AEO:0000171 name: primordium def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure [Term] id: AEO:0000172 name: limb def: "Appendage of an animal used for locomotion or grasping." [AEO:JB] is_a: AEO:0000193 ! appendage is_a: UBERON:0000491 ! solid compound organ [Term] id: AEO:0000173 name: surface sense organ def: "Multicellular anatomical structure with largely bona fide boundary that extends outwards from or is part of the organism surface and transduces some sensory stimulus to the nervous system." [AEO:JB] is_a: AEO:0000094 ! sense organ relationship: part_of AEO:0000154 ! organism surfacef [Term] id: AEO:0000174 name: gender-specific anatomical structure def: "A part of the body present only in a specific gender." [AEO:JB] is_a: UBERON:0000061 ! anatomical structure [Term] id: AEO:0000175 name: male anatomical structure def: "A part of the body present only in males." [AEO:JB] is_a: AEO:0000174 ! gender-specific anatomical structure [Term] id: AEO:0000176 name: female anatomical structure def: "A part of the body present only in females." [AEO:JB] is_a: AEO:0000174 ! gender-specific anatomical structure [Term] id: AEO:0000177 name: hermaphrodite anatomical structure def: "A part of the body present only in hermaphrodites." [AEO:JB] is_a: AEO:0000174 ! gender-specific anatomical structure [Term] id: AEO:0000178 name: fibrous joint def: "A flexible joint between two bones that is made of unossified connective tissue." [AEO:JB] is_a: AEO:0000081 ! matrix-based tissue relationship: has_part CL:0002320 ! connective tissue cell relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000179 name: joint-associated cartilage def: "The articular cartilage covering of the region of bone within a synoval joint." [AEO:JB] is_a: AEO:0000087 ! cartilage is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000058 ! chondroblast relationship: has_part CL:0000138 ! chondrocyte relationship: part_of AEO:0000083 ! endochondral bone relationship: part_of AEO:0000183 ! synovial joint [Term] id: AEO:0000180 name: non-joint-associated cartilage def: "Cartilage that may provide the template for an endochondral bone or that may be a disinct entity in the skeleton." [AEO:JB] is_a: AEO:0000087 ! cartilage is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000058 ! chondroblast relationship: has_part CL:0000138 ! chondrocyte [Term] id: AEO:0000181 name: synovial membrane def: "The epithelial membrane between bone ends that forms the lateral borders of the synovial cavity and secretes synovial fluid." [AEO:JB] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000485 ! columnar epithelium is_a: UBERON:0000486 ! multilaminar epithelium relationship: has_part CL:0000079 ! stratified epithelial cell relationship: part_of AEO:0000183 ! synovial joint [Term] id: AEO:0000183 name: synovial joint def: "A joint connecting two or more bones with cartilage at the bone ends and a synovial membrane that secretes synovial fluid conecting the bones and sealing the synovial cavity." [AEO:JB] is_a: UBERON:0000481 ! multi-tissue structure relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000185 name: exoskeletal tissue def: "A component of the exoskeleton." [AEO:JB] is_a: AEO:0000081 ! matrix-based tissue is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000658 ! cuticle secreting cell relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000186 name: body cavity def: "The cavity within the body that contains the visceral organs." [AEO:JB] is_a: UBERON:0000464 ! anatomical space [Term] id: AEO:0000187 name: multi-tissue structure with stem cells def: "Multi-tissue structure one of whose parts contains stem cells that can replace other parts." [AEO:JB] is_a: UBERON:0000481 ! multi-tissue structure [Term] id: AEO:0000188 name: acellular fluid anatomical entity def: "An acellular fluid portion of organism substance that is produced by the organism for some non-waste purpose." [AEO:JB] is_a: UBERON:0000463 ! non-tissue substance is_a: UBERON:0000476 ! acellular anatomical structure [Term] id: AEO:0000189 name: epithelial tissue with stem cells def: "Multi-tissue epithelial structure one of whose parts contains stem cells that can replace other parts." [AEO:JB] is_a: AEO:0000187 ! multi-tissue structure with stem cells [Term] id: AEO:0000192 name: anatomical surface feature def: "Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures." [CARO:MAH] synonym: "anatomical surface." RELATED [] is_obsolete: true [Term] id: AEO:0000193 name: appendage def: "Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified]. An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs." [CARO:MAH] is_a: UBERON:0000475 ! organism subdivision [Term] id: AEO:0000194 name: conceptus def: "All the products of the fertilized egg." [AEO:JB] is_a: UBERON:0000468 ! multi-cellular organism [Term] id: AEO:0000195 name: extraembryonic component def: "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." [AEO:JB] is_a: UBERON:0000481 ! multi-tissue structure relationship: part_of AEO:0000194 ! conceptus [Term] id: AEO:0000196 name: larval anatomical structure def: "An anatomical structure present in the larval form of an animal." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure relationship: part_of AEO:0000126 ! larva [Term] id: AEO:0000198 name: antenna def: "A head-associated surface sense organ." [CARO:MAH] is_a: AEO:0000173 ! surface sense organ relationship: part_of AEO:0000106 ! head [Term] id: AEO:0000199 name: mucous membrane def: "A membranous structure with more than one cell type, one or more of which secretes mucus, that lines body passages which communicate with the exterior." [AEO:JB] synonym: "mucosa" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure [Term] id: AEO:0000200 name: regenerating anatomical structure def: "An anatomical structure that, as part of its normal physiology, undergoes regeneration. Examples include endometrium and antlers." [AEO:JB] is_a: UBERON:0000061 ! anatomical structure [Term] id: AEO:0000201 name: afferent nerve def: "A group of neurons that provides a nervous response from a tissue." [AEO:JB] is_a: AEO:0000137 ! nerve is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000526 ! afferent neuron [Term] id: AEO:0000202 name: efferent nerve def: "A group of neurons that provides a nervous signal to a tissue." [AEO:JB] is_a: AEO:0000137 ! nerve is_a: AEO:0000148 ! developing mesenchymal condensation is_a: AEO:0000152 ! migrating mesenchyme population relationship: has_part CL:0000527 ! efferent neuron [Term] id: AEO:0000203 name: syncytium def: "An anatomical entity consisting of a single or a few multinucleated structures." [AEO.:JB] is_a: UBERON:0000479 ! simple tissue relationship: has_part CL:0000228 ! multinucleate cell [Term] id: AEO:0000204 name: pit def: "An roughly circular indentation in a surface." [AEO:JB] is_a: UBERON:0000015 ! anatomical surface [Term] id: AEO:0000205 name: protuberance def: "A roughly circular bulge in a surface." [AEO:JB] is_a: UBERON:0000015 ! anatomical surface [Term] id: AEO:0000206 name: migrating epithelium def: "An epithelium that extends its surface area by peripheral movement." [AEO:JB] is_a: UBERON:0000483 ! epithelium relationship: has_part CARO:0000077 ! epithelial cell [Term] id: AEO:0000207 name: blood vessel def: "An epithelial tube that transports blood." [AEO:JB] is_a: AEO:0000114 ! epithelial tube is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0006914 ! squamous epithelium relationship: has_part CL:0000071 ! blood vessel endothelial cell [Term] id: AEO:0000208 name: artery def: "An epithelial tube that transports blood away from the heart." [AEO:JB] is_a: AEO:0000207 ! blood vessel [Term] id: AEO:0000209 name: vein def: "An epithelial tube that transports blood towards the heart." [AEO:JB] is_a: AEO:0000207 ! blood vessel [Term] id: AEO:0000210 name: row def: "Anatomical group whose component structures are arranged in a row." [DBft:DOS] is_a: UBERON:0000480 ! anatomical group [Term] id: AEO:0000211 name: non-connected developing functional system def: "The sum of all the anlagen and primordia that will develop into a single functional system." [FBbt:DOS] is_a: AEO:0000125 ! developing anatomical structure is_a: UBERON:0000477 ! anatomical cluster [Term] id: AEO:0000212 name: sclerotome def: "The mesenchymal derivative of a somite that will migrate to surround the neural tube and form vertebrae." [AEO:JB] is_a: AEO:0000152 ! migrating mesenchyme population is_a: AEO:0001016 ! developing mesenchymal structure [Term] id: AEO:0000213 name: bone condensation def: "A delimited region of osteoblasts representing the early stages of bone formation." [AEO:JB] is_a: AEO:0000148 ! developing mesenchymal condensation is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part CL:0000062 ! osteoblast relationship: part_of AEO:0000168 ! skeletal system [Term] id: AEO:0000214 name: dermomyotome def: "The bilaminar epithelium formed from the myotome and dermatome." [AEO:JB] is_a: AEO:0000132 ! transitional anatomical structure is_a: UBERON:0000486 ! multilaminar epithelium relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: AEO:0000215 name: open cavity def: "A volume that is mainly bounded but has an opening to another cavity or to the outside." [JB:AEO] is_a: AEO:0000221 ! open anatomical space [Term] id: AEO:0000216 name: epithelial cord def: "A cord of epithelial cells without a lumen and usually several cells thick." [JB:AEO] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000486 ! multilaminar epithelium relationship: has_part CL:0000079 ! stratified epithelial cell [Term] id: AEO:0000217 name: migrating developing tissue def: "A simple coherent tissue or a localized population of similar cells that are actively migrating." [JB:AEO] is_a: AEO:0000125 ! developing anatomical structure [Term] id: AEO:0000218 name: developing epithelial placode def: "A domain of columnar epithelium in an embryo that represents the early stage of the development of the epithelial component of a new anatomical structure." [JB:AEO] is_a: AEO:0001007 ! developing epithelium relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: AEO:0000219 name: vascular plexus def: "A network of interlinked veins." [JB:AEO] is_a: AEO:0000118 ! epithelial plexus is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0006914 ! squamous epithelium relationship: has_part CL:0000071 ! blood vessel endothelial cell [Term] id: AEO:0000220 name: tooth def: "Each of a set of hard, bony enamel-coated structures in the jaws of most vertebrates, used for biting and chewing." [JB:AEO] is_a: UBERON:0000481 ! multi-tissue structure [Term] id: AEO:0000221 name: open anatomical space def: "An anatomical space with at least one opening to another space or the exterior." [JB:AEO] is_a: UBERON:0000464 ! anatomical space [Term] id: AEO:0000222 name: enclosed anatomical space def: "An anatomical space with no opening to another space or to the exterior." [JB:AEO] is_a: UBERON:0000464 ! anatomical space [Term] id: AEO:0000493 name: fat tissue def: "Tissue that is predominantly made of fat cells." [AEO:JB] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000479 ! simple tissue relationship: has_part CL:0000136 ! fat cell [Term] id: AEO:0001000 name: sensory ganglion def: "A ganglion containing sensory neurons." [JB:AEO] is_a: AEO:0000135 ! ganglion is_a: UBERON:0003714 ! neural tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part CL:0000101 ! sensory neuron relationship: has_part CL:0002573 ! Schwann cell [Term] id: AEO:0001001 name: autonomic ganglion def: "A ganglion that is part of the autonomic nervous system." [JB:AEO] is_a: AEO:0000135 ! ganglion is_a: UBERON:0003714 ! neural tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part CL:0000107 ! autonomic neuron relationship: has_part CL:0000526 ! afferent neuron relationship: has_part CL:0000527 ! efferent neuron relationship: has_part CL:0002573 ! Schwann cell [Term] id: AEO:0001002 name: capillary bed def: "A localized group of blood capillaries." [JB:AEO] is_a: AEO:0000118 ! epithelial plexus is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0006914 ! squamous epithelium relationship: has_part CL:0000071 ! blood vessel endothelial cell [Term] id: AEO:0001003 name: acellular extracellular matrix def: "An acellular structure typically composed of collagen, glycoproteins and glycosaminoglycans." [JB:AEO] is_a: UBERON:0000476 ! acellular anatomical structure [Term] id: AEO:0001004 name: fin def: "A flattened appendage on a marine animal." [JB:AEO, VAO:0000099] is_a: AEO:0000193 ! appendage [Term] id: AEO:0001005 name: secretion def: "A non-cellular substance released by a cell, gland or tissue." [JB:AEO] is_a: UBERON:0000463 ! non-tissue substance [Term] id: AEO:0001006 name: excreta def: "Excreta are bodily fluids consisting of waste matter, such as sweat or feces, discharged from the body." [JB:AEO] is_a: UBERON:0000463 ! non-tissue substance [Term] id: AEO:0001007 name: developing epithelium def: "An epithelium within an embryo or larva that is undergoing a major developmental change." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure is_a: UBERON:0000483 ! epithelium [Term] id: AEO:0001008 name: neuroepithelium def: "An embryonic or larval epithelium that is committed to form part of the nervous system." [AEO:JB] is_a: AEO:0001007 ! developing epithelium relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: AEO:0001009 name: proliferating neuroepithelium def: "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." [AEO:JB] is_a: AEO:0001008 ! neuroepithelium [Term] id: AEO:0001010 name: differentiating neuroepithelium def: "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." [AEO:JB] is_a: AEO:0001008 ! neuroepithelium is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000031 ! neuroblast relationship: has_part CL:0000468 ! neuroglioblast [Term] id: AEO:0001011 name: neuronal white matter def: "Neuronal tissue composed predominantly of axons." [AEO:JB] is_a: AEO:0000123 ! neural tissue [Term] id: AEO:0001012 name: neuronal grey matter def: "A neuronal tissue composed predominantly of nerve bodies and neuronal support cells." [AEO:JB] is_a: AEO:0000123 ! neural tissue [Term] id: AEO:0001013 name: neuronal column def: "An extended columnar domain of predominantly neuronal tissue in the central nervous system." [AEO:JB] is_a: AEO:0001012 ! neuronal grey matter is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part CL:0000127 ! astrocyte relationship: has_part CL:0000129 ! microglial cell [Term] id: AEO:0001014 name: differentiating neuronal condensation def: "A compact group of cells differentiating to become a ganglion or a neuronal nucleus." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure relationship: has_part CL:0000031 ! neuroblast relationship: has_part CL:0000468 ! neuroglioblast [Term] id: AEO:0001015 name: somite def: "An epithelial ball that forms from paraxial mesoderm." [JB:AEO] is_a: AEO:0000119 ! epithelial vesicle is_a: AEO:0000132 ! transitional anatomical structure [Term] id: AEO:0001016 name: developing mesenchymal structure def: "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure [Term] id: AEO:0001017 name: dermatome def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." [AEO:JB] is_a: AEO:0000217 ! migrating developing tissue is_a: AEO:0001016 ! developing mesenchymal structure [Term] id: AEO:0001018 name: myotome def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." [AEO:JB] is_a: AEO:0000217 ! migrating developing tissue is_a: AEO:0001016 ! developing mesenchymal structure [Term] id: AEO:0001019 name: developing germ cell population def: "A germ cell population that has not undergone meiosis." [AEO:JB] is_a: AEO:0000125 ! developing anatomical structure [Term] id: AEO:0001020 name: reproductive cell population def: "A population of cells that are predominantly immature or mature germ cells." [AEO:JB] is_a: UBERON:0000479 ! simple tissue relationship: has_part CL:0000586 ! germ cell [Term] id: AEO:0001021 name: stem cell population def: "A group of cells capable of regenerating themselves and also of producing one or more populations of differentiated cells." [AEO:JB] is_a: UBERON:0000479 ! simple tissue [Term] id: AcarDv:0000006 name: aged stage (anolis) namespace: lizard_developmental_stage def: "Lizard developmental stage that refers to a lizard who is over 24 months old." [Bgee:curator] comment: Green anoles can live up to seven years in captivity (see http://genomics.senescence.info/species/entry.php?species=Anolis_carolinensis). We arbitraly consider over 2 years as the starting point for aged stage. This is to improve as far as information is available. is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by UBERON:0018241 ! prime adult stage relationship: only_in_taxon NCBITaxon:28377 relationship: part_of UBERON:0000113 ! post-juvenile adult stage property_value: IAO:0000589 "aged stage (anolis)" xsd:string property_value: start_mph "24.0" xsd:float [Term] id: BFO:0000001 name: entity [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] is_a: BFO:0000001 ! entity relationship: part_of BFO:0000002 ! continuant [Term] id: BFO:0000003 name: occurrent namespace: FlyBase development CV def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] def: "An entity that has temporal parts and that happens, unfolds or develops through time. Sometimes also called perdurants." [BFOC:ANON] is_a: BFO:0000001 ! entity relationship: part_of BFO:0000003 ! occurrent [Term] id: BFO:0000004 name: independent continuant def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." [] is_a: BFO:0000002 ! continuant relationship: part_of BFO:0000004 ! independent continuant [Term] id: BFO:0000015 name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] is_a: BFO:0000003 ! occurrent [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000019 ! quality [Term] id: BFO:0000020 name: specifically dependent continuant def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." [] is_a: BFO:0000002 ! continuant relationship: part_of BFO:0000020 ! specifically dependent continuant [Term] id: BFO:0000030 name: object is_a: BFO:0000040 ! material entity [Term] id: BFO:0000031 name: generically dependent continuant is_a: BFO:0000002 ! continuant relationship: part_of BFO:0000031 ! generically dependent continuant [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant [Term] id: BFO:0000141 is_a: BFO:0000004 ! independent continuant [Term] id: BtauDv:0000006 name: aged stage (cow) namespace: cow_developmental_stage def: "Mature stage that refers to a cow who is over 12 years old, the usual upper limit for breeding age." [Bgee:curator] comment: Cows have been known to live over 20 years. is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by UBERON:0018241 ! prime adult stage relationship: only_in_taxon NCBITaxon:9913 relationship: part_of UBERON:0000113 ! post-juvenile adult stage property_value: IAO:0000589 "aged stage (cow)" xsd:string property_value: start_ypb "12.0" xsd:float [Term] id: CARO:0000003 name: anatomical structure is_a: CARO:0000006 ! material anatomical entity [Term] id: CARO:0000006 name: material anatomical entity is_a: BFO:0000040 ! material entity [Term] id: CARO:0000013 is_a: CL:0000000 ! cell [Term] id: CARO:0000048 name: gonochoristic organism def: "Multi-cellular organism that has male and female sexes." [CARO:MAH] synonym: "monoecious organism" RELATED [] is_a: UBERON:0000468 ! multi-cellular organism [Term] id: CARO:0000049 name: protandrous hermaphroditic organism def: "Sequential hermaphroditic organism that produces gametes first of the male sex, and then later of the female sex." [CARO:MAH] is_a: UBERON:0010895 ! sequential hermaphroditic organism [Term] id: CARO:0000050 name: protogynous hermaphroditic organism def: "Sequential hermaphroditic organism that produces gametes first of the female sex, and then later of the male sex." [CARO:MAH] is_a: UBERON:0010895 ! sequential hermaphroditic organism [Term] id: CARO:0000062 name: cell space def: "Anatomical space that is part of a cell." [CARO:mah] is_a: UBERON:0000464 ! anatomical space [Term] id: CARO:0000063 name: asexual organism def: "Multi-cellular organism that does not produce gametes." [CARO:MAH] is_a: UBERON:0000468 ! multi-cellular organism [Term] id: CARO:0000064 name: single cell organism def: "Cell that is an individual member of a species." [CARO:MAH] is_a: CL:0000003 ! native cell [Term] id: CARO:0000077 name: epithelial cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A.11.436] synonym: "Epitheliocyte" RELATED [] is_a: CL:0000063 ! cell by histology [Term] id: CEPH:0000000 name: eyelid is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000002 name: cephalopod eye is_a: UBERON:0000970 ! eye [Term] id: CEPH:0000004 name: accessory gland complex def: "The glandular complex in cirrates that forms sperm packets and is a counterpart of the spermatophore-forming complex of other cephalopods. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0005399 ! male reproductive gland relationship: only_in_taxon NCBITaxon:61743 ! Cirrata relationship: part_of CEPH:0000063 ! cirrate male reproductive system [Term] id: CEPH:0000005 name: acetabulum def: "A sucker of the sepia or cuttlefish and related animals." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000248 ! sucker [Term] id: CEPH:0000006 name: adult stage def: "A female that has mature eggs (these are frequently stored in the oviducts), or a male that has produced spermatophores (these are stored in Needham's sac)." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000105 ! life cycle stage [Term] id: CEPH:0000009 name: anal flap def: "A small flap on the lateral side of the anus." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "anal valve" EXACT [] is_a: UBERON:0003978 ! valve is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001245 ! anus [Term] id: CEPH:0000011 name: anterior salivary gland def: "Glands on or in the buccal mass that aid in preliminary digestion." [http://tolweb.org/accessory/Cephalopod_Digestive_System?acc_id=1993] is_a: UBERON:0001044 ! saliva-secreting gland relationship: part_of CEPH:0000039 ! buccal mass [Term] id: CEPH:0000012 name: antitragus def: "Knob that projects inward from the posterior surface of the central depression in the funnel locking-apparatus of some squids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000118 ! funnel-mantle locking-apparatus [Term] id: CEPH:0000014 name: areolar spot def: "Circular spots, generally light colored but often with complex pigmentation and of unknown function that occur in lines along the aboral surfaces of some arms and portions of the head in some opisthoteuthid cirrates." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001024 ! spot [Term] id: CEPH:0000015 name: arm def: "One of the circumoral appendages of cephalopods. In decapodiforms each member of the fourth pair of arms is modified to form a tentacle." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "circumoral arm" EXACT [] is_a: CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0000016 name: arm formula def: "The relative sizes of arms arranged according to their length. The largest arm is indicated first and the shortest last. An example arm formula is IV>III=II>I. Here arm IV is the largest, followed by arm III which is the same size as arm II and both are larger than arm I." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001059 ! appendage trait relationship: trait_of CEPH:0000015 ! arm [Term] id: CEPH:0000017 name: arm IV synonym: "ventral arm" RELATED [] is_a: CEPH:0000015 ! arm [Term] id: CEPH:0000018 name: armature of the arms def: "The grappling structures on the oral surfaces the arms and tentacles, including both suckers and hooks. " [http://tolweb.org/accessory/Armature_of_Cephalopod_Arms?acc_id=2018] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0000019 name: a-seriation def: "Type of cusp arrangement on the rachadian tooth of the radula: multiple cusps seem to move laterally when viewing successive rachadian teeth from adjacent rows. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001064 ! head trait [Term] id: CEPH:0000020 name: autotomy plane def: "Plane through an arm of an octopod that is predisposed to break when the arm is autotomized." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000466 ! immaterial anatomical entity [Term] id: CEPH:0000021 name: basal shelf def: "See cirrate shell terminology. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000023 name: beak def: "One of the two chitinous jaws of cephalopods. The dorsal beak is the "upper" beak and it inserts within the lower beak to tear tissue with a sissors-like cutting action." [http://tolweb.org/accessory/Cephalopod_Beak_Terminology?acc_id=1980] synonym: "rostrum" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: has_part CEPH:0000059 ! chitin [Term] id: CEPH:0000024 name: beak step def: "A ridge on the lower beak where the rostral edge merges onto the lateral wall. In most beaks the merger is smooth. This is a characteristic feature of the Onychoteuthidae." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0001026 ! ventral beak [Term] id: CEPH:0000028 name: branchial canal def: "A large opening at the base of each gill lamella and between the primary afferent and efferent blood vessels of the gill. A branchial canal is absent in Nautilus , sepioid decapodiformes and cirrate octopods." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000029 name: brachial crown def: "The combination of arms and tentacles that surround the mouth." [http://tolweb.org/accessory/Cephalopod_Brachial_and_Buccal_Crowns?acc_id=1957] is_a: UBERON:0000477 ! anatomical cluster relationship: surrounds UBERON:0000166 ! oral opening [Term] id: CEPH:0000030 name: brachial lobe of brain def: "The anterior-most part of the brain located ventral to the esophagus. The large axial nerve cords that run down the centers of the arms connect to this lobe. In octopods this lobe is fused with the rest of the subesophageal mass while in decapodiforms and Vampyroteuthis it is separate from the remaining brain." [http://tolweb.org/accessory/Cephalopod_Brain_Terminology?acc_id=1944] synonym: "anterior subesophageal mass" EXACT [] synonym: "anterior subesophageal mass of brain" EXACT [] is_a: CEPH:0000293 ! lobe of brain relationship: part_of CEPH:0000296 ! subesophageal mass of brain relationship: ventral_to UBERON:0001043 ! esophagus [Term] id: CEPH:0000031 name: branchial gland def: "Elongate gland adjacent to and paralleling the gill where the gill attaches to the mantle wall." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002530 ! gland [Term] id: CEPH:0000032 name: branchial heart def: "A pulsating gland at the base of the gill and through which the afferent blood to the gills flows. It contributes to the blood flow through the gill but also is the site of hemocyanin (the blood respiratory pigment) synthesis. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002530 ! gland [Term] id: CEPH:0000033 name: brachial photophore def: "Photophores located on the arms." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000198 ! photophore [Term] id: CEPH:0000034 name: brachial pillar def: "A very narrow and elongate anterior region of the head between the eyes and the base of the brachial crown. A branchial pillar is especially well developed in many young cranchiid squid." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: adjacent_to CEPH:0000029 ! brachial crown [Term] id: CEPH:0000035 name: cephalopod brain def: "Medial portion of the central nervous system. It includes the subesophageal and supraesophageal masses but generally does not include the large optic lobes." [http://tolweb.org/accessory/Cephalopod_Brain_Terminology?acc_id=1944] is_a: UBERON:0000955 ! brain [Term] id: CEPH:0000036 name: brooding def: "Incubation of eggs by the parent. A characteristic feature of incirrate octopods but also found in some squid (e.g., Gonatidae)." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001058 ! reproductive trait [Term] id: CEPH:0000037 name: buccal connective def: "Muscular membrane that runs from the buccal support to the base of the adjacent arm. The position of the connective on the fourth arms was recognized in the early 20th century as an important character in interpreting phylogenetic relationships among decapodiforms." [http://tolweb.org/accessory/Cephalopod_Brachial_and_Buccal_Crowns?acc_id=1957] is_a: UBERON:0000158 ! membranous layer [Term] id: CEPH:0000038 name: buccal crown def: "Umbrella-like structure that surrounds the mouth and is surrounded by the brachial crown. It consists of buccal supports and the buccal membrane. The buccal crown is present in most decapodiforms but absent from all octopodiforms." [http://tolweb.org/accessory/Cephalopod_Brachial_and_Buccal_Crowns?acc_id=1957] is_a: UBERON:0000477 ! anatomical cluster relationship: surrounded_by CEPH:0000029 ! brachial crown relationship: surrounds UBERON:0000166 ! oral opening [Term] id: CEPH:0000039 name: buccal mass def: "Muscular bulb at the beginning of the digestive system that contains the mouth, beaks, radula and various glands." [http://tolweb.org/accessory/Cephalopod_Digestive_System?acc_id=1993] synonym: "buccal system" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0001007 ! digestive system [Term] id: CEPH:0000040 name: buccal membrane def: "The muscular membrane that connects the buccal supports and together with the supports, forms the buccal crown. The pigmentation of the buccal membrane often differs from that of the adjacent oral surfaces of the arms." [http://tolweb.org/accessory/Cephalopod_Brachial_and_Buccal_Crowns?acc_id=1957] is_a: UBERON:0000158 ! membranous layer relationship: part_of CEPH:0000038 ! buccal crown relationship: part_of UBERON:0000033 ! head relationship: surrounds UBERON:0000165 ! mouth [Term] id: CEPH:0000041 name: buccal sucker def: "Small but normal suckers that are present on the oral surface of the buccal supports of some decapodiforms (bathyteuthid families, some loliginids and some sepiids)." [http://tolweb.org/accessory/Cephalopod_Brachial_and_Buccal_Crowns?acc_id=1957] is_a: CEPH:0000248 ! sucker [Term] id: CEPH:0000044 name: bursa copulatrix def: "A spermatophore receptacle found in some sepiolids and consisting of folded glandular epithelium of the lining of the mantle cavity just anterior to the oviduct opening." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001017 ! cephalopod sperm receptacle relationship: part_of UBERON:0006580 ! mantle cavity [Term] id: CEPH:0000045 name: caecal sac def: "The sac-like, thin-walled posterior portion of the caecum that lacks the internal, ciliated leaflets characteristic of the anterior portion of the caecum." [http://tolweb.org/accessory/Cephalopod_Digestive_System?acc_id=1993] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000046 ! caecum [Term] id: CEPH:0000046 name: caecum def: "Region of the digestive tract of all cephalopods between the stomach and intestine. It is the primary site of food absorption." [http://tolweb.org/accessory/Cephalopod_Digestive_System?acc_id=1993] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0001555 ! digestive tract [Term] id: CEPH:0000047 name: calcareous def: "Composed of calcium carbonate (CaCO3)" [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001061 ! shell trait [Term] id: CEPH:0000048 name: calamus def: "The conical papilla of the end-organ of the hectocotylus in many incirrate octopods. It is located at the distal termination of the sperm groove and usually lies adjacent to the last arm sucker." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0003102 ! surface structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure relationship: adjacent_to CEPH:0000248 ! sucker relationship: part_of CEPH:0000098 ! end organ [Term] id: CEPH:0000050 name: cement body def: "Structure in the spermatophore that allows adhesion of the discharged spermatophore to a female." [http://tolweb.org/accessory/Cephalopod_Spermatophore_Terminology?acc_id=1972] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000237 ! spermatophore [Term] id: CEPH:0000051 name: carpal sucker def: "Suckers in the locking apparatus at the base of the club." [http://tolweb.org/accessory/Cephalopod_Tentacle_Terminology?acc_id=1962] is_a: CEPH:0000248 ! sucker relationship: part_of CEPH:0000054 ! carpal locking apparatus [Term] id: CEPH:0000052 name: carpal knob def: "Knobs in the locking apparatus at the base of the club." [http://tolweb.org/accessory/Cephalopod_Tentacle_Terminology?acc_id=1962] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000054 ! carpal locking apparatus [Term] id: CEPH:0000053 name: carpus def: "The region of the tentacle that contains the carpal locking-apparatus " [http://tolweb.org/accessory/Cephalopod_Tentacle_Terminology?acc_id=1962] is_a: CEPH:0000307 ! circumoral appendage segment relationship: part_of CEPH:0000291 ! tentacular club [Term] id: CEPH:0000054 name: carpal locking apparatus def: "The region at the base of the tentacular club which has small suckers and knobs. The carpal suckers and knobs of one tentacle can adhere to their counterparts on the opposite tentacle which, thereby, holds the clubs together at their bases." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "proximal locking-apparatus" EXACT [] is_a: CEPH:0000307 ! circumoral appendage segment relationship: part_of CEPH:0000291 ! tentacular club [Term] id: CEPH:0000055 name: cartilaginous tubercle def: "Rigid cartilagenous spines, with one or several cusps, in the skin of certain squids and octopods." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000270 ! cephalopod tubercule is_a: UBERON:0002418 ! cartilage tissue is_a: UBERON:4100000 ! skeletal element projection [Term] id: CEPH:0000056 name: cephalic cartilage def: "Cartilage surrounding the posterior part of the brain of cephalopods and generally encompasing the statocysts. Anteriorly the cartilage thins into facia making a well-defined limit difficult to establish. The cartilage has a large central foramen through which the esophagus passes and minor foramina for nerves and blood vessels." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002418 ! cartilage tissue relationship: surrounds UBERON:0001043 ! esophagus [Term] id: CEPH:0000057 name: cephalic vein def: "Large vein that drains the head and lies on the ventral surface of the visceral sac, along side or dorsal to the intestine. The cephalic vein terminates by dividing into the two vena cavae, each of which passes through the "kidney" (nephridium), the branchial heart and into the gill." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0001638 ! vein [Term] id: CEPH:0000059 name: chitin def: "A mucopolysaccharide that is the major component of the cuticle (exoskeleton) of arthropods and a major component of the gladius and beaks of cephalopods (also found in many other phyla)." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000463 ! non-tissue substance [Term] id: CEPH:0000061 name: chromatophore def: "A pigment cell. In cephalopods the chromatophore is part of an organ composed of numerous cells including many slender muscle cells. Under nervous control, the muscles rapidly expand and flatten the pigment cell which spreads the pigment over a relatively broad area." [http://tolweb.org/accessory/Cephalopod_Chromatophore?acc_id=2038] is_a: CL:0000147 ! pigment cell [Term] id: CEPH:0000062 name: circularis muscle def: "A circular muscle found in the suckers of most sepioids and loliginids that surrounds the sucker at the base of the horny ring." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0001630 ! muscle organ [Term] id: CEPH:0000063 name: cirrate male reproductive system def: "The male reproductive tract of cirrates does not make typical spermatophores. As a result, the tract differs greatly from that of other coleoid cephalopods. " [http://tolweb.org/accessory/Cirrate_Male_Reproductive_Tract?acc_id=1486] is_a: UBERON:0000079 ! male reproductive system [Term] id: CEPH:0000064 name: cirrate octopod measurements def: "Measurements used in describing cirrates differ somewhat from other cephalopods. " [http://tolweb.org/accessory/Cirrate_Measurements_and_Indices?acc_id=1487] is_a: CEPH:0001065 ! whole organism trait [Term] id: CEPH:0000066 name: arm cirrus def: "Muscular, conical structures that arise from the sides of the arms of some octopodiforms. Cirri are homologous with trabeculae of decapodiforms." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001005 ! cirrus is_a: UBERON:0004253 ! skin muscle intersection_of: CEPH:0001005 ! cirrus intersection_of: part_of CEPH:0000015 ! arm relationship: part_of CEPH:0000015 ! arm [Term] id: CEPH:0000067 name: cephalopod coelom def: "An internal body cavity of mesodermal orgin that is lined by an epithelium. Cephalopods have two coeloms, the visceropericardial coelom and the nephridial coelom." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002323 ! coelemic cavity lumen [Term] id: CEPH:0000068 name: collar def: "Muscular structure extending from the nuchal cartilage to the funnel that forms a one-way valve that lets water enter the mantle cavity but closes as the mantle contracts thereby forcing exhalent water out through the funnel." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0003978 ! valve is_a: UBERON:0006581 ! mantle muscle relationship: part_of UBERON:0006580 ! mantle cavity [Term] id: CEPH:0000069 name: photophore color filter def: "Structures that alter the color of bioluminescent light." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000198 ! photophore [Term] id: CEPH:0000072 name: conus def: "The cup or cone-shaped posterior end of the gladius or cuttlebone of some cephalopods. It is not formed by the infolding of the vanes." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "cone" RELATED [] synonym: "conus flag" NARROW [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000124 ! gladius [Term] id: CEPH:0000073 name: conus field def: "Lateral portions of the gladius that are continuous posteriorly with the primary conus or its remnant and laterally with the edges of the vanes." [http://tolweb.org/accessory/Cephalopod_Gladius_Terminology?acc_id=1955] is_a: UBERON:0000061 ! anatomical structure relationship: continuous_with CEPH:0000072 ! conus relationship: part_of CEPH:0000124 ! gladius [Term] id: CEPH:0000074 name: cornea def: "Smooth, thin, turgid, transparent skin without muscles that covers the eyes to protect the eye lenses of incirrate octopods and some decapodiforms." [http://tolweb.org/accessory/Cephalopod_Cornea?acc_id=2057] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000002 ! cephalopod eye [Term] id: CEPH:0000075 name: counterillumination def: "The production of bioluminescent light by an animal to conceal its silhouette against the downwelling light. The process can allow an aninmal to become virtually invisible under dim directional light." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001062 ! integument trait [Term] id: CEPH:0000076 name: crest of hectocotylus def: "In loliginids a protective membrane on the hectocotylized arm can fuse with the adjacent suckerless papillae (former sucker stalks) to form a crest on the dorsal or ventral margins such that the original form of the papillae is obscured." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: GO:0016020 ! membrane relationship: part_of CEPH:0000130 ! hectocotylus [Term] id: CEPH:0000078 name: crop def: "Expansion (i.e. a broading or a side pocket) of the esophagus for storing food. Present in Nautilus and most octopodiforms." [http://tolweb.org/accessory/Cephalopod_Digestive_System?acc_id=1993] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000061 ! anatomical structure relationship: continuous_with UBERON:0001043 ! esophagus relationship: part_of UBERON:0001555 ! digestive tract [Term] id: CEPH:0000079 name: ctenoglossan radula def: "Radula in which the lateral teeth are multicuspid." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0004289 ! radula [Term] id: CEPH:0000080 name: cupped coil def: "The peculiar posterior end of the histioteuthis gladius that is rolled into a coil." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000124 ! gladius [Term] id: CEPH:0000081 name: cusp def: "A point or projection on a tooth of the radula or on a cartilagenous tubercule in the skin." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000082 name: cuttlebone def: "A calcareous oblong supporting part of the mantle of cuttlefishes" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} synonym: "sepion" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: CEPH:0001007 CEPH:0001008 ! phragmacone [Term] id: CEPH:0000083 name: dactylus def: "The narrow, distal portion of the tentacular club of most decapodiforms. In squids the dactylus is usually characterized by the ventral expansion of the club and the absence of a dorsal protective membrane." [http://tolweb.org/accessory/Cephalopod_Tentacle_Terminology?acc_id=1962] is_a: CEPH:0000307 ! circumoral appendage segment relationship: part_of CEPH:0000291 ! tentacular club [Term] id: CEPH:0000084 name: demersal def: "Living close to the ocean floor." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001060 ! habitat trait [Term] id: CEPH:0000085 name: demibranch def: "A half-gill formed from all the primary gill lamellae on one side of the gill." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000122 ! gill [Term] id: CEPH:0000086 name: diel vertical migration def: "Vertical animal migration during twilight. Many mesopelagic animals migrate at sunrise from near-surface waters to spend the day at greater depths then return to shallow depths at sunset where they spend the night. Some animals migrate vertically over 1000 m others migrate less than 100 m." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001060 ! habitat trait [Term] id: CEPH:0000087 name: digestive gland def: "Primary organ in cephalopods that secretes digestive enzymes. It is also important in absorption and excretion." [http://tolweb.org/accessory/Cephalopod_Digestive_System?acc_id=1993] is_a: UBERON:0003408 ! gland of digestive tract [Term] id: CEPH:0000088 name: digestive gland duct appendages (digda) def: "Outpockets of the ducts leading from the digestive gland that are covered with glandular epithelium." [http://tolweb.org/accessory/Cephalopod_Digestive_System?acc_id=1993] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000061 ! anatomical structure relationship: continuous_with CEPH:0000087 ! digestive gland relationship: has_part UBERON:0006799 ! glandular epithelium relationship: part_of UBERON:0001555 ! digestive tract [Term] id: CEPH:0000090 name: distal oviduct def: "An extension of the oviducal gland in octopods that often has the same general appearance as the oviduct proximal to the oviducal gland." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000993 ! oviduct relationship: continuous_with CEPH:0000193 ! oviducal gland [Term] id: CEPH:0000091 name: doratopsis stage def: "Peculiar paralarval stage of the Chiroteuthidae. The paralarva is very slender and can reach a large size." [http://tolweb.org/accessory/Chiroteuthid_Doratopsis_Stage?acc_id=656] synonym: "doratopsis" RELATED [] is_a: CEPH:0000194 ! paralarval stage [Term] id: CEPH:0000093 name: dorsal mantle cavity def: "Dorsal portion of the mantle cavity that completely surrounds the viscera in octopods. In decapodiforms and Vampyroteuthis the viscera are fused to the mantle and shell dorsally and the mantle cavity lies lateral and ventral to the viscera. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002553 ! anatomical cavity relationship: part_of UBERON:0006580 ! mantle cavity [Term] id: CEPH:0000094 name: efferent vein def: "vein carrying blood away from an organ." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0001638 ! vein [Term] id: CEPH:0000095 name: efferent nerve def: "nerve carring impulses away from the brain or specific ganglia." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0001021 ! nerve [Term] id: CEPH:0000096 name: egg mass def: "A large number of eggs encapsulated in a gelatinous matrix or a large number of such structures that are attached together. The egg mass of an oceanic squid can be a large, fragile gelatinous ball carrying many thousands of eggs. In contrast, the egg mass of a neritic squid (loliginid) can be composed of very tough capsules each carrying several hundred eggs with many capsules attached together at their bases and to the substrate to form an egg mass." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "egg case" RELATED [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: CEPH:0000097 name: ejaculatory apparatus def: "Portion of the spermatophore involved in the eversion of the sperm mass." [http://tolweb.org/accessory/Cephalopod_Spermatophore_Terminology?acc_id=1972] is_a: UBERON:0005156 ! reproductive structure relationship: part_of CEPH:0000237 ! spermatophore [Term] id: CEPH:0000098 name: end organ def: "The tip of the hectocotylus in incirrate octopods consisting of a calamus and ligula presumably for manipulating the spermatophore during copulation." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "end organ of hectocotylus" EXACT [] synonym: "terminal organ" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure relationship: part_of CEPH:0000130 ! hectocotylus [Term] id: CEPH:0000100 name: epithelial pigmentation def: "The pigmentation that is contained in epithelial cells which are unable to change their shape. Color in most cephalopods, however, is due to pigment granules that are contained in specialized organs, the chromatophore organs, that can change shape rapidly under nervous control. See chromatophores." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001062 ! integument trait [Term] id: CEPH:0000102 name: eye pore def: "Small pore just anterior to the cornea in some decapodiforms. The pore is the remnant of the large eye opening of oegopsids and connects fluid between the lens and the cornea with the exterior environment." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: adjacent_to CEPH:0000002 ! cephalopod eye [Term] id: CEPH:0000104 name: eyelid sinus def: "Indentation, often complex, of the anterior margin of the eyelid. " [http://tolweb.org/accessory/Cephalopod_Eyelid_Sinus?acc_id=1994] synonym: "optic sinus" EXACT [] synonym: "orbital sinus" EXACT [] is_a: UBERON:0003102 ! surface structure relationship: part_of CEPH:0000000 ! eyelid [Term] id: CEPH:0000105 name: fin angle def: "The angle between the longitudinal axis of the mantle and the posterior border of one fin." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001063 ! fin trait [Term] id: CEPH:0000106 name: fin attachment def: "A fin attaches to the shell, the mantle, the opposite fin or some combination of these. " [http://tolweb.org/accessory/Cephalopod_Fin_Attachment?acc_id=1974] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000112 ! fin [Term] id: CEPH:0000107 name: fin cartilage def: "Cartilage associated with the fins of all fin-bearing cephalopods. " [http://tolweb.org/accessory/Cephalopoda_Fin_Cartilage?acc_id=1969] is_a: UBERON:0002418 ! cartilage tissue relationship: part_of CEPH:0000112 ! fin [Term] id: CEPH:0000108 name: fin length def: "This measurement varies in different major taxa. " [http://tolweb.org/accessory/Cephalopod_Fin_Length?acc_id=2055] is_a: CEPH:0001063 ! fin trait [Term] id: CEPH:0000109 name: fin lobe def: "The portion of a fin that extends anteriorly from the fin's anterior point of attachment or posteriorly from the fin's posterior point of attachment. This is often called the "free" lobe." [http://tolweb.org/accessory/Composite_Squid?acc_id=1936] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000112 ! fin [Term] id: CEPH:0000110 name: fin position def: "Fins are located anterior to the termination of the muscular mantle (subterminal position) or mostly posterior to it (terminal position) or somewhere inbetween. " [http://tolweb.org/accessory/Cephalopod_Fin_Position?acc_id=2041] is_a: CEPH:0001063 ! fin trait [Term] id: CEPH:0000111 name: fin shape def: "Fins are classified, somewhat arbitrarily, by their shape as Sagittate, Rhomboid, Circular/Elliptical, Lanceolate, Ear-shaped, Ribbed, Lobate or skirt-like. " [http://tolweb.org/accessory/Decapodiform_Fin_Shapes?acc_id=2029] is_a: CEPH:0001063 ! fin trait [Term] id: CEPH:0000112 name: fin def: "A muscular flap that arises along the lateral or dorsolateral surface of the mantle of some cephalopods. Used for locomotion, steering and stabilization" [] is_a: UBERON:0003102 ! surface structure relationship: capable_of GO:0040011 ! locomotion [Term] id: CEPH:0000114 name: foveola def: "Transverse membranous fold of skin that forms a pocket in the funnel groove of ommastrephid squids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0013754 ! integumentary system layer relationship: part_of CEPH:0000117 ! funnel groove [Term] id: CEPH:0000115 name: obsolete free fin lobe def: "The portion of a fin that extends anteriorly from the fin's anterior point of attachment or posteriorly from the fin's posterior point of attachment." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_obsolete: true [Term] id: CEPH:0000116 name: funnel def: "The ventral, muscular tube through which water is expelled from the mantle cavity. The funnel is thought to have evolved from the molluscan foot." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "hyponome" RELATED [] synonym: "siphon" EXACT [] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000025 ! tube relationship: continuous_with UBERON:0006580 ! mantle cavity relationship: has_part UBERON:0001630 ! muscle organ [Term] id: CEPH:0000117 name: funnel groove def: "Depression on the posteroventral surface of the head in which the funnel lies. Most distinct in some squids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0003102 ! surface structure relationship: part_of CEPH:0000116 ! funnel [Term] id: CEPH:0000118 name: funnel-mantle locking-apparatus def: "The funnel component (generally cartilagenous) of a locking mechanism between the funnel and mantle. This lock, depending on its form, can either limit all movement between the funnel and mantle or allow just anterior-posterior slipping. See Mantle locking-apparatus." [http://tolweb.org/accessory/Cephalopod_Funnel_Locking-Apparatus?acc_id=1973] synonym: "funnel locking apparatus" EXACT [] synonym: "funnel locking-cartilage" RELATED [] is_a: UBERON:0002418 ! cartilage tissue relationship: part_of CEPH:0000116 ! funnel [Term] id: CEPH:0000119 name: funnel organ def: "The glandular structures on the internal dorsal and ventral surfaces of the funnel." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000062 ! organ relationship: part_of CEPH:0000116 ! funnel [Term] id: CEPH:0000120 name: funnel retractor muscle def: "Large muscles that attach to the corners of the funnel and run posteriorly to attach to the sides of the shell sac (generally near the base of the gills) or, in a some species, insert on the mantle wall." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0001630 ! muscle organ relationship: part_of CEPH:0000116 ! funnel [Term] id: CEPH:0000121 name: funnel valve def: "Semicircular muscular flap extending from and continuous with the posterodorsal funnel wall. The funnel valve apparently acts as a one-way valve to prevent inspiration of water through the funnel when mantle expansion draws in water to pass over the gills for respiration. A funnel valve in absent in octopods and some squids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0003978 ! valve intersection_of: UBERON:0003978 ! valve intersection_of: part_of CEPH:0000116 ! funnel relationship: part_of CEPH:0000116 ! funnel relationship: part_of UBERON:0002204 ! musculoskeletal system [Term] id: CEPH:0000122 name: gill def: "Primary organ for the exchange of respiratory gases between blood and sea water." [http://tolweb.org/articles/?article_id=4200] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000123 name: gill lamella def: "A complex gill leaflet that extends perpendicular to the axis of the gill and contains the respiratory epithelium. The lamella contains further subdivisions, the secondary and tertiary lamellae. In octopods the number of lamellae is a taxonomic character." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "gill lamellae" RELATED [] synonym: "primary lamella" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000122 ! gill [Term] id: CEPH:0000124 name: gladius def: "The chitinous remnant of the shell in many decapodiforms and Vampyroteuthis. It is generally feather-shaped and lies in the dorsal mid-line of the body along the full length of the mantle. The gladius lies within the shell sac which secretes it." [http://tolweb.org/accessory/Cephalopod_Gladius_Terminology?acc_id=1955] synonym: "gladii" RELATED [] synonym: "internal gladius" NARROW [] synonym: "pen" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: CEPH:0001007 UBERON:0006612 {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} ! shell relationship: has_part CEPH:0000059 ! chitin [Term] id: CEPH:0000126 name: half-orange gill def: "Gills of some cirrate octopods with broad primary lamellae whose arrangement looks similar to half of an orange. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000122 ! gill [Term] id: CEPH:0000127 name: hatchling stage def: "Young cephalopod that has just hatched from the egg." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "hatchling" RELATED [] is_a: UBERON:0000105 ! life cycle stage [Term] id: CEPH:0000129 name: head-mantle fusion def: "." [http://tolweb.org/accessory/Cephalopod_Dorsal_Head-Mantle_Fusion?acc_id=2020] is_a: CEPH:0001064 ! head trait is_a: CEPH:0001065 ! whole organism trait relationship: trait_of UBERON:0006575 ! mantle [Term] id: CEPH:0000130 name: hectocotylus def: "The modified arm in males used for transferring spermatophores to the female. In incirrates the hectocotylus is one member of arm pair III while in decapodiforms frequently one or both members of arm pair IV are modified. Many species of coleoid cephalopods lack a hectocotylus." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587, Wikipedia:Hectocotylus] synonym: "hectoctylized arm" EXACT [] is_a: CEPH:0000015 ! arm is_a: UBERON:0008811 {source="Wikipedia"} ! intromittent organ [Term] id: CEPH:0000131 name: heterodont radula def: "Radula with more than one cusp on the rhachidian tooth and, usually, the first lateral tooth." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0004289 ! radula [Term] id: CEPH:0000132 name: homodont radula def: "Radula with a single cusp on all teeth." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0004289 ! radula [Term] id: CEPH:0000133 name: obsolete holotype def: "The single specimen designated to represent a species name. It is an international standard of reference that provides objectivity for the species name." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_obsolete: true [Term] id: CEPH:0000134 name: hook def: "Horny structure that looks like a single claw and is derived from the inner sucker ring in some decapodiforms. Hooks may be found on the arms and/or tentacular clubs of squid. The relative advantage of hooks vs toothed rings is uncertain." [http://tolweb.org/accessory/Cephalopod_Hooks?acc_id=1983] is_a: UBERON:0000061 ! anatomical structure relationship: has_part CEPH:0000059 ! chitin relationship: part_of CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0000135 name: horizontal arm septum def: "Septa, extending the length of the arm (i.e., parallel to the arm axis), that roughly divides the arm into oral and aboral regions. This feature is a characteristic of the arms of cirrate octopods and the incirrate octopods of the family Bolitaenidae. The functional significance is unknown." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001027 ! septum relationship: part_of CEPH:0000015 ! arm [Term] id: CEPH:0000136 name: sucker ring def: "A chitinous ring that encircles a sucker. Found in cuttlefishes and squids" [] synonym: "horny ring of sucker" NARROW [] is_a: UBERON:0000061 ! anatomical structure relationship: surrounds CEPH:0000248 ! sucker [Term] id: CEPH:0000137 name: inferior frontal lobe system def: "A system of lobes in octopod brains: the paired posterior buccal, lateral inferior frontal and subfrontal lobes, and the single median inferior frontal lobe. They form a functional unit concerned with the chemotactile information from the arms and its use." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of CEPH:0000035 ! cephalopod brain [Term] id: CEPH:0000138 name: infundibilum def: "Exposed flat outer ring that forms the adhesive surface of the sucker" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0003102 ! surface structure relationship: part_of CEPH:0000248 ! sucker [Term] id: CEPH:0000139 name: ink sac def: "Organ composed of a gland that secretes ink, a sac that stores ink and a duct that connects it to the rectum. The ink sac generally appears black from the outside although it may be covered by silvery tissue in some species." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: secretes CEPH:0000285 ! ink relationship: secretes CEPH:0000285 ! ink [Term] id: CEPH:0000144 name: jet propulsion def: "This is the typical method of fast swimming in cephalopods. During jet propulsion, water is taken into the mantle cavity by expansion of the mantle. Water enters laterally at the sides of the head, passes over the collar, over the gills and leaves through the funnel when the mantle contracts. Mantle contraction causes water pressure in the mantle cavity to increase and forces the collar against the mantle wall. The collar, therefore, acts as a one-way valve to prevents water from leaving by the same route that it entered. The ventral wall of the funnel presses against the mantle during mantle contraction and seals that opening as well. Water, therefore, is forced through the funnel and out the funnel orifice. The force provided by the water leaving the funnel can be directed by movements of the funnel. Typically the water leaves the funnel anteriorly causing the cephalopod to jet backward (e.g. when escaping a predator) or the funnel is directed posteriorly causing the water to leave posteriorly and the animal to jet anteriorly (e.g. when pouncing on a prey). Some species are able to glide via this method." [http://tolweb.org/accessory/Cephalopod_Jet_Propulsion?acc_id=2060, Wikipedia:Ommastrephidae] is_a: GO:0040011 ! locomotion [Term] id: CEPH:0000145 name: keel def: "A muscular vane that extends dorsally from the aboral surface of the tentacular club of many species." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "club" RELATED [] synonym: "swimming membrane" NARROW [] is_a: CEPH:0000271 ! gladius vane relationship: part_of CEPH:0000291 ! tentacular club [Term] id: CEPH:0000147 name: lateral funnel adductor muscle def: "Muscles that support the lateral attachment of the funnel to the head. " [http://tolweb.org/accessory/Cephalopod_Lateral_Funnel_Adductor?acc_id=1963] is_a: UBERON:0000952 ! obsolete adductor muscle [Term] id: CEPH:0000148 name: lateral membrane of arm IV def: "The keels of arms IV are offset laterally and often enlarged to fully or partially conceal, protect or encase the adjacent tentacles. The latter function is most fully developed in the chiroteuthids and mastigoteuthids." [http://tolweb.org/accessory/Cephalopod_Brachial_and_Buccal_Crowns?acc_id=1957] synonym: "tentacular sheath" EXACT [http://tolweb.org/accessory/Cephalopod_Brachial_and_Buccal_Crowns?acc_id=1957] is_a: UBERON:0000158 ! membranous layer relationship: part_of CEPH:0000017 ! arm IV [Term] id: CEPH:0000149 name: lateral-line analogue def: "Sensory structure analogous to the lateral-line of fishes. The lateral-line analogue, which senses vibrations transmitted by the seawater, is located along a series of lines on the dorsal surface of the head with some sensory cells extending onto the bases of the arms." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000467 ! anatomical system [Term] id: CEPH:0000150 name: photophore lens def: "Structure in a photophore that can focus or disperse bioluminescent light." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000198 ! photophore [Term] id: CEPH:0000152 name: light guides def: "Structures in a photophores that direct light via internal reflection." [http://tolweb.org/accessory/Cephalopod_Photophore_Terminology?acc_id=2015] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000198 ! photophore [Term] id: CEPH:0000153 name: ligula def: "The portion of the sucker-free end-organ of the hectocotylus of many incirrate octopods that is generally elongate and longitudinally grooved. The ligula in octopodids is often spatulate in shape with transverse ridges. Spermatophores transferred along the sperm groove of the hectocotylus presumably enter the ligula which assists in their transfer to the female. Details of the use of the ligula are unknown." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0003102 ! surface structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure relationship: part_of CEPH:0000098 ! end organ [Term] id: CEPH:0000154 name: lip def: "Two concentric muscular, glandular rings of skin that surround the mouth and beaks." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0004253 ! skin muscle relationship: part_of UBERON:0002199 ! integument relationship: surrounds UBERON:0000166 ! oral opening [Term] id: CEPH:0000155 name: living chamber def: "Largest and most recently formed chamber of the Nautilus shell (also refers to numerous shells of fossil cephalopods) in which the animal resides." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001045 ! shell chamber [Term] id: CEPH:0000156 name: locking-apparatus of tentacular stalk def: "Continuation of the carpal locking apparatus down the oral face of the tentacular stalk. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000159 name: mantle locking-apparatus def: "The mantle component (usually fibrous) of the structure that "locks" the mantle to the funnel. This lock, depending on its form, can either restrict all movement between the funnel and mantle or allow just an anterior/posterior slippage." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "mantle locking cartilage" EXACT [] is_a: UBERON:0002418 ! cartilage tissue [Term] id: CEPH:0000160 name: mantle length def: "(ML) - The standard measure of length in coleoid cephalopods. In decapodiforms ML is measured along the dorsal midline from the mantle margin to the posterior tip of the body, excluding long tails. In octopodiforms ML is measured from a line joining the midpoint of the eyes rather than the anterior mantle margin since the latter is obscured by the head/mantle fusion." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001065 ! whole organism trait relationship: trait_of UBERON:0006575 ! mantle [Term] id: CEPH:0000161 name: mantle septum def: "A anteroposterior septum that connects the mantle wall with the visceral sac along the midline in the ventral mantle cavity. The ventral mantle artery runs along the anterior end of this septum. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "abdominal septum" EXACT [] is_a: CEPH:0001027 ! septum relationship: part_of UBERON:0006575 ! mantle [Term] id: CEPH:0000162 name: manus of tentacular club def: "The proximal, broad portion of the tentacular club. In squids the manus is generally equally expanded on both lateral margins and often includes enlarged suckers." [http://tolweb.org/accessory/Cephalopod_Tentacle_Terminology?acc_id=1962] synonym: "manus" BROAD [] is_a: CEPH:0000307 ! circumoral appendage segment relationship: part_of CEPH:0000291 ! tentacular club [Term] id: CEPH:0000163 name: mature stage def: "In cephalopods this term refers to sexual maturity which is determined for females by the presence of ova (mature eggs) free in the coelom or oviducts, and for males by the presence of spermatophores in Needham's sac." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000105 ! life cycle stage [Term] id: CEPH:0000169 name: molluscan foot def: "A major structure in molluscan morphology. In gastropods the foot is the muscular sole that the animal crawls with. In cephalopods the funnel, and possibly the arms and tentacles are derived from the molluscan foot. The evolutionary origin of the latter is still uncertain. They may represent outgrowths of the head (favored by anatomical evidence: nerve connections) or modifications of the molluscan foot that have migrated around the mouth (favored by embryological evidence: migration of arm primordia)." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "foot" BROAD [] is_a: UBERON:0000475 ! organism subdivision [Term] id: CEPH:0000170 name: neck def: "The region separating the posterior end of the cephalic cartilage and the collar. Only those cephalopods with elongate heads (e.g., chiroteuthids) have distinct necks." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000475 ! organism subdivision [Term] id: CEPH:0000171 name: Needham's sac def: "In males, the large storage sac for spermatophores that is an expanded region of the genital duct at the base of the penis." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "spermatophore sac" EXACT [] synonym: "spermatophoric sac" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure relationship: has_part CEPH:0000237 ! spermatophore relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: CEPH:0000172 name: nephridial coelom def: "The cavity of the renal sac. It connects with the exterior via the renal pore and with the visceropericardial coelom via a pair of slender ducts from the latter." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000067 ! cephalopod coelom relationship: part_of CEPH:0001037 ! renal sac [Term] id: CEPH:0000175 name: nidamental gland def: "Large glandular structures found in decapodiforms and Nautilus that lie in and open directly into the mantle cavity. The glands are composed of numerous lamellae that are involved in secretion of egg cases or the jelly of egg masses." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002530 ! gland relationship: located_in UBERON:0006580 ! mantle cavity [Term] id: CEPH:0000176 name: nuchal cartilage def: "An oblong cartilaginou plate on the posterodorsal surface of the head of most squids and cuttlefishes that articulates with a complementary structure on the inner surface of the anterodorsal surface of the mantle" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0002418 ! cartilage tissue relationship: part_of CEPH:0000180 ! nuchal region [Term] id: CEPH:0000177 name: nuchal crest def: "See Occipital crest." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000180 ! nuchal region [Term] id: CEPH:0000178 name: nuchal membrane def: "See occipital membrane." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000180 ! nuchal region [Term] id: CEPH:0000179 name: nuchal organ def: "Small sensory organ with photoreceptor-like sensory cells that is located in the nuchal region of, apparently, all coleoid cephalopods." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000062 ! organ relationship: part_of CEPH:0000180 ! nuchal region [Term] id: CEPH:0000180 name: nuchal region def: "The posterodorsal region of the head and the area immediately posterior to it. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000475 ! organism subdivision [Term] id: CEPH:0000181 name: occipital crest def: "Prominent transverse ridge in most decapodiforms that extends across the dorsal and along the lateral surfaces of the head at its posterior end." [http://tolweb.org/accessory/Cephalopod_Occipital_Region_Terminology?acc_id=1970] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000182 name: occipital fold def: "Fixed folds of the head integument that adjoin the nuchal crest posteriorly and are perpendicular to it. The function of the folds is uncertain." [http://tolweb.org/accessory/Cephalopod_Occipital_Region_Terminology?acc_id=1970] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0002199 ! integument [Term] id: CEPH:0000183 name: occipital membrane def: "A membrane connecting the main occipital folds at their posterior ends." [http://tolweb.org/accessory/Cephalopod_Occipital_Region_Terminology?acc_id=1970] is_a: UBERON:0000158 ! membranous layer [Term] id: CEPH:0000184 name: cephalopod olfactory organ def: "A chemosensory organ present on the head or neck in all coleoid cephalopods. The olfactory organ is thought to be the homologue of the rhinophore of Nautilus." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "rhinophore" RELATED [] is_a: UBERON:0002268 ! olfactory organ [Term] id: CEPH:0000185 name: ontogenetic descent def: "The progressively descent into a deeper-water habitat as a cephalopod grows older and larger. This distribution pattern is a particularly common in many pelagic cranchiid squids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001060 ! habitat trait [Term] id: CEPH:0000187 name: optic lobe of brain def: "Large lobes of the brain associated with the eyes. In octopods and some squids the optic lobes may be separated from the rest of the brain by an optic stalk of varying length. In Octopus the optic lobes contain 92 million cells compared with only 42 million in the main central mass of the brain (J. Young, 1963)." [http://tolweb.org/accessory/Cephalopod_Brain_Terminology?acc_id=1944] synonym: "optic lobe" EXACT [] is_a: CEPH:0000294 ! lobe of nervous system [Term] id: CEPH:0000191 name: outer statocyst capsule def: "Capsule in octopodiforms that is embedded in the cephalic cartilage and contains the statocyst capsule." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000056 ! cephalic cartilage [Term] id: CEPH:0000193 name: oviducal gland def: "Gland surrounding the end of the primary oviduct and responsible for secreting some of the external coatings over spawned eggs or, in incirrates, the cement at the base of the chorion stalk . In octopods it also acts as a spermatheca, and is located around the apparent middle of the oviduct. However, the "distal oviduct" is actually an extension of the oviducal gland. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002530 ! gland relationship: surrounds CEPH:0000286 ! primary oviduct [Term] id: CEPH:0000194 name: paralarval stage def: "First free-living, cephalopod life-history stage that is found in the near-surface plankton and that differs in both morphology and vertical distribution from older juveniles." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000105 ! life cycle stage [Term] id: CEPH:0000196 name: cephalopod penis def: "The long, muscular end of the male gonoduct that assists in transfering spermatophores to the female. Apparently, in species with a hectocotylus, the penis transfers spermatophores to the hectocotylus which in turn transfers them to the female. In species without a hectocotylus, the penis is often greatly elongate, capable of extending beyond the mantle cavity and can, apparently, transfer spermatophores directly to the female." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "terminal organ" BROAD octopoda [] {http://purl.org/dc/elements/1.1/source="http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587"} is_a: UBERON:0008811 {source="Wikipedia"} ! intromittent organ [Term] id: CEPH:0000197 name: photocyte def: "Cells in photophores that produce bioluminsecence." [http://tolweb.org/accessory/Cephalopod_Photophore_Terminology?acc_id=2015] is_a: BFO:0000002 ! continuant is_a: CL:0000000 ! cell relationship: part_of CEPH:0000198 ! photophore [Term] id: CEPH:0000198 name: photophore def: "Organ that produces bioluminescence or "living light." Photophores are often complex with various color filters, reflectors, light guides, lenses and chromatophores surrounding the site of light production, the photogenic region. The name of specific photophores often reflects their position on the animal. For example, the branchial photophore is at the base of the gill, the anal photophore lies at the side of the anus." [http://tolweb.org/accessory/Cephalopod_Photophore_Terminology?acc_id=2015] synonym: "light organ" EXACT [] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: capable_of GO:0008218 ! bioluminescence relationship: capable_of GO:0008218 ! bioluminescence [Term] id: CEPH:0000199 name: photophore location def: "Photophores are found in nearly any location in some squid. However, certain locations are the most common. " [http://tolweb.org/accessory/Cephalopod_Photophore_Locations?acc_id=1981] is_a: CEPH:0001062 ! integument trait relationship: trait_of CEPH:0000198 ! photophore [Term] id: CEPH:0000200 name: photosensitive vesicle def: "Non-image forming light-receptive organs located inside the cephalic cartilage in squid and on the stellate ganglion in octopods. They perform a variety of function." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000062 ! organ relationship: capable_of GO:0009584 ! detection of visible light [Term] id: CEPH:0000204 name: posterior buccal lobe def: "A fused pair of lobes that are the anterior-most lobes of the supraesophageal mass of the brain of decapodiforms but is incorporated into the anterior portion of the supraesophageal mass behind the superior buccal lobes in most octopodiforms. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "inferior frontal lobe" EXACT squid [] is_a: CEPH:0000295 ! buccal lobe [Term] id: CEPH:0000205 name: posterior lip gland def: "Large glands surrounding the buccal mass just posterior to the lips. They are especially well-developed in stauroteuthid cirrates." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002530 ! gland relationship: surrounds CEPH:0000039 ! buccal mass [Term] id: CEPH:0000206 name: posterior salivary gland def: "Glands generally located just posterior to the head whose secretion travels via a duct into the buccal mass." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0001044 ! saliva-secreting gland [Term] id: CEPH:0000207 name: primary conus is_a: CEPH:0000072 ! conus [Term] id: CEPH:0000208 name: protective membrane def: "A thin fold of integument along lateral angles of oral surface of arms and clubs lateral to suckers usually supported by trabeculae" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0000158 ! membranous layer relationship: part_of CEPH:0000291 ! tentacular club [Term] id: CEPH:0000210 name: proximal and distal fields def: "Some male opisthoteuthid cirrates have enlarged suckers located proximally on the arms (proximal fields) and/or distally on the arms (distal fields)." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0003102 ! surface structure [Term] id: CEPH:0000211 name: pseudomorph def: "A mass of ink and mucous that roughly has the dimensions of the cephalopod that secreted it. " [http://tolweb.org/accessory/Cephalopod_Pseudomorph_Function?acc_id=1964] is_a: UBERON:0000463 ! non-tissue substance relationship: has_part CEPH:0000285 ! ink [Term] id: CEPH:0000212 name: obsolete recent def: "Refers to an organism that is living or has lived within the past 10,000 years or to object formed or events within the past 10,000 years." [http://tolweb.org/accessory/Geological_Timescale?acc_id=1987] is_obsolete: true [Term] id: CEPH:0000213 name: photophore reflector def: "Structures in a photophore that reflects bioluminscence." [http://tolweb.org/accessory/Cephalopod_Photophore_Terminology?acc_id=2015] is_a: UBERON:0000476 ! acellular anatomical structure relationship: part_of CEPH:0000198 ! photophore [Term] id: CEPH:0000214 name: cephalopod radula def: "A toothed ribbon that lies in the buccal mass and that aids in movement of food into the esophagus." [http://tolweb.org/accessory/Cephalopod_Radula?acc_id=2035] is_a: UBERON:0004289 ! radula is_a: UBERON:0013765 ! digestive system element relationship: part_of CEPH:0000039 ! buccal mass [Term] id: CEPH:0000215 name: renal appendage def: "Structures that form the nephridium (=kidney). The renal appendages are outpocketings of the veins within the renal sac (primarily the venae cavae) that are covered with renal epithelium. The The renal sac communicates with the mantle cavity via the nephridial pore." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "kidney" RELATED [] synonym: "nephridium" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0001037 ! renal sac [Term] id: CEPH:0000216 name: rachis def: "Central axis of the gladius, often thickened, that typically extends the full length of the gladius and sometimes called the median field." [http://tolweb.org/accessory/Cephalopod_Gladius_Terminology?acc_id=1955] synonym: "median field" RELATED [] synonym: "rhachis" EXACT [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000124 ! gladius [Term] id: CEPH:0000217 name: rostrum def: "Portion of the gladius that extends posteriorly or posterodorsally from the conus. A distnct rostrum is found only in the Onychoteuthidae, Ancistrocheiridae, Lampadioteuthinae and Vampyroteuthidae. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "gladius" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of CEPH:0000124 ! gladius [Term] id: CEPH:0000218 name: saddle def: "The region of the shell of cirrates connecting the lateral wings. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0006612 ! shell [Term] id: CEPH:0000219 name: saddle-shaped def: "The shape of the shell with an elongate central region (saddle proper) and broad wings found in cirroteuthid cirrates." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001061 ! shell trait is_a: CEPH:0001065 ! whole organism trait relationship: trait_of CEPH:0000218 ! saddle [Term] id: CEPH:0000220 name: sagittate fin def: "The most common fin-shape in squids with anterior free fin-lobes, a relatively sharp lateral angle and posterior elongation. See fin shapes. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000112 ! fin [Term] id: CEPH:0000221 name: scales and tubercule def: "The skin of the mantle contains scales, tubercules and warts in various species. " [http://tolweb.org/accessory/Cephalopod_Mantle_Armature?acc_id=1997] is_a: UBERON:0003102 ! surface structure [Term] id: CEPH:0000222 name: secondary conus def: "A conical region at the posterior end of the gladius that is formed by an inrolling and fusion of the vanes. The ventral line of fusion is usually apparent. The secondary conus may be rather short or over half the gladius length." [http://tolweb.org/accessory/Cephalopod_Gladius_Terminology?acc_id=1955] is_a: CEPH:0000072 ! conus [Term] id: CEPH:0000223 name: secondary eyelid def: "An eyelid that covers the ventral part of the cornea. " [http://tolweb.org/accessory/Cephalopod_Secondary_Eyelid?acc_id=1976] synonym: "secondary fold" RELATED [] is_a: CEPH:0000000 ! eyelid [Term] id: CEPH:0000224 name: secondary fin def: "A non-muscular fin-shaped structure found in some chiroteuthids, located posterior to the true or primary fin. The secondary fin may act as a buoyancy organ." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000112 ! fin [Term] id: CEPH:0000225 name: secondary web def: "Web that extends from each arm to the primary web in some incirrate octopods. Separation of the arm from the primary web seems to be associated with feeding and/or defense (bell and baloon balloon postures) but the function is not well understood." [http://tolweb.org/accessory/Cephalopod_Primary_and_Secondary_Webs?acc_id=1696] is_a: CEPH:0000280 ! web [Term] id: CEPH:0000226 name: semelparous def: "A reproductive strategy in which females spawn once then die. Sometimes called terminal or "big-bang" spawners. Many cephalopods are semelparous but many are not." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001058 ! reproductive trait [Term] id: CEPH:0000227 name: semicrescent plate def: "(arm suckers) - A semicrescent plate on the proximal margin of the inner sucker arm rings of the loliginid squid Uroteuthis." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0001020 ! inner sucker ring [Term] id: CEPH:0000228 name: sepioid gill def: "Gills of some cirrate octopods that look superficially like gills of sepioids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000122 ! gill [Term] id: CEPH:0000229 name: shell sac def: "The sac that secretes the shell in the Coleoidea. The sac is composed of ectodermal epithelium that invaginates during embryonic development to form an internal sac." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: secretes UBERON:0006612 ! shell [Term] id: CEPH:0000230 name: side pocket def: "Pockets formed by small membranous folds of integument lateral to the foveola in the funnel groove in ommastrephid and thysanoteuthid squids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0003102 ! surface structure relationship: part_of CEPH:0000117 ! funnel groove [Term] id: CEPH:0000232 name: siphuncle def: "The tube-like extension of the body wall, coelom and an external covering tube that penetrates the phragmocone and regulates gas exchange into the phragmocone chambers." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000025 ! tube relationship: part_of CEPH:0001008 ! phragmacone [Term] id: CEPH:0000234 name: sperm mass def: "The coiled rope of sperm that lies within the spermatophore or spermatangia." [http://tolweb.org/accessory/Cephalopod_Spermatophore_Terminology?acc_id=1972] synonym: "rope of sperm" RELATED [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of CEPH:0000237 ! spermatophore [Term] id: CEPH:0000235 name: spermatangia def: "Discharged spermatophore which consists of the sperm mass surrounded by a membrane (the inner tunic) with the cement gland at one end." [http://tolweb.org/accessory/Cephalopod_Spermatophore_Terminology?acc_id=1972] is_a: CEPH:0000237 ! spermatophore [Term] id: CEPH:0000236 name: cephalopod spermathecum def: "Specialized sperm-storage structures found in the skin of some female decapodiforms or as pockets of the oviducal gland in octopods." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000994 ! spermathecum is_a: UBERON:0014404 ! female anatomical structure relationship: part_of UBERON:0000474 ! female reproductive system [Term] id: CEPH:0000237 name: spermatophore def: "A packet of sperm that is formed by the male and passed to the female during mating. In most coleoids, this packet is very complex and contains a "rope" of sperm (= sperm mass), an ejaculatory apparatus and a cement body. Except for the sperm, the entire structure is non-cellular and consists of a complex architecture of secreted material." [http://tolweb.org/accessory/Cephalopod_Spermatophore_Terminology?acc_id=1972] is_a: UBERON:0000477 ! anatomical cluster [Term] id: CEPH:0000240 name: stalk of tentacle def: "Region of the tentacle proximal to the club." [http://tolweb.org/accessory/Cephalopod_Tentacle_Terminology?acc_id=1962] is_a: CEPH:0000307 ! circumoral appendage segment relationship: part_of CEPH:0000256 ! tentacle relationship: proximal_to CEPH:0000291 ! tentacular club [Term] id: CEPH:0000241 name: stalked eye is_a: UBERON:0000970 ! eye [Term] id: CEPH:0000242 name: cephalopod statocyst def: "A sense-organ that detects gravity, angular accelerations and low-frequency sound. The statocyst is embedded within the cephalic cartlage and contains the statolith." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0006583 ! statocyst relationship: part_of CEPH:0000191 ! outer statocyst capsule [Term] id: CEPH:0000243 name: stellate ganglion def: "Major ganglion of the peripherial nervous system of neocoleoid cephalopods that controls nerves to the mantle muscles." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000045 ! ganglion [Term] id: CEPH:0000244 name: cephalopod stomach def: "A muscular organ of the digestive system where primary digestion occurs. The stomach is generally lined with cuticular ridges to aid in grinding food, and is supplied with digestive enzymes from the digestive gland. The stomach may be greatly expandable in size and serve as a storage area until food can be fully processed." [http://tolweb.org/accessory/Cephalopod_Digestive_System?acc_id=1993] is_a: UBERON:0000945 ! stomach [Term] id: CEPH:0000245 name: stylet def: "Remnant of the molluscan shell in incirrate octopods. It is generally a slender, pointed rod tightly surrounded by the shell sac and buried in the mantle muscle on either side of the mantle." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000475 ! organism subdivision [Term] id: CEPH:0000246 name: subadult stage def: "Stage at which all of the characters that typically define the species are present. The subadult stage follows the Juvenile Stage and precedes the Adult Stage. A subadult stage is defined in cephalopods since the adult phase is frequently abbreviated." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000105 ! life cycle stage [Term] id: CEPH:0000248 name: sucker def: "Muscular suction-cup on the arms and tentacles and occasionally on the buccal supports. The sucker consists of a cup-shaped portion, the acetabulum, and a flat, distal ring, the infundibulum, that contacts the substrate. Suckers of decapodiforms contain horny rings that often bear teeth or sometimes form hooks." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0003102 ! surface structure relationship: part_of CEPH:0000305 ! collection of suckers [Term] id: CEPH:0000249 name: sucker series def: "The longitudinal rows of suckers on the arms or tentacles of decapodiforms. Series (= longitudinal rows) contrasts with rows (= transverse rows) in describing sucker arrangement. In octopodiforms, sucker "series" is generally synonymous with "rows", the "longitudinal" component of the term is implied. Suckers can form distinct, regular series or indistinct, irregular series. " [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000305 ! collection of suckers relationship: part_of CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0000250 name: sucker stalk def: "The structure between the sucker and the arm. In octopods it is a cyclindrical structure about the same width as the sucker and in decapodiforms it is constricted into a conical pillar." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "pedicel" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: continuous_with CEPH:0000248 ! sucker relationship: continuous_with CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0000251 name: sucker teeth def: "Teeth on the inner horny sucker rings of some decapodiforms." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000248 ! sucker [Term] id: CEPH:0000252 name: superior buccal lobes def: "Lobes of the central nervous system that sit atop the esophagus where the latter enters the buccal mass in decapodiforms but are the anterior-most lobes of the supraesophageal mass of the brain of octopodiforms." [http://tolweb.org/accessory/Cephalopod_Brain_Terminology?acc_id=1944] is_a: CEPH:0000295 ! buccal lobe relationship: continuous_with UBERON:0001043 ! esophagus [Term] id: CEPH:0000253 name: superocular cirri def: "Muscular structures that can be raised or lowered above the eyes of octopodids but are apparent even when lowered." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0005090 ! muscle structure [Term] id: CEPH:0000254 name: suprabrachial commissure def: "Nerve commissure that passes dorsal to the esophagus in most octopodiforms and connects the right and left anterior subesophageal masses of the brain." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: dorsal_to UBERON:0001043 ! esophagus [Term] id: CEPH:0000255 name: cephalopod swimbladder def: "Gas-filled structure found in the dorsal region of the pelagic octopods, Ocythoe, Tremoctopus and Haliphron." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "gas bladder" BROAD [] synonym: "swim bladder" BROAD [] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000256 name: tentacle def: "Elongate 4th circumoral appendage of cuttlefish and squids used to capture prey. Divided into proximal stalk and distal club." [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} synonym: "arm" RELATED [Wikipedia:Cephalopod_limb] synonym: "limb" RELATED [Wikipedia:Cephalopod_limb] is_a: CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0000257 name: tentacle absence def: "Tentacles can be absent because the species lacks tentacles, they are accidentally lost during capture, or they are naturally lost at sexual maturity. " [http://tolweb.org/accessory/Tentacle_Absence_in_Cephalopods?acc_id=2046] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000256 ! tentacle [Term] id: CEPH:0000258 name: tentacle pad def: "Poorly understood and complex pad-like photophores that are found on the tentacular stalks of some chiroteuthidids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000256 ! tentacle [Term] id: CEPH:0000259 name: tentacle pocket def: "A pocket that surrounds the base of each tentacle and provides some room for tentacle retraction or contraction." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "tentacular pocket" EXACT [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000256 ! tentacle [Term] id: CEPH:0000261 name: tentacle thickness def: "." [http://tolweb.org/accessory/Cephalopod_Tentacle_Thickness?acc_id=2016] is_a: CEPH:0001059 ! appendage trait relationship: trait_of CEPH:0000256 ! tentacle [Term] id: CEPH:0000263 name: terminal fin def: "Fins that extend to the posterior end of the body." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000112 ! fin [Term] id: CEPH:0000264 name: terminal pad def: "A circlet or disc of small suckers at the tip of the tentacular club. The pad of one club can adhere to the pad of the other club which holds the clubs together at their tips." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "terminal pad of tentacular club" EXACT [] is_a: CEPH:0000258 ! tentacle pad [Term] id: CEPH:0000267 name: trabecula def: "Muscular cones or flaps that support the protective membranes on the arms and tentacular clubs in decapodiforms. These are thought to be homologous with the cirri of the octopodiformes." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "trabeculae" RELATED [] is_a: UBERON:0005090 ! muscle structure relationship: part_of CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0000268 name: tragus def: "Particular inward projecting knob in the funnel locking-apparatus of some squids. It is the knob found on the medial surface of the central depression." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0002418 ! cartilage tissue relationship: part_of CEPH:0000118 ! funnel-mantle locking-apparatus [Term] id: CEPH:0000269 name: truncate tooth def: "Teeth on the inner horny of rings of decapodiform suckers that do not terminate in a point but rather a broad, flat tip." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "truncate teeth" RELATED [] is_a: CEPH:0001038 ! tooth of sucker ring relationship: part_of CEPH:0001020 ! inner sucker ring [Term] id: CEPH:0000270 name: cephalopod tubercule def: "Structures with one or more cusps just beneath the surface epithelium. Tubercules may be cartilagenous, fibrous or of other structure and may be confined to the integument or extend deeper." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0005813 ! tubercle [Term] id: CEPH:0000271 name: gladius vane def: "Broad, lateral portions of the gladius that arise from the rhachis." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "lateral field" EXACT [] synonym: "vane" EXACT [] synonym: "wing" EXACT [] is_a: UBERON:0000061 ! anatomical structure relationship: adjacent_to CEPH:0000216 ! rachis relationship: part_of CEPH:0000124 ! gladius [Term] id: CEPH:0000273 name: ventral eyelid def: "An eyelid that can cover much of the cornea from a ventral position in many sepioids." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000000 ! eyelid [Term] id: CEPH:0000274 name: ventral shield def: "The optically modified ventral mantle of heteroteuthins that usually projects anteriorly beneath the head." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0001034 ! shield [Term] id: CEPH:0000275 name: vesicular tissue def: "Tissues found in some decapodiforms that contain numberous vesicles filled with water that usually contains ammonium chloride. The vesicles may be concentrated in certain structures (e.g., the ventral arms) or scattered throughout the animal. The light solution in the vesicles provide buoyant lift." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000479 ! simple tissue [Term] id: CEPH:0000276 name: visceral nucleus def: "A concentration of digestive organs that sometimes includes reproductive organs as well. In cranchiid squids the visceral nucleus is especially distinct: the small, spindle-shaped digestive gland contains the ink sac and is adjacent to the stomach and caecum and associated structures (eg, digestive gland duct appendages, renal appendages). In most cephalopods the concentration of these structures is not so extensive but whenever a concentration exists, a visceral nucleus is present." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "visceral hump" EXACT [BTO:0001448] is_a: UBERON:0000061 ! anatomical structure relationship: adjacent_to CEPH:0000046 ! caecum relationship: part_of UBERON:0001007 ! digestive system [Term] id: CEPH:0000277 name: visceral sac def: "The body posterior to the head surrounded by the mantle. The body wall in this region that incases the viscera is usually rather thin-walled, hence the name "visceral sac." The visceral sac is also called the "visceral dome."" [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "visceral dome" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0000278 name: visceropericardial coelom def: "The largest coelom in cephalopods except in the Octopoda where it is greatly reduced. Geneally it encloses the gonad, and partially the stomach, caecum and ventricle among other structures. Eggs and sperm are released into the coelom and picked up by the gonoducts. The visceropercardial coelom also communicates with the other cephalopod coelom, the nephridial coelom, and the mantle cavity via a pair of ducts that open at the base of the nephridial papillae." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CEPH:0000067 ! cephalopod coelom [Term] id: CEPH:0000279 name: water pore def: "One or two pairs of pores in the integument of the head that communicate with extensive spaces at the bases of arms on some pelagic argonautoid octopods." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000161 ! orifice relationship: part_of CEPH:0000280 ! web [Term] id: CEPH:0000280 name: web def: "Muscular membrane that extends between the arms of many octopodiforms but is reduced or absent in most decapodiforms." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000158 ! membranous layer relationship: attaches_to CEPH:0000015 ! arm [Term] id: CEPH:0000281 name: web nodule def: "Muscular rods embedded in the web of some cirrate octopods." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000280 ! web [Term] id: CEPH:0000282 name: white body def: "Amorphous organ near the optic lobes that forms white blood cells." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000062 ! organ [Term] id: CEPH:0000283 name: wing def: "(shell) - Lateral limbs of the shell of cirrate octopods" [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0006612 ! shell [Term] id: CEPH:0000284 name: leucophore def: "Reflective cells in the skin of some cephalopods containing numerous refractive granules on stalks that together produce a scattered reflection of ambient light." [http://tolweb.org/notes/?note_id=2646] is_a: CL:0000000 ! cell [Term] id: CEPH:0000285 name: ink is_a: UBERON:0000463 ! non-tissue substance [Term] id: CEPH:0000286 name: primary oviduct def: "Female gonoduct. The oviduct conducts eggs from the visceropericardial coelom, that holds the ovary, to the exterior and is often used to store eggs. In some argonautoid octopods eggs are fertilized and undergo either partial (Argonauta ) or complete (Ocythoe) embryonic development within the oviduct." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] is_a: UBERON:0000993 ! oviduct relationship: continuous_with CEPH:0000278 ! visceropericardial coelom [Term] id: CEPH:0000287 name: cephalopod ovary is_a: UBERON:0000992 ! ovary relationship: part_of CEPH:0000278 ! visceropericardial coelom [Term] id: CEPH:0000288 name: photosensitive vesicle of cephalic cartilage is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CEPH:0000200 ! photosensitive vesicle intersection_of: CEPH:0000200 ! photosensitive vesicle intersection_of: part_of CEPH:0000056 ! cephalic cartilage relationship: part_of CEPH:0000056 ! cephalic cartilage [Term] id: CEPH:0000289 name: photosensitive vesicle of stellate ganglion is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CEPH:0000200 ! photosensitive vesicle intersection_of: CEPH:0000200 ! photosensitive vesicle intersection_of: part_of CEPH:0000243 ! stellate ganglion relationship: part_of CEPH:0000243 ! stellate ganglion [Term] id: CEPH:0000290 name: obsolete brachial photophore is_obsolete: true [Term] id: CEPH:0000291 name: tentacular club def: "Terminal, usually expanded, grasping portion of tentacle that is armed with suckers or, in some groups, with suckers and hooks." [] {source="Terminal, usually expanded, grasping portion of tentacle that is armed with suckers or, in some groups, with suckers and hooks."} is_a: CEPH:0000307 ! circumoral appendage segment relationship: part_of CEPH:0000256 ! tentacle [Term] id: CEPH:0000292 name: optic nerve bundle def: "Large nerve bundles that run from the optic lobe to the eye." [http://tolweb.org/accessory/Cephalopoda_Glossary?acc_id=587] synonym: "optic stalk" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: continuous_with CEPH:0000187 ! optic lobe of brain relationship: continuous_with UBERON:0000970 ! eye [Term] id: CEPH:0000293 name: lobe of brain is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of CEPH:0000035 ! cephalopod brain [Term] id: CEPH:0000294 name: lobe of nervous system is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0001016 ! nervous system [Term] id: CEPH:0000295 name: buccal lobe is_a: CEPH:0000293 ! lobe of brain relationship: part_of CEPH:0000299 ! supraesophageal mass of brain [Term] id: CEPH:0000296 name: subesophageal mass of brain is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of CEPH:0000035 ! cephalopod brain [Term] id: CEPH:0000297 name: middle subesophageal mass of brain is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of CEPH:0000296 ! subesophageal mass of brain [Term] id: CEPH:0000298 name: posterior subesophageal mass of brain is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of CEPH:0000296 ! subesophageal mass of brain [Term] id: CEPH:0000299 name: supraesophageal mass of brain is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of CEPH:0000035 ! cephalopod brain [Term] id: CEPH:0000300 name: cephalopod trait [Term] id: CEPH:0000301 name: basal lobe of brain def: "Higher motor centers, located (for example) in the basal lobe (b.l.) control complex behaviors that involve the animal's whole body." [] is_a: CEPH:0000293 ! lobe of brain [Term] id: CEPH:0000302 name: superior frontal lobe system is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of CEPH:0000035 ! cephalopod brain [Term] id: CEPH:0000303 name: vertical frontal lobe system synonym: "vertical lobe" EXACT [] synonym: "VL" BROAD [] is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of CEPH:0000035 ! cephalopod brain [Term] id: CEPH:0000304 name: anal photophore def: "photophore at side of anus" [http://tolweb.org/accessory/Cephalopod_Photophore_Terminology?acc_id=2015] is_a: CEPH:0000198 ! photophore [Term] id: CEPH:0000305 name: collection of suckers is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000477 ! anatomical cluster relationship: has_part CEPH:0000248 ! sucker [Term] id: CEPH:0000306 name: transverse row of suckers is_a: CEPH:0000305 ! collection of suckers [Term] id: CEPH:0000307 name: circumoral appendage segment is_a: UBERON:0000475 ! organism subdivision relationship: part_of CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0000308 name: circumoral appendage def: "Any of the numerous arms or tentacles that arise from the head and surround the mouth of a cephalopod" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} synonym: "arm crown" RELATED [] synonym: "head appendage" RELATED [] is_a: UBERON:0000026 ! appendage [Term] id: CEPH:0000309 name: cephalopod size is_a: CEPH:0001065 ! whole organism trait [Term] id: CEPH:0000310 name: buccal membrane support def: "longitudinal muscular rod fused with buccal membrane" [] synonym: "buccal support" RELATED [] is_a: UBERON:0001630 ! muscle organ relationship: continuous_with CEPH:0000040 ! buccal membrane relationship: part_of CEPH:0000038 ! buccal crown [Term] id: CEPH:0001001 name: bullet-shaped mantle def: "posteriorly blunt rather than broad body (mantle) common in larval cephalopods" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: CEPH:0001065 ! whole organism trait [Term] id: CEPH:0001002 name: extrategumental chromatophore def: "A larval chromatophore located deep beneather the integument" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: CEPH:0000061 ! chromatophore [Term] id: CEPH:0001003 name: chromatophore field def: "Collection of chromatophores that produces species-specific patterns in discrete regions" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0000477 ! anatomical cluster relationship: has_part CEPH:0000061 ! chromatophore [Term] id: CEPH:0001004 name: tegumental chromatophore def: "Chromatophores located in or near surface integument" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: CEPH:0000061 ! chromatophore [Term] id: CEPH:0001005 name: cirrus is_a: UBERON:0003102 ! surface structure [Term] id: CEPH:0001006 name: body cirrus def: "A fleshy protruberance of skin that can be erected as a papilla, usually dorsal to the eyes" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: CEPH:0001005 ! cirrus [Term] id: CEPH:0001008 name: phragmacone def: "The phragmocone is the chambered portion of the shell of a cephalopod. It is divided by septa into camerae." [] {http://purl.org/dc/elements/1.1/source="http://en.wikipedia.org/wiki/Phragmocone"} is_a: UBERON:0000475 ! organism subdivision relationship: CEPH:0001007 CEPH:0000072 {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} ! conus relationship: has_part CEPH:0001045 ! shell chamber relationship: part_of UBERON:0006612 ! shell [Term] id: CEPH:0001009 name: corneal membrane def: "A thin turgid transparent membrane that covers the eyes of myopsid and sepioid cephalopods" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0000158 ! membranous layer relationship: part_of CEPH:0000074 ! cornea [Term] id: CEPH:0001010 name: gill length is_a: CEPH:0001066 ! gill trait [Term] id: CEPH:0001011 name: Koelicker organ def: "Minute bristle-like structure that covers the body of planktonic octopod larvae" [] is_a: UBERON:0000062 ! organ is_a: UBERON:0003102 ! surface structure [Term] id: CEPH:0001013 name: lanceola def: "Expanded portion of gladius vane" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0000064 ! organ part relationship: part_of CEPH:0000271 ! gladius vane [Term] id: CEPH:0001014 name: macula def: "Irregular spot capable of expanding or retracting" [] is_a: CEPH:0001024 ! spot [Term] id: CEPH:0001015 name: nuchal fold def: "One of a series of longitudinal folds or pleats of skin in the nuchal region" [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0003102 ! surface structure [Term] id: CEPH:0001016 name: ocellus synonym: "false eye spot" RELATED [] is_a: CEPH:0001024 ! spot [Term] id: CEPH:0001017 name: cephalopod sperm receptacle synonym: "A bulbous structure found in buccal region of femles of some cephalopods for retention of viable sperm until required for fertilization" RELATED [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0000994 ! spermathecum [Term] id: CEPH:0001018 name: spermatophore pad is_a: CEPH:0001017 ! cephalopod sperm receptacle [Term] id: CEPH:0001020 name: inner sucker ring is_a: CEPH:0000136 ! sucker ring [Term] id: CEPH:0001021 name: outer sucker ring is_a: CEPH:0000136 ! sucker ring [Term] id: CEPH:0001022 name: tail def: "Posterior extension of gladius and mantle epithelium. Frequently elongate." [] {http://purl.org/dc/elements/1.1/source="http://www.sil.si.edu/smithsoniancontributions/zoology/pdf_hi/sctz-0513.pdf"} is_a: UBERON:0000475 ! organism subdivision [Term] id: CEPH:0001023 name: branchial heart appendage synonym: "pericardial gland" EXACT [] is_a: UBERON:0000064 ! organ part relationship: part_of CEPH:0000032 ! branchial heart [Term] id: CEPH:0001024 name: spot is_a: UBERON:0003102 ! surface structure [Term] id: CEPH:0001025 name: dorsal beak synonym: "upper mandible" RELATED [] is_a: CEPH:0000023 ! beak [Term] id: CEPH:0001026 name: ventral beak synonym: "lower mandible" RELATED [] is_a: CEPH:0000023 ! beak [Term] id: CEPH:0001027 name: septum is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0001028 name: arm I synonym: "dorsal arm" EXACT [] is_a: CEPH:0000015 ! arm [Term] id: CEPH:0001029 name: arm II is_a: CEPH:0000015 ! arm [Term] id: CEPH:0001030 name: arm III is_a: CEPH:0000015 ! arm [Term] id: CEPH:0001031 name: external shell is_a: UBERON:0006612 ! shell [Term] id: CEPH:0001033 name: spermatophore groove def: "A channel or groove running along the length of the hectocotylus" [] {http://purl.org/dc/elements/1.1/source="ftp://ftp.fao.org/docrep/fao/009/w7192e/w7192e02.pdf"} is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure relationship: part_of CEPH:0000130 ! hectocotylus [Term] id: CEPH:0001034 name: shield is_a: UBERON:0000475 ! organism subdivision [Term] id: CEPH:0001035 name: dorsal shield def: "hard calcareous dorsal surface of the cuttlebone" [] {http://purl.org/dc/elements/1.1/source="ftp://ftp.fao.org/docrep/fao/009/w7192e/w7192e02.pdf"} is_a: CEPH:0001034 ! shield [Term] id: CEPH:0001036 name: epirenal body def: "glandular structures of unknown function which lie on either side of the renal papillae" [] {http://purl.org/dc/elements/1.1/source="ftp://ftp.fao.org/docrep/fao/009/w7192e/w7192e02.pdf"} is_a: UBERON:0002530 ! gland [Term] id: CEPH:0001037 name: renal sac synonym: "kidney" RELATED [] synonym: "nephridium" RELATED [] is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0001038 name: tooth of sucker ring is_a: UBERON:0000061 ! anatomical structure relationship: part_of CEPH:0000136 ! sucker ring [Term] id: CEPH:0001039 name: umbilicus def: "the central core of the chambered Nautilus shell, representing the juvenile shell with its initial coils" [] {http://purl.org/dc/elements/1.1/source="ftp://ftp.fao.org/docrep/fao/009/w7192e/w7192e02.pdf"} is_a: UBERON:0000475 ! organism subdivision relationship: only_in_taxon NCBITaxon:34572 ! Nautilus [Term] id: CEPH:0001040 name: web depth is_a: CEPH:0000300 ! cephalopod trait relationship: trait_of CEPH:0000280 ! web [Term] id: CEPH:0001041 name: beak length synonym: "hood length" RELATED [] is_a: CEPH:0001064 ! head trait relationship: trait_of CEPH:0000023 ! beak [Term] id: CEPH:0001042 name: lower rostral length synonym: "LRL" RELATED [] is_a: CEPH:0001041 ! beak length relationship: trait_of CEPH:0001026 ! ventral beak [Term] id: CEPH:0001043 name: upper rostral length synonym: "URL" RELATED [] is_a: CEPH:0001041 ! beak length relationship: trait_of CEPH:0001025 ! dorsal beak [Term] id: CEPH:0001044 name: spadix organ is_a: UBERON:0000062 ! organ relationship: part_of UBERON:0000033 ! head [Term] id: CEPH:0001045 name: shell chamber def: "Camerae (singular camera) are the spaces or chambers enclosed between two adjacent septa in the phragmocone of a nautiloid or ammonoid cephalopod. These can be seen in cross-sections of a nautilus shell and in the polished cross-sections of ammonites. In life these chambers are filled with gas, mediated by the siphuncle, and used to control buoyancy." [] {http://purl.org/dc/elements/1.1/source="http://en.wikipedia.org/wiki/Camera_%28cephalopod%29"} synonym: "phragmacone chamber" NARROW [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0006612 ! shell [Term] id: CEPH:0001046 name: shell septum is_a: CEPH:0001027 ! septum intersection_of: CEPH:0001027 ! septum intersection_of: part_of UBERON:0006612 ! shell relationship: part_of UBERON:0006612 ! shell [Term] id: CEPH:0001047 name: orthocone def: "An orthocone is a usually long straight shell of a nautiloid cephalopod." [] {http://purl.org/dc/elements/1.1/source="http://en.wikipedia.org/wiki/Orthocone"} is_a: CEPH:0001031 ! external shell [Term] id: CEPH:0001048 name: internal shell is_a: UBERON:0006612 ! shell [Term] id: CEPH:0001049 name: shell aperture def: "An opening in a mollusc shell" [] {http://purl.org/dc/elements/1.1/source="http://en.wikipedia.org/wiki/Aperture_%28mollusc%29"} is_a: UBERON:0004111 ! anatomical conduit relationship: part_of UBERON:0006612 ! shell [Term] id: CEPH:0001050 name: shell apex def: "the tip of the mollusc shell of a gastropod, scaphopod, or cephalopod mollusc." [] {http://purl.org/dc/elements/1.1/source="http://en.wikipedia.org/wiki/Apex_%28mollusc%29"} is_a: UBERON:0000061 ! anatomical structure [Term] id: CEPH:0001051 name: funnel component of funnel-mantle locking apparatus is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000064 ! organ part relationship: part_of CEPH:0000118 ! funnel-mantle locking-apparatus [Term] id: CEPH:0001052 name: mantle component of funnel-mantle locking apparatus is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: UBERON:0000064 ! organ part relationship: part_of CEPH:0000118 ! funnel-mantle locking-apparatus relationship: part_of UBERON:0006575 ! mantle [Term] id: CEPH:0001053 name: spermatophore gland is_a: UBERON:0005399 ! male reproductive gland [Term] id: CEPH:0001054 name: Ammonoidea synonym: "ammonites" EXACT [] is_a: NCBITaxon:6605 ! Cephalopoda [Term] id: CEPH:0001055 name: Goniatitida is_a: CEPH:0001054 ! Ammonoidea [Term] id: CEPH:0001056 name: Ceratitida is_a: CEPH:0001054 ! Ammonoidea [Term] id: CEPH:0001057 name: Ammonitida is_a: CEPH:0001054 ! Ammonoidea [Term] id: CEPH:0001058 name: reproductive trait is_a: CEPH:0000300 ! cephalopod trait [Term] id: CEPH:0001059 name: appendage trait is_a: CEPH:0000300 ! cephalopod trait intersection_of: CEPH:0000300 ! cephalopod trait intersection_of: trait_of UBERON:0000026 ! appendage relationship: trait_of CEPH:0000308 ! circumoral appendage [Term] id: CEPH:0001060 name: habitat trait is_a: CEPH:0000300 ! cephalopod trait [Term] id: CEPH:0001061 name: shell trait is_a: CEPH:0000300 ! cephalopod trait intersection_of: CEPH:0000300 ! cephalopod trait intersection_of: trait_of UBERON:0006612 ! shell relationship: trait_of UBERON:0006612 ! shell [Term] id: CEPH:0001062 name: integument trait is_a: CEPH:0000300 ! cephalopod trait intersection_of: CEPH:0000300 ! cephalopod trait intersection_of: trait_of UBERON:0002199 ! integument relationship: trait_of UBERON:0002199 ! integument [Term] id: CEPH:0001063 name: fin trait is_a: CEPH:0000300 ! cephalopod trait intersection_of: CEPH:0000300 ! cephalopod trait intersection_of: trait_of CEPH:0000112 ! fin relationship: trait_of CEPH:0000112 ! fin [Term] id: CEPH:0001064 name: head trait is_a: CEPH:0000300 ! cephalopod trait intersection_of: CEPH:0000300 ! cephalopod trait intersection_of: trait_of UBERON:0000033 ! head relationship: trait_of UBERON:0000033 ! head [Term] id: CEPH:0001065 name: whole organism trait is_a: CEPH:0000300 ! cephalopod trait [Term] id: CEPH:0001066 name: gill trait is_a: CEPH:0000300 ! cephalopod trait intersection_of: CEPH:0000300 ! cephalopod trait intersection_of: trait_of CEPH:0000122 ! gill relationship: trait_of CEPH:0000122 ! gill [Term] id: CEPH:0001067 name: iteroparous def: "characterized by multiple reproductive cycles over the course of its lifetime" [] is_a: CEPH:0001058 ! reproductive trait [Term] id: CEPH:0001068 name: organ of Hoeven is_a: UBERON:0002530 ! gland relationship: only_in_taxon NCBITaxon:32577 ! Nautiloidea [Term] id: CEPH:0001069 name: pyroform sac synonym: "pyroform gland" RELATED [] is_a: UBERON:0000062 ! organ [Term] id: CEPH:0001070 name: sexual size dimorphism is_a: CEPH:0001071 ! sexual dimorphism relationship: trait_of NCBITaxon:102882 ! Tremoctopus [Term] id: CEPH:0001071 name: sexual dimorphism is_a: CEPH:0001058 ! reproductive trait [Term] id: CEPH:0001072 name: buccal ganglion is_a: UBERON:0000045 ! ganglion [Term] id: CEPH:0001073 name: epithelial layer of gladius synonym: "epithelial layer of pen" RELATED [] synonym: "gladius epithelium" EXACT [] synonym: "pen epithelium" RELATED [] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of CEPH:0000124 ! gladius relationship: part_of CEPH:0000124 ! gladius [Term] id: CEPH:0001074 name: marginal epithelial layer of the gladius synonym: "marginal epithelial layer on the pen" RELATED [] is_a: CEPH:0001073 ! epithelial layer of gladius [Term] id: CEPH:0001075 name: ventral epithelial layer of gladius synonym: "ventral epithelial layer on the pen" RELATED [] is_a: CEPH:0001073 ! epithelial layer of gladius [Term] id: CEPH:0001076 name: iridophore is_a: CL:0000147 ! pigment cell [Term] id: CEPH:0001077 name: leucophore is_a: CL:0000147 ! pigment cell [Term] id: CHEBI:10545 name: electron is_a: CHEBI:36338 ! lepton [Term] id: CHEBI:131927 name: dicarboxylic acids and O-substituted derivatives is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:13850 name: apoprotein is_a: CHEBI:38560 ! simple protein [Term] id: CHEBI:138675 name: gas molecular entity is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:140325 name: secondary carboxamide is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:142163 name: 24G7 epitope is_a: CHEBI:24433 ! group [Term] id: CHEBI:15440 name: squalene is_a: CHEBI:35191 ! triterpene [Term] id: CHEBI:15841 name: polypeptide is_a: CHEBI:16670 ! peptide is_a: CHEBI:33839 ! macromolecule [Term] id: CHEBI:16247 name: phospholipid is_a: CHEBI:18059 ! lipid is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester [Term] id: CHEBI:16336 name: hyaluronic acid is_a: CHEBI:37395 ! mucopolysaccharide is_a: CHEBI:72813 ! exopolysaccharide [Term] id: CHEBI:16526 name: carbon dioxide is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:23014 ! carbon oxide is_a: CHEBI:64708 ! one-carbon compound [Term] id: CHEBI:16541 name: protein polypeptide chain is_a: CHEBI:15841 ! polypeptide relationship: has_part CHEBI:33700 ! proteinogenic amino-acid residue [Term] id: CHEBI:16646 name: carbohydrate is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16670 name: peptide is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:50047 ! organic amino compound relationship: has_part CHEBI:33708 ! amino-acid residue [Term] id: CHEBI:16990 name: bilirubin IXalpha is_a: CHEBI:35692 ! dicarboxylic acid is_a: CHEBI:36735 ! biladienes relationship: has_part CHEBI:142163 ! 24G7 epitope [Term] id: CHEBI:17029 name: chitin is_a: CHEBI:21638 ! N-acylglucosamine is_a: CHEBI:22506 ! aminoglycan [Term] id: CHEBI:17089 name: glycoprotein is_a: CHEBI:33837 ! conjugated protein is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:17761 name: ceramide is_a: CHEBI:26739 ! sphingolipid is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:18059 name: lipid is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:18085 name: glycosaminoglycan is_a: CHEBI:22506 ! aminoglycan [Term] id: CHEBI:18154 name: polysaccharide is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:18246 name: (1->4)-beta-D-glucan is_a: CHEBI:28793 ! beta-D-glucan [Term] id: CHEBI:21638 name: N-acylglucosamine is_a: CHEBI:21656 ! N-acyl-hexosamine is_a: CHEBI:24271 ! glucosamines [Term] id: CHEBI:21656 name: N-acyl-hexosamine is_a: CHEBI:24586 ! hexosamine [Term] id: CHEBI:22221 name: acyl group is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:22313 name: alkaline earth metal atom is_a: CHEBI:33318 ! main group element atom is_a: CHEBI:33521 ! metal atom is_a: CHEBI:33559 ! s-block element atom [Term] id: CHEBI:22314 name: alkali metal atom is_a: CHEBI:33318 ! main group element atom is_a: CHEBI:33521 ! metal atom is_a: CHEBI:33559 ! s-block element atom [Term] id: CHEBI:22506 name: aminoglycan is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:65212 ! polysaccharide derivative [Term] id: CHEBI:22563 name: anion is_a: CHEBI:24870 ! ion [Term] id: CHEBI:22868 name: bile salt is_a: CHEBI:36078 ! cholanoid is_a: CHEBI:38700 ! organic sodium salt [Term] id: CHEBI:22984 name: calcium atom is_a: CHEBI:22313 ! alkaline earth metal atom [Term] id: CHEBI:22985 name: calcium molecular entity is_a: CHEBI:33299 ! alkaline earth molecular entity relationship: has_part CHEBI:22984 ! calcium atom [Term] id: CHEBI:23004 name: carbamoyl group is_a: CHEBI:27207 ! univalent carboacyl group [Term] id: CHEBI:23014 name: carbon oxide is_a: CHEBI:25701 ! organic oxide is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:23016 name: carbonates is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:23019 name: carbonyl group is_a: CHEBI:51422 ! organodiyl group [Term] id: CHEBI:23044 name: carotenoid is_a: CHEBI:26935 ! tetraterpenoid [Term] id: CHEBI:23045 name: carotenol is_a: CHEBI:27325 ! xanthophyll [Term] id: CHEBI:23079 name: cerebroside is_a: CHEBI:17761 ! ceramide is_a: CHEBI:25513 ! neutral glycosphingolipid [Term] id: CHEBI:23213 name: choline ester is_a: CHEBI:35701 ! ester [Term] id: CHEBI:23217 name: cholines is_a: CHEBI:35267 ! quaternary ammonium ion [Term] id: CHEBI:23367 name: molecular entity is_a: BFO:0000030 ! object is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:23906 name: monoatomic cation is_a: CHEBI:24867 ! monoatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:24271 name: glucosamines is_a: CHEBI:24586 ! hexosamine [Term] id: CHEBI:24402 name: glycosphingolipid is_a: CHEBI:26739 ! sphingolipid is_a: CHEBI:33563 ! glycolipid [Term] id: CHEBI:24431 name: chemical entity [Term] id: CHEBI:24433 name: group is_a: CHEBI:24431 ! chemical entity relationship: has_part CHEBI:33250 ! atom [Term] id: CHEBI:24532 name: organic heterocyclic compound is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33832 ! organic cyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:24586 name: hexosamine is_a: CHEBI:60926 ! amino monosaccharide [Term] id: CHEBI:24632 name: hydrocarbon is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:24651 name: hydroxides is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:43176 ! hydroxy group [Term] id: CHEBI:24833 name: oxoacid is_a: CHEBI:24651 ! hydroxides [Term] id: CHEBI:24835 name: inorganic molecular entity is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:24866 name: salt is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:22563 ! anion relationship: has_part CHEBI:36916 ! cation [Term] id: CHEBI:24867 name: monoatomic ion is_a: CHEBI:24870 ! ion is_a: CHEBI:33238 ! monoatomic entity [Term] id: CHEBI:24868 name: organic salt is_a: CHEBI:24866 ! salt [Term] id: CHEBI:24870 name: ion is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:24913 name: isoprenoid is_a: CHEBI:18059 ! lipid [Term] id: CHEBI:25046 name: linear tetrapyrrole is_a: CHEBI:26932 ! tetrapyrrole [Term] id: CHEBI:25213 name: metal cation is_a: CHEBI:23906 ! monoatomic cation is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:25367 name: molecule is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:25414 name: monoatomic monocation is_a: CHEBI:23906 ! monoatomic cation [Term] id: CHEBI:25513 name: neutral glycosphingolipid is_a: CHEBI:24402 ! glycosphingolipid [Term] id: CHEBI:25555 name: nitrogen atom is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33300 ! pnictogen [Term] id: CHEBI:25585 name: nonmetal atom is_a: CHEBI:33250 ! atom [Term] id: CHEBI:25696 name: organic anion is_a: CHEBI:22563 ! anion is_a: CHEBI:25699 ! organic ion [Term] id: CHEBI:25697 name: organic cation is_a: CHEBI:25699 ! organic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:25699 name: organic ion is_a: CHEBI:24870 ! ion is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:25701 name: organic oxide is_a: CHEBI:25741 ! oxide is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:25703 name: organic phosphate is_a: CHEBI:25710 ! organophosphorus compound is_a: CHEBI:26020 ! phosphate [Term] id: CHEBI:25704 name: organic sulfate is_a: CHEBI:26820 ! sulfates [Term] id: CHEBI:25710 name: organophosphorus compound is_a: CHEBI:26082 ! phosphorus molecular entity is_a: CHEBI:33285 ! heteroorganic entity [Term] id: CHEBI:25741 name: oxide is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:25805 name: oxygen atom is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen [Term] id: CHEBI:25806 name: oxygen molecular entity is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:25805 ! oxygen atom [Term] id: CHEBI:26020 name: phosphate is_a: CHEBI:26079 ! phosphoric acid derivative [Term] id: CHEBI:26079 name: phosphoric acid derivative is_a: CHEBI:36359 ! phosphorus oxoacid derivative [Term] id: CHEBI:26082 name: phosphorus molecular entity is_a: CHEBI:33302 ! pnictogen molecular entity relationship: has_part CHEBI:28659 ! phosphorus atom [Term] id: CHEBI:26214 name: porphyrins is_a: CHEBI:36309 ! cyclic tetrapyrrole [Term] id: CHEBI:26469 name: quaternary nitrogen compound is_a: CHEBI:35352 ! organonitrogen compound relationship: has_part CHEBI:35267 ! quaternary ammonium ion [Term] id: CHEBI:26708 name: sodium atom is_a: CHEBI:22314 ! alkali metal atom [Term] id: CHEBI:26712 name: sodium molecular entity is_a: CHEBI:33296 ! alkali metal molecular entity relationship: has_part CHEBI:26708 ! sodium atom [Term] id: CHEBI:26714 name: sodium salt is_a: CHEBI:26712 ! sodium molecular entity is_a: CHEBI:35479 ! alkali metal salt relationship: has_part CHEBI:29101 ! sodium(1+) [Term] id: CHEBI:26739 name: sphingolipid is_a: CHEBI:18059 ! lipid is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:26819 name: sulfuric ester is_a: CHEBI:35701 ! ester is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:26820 name: sulfates is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:26833 name: sulfur atom is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen [Term] id: CHEBI:26835 name: sulfur molecular entity is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:26833 ! sulfur atom [Term] id: CHEBI:26873 name: terpenoid is_a: CHEBI:24913 ! isoprenoid [Term] id: CHEBI:26932 name: tetrapyrrole is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38077 ! polypyrrole [Term] id: CHEBI:26935 name: tetraterpenoid is_a: CHEBI:26873 ! terpenoid [Term] id: CHEBI:27207 name: univalent carboacyl group is_a: CHEBI:37838 ! carboacyl group [Term] id: CHEBI:27325 name: xanthophyll is_a: CHEBI:23044 ! carotenoid [Term] id: CHEBI:27369 name: zwitterion is_a: CHEBI:51151 ! dipolar compound [Term] id: CHEBI:27547 name: zeaxanthin is_a: CHEBI:23045 ! carotenol [Term] id: CHEBI:27594 name: carbon atom is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33306 ! carbon group element atom [Term] id: CHEBI:28659 name: phosphorus atom is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33300 ! pnictogen [Term] id: CHEBI:28793 name: beta-D-glucan is_a: CHEBI:37163 ! glucan [Term] id: CHEBI:28838 name: lutein is_a: CHEBI:23045 ! carotenol [Term] id: CHEBI:28963 name: amino sugar is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:29101 name: sodium(1+) is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:37246 ! elemental sodium is_a: CHEBI:60242 ! monovalent inorganic cation [Term] id: CHEBI:29108 name: calcium(2+) is_a: CHEBI:30412 ! monoatomic dication is_a: CHEBI:39123 ! calcium cation is_a: CHEBI:60240 ! divalent metal cation [Term] id: CHEBI:30412 name: monoatomic dication is_a: CHEBI:23906 ! monoatomic cation [Term] id: CHEBI:32988 name: amide is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:3311 name: calcium carbonate is_a: CHEBI:35156 ! calcium salt is_a: CHEBI:46721 ! carbonate salt is_a: CHEBI:64708 ! one-carbon compound [Term] id: CHEBI:33233 name: fundamental particle is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:33238 name: monoatomic entity is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33241 name: oxoacid derivative is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:33245 name: organic fundamental parent is_a: CHEBI:37175 ! organic hydride is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33246 name: inorganic group is_a: CHEBI:24433 ! group [Term] id: CHEBI:33247 name: organic group is_a: CHEBI:24433 ! group [Term] id: CHEBI:33249 name: organyl group is_a: CHEBI:51447 ! organic univalent group [Term] id: CHEBI:33250 name: atom is_a: CHEBI:24431 ! chemical entity relationship: has_part CHEBI:10545 ! electron relationship: has_part CHEBI:33252 ! atomic nucleus [Term] id: CHEBI:33252 name: atomic nucleus is_a: CHEBI:36347 ! nuclear particle relationship: has_part CHEBI:33253 ! nucleon [Term] id: CHEBI:33253 name: nucleon is_a: CHEBI:36339 ! baryon is_a: CHEBI:36347 ! nuclear particle [Term] id: CHEBI:33256 name: primary amide is_a: CHEBI:32988 ! amide [Term] id: CHEBI:33259 name: elemental molecular entity is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:33273 name: polyatomic anion is_a: CHEBI:22563 ! anion is_a: CHEBI:36358 ! polyatomic ion [Term] id: CHEBI:33285 name: heteroorganic entity is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33296 name: alkali metal molecular entity is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:22314 ! alkali metal atom [Term] id: CHEBI:33299 name: alkaline earth molecular entity is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:22313 ! alkaline earth metal atom [Term] id: CHEBI:33300 name: pnictogen is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33302 name: pnictogen molecular entity is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33300 ! pnictogen [Term] id: CHEBI:33303 name: chalcogen is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33304 name: chalcogen molecular entity is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33303 ! chalcogen [Term] id: CHEBI:33306 name: carbon group element atom is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33318 name: main group element atom is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33424 name: sulfur oxoacid derivative is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33241 ! oxoacid derivative [Term] id: CHEBI:33504 name: alkali metal cation is_a: CHEBI:25213 ! metal cation [Term] id: CHEBI:33513 name: alkaline earth cation is_a: CHEBI:25213 ! metal cation is_a: CHEBI:33299 ! alkaline earth molecular entity [Term] id: CHEBI:33521 name: metal atom is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33559 name: s-block element atom is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33560 name: p-block element atom is_a: CHEBI:33318 ! main group element atom [Term] id: CHEBI:33563 name: glycolipid is_a: CHEBI:35740 ! liposaccharide [Term] id: CHEBI:33575 name: carboxylic acid is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36586 ! carbonyl compound is_a: CHEBI:64709 ! organic acid relationship: has_part CHEBI:46883 ! carboxy group [Term] id: CHEBI:33579 name: main group molecular entity is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:33318 ! main group element atom [Term] id: CHEBI:33582 name: carbon group molecular entity is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33306 ! carbon group element atom [Term] id: CHEBI:33595 name: cyclic compound is_a: CHEBI:25367 ! molecule [Term] id: CHEBI:33608 name: hydrogen molecular entity is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:49637 ! hydrogen atom [Term] id: CHEBI:33635 name: polycyclic compound is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33655 name: aromatic compound is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33659 name: organic aromatic compound is_a: CHEBI:33655 ! aromatic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33674 name: s-block molecular entity is_a: CHEBI:33579 ! main group molecular entity relationship: has_part CHEBI:33559 ! s-block element atom [Term] id: CHEBI:33675 name: p-block molecular entity is_a: CHEBI:33579 ! main group molecular entity relationship: has_part CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33692 name: hydrides is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:33694 name: biomacromolecule is_a: CHEBI:33839 ! macromolecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33695 name: information biomacromolecule is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:33700 name: proteinogenic amino-acid residue is_a: CHEBI:33710 ! alpha-amino-acid residue [Term] id: CHEBI:33702 name: polyatomic cation is_a: CHEBI:36358 ! polyatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:33708 name: amino-acid residue is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:33710 name: alpha-amino-acid residue is_a: CHEBI:33708 ! amino-acid residue [Term] id: CHEBI:33832 name: organic cyclic compound is_a: CHEBI:33595 ! cyclic compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:33833 name: heteroarene is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:33837 name: conjugated protein is_a: CHEBI:36080 ! protein [Term] id: CHEBI:33839 name: macromolecule is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:35155 name: elemental calcium is_a: CHEBI:22985 ! calcium molecular entity [Term] id: CHEBI:35156 name: calcium salt is_a: CHEBI:22985 ! calcium molecular entity is_a: CHEBI:36364 ! alkaline earth salt relationship: has_part CHEBI:29108 ! calcium(2+) [Term] id: CHEBI:35186 name: terpene is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:24913 ! isoprenoid [Term] id: CHEBI:35191 name: triterpene is_a: CHEBI:35186 ! terpene [Term] id: CHEBI:35267 name: quaternary ammonium ion is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative [Term] id: CHEBI:35274 name: ammonium ion derivative is_a: CHEBI:33702 ! polyatomic cation is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35281 name: onium betaine is_a: CHEBI:27369 ! zwitterion [Term] id: CHEBI:35284 name: ammonium betaine is_a: CHEBI:26469 ! quaternary nitrogen compound is_a: CHEBI:35281 ! onium betaine [Term] id: CHEBI:35341 name: steroid is_a: CHEBI:18059 ! lipid is_a: CHEBI:51958 ! organic polycyclic compound [Term] id: CHEBI:35352 name: organonitrogen compound is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35406 name: oxoanion is_a: CHEBI:25741 ! oxide is_a: CHEBI:33273 ! polyatomic anion [Term] id: CHEBI:35479 name: alkali metal salt is_a: CHEBI:24866 ! salt is_a: CHEBI:33296 ! alkali metal molecular entity [Term] id: CHEBI:35507 name: natural product fundamental parent is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:35604 name: carbon oxoanion is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35605 name: carbon oxoacid is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35692 name: dicarboxylic acid is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives is_a: CHEBI:33575 ! carboxylic acid [Term] id: CHEBI:35701 name: ester is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35722 name: sulfated glycosaminoglycan is_a: CHEBI:18085 ! glycosaminoglycan is_a: CHEBI:35724 ! carbohydrate sulfate [Term] id: CHEBI:35724 name: carbohydrate sulfate is_a: CHEBI:25704 ! organic sulfate is_a: CHEBI:26819 ! sulfuric ester is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:35740 name: liposaccharide is_a: CHEBI:18059 ! lipid is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:35786 name: phosphosphingolipid is_a: CHEBI:16247 ! phospholipid is_a: CHEBI:26739 ! sphingolipid [Term] id: CHEBI:35794 name: tetrapyrrole fundamental parent is_a: CHEBI:26932 ! tetrapyrrole is_a: CHEBI:35507 ! natural product fundamental parent [Term] id: CHEBI:36078 name: cholanoid is_a: CHEBI:35341 ! steroid [Term] id: CHEBI:36080 name: protein is_a: CHEBI:33695 ! information biomacromolecule relationship: has_part CHEBI:16541 ! protein polypeptide chain [Term] id: CHEBI:36277 name: bile acid salt is_a: CHEBI:24868 ! organic salt is_a: CHEBI:36078 ! cholanoid [Term] id: CHEBI:36309 name: cyclic tetrapyrrole is_a: CHEBI:26932 ! tetrapyrrole is_a: CHEBI:47882 ! cyclic polypyrrole [Term] id: CHEBI:36338 name: lepton is_a: CHEBI:33233 ! fundamental particle is_a: CHEBI:36340 ! fermion [Term] id: CHEBI:36339 name: baryon is_a: CHEBI:36340 ! fermion is_a: CHEBI:36344 ! hadron [Term] id: CHEBI:36340 name: fermion is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36342 name: subatomic particle [Term] id: CHEBI:36343 name: composite particle is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36344 name: hadron is_a: CHEBI:36343 ! composite particle [Term] id: CHEBI:36347 name: nuclear particle is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36357 name: polyatomic entity is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:24433 ! group [Term] id: CHEBI:36358 name: polyatomic ion is_a: CHEBI:24870 ! ion is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:36359 name: phosphorus oxoacid derivative is_a: CHEBI:33241 ! oxoacid derivative is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives [Term] id: CHEBI:36360 name: phosphorus oxoacids and derivatives is_a: CHEBI:26082 ! phosphorus molecular entity [Term] id: CHEBI:36364 name: alkaline earth salt is_a: CHEBI:24866 ! salt is_a: CHEBI:33299 ! alkaline earth molecular entity [Term] id: CHEBI:36498 name: galactosylceramide is_a: CHEBI:23079 ! cerebroside is_a: CHEBI:5254 ! galactolipid is_a: CHEBI:62941 ! glycosylceramide [Term] id: CHEBI:36586 name: carbonyl compound is_a: CHEBI:36587 ! organic oxo compound is_a: CHEBI:36963 ! organooxygen compound relationship: has_part CHEBI:23019 ! carbonyl group [Term] id: CHEBI:36587 name: organic oxo compound is_a: CHEBI:72695 ! organic molecule relationship: has_part CHEBI:46629 ! oxo group [Term] id: CHEBI:36700 name: phosphocholines is_a: CHEBI:23213 ! choline ester is_a: CHEBI:23217 ! cholines is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester [Term] id: CHEBI:36735 name: biladienes is_a: CHEBI:25046 ! linear tetrapyrrole [Term] id: CHEBI:36914 name: inorganic ion is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36915 name: inorganic cation is_a: CHEBI:36914 ! inorganic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:36916 name: cation is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36962 name: organochalcogen compound is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36963 name: organooxygen compound is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:37163 name: glucan is_a: CHEBI:37164 ! homopolysaccharide [Term] id: CHEBI:37164 name: homopolysaccharide is_a: CHEBI:18154 ! polysaccharide [Term] id: CHEBI:37175 name: organic hydride is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37246 name: elemental sodium is_a: CHEBI:26712 ! sodium molecular entity [Term] id: CHEBI:37395 name: mucopolysaccharide is_a: CHEBI:18085 ! glycosaminoglycan [Term] id: CHEBI:37397 name: chondroitin sulfate is_a: CHEBI:35722 ! sulfated glycosaminoglycan is_a: CHEBI:37395 ! mucopolysaccharide [Term] id: CHEBI:37577 name: heteroatomic molecular entity is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:37622 name: carboxamide is_a: CHEBI:33256 ! primary amide is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound relationship: has_part CHEBI:23004 ! carbamoyl group [Term] id: CHEBI:37734 name: phosphoric ester is_a: CHEBI:26079 ! phosphoric acid derivative is_a: CHEBI:35701 ! ester [Term] id: CHEBI:37826 name: sulfuric acid derivative is_a: CHEBI:33424 ! sulfur oxoacid derivative [Term] id: CHEBI:37838 name: carboacyl group is_a: CHEBI:22221 ! acyl group [Term] id: CHEBI:38077 name: polypyrrole is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38101 name: organonitrogen heterocyclic compound is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38560 name: simple protein is_a: CHEBI:36080 ! protein [Term] id: CHEBI:38700 name: organic sodium salt is_a: CHEBI:24868 ! organic salt is_a: CHEBI:26714 ! sodium salt [Term] id: CHEBI:39015 name: apolipoprotein is_a: CHEBI:13850 ! apoprotein [Term] id: CHEBI:39022 name: inclusion compound is_a: CHEBI:50967 ! non-covalently-bound molecular entity [Term] id: CHEBI:39024 name: clathrate compound is_a: CHEBI:39022 ! inclusion compound [Term] id: CHEBI:39123 name: calcium cation is_a: CHEBI:33513 ! alkaline earth cation is_a: CHEBI:39124 ! calcium ion [Term] id: CHEBI:39124 name: calcium ion is_a: CHEBI:25213 ! metal cation is_a: CHEBI:35155 ! elemental calcium [Term] id: CHEBI:41609 name: carbonate is_a: CHEBI:35604 ! carbon oxoanion [Term] id: CHEBI:43176 name: hydroxy group is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:46629 name: oxo group is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:46662 name: mineral is_a: CHEBI:60004 ! mixture [Term] id: CHEBI:46719 name: calcite is_a: CHEBI:3311 ! calcium carbonate is_a: CHEBI:46720 ! carbonate mineral [Term] id: CHEBI:46720 name: carbonate mineral is_a: CHEBI:46662 ! mineral is_a: CHEBI:46721 ! carbonate salt [Term] id: CHEBI:46721 name: carbonate salt is_a: CHEBI:23016 ! carbonates relationship: has_part CHEBI:41609 ! carbonate [Term] id: CHEBI:46723 name: phosphate mineral is_a: CHEBI:46662 ! mineral [Term] id: CHEBI:46883 name: carboxy group is_a: CHEBI:33249 ! organyl group [Term] id: CHEBI:47882 name: cyclic polypyrrole is_a: CHEBI:38077 ! polypyrrole [Term] id: CHEBI:49637 name: hydrogen atom is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33559 ! s-block element atom [Term] id: CHEBI:50047 name: organic amino compound is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:50860 name: organic molecular entity is_a: CHEBI:33582 ! carbon group molecular entity relationship: has_part CHEBI:27594 ! carbon atom [Term] id: CHEBI:50967 name: non-covalently-bound molecular entity is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:51143 name: nitrogen molecular entity is_a: CHEBI:33302 ! pnictogen molecular entity relationship: has_part CHEBI:25555 ! nitrogen atom [Term] id: CHEBI:51151 name: dipolar compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:51422 name: organodiyl group is_a: CHEBI:51446 ! organic divalent group [Term] id: CHEBI:51446 name: organic divalent group is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51447 name: organic univalent group is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51958 name: organic polycyclic compound is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:52254 name: apatite is_a: CHEBI:46723 ! phosphate mineral [Term] id: CHEBI:52255 name: hydroxylapatite is_a: CHEBI:52254 ! apatite [Term] id: CHEBI:5254 name: galactolipid is_a: CHEBI:33563 ! glycolipid [Term] id: CHEBI:5686 name: heterocyclic compound is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:59999 name: chemical substance is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:60004 name: mixture is_a: CHEBI:59999 ! chemical substance [Term] id: CHEBI:60240 name: divalent metal cation is_a: CHEBI:25213 ! metal cation is_a: CHEBI:64641 ! divalent inorganic cation [Term] id: CHEBI:60242 name: monovalent inorganic cation is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:60924 name: keratan sulfate is_a: CHEBI:35722 ! sulfated glycosaminoglycan is_a: CHEBI:37395 ! mucopolysaccharide [Term] id: CHEBI:60926 name: amino monosaccharide is_a: CHEBI:28963 ! amino sugar [Term] id: CHEBI:62941 name: glycosylceramide is_a: CHEBI:17761 ! ceramide is_a: CHEBI:24402 ! glycosphingolipid [Term] id: CHEBI:63299 name: carbohydrate derivative is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:64389 name: biogenic silica is_a: CHEBI:64391 ! biogenic mineral is_a: CHEBI:64393 ! hydrated silica [Term] id: CHEBI:64391 name: biogenic mineral is_a: CHEBI:46662 ! mineral is_a: CHEBI:64392 ! biogenic substance [Term] id: CHEBI:64392 name: biogenic substance is_a: CHEBI:59999 ! chemical substance [Term] id: CHEBI:64393 name: hydrated silica is_a: CHEBI:46662 ! mineral [Term] id: CHEBI:64583 name: sphingomyelin is_a: CHEBI:140325 ! secondary carboxamide is_a: CHEBI:35284 ! ammonium betaine is_a: CHEBI:35786 ! phosphosphingolipid is_a: CHEBI:36700 ! phosphocholines [Term] id: CHEBI:64641 name: divalent inorganic cation is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:64708 name: one-carbon compound is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:64709 name: organic acid is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:6495 name: lipoprotein is_a: CHEBI:33837 ! conjugated protein is_a: CHEBI:39024 ! clathrate compound relationship: has_part CHEBI:39015 ! apolipoprotein [Term] id: CHEBI:65212 name: polysaccharide derivative is_a: CHEBI:33694 ! biomacromolecule is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:72695 name: organic molecule is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72813 name: exopolysaccharide is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:78616 name: carbohydrates and carbohydrate derivatives is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:8337 name: porphyrin is_a: CHEBI:26214 ! porphyrins is_a: CHEBI:35794 ! tetrapyrrole fundamental parent [Term] id: CL:0000000 name: cell namespace: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [] def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 is_a: GO:0005623 ! cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: CL:0000001 name: primary cultured cell namespace: cell def: "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." [] comment: Covers cells actively being cultured or stored in a quiescent state for future use. synonym: "primary cell culture cell" EXACT [] synonym: "primary cell line cell" RELATED [] synonym: "unpassaged cultured cell" EXACT [] xref: BTO:0002290 is_a: CL:0000010 ! cultured cell [Term] id: CL:0000002 name: obsolete immortal cell line cell namespace: cell def: "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." [] comment: Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "continuous cell line cell" EXACT [] synonym: "permanent cell line cell" EXACT [] is_obsolete: true replaced_by: CLO:0000019 [Term] id: CL:0000003 name: cell name: native cell namespace: cell def: "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." [] def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:MAH] comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12). subset: ubprop:upper_level synonym: "cell in vivo" NARROW [] xref: CARO:0000013 is_a: CL:0000000 ! cell is_a: UBERON:0000061 ! anatomical structure [Term] id: CL:0000004 name: obsolete cell by organism namespace: cell def: "OBSOLETE: A classification of cells by the organisms within which they are contained." [] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000005 name: fibroblast neural crest derived namespace: cell is_a: CL:0000057 ! fibroblast is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell namespace: cell synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! receptor cell intersection_of: CL:0000197 ! receptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000007 name: early embryonic cell namespace: cell def: "A cell found in the embryo before the formation of all the gem layers is complete." [] is_a: CL:0002321 ! embryonic cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000008 name: migratory cranial neural crest cell namespace: cell is_a: CL:0000333 ! migratory neural crest cell relationship: existence_ends_during_or_before ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 [Term] id: CL:0000009 name: obsolete fusiform initial namespace: cell alt_id: CL:0000274 def: "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [] comment: replaced_by: PO:0000079 synonym: "xylem initial" RELATED [] synonym: "xylem mother cell" RELATED [] is_obsolete: true [Term] id: CL:0000010 name: cultured cell namespace: cell def: "A cell in vitro that is or has been maintained or propagated as part of a cell culture." [] comment: Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture. is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000011 name: migratory trunk neural crest cell namespace: cell is_a: CL:0000333 ! migratory neural crest cell relationship: existence_ends_during_or_before ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 relationship: part_of UBERON:0003083 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! trunk neural crest [Term] id: CL:0000012 name: cell by class name: obsolete cell by class namespace: cell comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_a: CARO:0000013 is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000013 name: obsolete dentine secreting cell namespace: cell is_obsolete: true consider: CL:0000140 [Term] id: CL:0000014 name: germ line stem cell namespace: cell synonym: "germline stem cell" EXACT [] is_a: CL:0000034 ! stem cell is_a: CL:0000039 ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000015 name: male germ cell namespace: cell xref: FMA:72290 xref: MA:0002765 xref: ncithesaurus:Spermatogenic_Cell xref: VHOG:0001531 is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0007283 ! spermatogenesis relationship: capable_of GO:0007283 ! spermatogenesis [Term] id: CL:0000016 name: male germ line stem cell namespace: cell is_a: CL:0000014 ! germ line stem cell is_a: CL:0000015 ! male germ cell [Term] id: CL:0000017 name: spermatocyte namespace: cell def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [] xref: BTO:0001275 xref: CALOHA:TS-0951 xref: EMAPA:31484 xref: FBbt:00004936 xref: FMA:84049 xref: WBbt:0006799 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000015 ! male germ cell is_a: FBbt:00057011 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! male germline cell (Drosophila) is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure intersection_of: CL:0000015 ! male germ cell intersection_of: capable_of GO:0048137 relationship: capable_of GO:0048137 relationship: develops_from CL:0000020 ! spermatogonium relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000043 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Juvenile:Days 45-89 relationship: part_of FBbt:00005258 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! spermatocyte cyst (Drosophila) relationship: part_of UBERON:0000473 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! testis [Term] id: CL:0000018 name: spermatid namespace: cell def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [] synonym: "nematoblast" EXACT [] xref: BTO:0001274 xref: CALOHA:TS-0950 xref: EMAPA:31486 xref: FBbt:00004942 xref: FMA:72294 xref: WBbt:0006800 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000015 ! male germ cell is_a: CL:0000413 ! haploid cell is_a: FBbt:00057011 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! male germline cell (Drosophila) relationship: capable_of GO:0001675 relationship: capable_of GO:0007288 relationship: capable_of GO:0007289 relationship: develops_from CL:0000657 ! secondary spermatocyte relationship: develops_from WBbt:0008592 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! secondary spermatocyte (C elegans) relationship: part_of FBbt:00005287 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! spermatid cyst (Drosophila) [Term] id: CL:0000019 name: sperm namespace: cell def: "A mature male germ cell that develops from a spermatid." [] synonym: "sperm cell" EXACT [] synonym: "spermatozoid" EXACT [] synonym: "spermatozoon" EXACT [] xref: BTO:0001277 xref: BTO:0002046 xref: CALOHA:TS-0949 xref: FBbt:00004954 xref: FMA:67338 xref: WBbt:0006798 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000064 ! ciliated cell is_a: CL:0000219 ! motile cell is_a: CL:0000408 ! male gamete is_a: CL:0000670 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! primordial germ cell is_a: FBbt:00057011 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! male germline cell (Drosophila) intersection_of: CL:0000408 ! male gamete intersection_of: capable_of GO:0030317 ! flagellated sperm motility intersection_of: capable_of GO:0048240 ! sperm capacitation relationship: capable_of GO:0030317 ! flagellated sperm motility relationship: capable_of GO:0048240 ! sperm capacitation relationship: develops_from CL:0000018 ! spermatid relationship: develops_from FBbt:00005320 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! individualization stage spermatid (Drosophila) relationship: part_of UBERON:0000473 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! testis [Term] id: CL:0000020 name: spermatogonium namespace: cell def: "An euploid male germ cell of an early stage of spermatogenesis." [] xref: BTO:0000958 xref: CALOHA:TS-2193 xref: EMAPA:31482 xref: FBbt:00004935 xref: FMA:72291 is_a: CL:0000015 ! male germ cell is_a: FBbt:00057011 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! male germline cell (Drosophila) is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: develops_from CL:0000087 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! male germ line stem cell (sensu Nematoda and Protostomia) relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of FBbt:00007138 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! spermatogonial cyst (Drosophila) relationship: part_of UBERON:0000473 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! testis [Term] id: CL:0000021 name: female germ cell namespace: cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0048477 ! oogenesis relationship: capable_of GO:0048477 ! oogenesis [Term] id: CL:0000022 name: female germ line stem cell namespace: cell is_a: CL:0000014 ! germ line stem cell is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000023 name: oocyte namespace: cell def: "A female germ cell that has entered meiosis." [] synonym: "oogonium" RELATED [] xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FBbt:00004886 xref: FMA:18644 xref: WBbt:0006797 is_a: CL:0000021 ! female germ cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure is_a: UBERON:0007198 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! hermaphrodite anatomical structure relationship: develops_from FBbt:00014874 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! presumptive oocyte (Drosophila) relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000042 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Juvenile:Days 30-44 relationship: part_of UBERON:0001305 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ovarian follicle relationship: part_of UBERON:0003199 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! egg chamber [Term] id: CL:0000024 name: oogonial cell namespace: cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [] xref: FMA:83673 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: capable_of GO:0000278 ! mitotic cell cycle relationship: capable_of GO:0000278 ! mitotic cell cycle relationship: develops_from CL:0000670 ! primordial germ cell [Term] id: CL:0000025 name: egg cell namespace: cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [] synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: BTO:0000369 xref: BTO:0003801 xref: CALOHA:TS-2191 xref: FBbt:00057012 xref: FMA:67343 xref: MA:0000388 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000675 ! female gamete is_a: UBERON:0005156 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! reproductive structure relationship: develops_from CL:0000023 ! oocyte [Term] id: CL:0000026 name: invertebrate nurse cell namespace: cell def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [] synonym: "nurse cell" RELATED [] xref: BTO:0000953 xref: FBbt:00004878 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000039 ! germ line cell is_a: CL:0000412 ! polyploid cell relationship: develops_from CL:0000722 ! cystoblast relationship: develops_from FBbt:01004878 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! presumptive nurse cell (Drosophila) relationship: part_of UBERON:0003199 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! egg chamber [Term] id: CL:0000027 name: smooth muscle cell neural crest derived namespace: cell is_a: CL:0000192 ! smooth muscle cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000192 ! smooth muscle cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000028 name: CNS neuron (sensu Nematoda and Protostomia) namespace: cell is_a: CL:2000029 ! central nervous system neuron relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000029 name: neuron neural crest derived namespace: cell is_a: CL:0000540 ! neuron is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000540 ! neuron intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000030 name: glioblast namespace: cell xref: FBbt:00005145 is_a: CL:0000055 ! non-terminally differentiated cell is_a: FBbt:00007008 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic precursor cell (Drosophila) is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000133 ! neurectodermal cell relationship: develops_from UBERON:0002346 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neurectoderm relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites relationship: part_of UBERON:0001016 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! nervous system [Term] id: CL:0000031 name: neuroblast namespace: cell def: "A cell that will develop into a neuron often after a migration phase." [] xref: BTO:0000930 xref: FBbt:00005146 xref: FMA:70563 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell is_a: FBbt:00007344 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic stem cell (Drosophila) [Term] id: CL:0000032 name: neuroplacodal cell namespace: cell def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [] synonym: "neural placode cell" EXACT [] is_a: CL:0002321 ! embryonic cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000114 ! surface ectodermal cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000033 name: apocrine cell namespace: cell def: "An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance." [] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000034 name: stem cell namespace: cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A.11.872] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000144 ! obsolete cell by function is_a: CL:0011115 ! precursor cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0017145 ! stem cell division relationship: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000035 name: single fate stem cell namespace: cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [] synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000036 name: epithelial fate stem cell namespace: cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000037 name: hematopoietic stem cell namespace: cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [] comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:70337 xref: FMA:86475 xref: VHOG:0001485 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: capable_of GO:0002244 relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell relationship: existence_starts_during_or_after ZFS:0000030 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-15 relationship: part_of UBERON:0002390 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! hematopoietic system [Term] id: CL:0000038 name: erythroid progenitor cell namespace: cell def: "A progenitor cell committed to the erythroid lineage." [] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000039 name: germ line cell namespace: cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: ubprop:upper_level is_a: CL:0000144 ! obsolete cell by function is_a: CL:0000548 ! animal cell relationship: capable_of GO:0022414 ! reproductive process [Term] id: CL:0000040 name: monoblast namespace: cell def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. synonym: "CFU-M" RELATED [] synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] xref: CALOHA:TS-1195 xref: FMA:83553 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor relationship: has_part CP:0000028 relationship: has_part GO:0000791 relationship: has_part GO:0005730 relationship: has_part PR:000001012 [Term] id: CL:0000041 name: mature eosinophil namespace: cell def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [] comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP. synonym: "mature eosinocyte" EXACT [] synonym: "mature eosinophil leucocyte" EXACT [] synonym: "mature eosinophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000771 ! eosinophil is_a: CL:0002242 ! nucleate cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0002495 relationship: capable_of GO:0002540 relationship: capable_of GO:0045730 relationship: develops_from CL:0000774 ! band form eosinophil relationship: has_part CP:0000025 relationship: has_part PR:000007152 relationship: has_part PR:000007857 relationship: has_part PR:000007858 relationship: has_part PR:000009129 relationship: has_part PR:000014046 relationship: has_part PR:000014047 relationship: has_part PR:000022006 [Term] id: CL:0000042 name: neutrophilic myeloblast namespace: cell def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." [] comment: These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. synonym: "neutrophilic granuloblast" RELATED [] is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000835 ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: capable_of GO:0030223 intersection_of: has_part PR:000001944 intersection_of: has_part PR:000005307 intersection_of: has_part PR:000007857 intersection_of: has_part PR:000010799 intersection_of: has_part PR:000014362 relationship: develops_from CL:0000834 ! neutrophil progenitor cell relationship: has_part PR:000001944 relationship: has_part PR:000005307 relationship: has_part PR:000007857 relationship: has_part PR:000010799 relationship: has_part PR:000014362 [Term] id: CL:0000043 name: mature basophil namespace: cell alt_id: CL:0000739 def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [] comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4. synonym: "mature basophil leucocyte" EXACT [] synonym: "mature basophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0001026 xref: CALOHA:TS-0688 is_a: CL:0000767 ! basophil is_a: CL:0002242 ! nucleate cell is_a: CL:0002274 ! histamine secreting cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000767 ! basophil intersection_of: capable_of GO:0002349 intersection_of: capable_of GO:0002351 ! serotonin production involved in inflammatory response intersection_of: capable_of GO:0002830 intersection_of: capable_of GO:0008015 ! blood circulation intersection_of: capable_of GO:0032616 intersection_of: capable_of GO:0032633 intersection_of: capable_of GO:0048295 intersection_of: has_part CP:0000025 relationship: capable_of GO:0002349 relationship: capable_of GO:0002351 ! serotonin production involved in inflammatory response relationship: capable_of GO:0002830 relationship: capable_of GO:0032616 relationship: capable_of GO:0032633 relationship: capable_of GO:0048295 relationship: develops_from CL:0000770 ! band form basophil relationship: has_part CP:0000025 [Term] id: CL:0000045 name: obsolete thymus processed stem cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead. is_obsolete: true [Term] id: CL:0000046 name: obsolete bursa processed stem cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead. is_obsolete: true [Term] id: CL:0000047 name: neuronal stem cell namespace: cell def: "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." [] synonym: "neural stem cell" EXACT [] synonym: "NSC" EXACT [] xref: BTO:0002881 xref: CALOHA:TS-2360 xref: FMA:86684 is_a: CL:0000048 ! multi fate stem cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000048 name: multi fate stem cell namespace: cell def: "A stem cell that can give rise to multiple lineages of cells." [] synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 is_a: CL:0000034 ! stem cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000049 name: common myeloid progenitor namespace: cell def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). synonym: "CFU-GEMM" RELATED [] synonym: "CFU-S" RELATED [] synonym: "CMP" EXACT [] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [] synonym: "myeloid stem cell" RELATED [] synonym: "pluripotent stem cell (bone marrow)" RELATED [] xref: BTO:0004730 is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell namespace: cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [] comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030218 intersection_of: capable_of GO:0030219 relationship: capable_of GO:0030218 relationship: capable_of GO:0030219 [Term] id: CL:0000051 name: common lymphoid progenitor namespace: cell alt_id: CL:0000044 def: "A oligopotent progenitor cell committed to the lymphoid lineage." [] comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. synonym: "CLP" EXACT [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] synonym: "ELP" RELATED [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011115 ! precursor cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030098 ! lymphocyte differentiation relationship: capable_of GO:0030098 ! lymphocyte differentiation relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000030 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-15 [Term] id: CL:0000052 name: totipotent stem cell namespace: cell def: "A stem cell from which all cells of the body can form." [] synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000054 name: bone matrix secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000055 name: non-terminally differentiated cell namespace: cell def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] comment: define using PATO mulit-potent or oligopotent? synonym: "blast cell" EXACT [] synonym: "blast cell" RELATED [] xref: BTO:0000125 xref: FMA:84782 is_a: CL:0000012 ! cell by class is_a: CL:0011115 ! precursor cell [Term] id: CL:0000056 name: myoblast namespace: cell def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [] xref: BTO:0000222 xref: CALOHA:TS-0650 xref: FBbt:00005083 xref: FMA:70335 xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell is_a: FBbt:00007008 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic precursor cell (Drosophila) relationship: develops_from CL:0000355 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! multi-potent skeletal muscle stem cell relationship: existence_starts_during_or_after ZFS:0000023 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:1-4 somites [Term] id: CL:0000057 name: fibroblast namespace: cell def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://63.198.234.228/OpenFMA/Fibroblast.html, ISBN:0517223651, MESH:A.11.329.228] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: VHOG:0001482 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000058 name: chondroblast namespace: cell def: "An immature cartilage-producing cell found in growing cartilage." [GOC:tfm, ISBN:0618947256] def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [] synonym: "chrondoplast" EXACT [] synonym: "chrondoplast" RELATED [] xref: BTO:0003607 xref: FMA:66783 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000667 ! collagen secreting cell relationship: develops_from CL:0000222 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesodermal cell relationship: develops_from CL:0007009 ! prechondroblast relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 [Term] id: CL:0000059 name: ameloblast namespace: cell alt_id: CL:0000053 alt_id: CL:0000139 def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [] comment: non-encoded relationship from VSAO produces VSAO:0000066 synonym: "amelocyte" EXACT [] synonym: "enamel secreting cell" EXACT [] xref: BTO:0001663 xref: FMA:70576 is_a: CL:0000146 ! simple columnar epithelial cell is_a: CL:0000151 ! secretory cell is_a: CL:0002077 ! ecto-epithelial cell is_a: UBERON:0004119 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: capable_of GO:0097186 relationship: develops_from CL:0007000 ! preameloblast relationship: develops_from UBERON:0003843 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! dental epithelium relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: CL:0000060 name: odontoblast namespace: cell def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [] comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin. xref: BTO:0001769 xref: CALOHA:TS-0696 xref: FMA:62999 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0001035 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! bone cell is_a: CL:0002148 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! dental pulp cell is_a: CL:0002159 ! general ecto-epithelial cell is_a: CL:0002251 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! epithelial cell of alimentary canal is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0007003 ! preodontoblast relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: CL:0000061 name: cementoblast namespace: cell alt_id: CL:0000859 def: "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." [] comment: Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth. synonym: "cementum secreting cell" EXACT [] xref: CALOHA:TS-1164 xref: FMA:63002 is_a: CL:0000062 ! osteoblast is_a: CL:0000151 ! secretory cell is_a: UBERON:0000078 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mixed ectoderm/mesoderm/endoderm-derived structure relationship: develops_from CL:0007002 ! precementoblast relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: CL:0000062 name: osteoblast namespace: cell def: "A bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [MESH:A.11.329.629] def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [] comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020 xref: BTO:0001593 xref: CALOHA:TS-0720 xref: FMA:66780 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000008 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! migratory cranial neural crest cell relationship: develops_from CL:0000375 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! obsolete osteoprogenitor cell relationship: develops_from CL:0007010 ! preosteoblast [Term] id: CL:0000063 name: cell by histology name: obsolete cell by histology namespace: cell def: "A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm] def: "OBSOLETE: A classification of cells by their microscopic appearance." [] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_a: CL:0000012 ! cell by class is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000064 name: ciliated cell namespace: cell def: "A cell that has a filiform extrusion of the cell surface." [] xref: VHOG:0001532 xref: XAO:0000031 is_a: CL:0000003 ! native cell is_a: PORO:0000914 ! flagellated cell is_a: UBERON:0004121 {gci_relation="part_of", gci_filler="NCBITaxon:8353"} ! ectoderm-derived structure intersection_of: CL:0000003 ! native cell intersection_of: has_part GO:0005929 ! cilium relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after XAO:1000038 {gci_relation="part_of", gci_filler="NCBITaxon:8353"} ! NF stage 22 (Xenopus) relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0001003 {gci_relation="part_of", gci_filler="NCBITaxon:8353"} ! skin epidermis [Term] id: CL:0000065 name: ependymal cell namespace: cell def: "A neurectoderm derived cell that lines the neural lumen." [] synonym: "ependymocyte" EXACT [] xref: BTO:0001724 xref: FMA:70550 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural cell relationship: develops_from CL:0000710 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neurecto-epithelial cell [Term] id: CL:0000066 name: epithelial cell namespace: cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [] synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FBbt:00000124 xref: FMA:66768 xref: WBbt:0003672 is_a: CL:0000548 ! animal cell is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000483 ! epithelium relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0000483 ! epithelium [Term] id: CL:0000067 name: ciliated epithelial cell namespace: cell def: "An epithelial cell that has a cilia." [] xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: has_part GO:0005929 ! cilium [Term] id: CL:0000068 name: duct epithelial cell namespace: cell is_a: CARO:0000077 ! epithelial cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000058 ! duct relationship: part_of UBERON:0000058 ! duct [Term] id: CL:0000069 name: branched duct epithelial cell namespace: cell is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000070 name: obsolete epithelial cell of gland namespace: cell is_obsolete: true [Term] id: CL:0000071 name: blood vessel endothelial cell namespace: cell def: "An endothelial cell that lines the vasculature." [GOC:tfm] synonym: "Cuboidal endothelial cell of vascular tree" RELATED [] synonym: "cuboidal endothelial cell of vascular tree" EXACT [] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0004638 ! blood vessel endothelium relationship: develops_from CL:0002546 ! embryonic blood vessel endothelial progenitor cell relationship: develops_from ZFA:0005773 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! embryonic blood vessel endothelial progenitor cell (Danio) relationship: part_of UBERON:0004638 ! blood vessel endothelium [Term] id: CL:0000072 name: non-branched duct epithelial cell namespace: cell is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000073 name: barrier epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000074 name: obsolete epithem cell namespace: cell def: "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [] comment: replaced_by: PO:0000066 is_obsolete: true [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell namespace: cell is_a: CARO:0000077 ! epithelial cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000076 name: squamous epithelial cell namespace: cell xref: CALOHA:TS-1249 is_a: CARO:0000077 ! epithelial cell is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell namespace: cell def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [] synonym: "mesotheliocyte" EXACT [] xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000078 name: peridermal cell namespace: cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000079 name: stratified epithelial cell namespace: cell is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CARO:0000077 ! epithelial cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000357 ! stratified epithelial stem cell [Term] id: CL:0000080 name: circulating cell namespace: cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000003 ! native cell is_a: CL:0000144 ! obsolete cell by function intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0000179 ! haemolymphatic fluid [Term] id: CL:0000081 name: blood cell namespace: cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] xref: FMA:62844 is_a: CL:0000988 ! hematopoietic cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0008015 ! blood circulation relationship: capable_of GO:0008015 ! blood circulation relationship: existence_starts_during_or_after ZFS:0000028 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:26+ somites relationship: part_of UBERON:0000178 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! blood [Term] id: CL:0000082 name: epithelial cell of lung namespace: cell synonym: "lung epithelial cell" EXACT [] xref: BTO:0004299 is_a: CL:0000066 ! epithelial cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0000115 ! lung epithelium [Term] id: CL:0000083 name: epithelial cell of pancreas namespace: cell def: "An epithelial cell of the pancreas." [] synonym: "pancreas epithelial cell" EXACT [] synonym: "pancreatic epithelial cell" EXACT [] xref: BTO:0000028 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0000223 ! endodermal cell relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000084 name: T cell namespace: cell alt_id: CL:0000804 alt_id: CL:0000812 def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [] synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] xref: BTO:0000782 xref: CALOHA:TS-1001 xref: FMA:62870 xref: VHOG:0001479 is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: capable_of GO:0002456 relationship: capable_of GO:0002456 relationship: develops_from CL:0000827 ! pro-T cell [Term] id: CL:0000085 name: germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000086 name: germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004861 is_a: CL:0000014 ! germ line stem cell is_a: FBbt:00004860 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! germline cell (Drosophila) is_a: FBbt:00007014 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! stem cell (Drosophila) [Term] id: CL:0000087 name: male germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004929 is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) is_a: FBbt:00057011 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! male germline cell (Drosophila) relationship: part_of FBbt:00005259 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! germinal proliferation center (Drosophila) [Term] id: CL:0000088 name: female germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004873 is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) relationship: part_of FBbt:00004867 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! germarium region 1 (Drosophila) [Term] id: CL:0000089 name: male germ line stem cell (sensu Vertebrata) namespace: cell synonym: "spermatogonial stem cell" EXACT [] is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000090 name: female germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000091 name: Kupffer cell namespace: cell def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [] comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. synonym: "hepatic macrophage" EXACT [] synonym: "littoral cell of hepatic sinusoid" EXACT [] synonym: "liver macrophage" EXACT [] synonym: "macrophagocytus stellatus" EXACT [] synonym: "stellate cell of von Kupffer" EXACT [] synonym: "von Kupffer cell" EXACT [] xref: BTO:0000685 xref: FMA:14656 is_a: CL:0000864 ! tissue-resident macrophage relationship: capable_of GO:0034102 relationship: has_part PR:000001012 relationship: has_part PR:000001813 relationship: has_part PR:000001925 relationship: has_part PR:000002064 [Term] id: CL:0000092 name: osteoclast namespace: cell def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. synonym: "chondroclast" RELATED [] xref: BTO:0000968 xref: CALOHA:TS-0721 xref: FMA:66781 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0001035 ! bone cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0045453 relationship: develops_from CL:0000576 ! monocyte relationship: has_part PR:000001850 relationship: has_part PR:000001937 relationship: has_part PR:000001944 relationship: has_part PR:000001954 relationship: has_part PR:000002062 relationship: has_part PR:000007597 relationship: has_part PR:000011178 [Term] id: CL:0000093 name: obsolete osteochondroclast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using 'osteoclast ; CL:0000092' instead. is_obsolete: true [Term] id: CL:0000094 name: granulocyte namespace: cell def: "A leukocyte with abundant granules in the cytoplasm." [] synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] xref: BTO:0000539 xref: BTO:0001026 xref: CALOHA:TS-0422 xref: FMA:62854 is_a: CL:0000081 ! blood cell is_a: CL:0000766 ! myeloid leukocyte relationship: has_part GO:0030141 relationship: has_part PR:000001012 relationship: has_part PR:000001332 relationship: has_part PR:000001969 [Term] id: CL:0000095 name: neuron associated cell namespace: cell is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000096 name: mature neutrophil namespace: cell def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [] comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). synonym: "mature neutrocyte" EXACT [] synonym: "mature neutrophil leucocyte" EXACT [] synonym: "mature neutrophil leukocyte" EXACT [] synonym: "mature neutrophilic leucocyte" EXACT [] synonym: "mature neutrophilic leukocyte" EXACT [] synonym: "PMN" EXACT [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" EXACT [] synonym: "polynuclear neutrophilic leucocyte" EXACT [] synonym: "polynuclear neutrophilic leukocyte" EXACT [] xref: BTO:0003473 is_a: CL:0000234 ! phagocyte is_a: CL:0000775 ! neutrophil is_a: CL:0002242 ! nucleate cell relationship: capable_of GO:0002536 relationship: capable_of GO:0002690 relationship: capable_of GO:0032637 relationship: develops_from CL:0000560 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! band form neutrophil relationship: has_part CP:0000000 relationship: has_part CP:0000025 relationship: has_part GO:0070820 relationship: has_part PR:000001256 relationship: has_part PR:000001257 relationship: has_part PR:000001456 relationship: has_part PR:000001483 relationship: has_part PR:000001944 relationship: has_part PR:000007597 [Term] id: CL:0000097 name: mast cell namespace: cell def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [] comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. synonym: "histaminocyte" EXACT [] synonym: "labrocyte" EXACT [] synonym: "mastocyte" EXACT [] synonym: "tissue basophil" RELATED [] xref: BTO:0000830 xref: CALOHA:TS-0603 xref: FMA:66784 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002274 ! histamine secreting cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0002349 relationship: capable_of GO:0002539 relationship: capable_of GO:0002660 relationship: capable_of GO:0002690 relationship: capable_of GO:0002830 relationship: capable_of GO:0030210 relationship: develops_from CL:0000831 ! mast cell progenitor relationship: has_part GO:0030141 relationship: has_part PR:000001255 relationship: has_part PR:000002065 relationship: has_part PR:000006169 relationship: has_part PR:000007431 [Term] id: CL:0000098 name: sensory epithelial cell namespace: cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! receptor cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: develops_from CL:0000710 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neurecto-epithelial cell [Term] id: CL:0000099 name: interneuron namespace: cell def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A.08.663.358] xref: BTO:0003811 xref: FBbt:00005125 xref: FMA:67313 xref: WBbt:0005113 is_a: CL:0000540 ! neuron [Term] id: CL:0000100 name: motor neuron namespace: cell def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [] synonym: "anterior horn cell" NARROW [] synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: FMA:83617 xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000101 name: sensory neuron namespace: cell def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] xref: BTO:0001037 xref: FBbt:00005124 xref: FMA:84649 xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron is_a: FBbt:00007693 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! sensory system neuron (Drosophila) intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000102 name: polymodal neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000103 name: bipolar neuron namespace: cell def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [] xref: FMA:67282 is_a: CL:0000099 ! interneuron is_a: CL:0000748 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! retinal bipolar neuron relationship: part_of UBERON:0001791 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! inner nuclear layer of retina [Term] id: CL:0000104 name: multipolar neuron namespace: cell def: "Neuron with an axon and two or more dendrites." [] xref: FMA:67287 is_a: CL:0000540 ! neuron [Term] id: CL:0000105 name: pseudounipolar neuron namespace: cell def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." [] xref: FMA:67305 is_a: CL:0000540 ! neuron [Term] id: CL:0000106 name: unipolar neuron namespace: cell def: "Neuron with one neurite that extends from the cell body." [] xref: FMA:67278 is_a: CL:0000540 ! neuron [Term] id: CL:0000107 name: autonomic neuron namespace: cell def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm] xref: FMA:80121 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002410 ! autonomic nervous system relationship: part_of UBERON:0002410 ! autonomic nervous system [Term] id: CL:0000108 name: cholinergic neuron namespace: cell def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [] xref: BTO:0004902 xref: FMA:84796 xref: WBbt:0006840 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: CL:0000109 name: adrenergic neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000110 name: peptidergic neuron namespace: cell is_a: CL:0000540 ! neuron relationship: capable_of GO:0002790 ! peptide secretion [Term] id: CL:0000111 name: peripheral neuron namespace: cell def: "A neuron that is part of nerve found outside the central nervous system." [] xref: FMA:84664 is_a: CL:0000540 ! neuron [Term] id: CL:0000112 name: columnar neuron namespace: cell synonym: "columnar neuron" RELATED [] is_a: CL:0000540 ! neuron [Term] id: CL:0000113 name: mononuclear phagocyte namespace: cell def: "A vertebrate phagocyte with a single nucleus." [] xref: BTO:0001433 is_a: CL:0000226 ! single nucleate cell is_a: CL:0000518 ! phagocyte (sensu Vertebrata) [Term] id: CL:0000114 name: surface ectodermal cell namespace: cell synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [] xref: FMA:72552 is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000115 name: endothelial cell namespace: cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [] comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. synonym: "endotheliocyte" EXACT [] xref: BTO:0001176 xref: CALOHA:TS-0278 xref: FMA:66772 is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000116 name: pioneer neuron namespace: cell def: "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." [] xref: FBbt:00005128 is_a: CL:0000540 ! neuron relationship: existence_ends_during_or_before ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 relationship: existence_starts_during_or_after ZFS:0000028 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:26+ somites relationship: part_of UBERON:0003050 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! olfactory placode [Term] id: CL:0000117 name: CNS neuron (sensu Vertebrata) namespace: cell is_a: CL:2000029 ! central nervous system neuron relationship: develops_from CL:0000337 ! neuroblast (sensu Vertebrata) [Term] id: CL:0000118 name: basket cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000119 name: cerebellar Golgi cell namespace: cell def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [] synonym: "cerebellar Golgi neuron" EXACT [] synonym: "cerebellum Golgi cell" EXACT [] synonym: "Golgi cell" EXACT [] synonym: "Golgi neuron" EXACT [] is_a: CL:0000402 ! CNS interneuron is_a: CL:0011005 ! GABAergic interneuron is_a: CL:1001611 ! cerebellar neuron relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] id: CL:0000120 name: granule cell namespace: cell xref: BTO:0003393 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) relationship: part_of UBERON:0000955 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! brain [Term] id: CL:0000121 name: Purkinje cell namespace: cell def: "The output neuron of the cerebellar cortex." [] synonym: "cerebellar Purkinje cell" EXACT [] synonym: "cerebellum Purkinje cell" EXACT [] synonym: "Purkinje neuron" EXACT [] synonym: "Purkinje's cell" EXACT [] xref: BTO:0001011 xref: CALOHA:TS-0845 xref: FMA:67969 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:0000527 ! efferent neuron is_a: CL:1001611 ! cerebellar neuron relationship: part_of UBERON:0002129 ! cerebellar cortex relationship: part_of UBERON:2002240 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Purkinje cell layer corpus cerebelli relationship: part_of UBERON:2002241 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Purkinje cell layer valvula cerebelli [Term] id: CL:0000122 name: stellate neuron namespace: cell xref: BTO:0002316 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000123 name: neuron associated cell (sensu Vertebrata) namespace: cell is_a: CL:0000095 ! neuron associated cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000124 name: glial cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005144 is_a: CL:0000125 ! glial cell is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) relationship: develops_from CL:0000340 ! glioblast (sensu Nematoda and Protostomia) [Term] id: CL:0000125 name: glial cell namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A.08.637] synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] synonym: "neuroglial cell" RELATED [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000030 ! glioblast relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000028 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:26+ somites [Term] id: CL:0000126 name: macroglial cell namespace: cell def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544] synonym: "Macrogliocyte" RELATED [] synonym: "macrogliocyte" EXACT [] xref: BTO:0000771 xref: CALOHA:TS-2027 xref: FMA:54538 is_a: CL:0000243 ! glial cell (sensu Vertebrata) [Term] id: CL:0000127 name: astrocyte namespace: cell def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:_tfm, GOC:dsd, MESH:A.08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. synonym: "astrocytic glia" EXACT [] synonym: "astrocytic glia" RELATED [] xref: BTO:0000099 xref: CALOHA:TS-0060 xref: FMA:54537 is_a: CL:0000128 ! oligodendrocyte [Term] id: CL:0000128 name: oligodendrocyte namespace: cell def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [MESH:A.08.637.600] comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative. synonym: "oligodendroglia" RELATED [] synonym: "OLs" EXACT [] xref: BTO:0000962 xref: CALOHA:TS-0709 xref: FMA:54540 is_a: CL:0000126 ! macroglial cell relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000129 name: microglial cell namespace: cell def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275] comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. synonym: "brain macrophage" BROAD [] synonym: "brain macrophage" RELATED [] synonym: "brain-resident macrophage" EXACT [] synonym: "brain-resident macrophage" RELATED [] synonym: "hortega cells" EXACT [] synonym: "hortega cells" RELATED [http://www.copewithcytokines.de/] synonym: "MF.microglia.CNS" RELATED [] synonym: "microglia" EXACT [] synonym: "microglia" RELATED [] synonym: "microgliocyte" EXACT [] synonym: "microgliocyte" RELATED [http://www.copewithcytokines.de/] xref: BTO:0000078 xref: BTO:0000962 xref: FMA:54539 xref: FMA:54540 is_a: CL:0000243 ! glial cell (sensu Vertebrata) is_a: CL:0000878 ! central nervous system macrophage relationship: capable_of GO:0045087 relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: has_part PR:000001012 relationship: has_part PR:000001813 relationship: has_part PR:000002064 [Term] id: CL:0000130 name: neuron associated cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000095 ! neuron associated cell [Term] id: CL:0000131 name: gut endothelial cell namespace: cell is_a: CL:0000115 ! endothelial cell is_a: CL:0002251 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! epithelial cell of alimentary canal is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000223 ! endodermal cell relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites [Term] id: CL:0000132 name: corneal endothelial cell namespace: cell def: "Cell of the single layer of large flattened cells covering the surface of the cornea." [] xref: CALOHA:TS-0172 xref: FMA:70614 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001985 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! corneal endothelium [Term] id: CL:0000133 name: neurectodermal cell namespace: cell def: "Ectoderm destined to be nervous tissue." [] synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell is_a: UBERON:0004121 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ectoderm-derived structure relationship: develops_from CL:0000221 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ectodermal cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000134 name: mesenchymal cell name: mesenchymal stem cell namespace: cell alt_id: CL:0002452 def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:_17986482, PMID:_19960544] def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. synonym: "BMSC" NARROW [] synonym: "BMSC" RELATED [] synonym: "bone marrow stromal cells" NARROW [] synonym: "bone marrow stromal cells" RELATED [] synonym: "CFU-F" RELATED [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "colony-forming unit-fibroblast" RELATED [] synonym: "marrow stromal cells" NARROW [] synonym: "marrow stromal cells" RELATED [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal progenitor cells" RELATED [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED [] synonym: "MSC" RELATED [PMID:11378515] synonym: "Stem Cells, Mesenchymal" RELATED [MESH:D044982] synonym: "stem cells, mesenchymal" RELATED [] xref: BTO:0002625 xref: BTO:0003298 xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000063 ! cell by histology is_a: CL:0000219 ! motile cell is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: capable_of GO:0001649 relationship: capable_of GO:0016477 ! cell migration relationship: capable_of GO:0030182 relationship: capable_of GO:0030855 ! epithelial cell differentiation relationship: capable_of GO:0045444 relationship: capable_of GO:0055007 relationship: capable_of GO:0060591 relationship: develops_from CL:0000222 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesodermal cell relationship: has_part PR:000001345 relationship: has_part PR:000001800 relationship: has_part PR:000001843 [Term] id: CL:0000135 name: fibrocyte namespace: cell def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [] comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A. xref: FMA:63879 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: capable_of GO:0002495 intersection_of: capable_of GO:0045766 ! positive regulation of angiogenesis relationship: capable_of GO:0002495 relationship: capable_of GO:0045766 ! positive regulation of angiogenesis relationship: develops_from CL:0000057 ! fibroblast [Term] id: CL:0000136 name: fat cell namespace: cell alt_id: CL:0000450 def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A.11.329.114] synonym: "adipocyte" EXACT [] synonym: "adipocyte" RELATED [] synonym: "adipose cell" EXACT [] synonym: "adipose cell" RELATED [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000137 name: osteocyte namespace: cell def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 synonym: "bone cell" BROAD [] xref: BTO:0002038 xref: CALOHA:TS-1167 xref: FMA:66779 xref: VSAO:0000124 is_a: CL:0001035 ! bone cell is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0002481 ! bone tissue relationship: part_of ZFA:0005734 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! lacunocanalicular system (Danio) [Term] id: CL:0000138 name: chondrocyte namespace: cell def: "Polymorphic cell that form cartilage." [MESH:A.11.329.171] def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [] synonym: "cartilage cell" EXACT [] synonym: "cartilage cell" RELATED [] xref: BTO:0000249 xref: CALOHA:TS-0138 xref: FMA:66782 is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: develops_from CL:0000058 ! chondroblast [Term] id: CL:0000139 is_a: UBERON:0004119 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! endoderm-derived structure is_a: UBERON:0010314 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! structure with developmental contribution from neural crest relationship: develops_from CL:0000059 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ameloblast [Term] id: CL:0000140 name: odontocyte namespace: cell def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [] is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0000078 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mixed ectoderm/mesoderm/endoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000060 ! odontoblast relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000141 name: cementocyte namespace: cell def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [] comment: CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def). xref: FMA:63003 is_a: CL:0000137 ! osteocyte is_a: UBERON:0000078 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mixed ectoderm/mesoderm/endoderm-derived structure relationship: develops_from CL:0000061 ! cementoblast relationship: develops_from CL:0000134 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesenchymal cell relationship: existence_starts_during_or_after ZFS:0000033 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Hatching:Long-pec relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: part_of UBERON:2000694 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ceratobranchial 5 tooth [Term] id: CL:0000142 name: hyalocyte namespace: cell def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." [] synonym: "vitreous cell" RELATED [] xref: BTO:0004271 xref: FMA:70620 is_a: CL:0000499 ! stromal cell [Term] id: CL:0000143 name: guidepost cell namespace: cell is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000144 name: cell by function name: obsolete cell by function namespace: cell def: "A classification of cells by their primary end goal or behavior." [FB:ma] def: "OBSOLETE: A classification of cells by their primary end goal or behavior." [] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_a: CL:0000012 ! cell by class is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000145 name: professional antigen presenting cell namespace: cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. synonym: "APC" BROAD [] is_a: CL:0000473 ! defensive cell relationship: capable_of GO:0002504 [Term] id: CL:0000146 name: simple columnar epithelial cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000147 name: pigment cell namespace: cell def: "A pigment cell is a cell that contains pigment granules." [] synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000027 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:20-25 somites [Term] id: CL:0000148 name: melanocyte namespace: cell alt_id: CL:0000572 def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [] synonym: "melanophore" NARROW [] xref: BTO:0000847 xref: CALOHA:TS-0613 xref: FMA:70545 xref: VHOG:0001679 is_a: CL:0000147 ! pigment cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000147 ! pigment cell intersection_of: develops_from CL:0000541 ! melanoblast intersection_of: has_part GO:0042470 relationship: develops_from CL:0000541 ! melanoblast relationship: existence_starts_during_or_after ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 relationship: has_part GO:0042470 relationship: part_of UBERON:0002199 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! integument [Term] id: CL:0000149 name: visual pigment cell namespace: cell synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell namespace: cell def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [] xref: CALOHA:TS-2085 xref: FMA:86494 is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell is_a: CL:0002371 ! somatic cell relationship: part_of UBERON:0006799 ! glandular epithelium [Term] id: CL:0000151 name: secretory cell namespace: cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] xref: BTO:0003659 xref: FMA:86916 is_a: CL:0000003 ! native cell is_a: CL:0000144 ! obsolete cell by function intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0032940 ! secretion by cell relationship: capable_of GO:0032940 ! secretion by cell [Term] id: CL:0000152 name: exocrine cell namespace: cell def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [] xref: FMA:16014 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002365 ! exocrine gland relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0002365 ! exocrine gland [Term] id: CL:0000153 name: glycosaminoglycan secreting cell namespace: cell def: "A cell that secretes glycosaminoglycans." [] synonym: "GAG secreting cell" EXACT [] synonym: "hyaluronic acid secreting cell" NARROW [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0009306 ! protein secretion relationship: capable_of GO:0009306 ! protein secretion [Term] id: CL:0000155 name: peptic cell namespace: cell def: "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen." [] synonym: "chief cell of stomach" EXACT [] synonym: "gastric chief cell" EXACT [] synonym: "pepsinogen secreting cell" EXACT [] synonym: "zymogenic cell" EXACT [] xref: FMA:62902 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002659 ! glandular cell of stomach [Term] id: CL:0000156 name: obsolete antibody secreting cell namespace: cell def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." [] comment: Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000157 name: surfactant secreting cell namespace: cell def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0043129 relationship: capable_of GO:0043129 [Term] id: CL:0000158 name: club cell namespace: cell def: "Epithelial progenitor cell of the lung. Club cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Club cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." [] synonym: "bronchiolar non-ciliated cell" EXACT [] synonym: "Clara cell" EXACT [] synonym: "club cell of bronchiole" EXACT [] xref: BTO:0004811 xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002328 ! bronchial epithelial cell relationship: has_part GO:0005902 ! microvillus [Term] id: CL:0000159 name: seromucus secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000160 name: goblet cell namespace: cell def: "A cell of the epithelial lining that produce and secrete mucins." [] synonym: "chalice cell" EXACT [] xref: BTO:0001540 xref: FMA:13148 xref: http://en.wikipedia.org/wiki/Goblet_cell is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell [Term] id: CL:0000161 name: acid secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0046717 ! acid secretion relationship: capable_of GO:0046717 ! acid secretion relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000162 name: parietal cell namespace: cell def: "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." [] synonym: "oxyntic cell" EXACT [] xref: BTO:0001780 xref: FMA:62901 is_a: CL:0000161 ! acid secreting cell is_a: CL:0002659 ! glandular cell of stomach [Term] id: CL:0000163 name: endocrine cell namespace: cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [] synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0060986 ! endocrine hormone secretion relationship: capable_of GO:0060986 ! endocrine hormone secretion relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites relationship: part_of UBERON:0002368 ! endocrine gland [Term] id: CL:0000164 name: enteroendocrine cell namespace: cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [] xref: BTO:0003865 xref: FMA:62930 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell namespace: cell def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A.06.688] synonym: "neurosecretory cell" EXACT [] synonym: "neurosecretory cell" RELATED [] xref: BTO:0002691 xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000166 name: chromaffin cell namespace: cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [] synonym: "phaeochromocyte" EXACT [] xref: BTO:0000259 xref: FMA:69263 is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000167 name: peptide hormone secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030072 ! peptide hormone secretion relationship: capable_of GO:0030072 ! peptide hormone secretion relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000168 name: insulin secreting cell namespace: cell xref: BTO:0000783 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030073 ! insulin secretion relationship: capable_of GO:0030073 ! insulin secretion [Term] id: CL:0000169 name: type B pancreatic cell namespace: cell def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [] comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. synonym: "B-cell of pancreatic islet" EXACT [] synonym: "beta cell" BROAD [] synonym: "beta cell islet" RELATED [] synonym: "beta cell of pancreatic islet" EXACT [] synonym: "insulin-secreting cell" EXACT [] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic B-cell" EXACT [] synonym: "pancreatic beta cell" EXACT [] synonym: "pancreatic islet core" EXACT [] synonym: "type B enteroendocrine cell" EXACT [] xref: BTO:0000783 xref: EV:0200009 xref: FMA:70586 xref: MA:0002419 xref: ncithesaurus:Beta_Cell is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000168 ! insulin secreting cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: capable_of GO:0030073 ! insulin secretion intersection_of: part_of UBERON:0000006 ! islet of Langerhans relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:2001371 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pancreatic system [Term] id: CL:0000170 name: glucagon secreting cell namespace: cell def: "A cell that secretes glucagon." [] synonym: "glucagon-secreting cell" EXACT [] xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070091 ! glucagon secretion relationship: capable_of GO:0070091 ! glucagon secretion [Term] id: CL:0000171 name: pancreatic A cell namespace: cell def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [] synonym: "alpha cell of iselt of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] xref: BTO:0000990 xref: FMA:70585 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:2001371 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pancreatic system [Term] id: CL:0000172 name: somatostatin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070253 ! somatostatin secretion relationship: capable_of GO:0070253 ! somatostatin secretion [Term] id: CL:0000173 name: pancreatic D cell namespace: cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [] synonym: "D-cell of pancreatic islet" EXACT [] synonym: "delta cell of islet" EXACT [] synonym: "delta cell of pancreatic islet" EXACT [] synonym: "pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "somatostatin-secreting pancreatic cell" EXACT [] xref: BTO:0000803 xref: FMA:70587 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans [Term] id: CL:0000174 name: steroid hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035929 ! steroid hormone secretion relationship: capable_of GO:0035929 ! steroid hormone secretion relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000175 name: luteal cell namespace: cell def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [] synonym: "lutein cell" EXACT [] xref: BTO:0003939 xref: FMA:18688 is_a: CL:0000179 ! progesterone secreting cell is_a: CL:0002132 ! stromal cell of ovary relationship: part_of UBERON:0002512 ! corpus luteum [Term] id: CL:0000176 name: ecdysteroid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0045457 relationship: capable_of GO:0045457 [Term] id: CL:0000177 name: testosterone secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035936 relationship: capable_of GO:0035936 [Term] id: CL:0000178 name: Leydig cell namespace: cell def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [] comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated synonym: "interstitial cell" BROAD [] synonym: "interstitial cell of Leydig" EXACT [] xref: BTO:0000755 xref: CALOHA:TS-1150 xref: EMAPA:29655 xref: FMA:72297 is_a: CL:0000177 ! testosterone secreting cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0005212 ! Leydig cell region of testis [Term] id: CL:0000179 name: progesterone secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0042701 ! progesterone secretion relationship: capable_of GO:0042701 ! progesterone secretion [Term] id: CL:0000180 name: estradiol secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035938 relationship: capable_of GO:0035938 [Term] id: CL:0000181 name: metabolising cell namespace: cell def: "A cell whose primary function is intermediary metabolism." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000182 name: hepatocyte namespace: cell def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [] comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. xref: BTO:0000575 xref: CALOHA:TS-0454 xref: FMA:14515 is_a: CL:0000066 ! epithelial cell is_a: CL:0000181 ! metabolising cell is_a: CL:0000417 ! endopolyploid cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004119 ! endoderm-derived structure relationship: capable_of GO:0006699 ! bile acid biosynthetic process relationship: capable_of GO:0098754 relationship: develops_from CL:0005026 ! hepatoblast relationship: develops_from ZFA:0009398 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! hepatoblast (Danio) relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000183 name: contractile cell namespace: cell def: "A cell whose primary function is to shorten." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000185 name: myoepithelial cell namespace: cell def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [] synonym: "basket epithelial cell" EXACT [] synonym: "myoepitheliocyte" EXACT [] xref: BTO:0002309 xref: CALOHA:TS-2379 xref: FMA:67799 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000183 ! contractile cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000186 name: myofibroblast cell namespace: cell def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [] comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha. synonym: "MFB" EXACT [] is_a: CL:0000183 ! contractile cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000187 name: muscle cell namespace: cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A.11.620] synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] synonym: "myocyte" RELATED [] xref: BTO:0000888 xref: BTO:0000902 xref: CALOHA:TS-2032 xref: FBbt:00005074 xref: FMA:67328 xref: WBbt:0003675 is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000056 ! myoblast relationship: existence_starts_during_or_after ZFS:0000023 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:1-4 somites relationship: part_of UBERON:0001015 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! musculature relationship: part_of UBERON:0001630 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! muscle organ [Term] id: CL:0000188 name: cell of skeletal muscle name: skeletal muscle cell namespace: cell def: "A somatic cell located in skeletal muscle." [GOC:tfm] synonym: "skeletal muscle cell" EXACT [] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 is_a: CL:0000187 ! muscle cell is_a: ZFA:0005784 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! striated muscle cell (Danio) intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: develops_from CL:0000515 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! skeletal muscle myoblast relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000189 name: slow muscle cell namespace: cell def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [] synonym: "slow muscle fiber" RELATED [] xref: FMA:84448 is_a: CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000857 ! slow muscle myoblast relationship: develops_from UBERON:0003082 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! myotome relationship: develops_from ZFA:0001373 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! migratory slow muscle precursor cell (Danio) [Term] id: CL:0000190 name: fast muscle cell namespace: cell def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." [] synonym: "glycolytic muscle fiber" EXACT [] is_a: CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000858 ! fast muscle myoblast relationship: develops_from UBERON:0003082 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! myotome relationship: existence_starts_during_or_after ZFS:0000024 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:5-9 somites [Term] id: CL:0000192 name: smooth muscle cell namespace: cell alt_id: CL:0000191 def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [MESH:A.11.620.520, MESH:D032389, PMID:9315361] synonym: "myocytes, smooth muscle" EXACT [] synonym: "myocytes, smooth muscle" RELATED [MESH:D032389] synonym: "non-striated muscle cell" NARROW [] synonym: "non-striated muscle cell" RELATED [] synonym: "SMCs" EXACT [] synonym: "SMCs" RELATED [PMID:9315361] synonym: "smooth muscle fiber" EXACT [] synonym: "smooth muscle fiber" RELATED [] xref: BTO:0004576 xref: CALOHA:TS-2159 xref: FMA:14072 is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: develops_from CL:0000514 ! smooth muscle myoblast relationship: part_of UBERON:0001135 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! smooth muscle tissue [Term] id: CL:0000193 name: cardiac muscle cell (sensu Arthopoda) namespace: cell alt_id: CL:0000466 def: "A striated muscle cell of an arthropod heart that participates in heart contraction." [] is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: develops_from CL:0000465 ! cardioblast (sensu Arthropoda) relationship: develops_from CL:0000465 ! cardioblast (sensu Arthropoda) [Term] id: CL:0000194 name: obsolete nodal cardiac cell namespace: cell comment: Consider CL:0002072. is_obsolete: true [Term] id: CL:0000195 name: obsolete Purkinje fiber namespace: cell is_obsolete: true [Term] id: CL:0000196 name: flight muscle cell namespace: cell is_a: CL:0008003 ! somatic muscle myotube [Term] id: CL:0000197 name: receptor cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000198 name: pain receptor cell namespace: cell def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [] comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship synonym: "nociceptor" EXACT [] synonym: "nocireceptor" EXACT [] is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000199 name: mechanoreceptor cell namespace: cell def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [] synonym: "mechanoreceptor" RELATED [] is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception [Term] id: CL:0000200 name: touch receptor cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch relationship: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch [Term] id: CL:0000202 name: auditory hair cell namespace: cell alt_id: CL:0000201 def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [] comment: In mammals these cells are located in the organ of Corti. synonym: "auditory receptor cell" EXACT [] synonym: "cochlear hair cell" EXACT [] synonym: "inner ear hair cell" RELATED [] synonym: "inner ear receptor cell" RELATED [] xref: FMA:62364 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002374 ! ear hair cell is_a: CL:0002491 ! auditory epithelial cell is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002227 ! spiral organ of cochlea [Term] id: CL:0000203 name: gravity sensitive cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: capable_of GO:0070999 relationship: capable_of GO:0070999 [Term] id: CL:0000204 name: acceleration receptive cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000205 name: thermoreceptor cell namespace: cell def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: capable_of GO:0050960 ! detection of temperature stimulus involved in thermoception relationship: capable_of GO:0050960 ! detection of temperature stimulus involved in thermoception [Term] id: CL:0000206 name: chemoreceptor cell namespace: cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [] is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception relationship: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception [Term] id: CL:0000207 name: olfactory receptor cell namespace: cell synonym: "odorant receptor cell" EXACT [] synonym: "olfactory receptor neuron" EXACT [] synonym: "olfactory sensory neuron" EXACT [] synonym: "Schultze's cell" EXACT [] xref: BTO:0004185 xref: FMA:67860 xref: Wikipedia:Olfactory_receptor_neuron is_a: CL:0000206 ! chemoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites relationship: part_of UBERON:0005725 ! olfactory system [Term] id: CL:0000208 name: pH receptor cell namespace: cell is_a: CL:0000206 ! chemoreceptor cell [Term] id: CL:0000209 name: taste receptor cell namespace: cell def: "A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste." [] synonym: "taste bud cell" EXACT [] xref: FMA:67910 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0000362 ! epidermal cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002076 ! endo-epithelial cell is_a: CL:2000032 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of UBERON:0001727 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! taste bud relationship: part_of UBERON:0002025 ! stratum basale of epidermis [Term] id: CL:0000210 name: photoreceptor cell namespace: cell def: "A cell specialized to detect and transduce light." [] xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FBbt:00004211 xref: FMA:86740 is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception relationship: capable_of GO:0016056 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! rhodopsin mediated signaling pathway relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception [Term] id: CL:0000211 name: electrically active cell namespace: cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000003 ! native cell is_a: CL:0000144 ! obsolete cell by function relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000212 name: absorptive cell namespace: cell def: "A cell that takes up and metabolizes substances." [] is_a: CL:0000003 ! native cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000213 name: lining cell namespace: cell def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [] synonym: "boundary cell" EXACT [] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell namespace: cell def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." [] synonym: "hyaluronic acid secreting cell" NARROW [] synonym: "synoviocyte" EXACT [] xref: BTO:0003652 xref: CALOHA:TS-0995 xref: FMA:66786 is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: part_of UBERON:0002018 ! synovial membrane of synovial joint relationship: part_of UBERON:0002018 ! synovial membrane of synovial joint [Term] id: CL:0000215 name: barrier cell namespace: cell def: "A cell whose primary function is to prevent the transport of stuff across compartments." [] is_a: CL:0000003 ! native cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000216 name: Sertoli cell namespace: cell def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [] xref: BTO:0001238 xref: CALOHA:TS-0922 xref: FMA:72298 xref: VHOG:0001348 is_a: CL:0000511 ! androgen binding protein secreting cell is_a: CL:0000630 ! supportive cell is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000630 ! supportive cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: existence_starts_during_or_after ZFS:0000041 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Days 21-29 [Term] id: CL:0000217 name: insulating cell namespace: cell is_a: CL:0000215 ! barrier cell [Term] id: CL:0000218 name: myelinating Schwann cell namespace: cell def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [] synonym: "neurilemmal cell" EXACT [] synonym: "peripheral neuroglial cell" BROAD [] synonym: "Schwann cell" BROAD [] xref: CALOHA:TS-0898 xref: FMA:62121 is_a: CL:0000217 ! insulating cell is_a: CL:0000328 ! myelin accumulating cell is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002377 ! immature Schwann cell relationship: existence_starts_during_or_after ZFS:0000033 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Hatching:Long-pec [Term] id: CL:0000219 name: motile cell namespace: cell def: "A cell that moves by its own activities." [] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0048870 ! cell motility relationship: capable_of GO:0048870 ! cell motility relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000220 name: obsolete cell by lineage namespace: cell comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000221 name: ectodermal cell namespace: cell def: "A cell of the outer of the three germ layers of the embryo." [] synonym: "ectoderm cell" EXACT [] xref: FMA:72549 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0002321 ! embryonic cell relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000020 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Gastrula:75%-epiboly relationship: part_of UBERON:0000924 ! ectoderm [Term] id: CL:0000222 name: mesodermal cell namespace: cell def: "A cell of the middle germ layer of the embryo." [] synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0002321 ! embryonic cell relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000020 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Gastrula:75%-epiboly relationship: part_of UBERON:0000926 ! mesoderm [Term] id: CL:0000223 name: endodermal cell namespace: cell def: "A cell of the inner of the three germ layers of the embryo." [] synonym: "endoderm cell" EXACT [] xref: FMA:72555 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0002321 ! embryonic cell relationship: existence_ends_during_or_before ZFS:0000035 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Protruding-mouth relationship: existence_starts_during_or_after ZFS:0000020 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Gastrula:75%-epiboly relationship: part_of UBERON:0000925 ! endoderm [Term] id: CL:0000224 name: cell by nuclear number name: obsolete cell by nuclear number namespace: cell def: "A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm] def: "OBSOLETE: A classification of cells by the number of their nuclei." [] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_a: CL:0000012 ! cell by class is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000225 name: anucleate cell namespace: cell def: "A cell that lacks a nucleus." [] synonym: "non-nucleated cell" EXACT [] xref: FMA:68647 is_a: CL:0000003 ! native cell [Term] id: CL:0000226 name: single nucleate cell namespace: cell def: "A cell with a single nucleus." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000227 name: binucleate cell namespace: cell is_a: CL:0000228 ! multinucleate cell [Term] id: CL:0000228 name: multinucleate cell namespace: cell def: "A cell with more than one nucleus." [FB:ma] synonym: "syncitium" EXACT [] synonym: "syncitium" RELATED [] synonym: "syncytial cell" EXACT [] synonym: "syncytial cell" RELATED [] synonym: "syncytium" EXACT [] synonym: "syncytium" RELATED [] xref: AEO:0000203 xref: WBbt:0008074 is_a: CL:0002242 ! nucleate cell [Term] id: CL:0000229 name: obsolete lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead. is_obsolete: true [Term] id: CL:0000230 name: obsolete T lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead. is_obsolete: true [Term] id: CL:0000231 name: obsolete B lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000232 name: erythrocyte namespace: cell def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [] synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 xref: CALOHA:TS-0290 xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 ! erythroid lineage cell relationship: develops_from CL:0000558 ! reticulocyte [Term] id: CL:0000233 name: platelet namespace: cell def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [] comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. synonym: "anucleate thrombocyte" EXACT [] synonym: "blood platelet" EXACT [] synonym: "enucleate thrombocyte" EXACT [] xref: BTO:0000132 xref: CALOHA:TS-0803 xref: FMA:62851 is_a: CL:0000081 ! blood cell is_a: CL:0000225 ! anucleate cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000763 ! myeloid cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0007596 ! blood coagulation relationship: develops_from CL:0000556 ! megakaryocyte [Term] id: CL:0000234 name: phagocyte namespace: cell def: "Any cell capable of ingesting particulate matter via phagocytosis." [] xref: BTO:0001044 xref: FMA:83806 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0006909 ! phagocytosis relationship: capable_of GO:0006909 ! phagocytosis [Term] id: CL:0000235 name: macrophage namespace: cell def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [] comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. synonym: "histiocyte" EXACT [] xref: BTO:0000801 xref: CALOHA:TS-0587 xref: FMA:63261 xref: FMA:83585 is_a: CL:0000234 ! phagocyte is_a: CL:0000766 ! myeloid leukocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: capable_of GO:0006909 ! phagocytosis intersection_of: capable_of GO:0031268 relationship: capable_of GO:0031268 relationship: develops_from CL:0000576 ! monocyte relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites [Term] id: CL:0000236 name: B cell namespace: cell def: "A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity." [] synonym: "B lymphocyte" EXACT [] synonym: "B-cell" EXACT [] synonym: "B-lymphocyte" EXACT [] xref: BTO:0000776 xref: CALOHA:TS-0068 xref: FMA:62869 xref: VHOG:0001480 is_a: CL:0000945 ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: capable_of GO:0019724 relationship: capable_of GO:0019724 [Term] id: CL:0000237 name: keratinizing barrier epithelial cell namespace: cell is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:0000311 ! keratin accumulating cell is_a: CL:0002077 ! ecto-epithelial cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000238 name: non keratinizing barrier epithelial cell namespace: cell is_a: CL:0000240 ! stratified squamous epithelial cell [Term] id: CL:0000239 name: brush border epithelial cell namespace: cell is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000240 name: stratified squamous epithelial cell namespace: cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000241 name: stratified cuboidal epithelial cell namespace: cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000242 name: Merkel cell namespace: cell def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [] synonym: "Merkel's cell" EXACT [] xref: FMA:70548 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000312 ! keratinocyte is_a: CL:0000710 ! neurecto-epithelial cell relationship: part_of UBERON:0002025 ! stratum basale of epidermis [Term] id: CL:0000243 name: glial cell (sensu Vertebrata) namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A.08.637] is_a: CL:0000125 ! glial cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000244 name: transitional epithelial cell namespace: cell def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [] xref: FMA:66778 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000245 name: obsolete passage cell namespace: cell def: "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [] comment: replaced_by: PO:0000353 is_obsolete: true [Term] id: CL:0000246 name: Mauthner neuron namespace: cell is_a: CL:0000099 ! interneuron is_a: UBERON:0010314 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! structure with developmental contribution from neural crest relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000027 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:20-25 somites relationship: part_of UBERON:0001896 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! medulla oblongata relationship: part_of UBERON:0005511 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! rhombomere 4 [Term] id: CL:0000247 name: Rohon-Beard neuron namespace: cell def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." [] synonym: "RB neuron" RELATED [] synonym: "Rohon Beard cell" EXACT [] synonym: "Rohon-Beard cell" EXACT [] xref: AAO:0010316 xref: EFO:0003711 xref: VHOG:0001484 is_a: CL:0000531 ! primary sensory neuron relationship: existence_ends_during_or_before ZFS:0000040 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Days 14-20 [Term] id: CL:0000248 name: obsolete microsporocyte namespace: cell def: "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [] comment: replaced_by: PO:0020047 synonym: "pollen mother cell" EXACT [] synonym: "primary sporogenous cell" EXACT [] is_obsolete: true [Term] id: CL:0000249 name: hatching gland cell namespace: cell is_a: CL:0000151 ! secretory cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000250 name: obsolete megaspore namespace: cell def: "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [] comment: replaced_by: PO:0020019 is_obsolete: true [Term] id: CL:0000251 name: extramedullary cell namespace: cell is_a: CL:0000101 ! sensory neuron [Term] id: CL:0000252 name: obsolete microspore namespace: cell def: "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [] comment: replaced_by: PO:0020048 is_obsolete: true [Term] id: CL:0000253 name: eurydendroid cell namespace: cell is_a: CL:0000527 ! efferent neuron is_a: CL:1001611 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! cerebellar neuron relationship: part_of UBERON:2000603 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! valvula cerebelli [Term] id: CL:0000254 name: obsolete egg cell namespace: cell def: "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." [] comment: replaced_by: PO:0020094 synonym: "female gametophyte egg cell" EXACT [] is_obsolete: true [Term] id: CL:0000255 name: eukaryotic cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000256 name: uric acid accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000257 name: Mycetozoan cell namespace: cell is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000258 name: obsolete fiber tracheid namespace: cell def: "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [] comment: replaced_by: PO:0000355 is_obsolete: true [Term] id: CL:0000259 name: obsolete aggregate cell is_obsolete: true replaced_by: DDANAT:0000403 [Term] id: CL:0000260 name: obsolete mucilage cell namespace: cell def: "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [] comment: replaced_by: PO:0000373 is_obsolete: true [Term] id: CL:0000261 name: anterior cell namespace: cell comment: Obsoleted becuase this term has an overly general name, no definition, and by it's classification appears to refer to a very specific cell type in dictystelium. If needed, the term should be in DDANAT - probably as a subclass of http://purl.obolibrary.org/obo/DDANAT_0000002 is_obsolete: true consider: false consider: http://purl.obolibrary.org/obo/DDANAT_0000002 [Term] id: CL:0000262 name: obsolete guard mother cell namespace: cell def: "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." [] comment: replaced_by: PO:0000351 is_obsolete: true [Term] id: CL:0000263 name: obsolete vegetative cell (sensu Mycetozoa) is_obsolete: true replaced_by: DDANAT:0000002 [Term] id: CL:0000264 name: obsolete phloem initial namespace: cell def: "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [] comment: replaced_by: PO:0000400 synonym: "phloem mother cell" EXACT [] is_obsolete: true [Term] id: CL:0000265 name: obsolete anterior like cell is_obsolete: true replaced_by: DDANAT:0000404 [Term] id: CL:0000266 name: obsolete meristemoid namespace: cell def: "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [] comment: replaced_by: PO:0004011 is_obsolete: true [Term] id: CL:0000267 name: obsolete prespore cell is_obsolete: true replaced_by: DDANAT:0000405 [Term] id: CL:0000268 name: obsolete sieve element namespace: cell def: "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [] is_obsolete: true [Term] id: CL:0000269 name: obsolete prestalk cell is_obsolete: true replaced_by: DDANAT:0000406 [Term] id: CL:0000270 name: obsolete subsidiary cell namespace: cell def: "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [] comment: replaced_by: PO:0000284 is_obsolete: true [Term] id: CL:0000271 name: obsolete prestalk A cell is_obsolete: true replaced_by: DDANAT:0000408 [Term] id: CL:0000272 name: obsolete cambial initial namespace: cell def: "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [] comment: replaced_by PO:0000295 is_obsolete: true [Term] id: CL:0000273 name: obsolete prestalk AB cell is_obsolete: true replaced_by: DDANAT:0000410 [Term] id: CL:0000275 name: obsolete prestalk B cell is_obsolete: true replaced_by: DDANAT:0000409 [Term] id: CL:0000276 name: obsolete sclerenchyma cell namespace: cell def: "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [] comment: replaced_by: PO:0000077 is_obsolete: true [Term] id: CL:0000277 name: obsolete prestalk I cell namespace: cell def: "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [] comment: This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology. is_obsolete: true replaced_by: DDANAT:0000406 [Term] id: CL:0000278 name: obsolete central cell namespace: cell def: "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [] comment: replaced_by: PO:0020090 is_obsolete: true [Term] id: CL:0000279 name: obsolete prestalk 0 cell is_obsolete: true replaced_by: DDANAT:0000407 [Term] id: CL:0000280 name: obsolete generative cell namespace: cell def: "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." [] comment: replaced_by: PO:0020097 is_obsolete: true [Term] id: CL:0000281 name: obsolete pstAB/ALC is_obsolete: true replaced_by: DDANAT:0000411 [Term] id: CL:0000282 name: obsolete trichome namespace: cell def: "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [] comment: replaced_by: PO:0000282 is_obsolete: true [Term] id: CL:0000283 name: obsolete pstO/ALC is_obsolete: true replaced_by: DDANAT:0000412 [Term] id: CL:0000284 name: obsolete companion cell namespace: cell def: "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [] comment: replaced_by: PO:0000071 is_obsolete: true [Term] id: CL:0000285 name: obsolete stalk cell is_obsolete: true replaced_by: DDANAT:0000413 [Term] id: CL:0000286 name: hyphal cell namespace: cell def: "A cell of a filament of a fungal mycelium." [] is_a: CL:0000521 ! fungal cell [Term] id: CL:0000287 name: eye photoreceptor cell namespace: cell is_a: CL:0000210 ! photoreceptor cell is_a: CL:0010009 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! camera-type eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0001787 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! photoreceptor layer of retina relationship: part_of UBERON:0001789 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! outer nuclear layer of retina [Term] id: CL:0000288 name: obsolete synergid namespace: cell def: "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [] comment: replaced_by: PO:0000191 is_obsolete: true [Term] id: CL:0000289 name: obsolete chemotactic amoeboid cell (sensu Mycetozoa) is_obsolete: true replaced_by: DDANAT:0000402 [Term] id: CL:0000290 name: obsolete xylem fiber cell namespace: cell def: "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [] comment: replaced_by: PO:0000274 is_obsolete: true [Term] id: CL:0000291 name: obsolete spore (sensu Mycetozoa) is_obsolete: true replaced_by: DDANAT:0000414 [Term] id: CL:0000292 name: obsolete guard cell namespace: cell def: "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [] comment: replaced_by: PO:0000293 synonym: "stomatal guard cell" EXACT [] is_obsolete: true [Term] id: CL:0000293 name: structural cell namespace: cell def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000294 name: obsolete sieve cell namespace: cell def: "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [] is_obsolete: true [Term] id: CL:0000295 name: somatotropin secreting cell namespace: cell alt_id: CL:0000471 def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [] synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:2000004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pituitary gland cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030252 relationship: capable_of GO:0030252 relationship: existence_starts_during_or_after ZFS:0000033 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Hatching:Long-pec relationship: part_of ZFA:0005581 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! proximal pars anterior (Danio) [Term] id: CL:0000296 name: obsolete vegetative cell namespace: cell def: "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [] comment: replaced_by: PO:0020099 is_obsolete: true [Term] id: CL:0000297 name: obsolete socket cell namespace: cell def: "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." [] comment: replaced_by: PO:0000115 is_obsolete: true [Term] id: CL:0000298 name: obsolete xylem element namespace: cell def: "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." [] comment: replaced_by: PO:0000273 is_obsolete: true [Term] id: CL:0000299 name: obsolete trichoblast namespace: cell def: "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [] comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262). is_obsolete: true [Term] id: CL:0000300 name: gamete namespace: cell def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [] synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: CALOHA:TS-0395 xref: FBbt:00005412 xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 ! germ cell is_a: FBbt:00004860 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! germline cell (Drosophila) is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: capable_of GO:0009566 relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000041 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Days 21-29 relationship: part_of UBERON:0000991 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! gonad relationship: part_of UBERON:0000991 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! gonad [Term] id: CL:0000301 name: pole cell namespace: cell xref: FBbt:00000092 is_a: CL:0000670 ! primordial germ cell is_a: FBbt:00004860 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! germline cell (Drosophila) relationship: develops_from FBbt:00000091 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! pole bud (Drosophila) relationship: part_of FBbt:00005311 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! stage 5 embryo (Drosophila) relationship: part_of FBbt:00005331 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! dorsal closure embryo (Drosophila) relationship: part_of UBERON:0000323 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! late embryo relationship: part_of UBERON:0004734 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! gastrula [Term] id: CL:0000302 name: obsolete IgM B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000303 name: obsolete IgG B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000304 name: obsolete IgA B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000305 name: obsolete IgE B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000306 name: crystallin accumulating cell namespace: cell synonym: "lens cell" EXACT [] xref: FBbt:00004193 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0009001 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! compound eye retinal cell is_a: FBbt:00005163 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! sensory organ cell (Drosophila) relationship: part_of UBERON:0000971 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! ommatidium [Term] id: CL:0000307 name: tracheal epithelial cell namespace: cell alt_id: CL:1000474 def: "An epithelial cell found in the trachea." [] comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' synonym: "tracheocyte" EXACT [] xref: FMA:74793 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from CL:0000377 ! tracheoblast relationship: part_of UBERON:0003126 ! trachea [Term] id: CL:0000308 name: metal ion accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000309 name: copper accumulating cell namespace: cell synonym: "cuprophilic cell" EXACT [] is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000310 name: iron accumulating cell namespace: cell is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000311 name: keratin accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000312 name: keratinocyte namespace: cell alt_id: CL:0002185 def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [] comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. synonym: "keratinized cell of epidermis" EXACT [] synonym: "malpighian cell" EXACT [] xref: BTO:0000667 xref: CALOHA:TS-0500 xref: FMA:62879 is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: capable_of GO:0002775 relationship: capable_of GO:0002776 relationship: capable_of GO:0090023 relationship: part_of UBERON:0001003 ! skin epidermis [Term] id: CL:0000313 name: serous secreting cell namespace: cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [] synonym: "serous cell" EXACT [] xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000314 name: milk secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000315 name: tears secreting cell namespace: cell def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000316 name: obsolete ray initial namespace: cell def: "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [] comment: replaced_by: PO:0000082 is_obsolete: true [Term] id: CL:0000317 name: sebum secreting cell namespace: cell def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [] synonym: "sebocyte" EXACT [] is_a: CL:0000152 ! exocrine cell is_a: CL:2000021 ! sebaceous gland native cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0001821 ! sebaceous gland [Term] id: CL:0000318 name: sweat secreting cell namespace: cell def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [] is_a: CL:0000150 ! glandular epithelial cell [Term] id: CL:0000319 name: mucus secreting cell namespace: cell synonym: "mucous cell" EXACT [] xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070254 ! mucus secretion relationship: capable_of GO:0070254 ! mucus secretion relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites relationship: part_of UBERON:0002199 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! integument relationship: part_of UBERON:0002405 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! immune system [Term] id: CL:0000320 name: obsolete megasporocyte namespace: cell def: "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [] comment: replaced_by: PO:0000431 synonym: "archesporial cell" EXACT [] synonym: "megaspore mother cell" EXACT [] is_obsolete: true [Term] id: CL:0000321 name: seminal fluid secreting cell namespace: cell is_a: CL:0000151 ! secretory cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000322 name: pneumocyte namespace: cell def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [] synonym: "alveolar epithelial cell" EXACT [] synonym: "pneumonocyte" EXACT [] xref: BTO:0000395 xref: CALOHA:TS-2168 xref: FMA:62499 is_a: CL:0010003 ! epithelial cell of alveolus of lung relationship: part_of UBERON:0004821 ! pulmonary alveolus epithelium [Term] id: CL:0000323 name: lysozyme secreting cell namespace: cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000324 name: metanephric mesenchyme stem cell namespace: cell is_a: CL:0000134 ! mesenchymal cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000325 name: stuff accumulating cell namespace: cell def: "A cell that is specialised to accumulate a particular substance(s)." [] subset: ubprop:upper_level is_a: CL:0000003 ! native cell [Term] id: CL:0000326 name: glycogen accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000327 name: extracellular matrix secreting cell namespace: cell is_a: CL:0000151 ! secretory cell is_a: CL:0000499 ! stromal cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070278 ! extracellular matrix constituent secretion relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion [Term] id: CL:0000328 name: myelin accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000329 name: oxygen accumulating cell namespace: cell is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0015671 relationship: capable_of GO:0015671 relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000330 name: obsolete collenchymal cell namespace: cell def: "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." [] comment: replaced_by: PO:0000075 is_obsolete: true [Term] id: CL:0000331 name: obsolete tracheid namespace: cell def: "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [] comment: replaced_by: PO:0000301 is_obsolete: true [Term] id: CL:0000332 name: obsolete atrichoblast namespace: cell def: "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [] comment: replaced_by: PO:0020090 synonym: "non-hair cell" RELATED [] is_obsolete: true [Term] id: CL:0000333 name: migratory neural crest cell namespace: cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0007004 ! premigratory neural crest cell relationship: existence_ends_during_or_before ZFS:0000031 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-25 relationship: existence_starts_during_or_after ZFS:0000023 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:1-4 somites relationship: part_of UBERON:0010170 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! region of neural crest [Term] id: CL:0000334 name: vegetative cell (sensu Fungi) namespace: cell synonym: "yeast-form" RELATED [] xref: BTO:0002307 xref: FAO:0000032 is_a: CL:0000521 ! fungal cell [Term] id: CL:0000335 name: mesenchyme condensation cell namespace: cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0000134 ! mesenchymal cell is_a: CL:0008019 ! mesenchymal cell relationship: develops_from CL:0000134 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesenchymal cell [Term] id: CL:0000336 name: adrenal medulla chromaffin cell namespace: cell alt_id: CL:1000422 def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [] synonym: "medullary chromaffin cell of adrenal gland" EXACT [] xref: FMA:69262 is_a: CL:0000457 ! biogenic amine secreting cell is_a: CL:1000426 ! chromaffin cell of adrenal gland intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0001236 ! adrenal medulla relationship: develops_from CL:0000011 ! migratory trunk neural crest cell relationship: part_of UBERON:0001236 ! adrenal medulla [Term] id: CL:0000337 name: neuroblast (sensu Vertebrata) namespace: cell def: "An embryonic cell that develops into a nerve cell or neuron." [] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000338 name: neuroblast (sensu Nematoda and Protostomia) namespace: cell synonym: "neuroblast" BROAD [] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000339 name: glioblast (sensu Vertebrata) namespace: cell def: "An early neural cell developing from the early ependymal cell of the neural tube." [] synonym: "spongioblast" EXACT [] xref: FMA:70564 is_a: CL:0000030 ! glioblast is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000340 name: glioblast (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000030 ! glioblast is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000341 name: pigment cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000147 ! pigment cell [Term] id: CL:0000342 name: pigment cell (sensu Vertebrata) namespace: cell def: "Any animal cell containing pigment granules." [] is_a: CL:0000147 ! pigment cell relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000343 name: visual pigment cell (sensu Vertebrata) namespace: cell def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." [] xref: FMA:63846 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000342 ! pigment cell (sensu Vertebrata) is_a: UBERON:0004121 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ectoderm-derived structure intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: capable_of GO:0050908 ! detection of light stimulus involved in visual perception relationship: capable_of GO:0050908 ! detection of light stimulus involved in visual perception relationship: existence_starts_during_or_after ZFS:0000030 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-15 relationship: part_of UBERON:0000966 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! retina [Term] id: CL:0000344 name: obsolete non-visual cell (sensu Vertebrata) namespace: cell is_obsolete: true [Term] id: CL:0000345 name: dental papilla cell namespace: cell def: "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [] comment: Merge with odontoblast? is_a: CL:0008019 ! mesenchymal cell is_a: UBERON:0004119 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! endoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001763 ! odontogenic papilla [Term] id: CL:0000346 name: hair follicle dermal papilla cell namespace: cell def: "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." [] comment: Are these really all stem cells? is_a: CL:0000134 ! mesenchymal cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0000412 ! dermal papilla relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: part_of UBERON:0000412 ! dermal papilla [Term] id: CL:0000347 name: scleral cell namespace: cell def: "A cell of the sclera of the eye." [] is_a: CL:0000293 ! structural cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001773 ! sclera relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0001773 ! sclera [Term] id: CL:0000348 name: choroidal cell of the eye namespace: cell def: "A cell of the choroid of the eye." [] is_a: CL:0000293 ! structural cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001776 ! optic choroid relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0001776 ! optic choroid [Term] id: CL:0000349 name: extraembryonic cell namespace: cell is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000478 ! extraembryonic structure relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0000478 ! extraembryonic structure [Term] id: CL:0000350 name: amnioserosal cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0010302 ! amnioserosa relationship: part_of UBERON:0010302 ! amnioserosa [Term] id: CL:0000351 name: trophoblast cell namespace: cell def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [] synonym: "trophoblastic cell" EXACT [] xref: FMA:83028 is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0000358 ! blastocyst relationship: part_of UBERON:0000358 ! blastocyst [Term] id: CL:0000352 name: epiblast cell namespace: cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell namespace: cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [] synonym: "blastomere" EXACT [] xref: BTO:0001473 xref: FMA:72551 is_a: CARO:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} is_a: CARO:0000003 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! anatomical structure is_a: CL:0000007 ! early embryonic cell relationship: existence_ends_during_or_before ZFS:0000022 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Gastrula:Bud relationship: existence_starts_during_or_after ZFS:0000016 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Blastula:30%-epiboly relationship: part_of UBERON:0004750 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! blastoderm [Term] id: CL:0000354 name: blastemal cell namespace: cell synonym: "blastema cell" EXACT [] xref: ncithesaurus:Blastemal_Cell is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell namespace: cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [] comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. xref: FMA:86767 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000188 ! skeletal muscle cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000356 name: hair matrix stem cell namespace: cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000357 name: stratified epithelial stem cell namespace: cell is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000358 name: sphincter associated smooth muscle cell namespace: cell def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004590 ! sphincter muscle relationship: part_of UBERON:0004590 ! sphincter muscle [Term] id: CL:0000359 name: vascular associated smooth muscle cell namespace: cell def: "A smooth muscle cell assocatiated with the vasculature." [] synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002049 ! vasculature relationship: part_of UBERON:0002049 ! vasculature [Term] id: CL:0000360 name: morula cell namespace: cell def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000007 ! early embryonic cell relationship: part_of UBERON:0000085 ! morula [Term] id: CL:0000361 name: gastrula cell namespace: cell def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000007 ! early embryonic cell relationship: existence_ends_during_or_before ZFS:0000019 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Gastrula:Shield relationship: existence_starts_during_or_after ZFS:0000017 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Gastrula:50%-epiboly relationship: part_of UBERON:0004734 ! gastrula [Term] id: CL:0000362 name: epidermal cell namespace: cell alt_id: CL:1000396 def: "An epithelial cell of the integument (the outer layer of an organism)." [] synonym: "cell of epidermis" EXACT [] synonym: "epithelial cell of skin" NARROW [] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007376 ! outer epithelium relationship: part_of UBERON:0007376 ! outer epithelium [Term] id: CL:0000363 name: obsolete axial cell namespace: cell def: "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [] comment: replaced_by: PO:0000081 is_obsolete: true [Term] id: CL:0000364 name: obsolete ray cell namespace: cell def: "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [] is_obsolete: true [Term] id: CL:0000365 name: animal zygote namespace: cell def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [] synonym: "zygote" BROAD [] xref: BTO:0000854 xref: EHDAA2:0004546 xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell relationship: existence_ends_during_or_before HsapDv:0000003 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! CS01 relationship: existence_starts_during_or_after HsapDv:0000003 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! CS01 [Term] id: CL:0000366 name: obsolete sperm cell (sensu Viridiplantae) namespace: cell def: "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." [] comment: replaced_by: PO:0000084 synonym: "gametophyte sperm cell" RELATED [] synonym: "male gametophyte sperm cell" RELATED [] synonym: "pollen germ cell" RELATED [] is_obsolete: true [Term] id: CL:0000367 name: sheath cell (sensu Nematoda) namespace: cell synonym: "glial cell (sensu Nematoda)" RELATED [] is_a: CL:0000619 ! support cell (sensu Nematoda) [Term] id: CL:0000368 name: obsolete myrosin cell namespace: cell def: "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [] comment: replaced_by: PO:0000352 is_obsolete: true [Term] id: CL:0000370 name: obsolete transfer cell namespace: cell def: "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [] comment: replaced_by: PO:0000078 synonym: "intermediary cell" RELATED [] is_obsolete: true [Term] id: CL:0000371 name: protoplast namespace: cell def: "The cell protoplasm after removal of the cell wall." [] is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000372 name: tormogen cell namespace: cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." [] synonym: "socket cell" BROAD [] xref: FBbt:00005171 is_a: CL:0000463 ! epidermal cell (sensu arthropoda) is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! neural cell is_a: FBbt:00007254 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! eo support cell (Drosophila) relationship: develops_from FBbt:00005166 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! external sensory organ precursor cell IIa (Drosophila) [Term] id: CL:0000373 name: histoblast namespace: cell xref: FBbt:00001789 is_a: CL:0000146 ! simple columnar epithelial cell is_a: FBbt:00001760 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! embryonic/larval imaginal precursor (Drosophila) relationship: develops_from FBbt:00016022 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! abdominal histoblast primordium (Drosophila) relationship: part_of UBERON:0000323 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! late embryo [Term] id: CL:0000374 name: trichogen cell namespace: cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." [] synonym: "hair cell" BROAD [] xref: BTO:0004744 xref: FBbt:00005169 is_a: CL:0000463 ! epidermal cell (sensu arthropoda) is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! neural cell is_a: FBbt:00007254 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! eo support cell (Drosophila) relationship: develops_from FBbt:00005166 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! external sensory organ precursor cell IIa (Drosophila) [Term] id: CL:0000375 name: obsolete osteoprogenitor cell namespace: cell xref: BTO:0002051 is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: develops_from CL:0000335 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesenchyme condensation cell is_obsolete: true replaced_by: CL:0007010 [Term] id: CL:0000376 name: humidity receptor cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000377 name: tracheoblast namespace: cell is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000378 name: support cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000379 name: sensory processing neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000380 name: thecogen cell namespace: cell def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." [] synonym: "fly sheath cell" EXACT [] is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000381 name: neurosecretory neuron namespace: cell xref: FBbt:00005130 is_a: CL:0000151 ! secretory cell is_a: CL:0000527 ! efferent neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0046879 ! hormone secretion relationship: capable_of GO:0046879 ! hormone secretion [Term] id: CL:0000382 name: scolopale cell namespace: cell xref: FBbt:00005219 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) is_a: FBbt:00005156 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! mechanosensory sensory organ (Drosophila) is_a: FBbt:00007233 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! internal sensillum (Drosophila) relationship: part_of UBERON:0001038 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! chordotonal organ [Term] id: CL:0000383 name: nephrogenic mesenchyme stem cell namespace: cell is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000384 name: ligament cell namespace: cell is_a: CL:0000630 ! supportive cell relationship: part_of UBERON:0000211 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ligament [Term] id: CL:0000385 name: prohemocyte (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005062 is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia) is_a: FBbt:00007008 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic precursor cell (Drosophila) is_a: FBbt:00025999 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! head mesoderm derivative (Drosophila) relationship: part_of FBbt:00005247 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! embryonic hemocyte primordium (Drosophila) [Term] id: CL:0000386 name: attachment cell namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000387 name: hemocyte (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005063 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) relationship: capable_of GO:0035010 relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia) relationship: part_of UBERON:0002323 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! coelemic cavity lumen [Term] id: CL:0000388 name: tendon cell namespace: cell def: "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." [] synonym: "muscle attachment cell" EXACT [] synonym: "tenocyte" RELATED [] is_a: CL:0000135 ! fibrocyte is_a: CL:0000386 ! attachment cell is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural cell intersection_of: CL:0000135 ! fibrocyte intersection_of: part_of UBERON:0000043 ! tendon relationship: part_of UBERON:0000043 ! tendon [Term] id: CL:0000389 name: socket cell (sensu Nematoda) namespace: cell is_a: CL:0000619 ! support cell (sensu Nematoda) is_a: CL:0000658 ! cuticle secreting cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000390 name: blood cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000081 ! blood cell [Term] id: CL:0000391 name: podocyte (sensu Diptera) namespace: cell def: "An insect immune cell that develops from plasmatocyte." [] xref: FBbt:00001688 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) relationship: develops_from CL:0000394 ! plasmatocyte [Term] id: CL:0000392 name: crystal cell namespace: cell xref: FMA:63847 is_a: CL:0000391 ! podocyte (sensu Diptera) [Term] id: CL:0000393 name: electrically responsive cell namespace: cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000394 name: plasmatocyte namespace: cell xref: FBbt:00001685 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) is_a: FBbt:00001684 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! embryonic/larval hemocyte (Drosophila) is_a: FBbt:00005916 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! head mesoderm derived embryonic hemocyte (Drosophila) relationship: develops_from FBbt:00005249 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! proplasmatocyte (Drosophila) [Term] id: CL:0000395 name: procrystal cell namespace: cell xref: FBbt:00001689 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) relationship: part_of FBbt:00017007 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! crystal cell primordium (Drosophila) [Term] id: CL:0000396 name: lamellocyte namespace: cell xref: FBbt:00001687 is_a: CL:0000394 ! plasmatocyte relationship: develops_from FBbt:00005248 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! prolamellocyte (Drosophila) [Term] id: CL:0000397 name: ganglion interneuron namespace: cell is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0000045 ! ganglion relationship: part_of UBERON:0000045 ! ganglion [Term] id: CL:0000398 name: polygonal cell namespace: cell xref: FBbt:00001691 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000399 name: obsolete phloem element namespace: cell def: "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." [] is_obsolete: true [Term] id: CL:0000400 name: obsolete pavement cell namespace: cell def: "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [] comment: replaced_by: PO:0000332 is_obsolete: true [Term] id: CL:0000401 name: macrophage (sensu Diptera) namespace: cell xref: FBbt:00001686 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000402 name: CNS interneuron namespace: cell is_a: CL:0000099 ! interneuron is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000404 name: electrically signaling cell namespace: cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000405 name: neuroepidermoblast namespace: cell xref: FBbt:00005148 is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) is_a: FBbt:00001332 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! embryonic neuroblast (Drosophila) [Term] id: CL:0000406 name: CNS short range interneuron namespace: cell is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000407 name: scolopidial ligament cell namespace: cell xref: FBbt:00005221 is_a: CARO:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} is_a: CARO:0000003 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! anatomical structure is_a: CL:0000384 ! ligament cell is_a: FBbt:00005163 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! sensory organ cell (Drosophila) relationship: part_of CL:0000382 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! scolopale cell [Term] id: CL:0000408 name: male gamete namespace: cell xref: BTO:0001277 xref: CALOHA:TS-0949 is_a: CL:0000015 ! male germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000409 name: scolopidial sheath cell namespace: cell xref: FBbt:00005219 is_a: CL:0000098 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! sensory epithelial cell is_a: CL:0000618 ! sheath cell is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! neural cell is_a: FBbt:00005163 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! sensory organ cell (Drosophila) relationship: part_of CL:0000382 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! scolopale cell [Term] id: CL:0000410 name: CNS long range interneuron namespace: cell is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000411 name: flatworm hypodermal cell namespace: cell def: "An epithelial cell of the hypodermis of flatworms." [] xref: WBbt:0007846 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0000362 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! epidermal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000412 name: polyploid cell namespace: cell def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000413 name: haploid cell namespace: cell def: "A cell whose nucleus contains a single haploid genome." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000414 name: cell by ploidy name: obsolete cell by ploidy namespace: cell def: "A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm] def: "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate. is_a: CL:0000012 ! cell by class is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0000255 consider: CL:0001034 [Term] id: CL:0000415 name: diploid cell namespace: cell def: "A cell whose nucleus has two haploid genomes." [] xref: FMA:72300 is_a: CL:0000003 ! native cell [Term] id: CL:0000416 name: polytene cell namespace: cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000417 name: endopolyploid cell namespace: cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000418 name: arcade cell namespace: cell def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." [] xref: WBbt:0005793 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: WBbt:0005754 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! interfacial epithelial cell (C elegans) [Term] id: CL:0000419 name: seam cell namespace: cell def: "An epithelial fate stem cell found in flatworms." [] xref: BTO:0003039 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000420 name: syncytial epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000421 name: coelomocyte namespace: cell def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." [] xref: BTO:0002856 xref: WBbt:0005751 is_a: CL:0000080 ! circulating cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) relationship: part_of WBbt:0005749 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! coelomic system (C elegans) [Term] id: CL:0000422 name: mitogenic signaling cell namespace: cell def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000423 name: tip cell namespace: cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000424 name: excretory cell namespace: cell def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [] xref: WBbt:0005812 is_a: CL:0000151 ! secretory cell relationship: part_of UBERON:0001008 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! renal system [Term] id: CL:0000425 name: pore cell namespace: cell def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [] is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000426 name: scaffold cell namespace: cell is_a: CL:0000445 ! apoptosis fated cell [Term] id: CL:0000427 name: GLR cell namespace: cell def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." [] is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000428 name: yolk cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000349 ! extraembryonic cell is_a: UBERON:2000084 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! yolk relationship: existence_ends_during_or_before ZFS:0000037 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Day 5 [Term] id: CL:0000429 name: imaginal disc cell namespace: cell is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000430 name: xanthophore cell namespace: cell def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [] synonym: "xanthophore" RELATED [] is_a: CL:0000147 ! pigment cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0005002 ! xanthoblast relationship: existence_starts_during_or_after ZFS:0000032 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:High-pec relationship: part_of UBERON:0002199 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! integument [Term] id: CL:0000431 name: iridophore namespace: cell def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [] synonym: "guanophore" RELATED [] is_a: CL:0000147 ! pigment cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0005001 ! iridoblast relationship: existence_starts_during_or_after ZFS:0000032 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:High-pec relationship: part_of UBERON:0002199 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! integument [Term] id: CL:0000432 name: reticular cell namespace: cell def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." [] synonym: "reticulum cell" EXACT [] xref: FMA:62877 is_a: CL:0000057 ! fibroblast [Term] id: CL:0000433 name: obsolete functional megaspore namespace: cell def: "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [] comment: replaced_by: PO:0000244 is_obsolete: true [Term] id: CL:0000434 name: eccrine cell namespace: cell def: "A secretory cell that discharges its product without loss of cytoplasm." [] is_a: CL:0000150 ! glandular epithelial cell [Term] id: CL:0000435 name: alkali secreting cell namespace: cell is_a: CL:0000151 ! secretory cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000436 name: vaginal lubricant secreting cell namespace: cell is_a: CL:0000151 ! secretory cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0000996 ! vagina [Term] id: CL:0000437 name: gonadtroph namespace: cell def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [] synonym: "delta basophil" EXACT [] synonym: "follicle stimulating hormone secreting cell" EXACT [] synonym: "gonadotrope" EXACT [] synonym: "gonadotrope cell" EXACT [] synonym: "gonadotroph" EXACT [] synonym: "gonadotropic cell" EXACT [] synonym: "pituitary delta cell" EXACT [] xref: BTO:0002482 xref: FMA:83100 is_a: CL:0000438 ! luteinizing hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis [Term] id: CL:0000438 name: luteinizing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [] is_a: CL:0000163 ! endocrine cell is_a: CL:2000004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pituitary gland cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0032275 relationship: capable_of GO:0032275 relationship: part_of ZFA:0005581 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! proximal pars anterior (Danio) [Term] id: CL:0000439 name: prolactin secreting cell namespace: cell def: "A peptide hormone cell that secretes prolactin." [] is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:2000004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pituitary gland cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070459 relationship: capable_of GO:0070459 relationship: existence_starts_during_or_after ZFS:0000035 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Protruding-mouth relationship: part_of ZFA:0005580 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! rostral pars anterior (Danio) [Term] id: CL:0000440 name: melanocyte stimulating hormone secreting cell namespace: cell def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [] synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] xref: BTO:0002277 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:2000004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pituitary gland cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0036160 relationship: capable_of GO:0036160 relationship: existence_starts_during_or_after ZFS:0000027 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:20-25 somites relationship: part_of UBERON:0002432 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pars intermedia of adenohypophysis [Term] id: CL:0000441 name: follicle stem cell namespace: cell xref: FBbt:00004903 is_a: CL:0000036 ! epithelial fate stem cell is_a: FBbt:00006010 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! gonadal somatic stem cell (Drosophila) is_a: FBbt:00006030 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell of ovary (Drosophila) relationship: part_of FBbt:00004866 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! germarium (Drosophila) [Term] id: CL:0000442 name: follicular dendritic cell namespace: cell def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [] comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. xref: BTO:0004267 xref: FMA:83037 is_a: CL:0000473 ! defensive cell [Term] id: CL:0000443 name: calcitonin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0036161 ! calcitonin secretion relationship: capable_of GO:0036161 ! calcitonin secretion [Term] id: CL:0000444 name: obliquely striated muscle cell namespace: cell def: "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." [] comment: Examples include the somatic muscles of nemotodes and cephalopods. is_a: CL:0000737 ! striated muscle cell [Term] id: CL:0000445 name: apoptosis fated cell namespace: cell is_a: CL:0000003 ! native cell is_a: CL:0000144 ! obsolete cell by function [Term] id: CL:0000446 name: chief cell of parathyroid gland namespace: cell def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [] synonym: "parathyroid chief cell" EXACT [] synonym: "parathyroid gland chief cell" EXACT [] synonym: "parathyroid hormone secreting cell" EXACT [] synonym: "principal cell of parathyroid gland" EXACT [] xref: BTO:0004712 xref: CALOHA:TS-2140 xref: FMA:69078 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002260 ! epithelial cell of parathyroid gland [Term] id: CL:0000447 name: carbohydrate secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000448 name: white fat cell namespace: cell def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [] synonym: "white adipocyte" RELATED [] synonym: "white adipose cell" EXACT [] synonym: "white fat cell" EXACT [] xref: CALOHA:TS-1119 xref: FMA:83434 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002334 ! preadipocyte relationship: part_of UBERON:0001347 ! white adipose tissue [Term] id: CL:0000449 name: brown fat cell namespace: cell def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [] synonym: "brown adipocyte" EXACT [] synonym: "brown adipose cell" EXACT [] xref: CALOHA:TS-0099 xref: FMA:83435 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002335 ! brown preadipocyte relationship: part_of UBERON:0001348 ! brown adipose tissue [Term] id: CL:0000451 name: dendritic cell namespace: cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [] synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] xref: BTO:0002042 xref: CALOHA:TS-0194 xref: FMA:83036 is_a: CL:0000738 ! leukocyte relationship: capable_of GO:0001816 relationship: capable_of GO:0019882 relationship: capable_of GO:0045580 ! regulation of T cell differentiation relationship: has_part GO:0042613 [Term] id: CL:0000452 name: thyroid hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000453 name: Langerhans cell namespace: cell def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. synonym: "Langerhans' cell" EXACT [] synonym: "LC" EXACT [] xref: BTO:0000705 xref: CALOHA:TS-2375 xref: FMA:63072 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell relationship: capable_of GO:0002828 relationship: develops_from CL:0000763 ! myeloid cell relationship: has_part PR:000001293 [Term] id: CL:0000454 name: epinephrine secreting cell namespace: cell def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [] synonym: "adrenaline secreting cell" EXACT [] synonym: "epinephrin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0048242 relationship: capable_of GO:0048242 [Term] id: CL:0000455 name: obsolete starch sheath cell namespace: cell def: "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." [] comment: replaced_by: PO:0004531 is_obsolete: true [Term] id: CL:0000456 name: mineralocorticoid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035931 ! mineralocorticoid secretion relationship: capable_of GO:0035931 ! mineralocorticoid secretion [Term] id: CL:0000457 name: biogenic amine secreting cell namespace: cell is_a: CL:0000151 ! secretory cell relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000458 name: serotonin secreting cell namespace: cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [] synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0001820 ! serotonin secretion relationship: capable_of GO:0001820 ! serotonin secretion [Term] id: CL:0000459 name: noradrenergic cell namespace: cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [] synonym: "noradrenaline secreting cell" EXACT [] synonym: "norepinephrin secreting cell" EXACT [] synonym: "norepinephrine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0048243 ! norepinephrine secretion relationship: capable_of GO:0048243 ! norepinephrine secretion [Term] id: CL:0000460 name: glucocorticoid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035933 relationship: capable_of GO:0035933 [Term] id: CL:0000462 name: adepithelial cell namespace: cell xref: FBbt:00003219 is_a: CL:0000680 ! muscle precursor cell is_a: FBbt:00003232 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! adult muscle precursor cell (Drosophila) relationship: continuous_with FBbt:00001761 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! imaginal disc (Drosophila) [Term] id: CL:0000463 name: epidermal cell (sensu arthropoda) namespace: cell def: "An epidermal cell that secretes chitinous cuticle from its apical side." [] comment: While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ. is_a: CL:0000362 ! epidermal cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000464 ! epidermoblast [Term] id: CL:0000464 name: epidermoblast namespace: cell def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." [] xref: FBbt:00004994 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: FBbt:00007008 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic precursor cell (Drosophila) is_a: FBbt:00007325 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! epidermal cell (Drosophila) relationship: develops_from CL:0000114 ! surface ectodermal cell relationship: part_of FBbt:00005533 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! ventral epidermis primordium (Drosophila) relationship: part_of UBERON:0000323 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! late embryo [Term] id: CL:0000465 name: cardioblast (sensu Arthropoda) namespace: cell xref: FBbt:00001666 is_a: CL:0010021 ! cardiac myoblast [Term] id: CL:0000467 name: adrenocorticotropic hormone secreting cell namespace: cell alt_id: CL:0000640 def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [] synonym: "ACTH secreting cell" EXACT [] synonym: "adrenocorticotrophic hormone secreting cell" EXACT [] synonym: "corticotrophin hormone secreting cell" EXACT [] synonym: "corticotropin hormone secreting cell" EXACT [] synonym: "corticotropin secreting cell" EXACT [] is_a: CL:0000163 ! endocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:2000004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pituitary gland cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0051458 relationship: capable_of GO:0051458 relationship: existence_starts_during_or_after ZFS:0000035 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Protruding-mouth relationship: part_of ZFA:0005580 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! rostral pars anterior (Danio) [Term] id: CL:0000468 name: neuroglioblast namespace: cell xref: FBbt:00005147 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell is_a: FBbt:00001332 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! embryonic neuroblast (Drosophila) [Term] id: CL:0000469 name: ganglion mother cell namespace: cell xref: FBbt:00005149 is_a: CL:0000468 ! neuroglioblast relationship: develops_from CL:0000031 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! neuroblast [Term] id: CL:0000470 name: digestive enzyme secreting cell namespace: cell is_a: CL:0000154 ! protein secreting cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites relationship: part_of UBERON:0001007 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! digestive system [Term] id: CL:0000472 name: obsolete chlorenchyma cell namespace: cell def: "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [] comment: replaced_by: PO:0000076 is_obsolete: true [Term] id: CL:0000473 name: defensive cell namespace: cell def: "A cell whose primary function is to protect the organism." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000474 name: pericardial nephrocyte namespace: cell def: "an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." [] synonym: "pericardial cell" NARROW [] xref: FBbt:00005058 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) relationship: part_of UBERON:0001009 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! circulatory system [Term] id: CL:0000475 name: obsolete degenerate megaspore namespace: cell def: "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [] comment: replaced_by: PO:0000245 is_obsolete: true [Term] id: CL:0000476 name: thyrotroph namespace: cell def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [] synonym: "beta-basophil" EXACT [] synonym: "thyroid stimulating hormone secreting cell" EXACT [] synonym: "thyrotrope" EXACT [] xref: FMA:83099 is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis relationship: capable_of GO:0070460 relationship: existence_starts_during_or_after ZFS:0000033 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Hatching:Long-pec relationship: part_of ZFA:0005581 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! proximal pars anterior (Danio) [Term] id: CL:0000477 name: follicle cell namespace: cell comment: Editors note: check this. Currently used in goxp synonym: "ovarian follicle cell" EXACT [] xref: FBbt:00004904 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:2000064 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! ovarian surface epithelial cell is_a: FBbt:00006030 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell of ovary (Drosophila) relationship: develops_from CL:0000441 ! follicle stem cell relationship: part_of UBERON:0003199 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! egg chamber [Term] id: CL:0000478 name: oxytocin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000479 name: vasopressin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000480 name: secretin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes secretin stimulating hormone" [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000481 name: cholecystokin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000482 name: juvenile hormone secreting cell namespace: cell def: "An endocrine cell that secretes juvenile hormone." [] is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0045443 relationship: capable_of GO:0045443 [Term] id: CL:0000483 name: bombesin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000484 name: connective tissue type mast cell namespace: cell def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [] comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(TC)" EXACT [] synonym: "MCTC" EXACT [] synonym: "TC mast cells" EXACT [] is_a: CL:0000097 ! mast cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000097 ! mast cell intersection_of: part_of UBERON:0002384 ! connective tissue [Term] id: CL:0000485 name: mucosal type mast cell namespace: cell def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [] comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(T)" EXACT [] synonym: "MCT" EXACT [] synonym: "T mast cells" EXACT [] is_a: CL:0000097 ! mast cell intersection_of: CL:0000097 ! mast cell intersection_of: capable_of GO:0002540 intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue relationship: capable_of GO:0002540 relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: CL:0000486 name: garland cell namespace: cell def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." [] synonym: "garland nephrocyte" BROAD [] xref: BTO:0004596 xref: FBbt:00005059 is_a: CL:0000227 ! binucleate cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) relationship: part_of UBERON:0001009 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! circulatory system [Term] id: CL:0000487 name: oenocyte namespace: cell def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." [] xref: FBbt:00004995 is_a: CL:0000151 ! secretory cell is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) relationship: part_of UBERON:0007376 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! outer epithelium [Term] id: CL:0000488 name: visible light photoreceptor cell namespace: cell def: "A photoreceptor cell that detects visible light." [] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: capable_of GO:0009584 ! detection of visible light relationship: capable_of GO:0009584 ! detection of visible light [Term] id: CL:0000489 name: scotopic photoreceptor cell namespace: cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000490 name: photopic photoreceptor cell namespace: cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000491 name: obsolete cytotoxic T cell namespace: cell def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." [] comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation. is_obsolete: true [Term] id: CL:0000492 name: CD4-positive helper T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [] synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] synonym: "CD4-positive T-helper cell" EXACT [] xref: CALOHA:TS-1146 xref: FMA:70572 is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: capable_of GO:0001816 relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000493 name: obsolete regulatory T cell namespace: cell def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." [] comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead. is_obsolete: true [Term] id: CL:0000494 name: UV sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that detects ultraviolet light." [] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: capable_of GO:0009589 relationship: capable_of GO:0009589 [Term] id: CL:0000495 name: blue sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to blue light." [] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000496 name: green sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to green light." [] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000497 name: red sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to red light." [] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000498 name: inhibitory interneuron namespace: cell def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [] xref: FMA:84776 is_a: CL:0000099 ! interneuron [Term] id: CL:0000499 name: stromal cell namespace: cell def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A.11.329.830] xref: BTO:0002064 xref: FMA:83624 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000500 name: follicular epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000501 name: granulosa cell namespace: cell def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [] synonym: "granulosa cell of ovary" EXACT [] xref: BTO:0000542 xref: CALOHA:TS-0729 xref: FMA:18718 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002174 ! follicular cell of ovary [Term] id: CL:0000502 name: type D enteroendocrine cell namespace: cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [] synonym: "D cell" EXACT [] xref: FMA:62935 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell relationship: part_of UBERON:0001007 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! digestive system [Term] id: CL:0000503 name: theca cell namespace: cell def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000499 ! stromal cell is_a: CL:0000593 ! androgen secreting cell [Term] id: CL:0000504 name: enterochromaffin-like cell namespace: cell def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." [] comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell. synonym: "ECL" EXACT [] xref: BTO:0002692 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell [Term] id: CL:0000505 name: substance P secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes substance P." [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000506 name: enkephalin secreting cell namespace: cell def: "An endorphine cell that secretes enkephalin." [] is_a: CL:0000507 ! endorphin secreting cell [Term] id: CL:0000507 name: endorphin secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes endorphin." [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000508 name: type G enteroendocrine cell namespace: cell def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [] synonym: "G cell" EXACT [] xref: BTO:0004108 xref: FMA:67609 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0000509 ! gastrin secreting cell is_a: CL:0002180 ! mucous cell of stomach relationship: part_of UBERON:0004997 ! mucosa of pyloric antrum [Term] id: CL:0000509 name: gastrin secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes gastrin." [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000510 name: paneth cell namespace: cell def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [] xref: BTO:0000993 xref: FMA:62897 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000323 ! lysozyme secreting cell is_a: CL:0002563 ! intestinal epithelial cell [Term] id: CL:0000511 name: androgen binding protein secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes androgen binding protein." [] is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000512 name: paracrine cell namespace: cell def: "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." [] is_a: CL:0000151 ! secretory cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000513 name: cardiac muscle myoblast namespace: cell alt_id: CL:0000714 def: "A precursor cell destined to differentiate into cardiac muscle cell." [] synonym: "cardiac muscle progenitor cell" EXACT [] synonym: "cardiomyocyte progenitor cell" EXACT [] xref: FMA:84797 is_a: CL:0002494 ! cardiocyte is_a: CL:0010021 ! cardiac myoblast relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0001133 ! cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast namespace: cell def: "A precursor cell destined to differentiate into smooth muscle myocytes." [] synonym: "myoblast, smooth muscle" EXACT [] synonym: "satellite cell" RELATED [] xref: FMA:84798 is_a: CL:0000056 ! myoblast relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000515 name: skeletal muscle myoblast namespace: cell def: "A myoblast that differentiates into skeletal muscle fibers." [] synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 is_a: CL:0000056 ! myoblast relationship: develops_from CL:0000355 ! multi-potent skeletal muscle stem cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000516 name: perineuronal satellite cell namespace: cell def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [] synonym: "perineural satellite cell" EXACT [] synonym: "perineuronal satellite oligodendroglial cell" EXACT [] synonym: "satellite oligodendrocyte" EXACT [] xref: FMA:54550 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000243 ! glial cell (sensu Vertebrata) [Term] id: CL:0000517 name: macrophage derived foam cell namespace: cell def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [] is_a: CL:0000891 ! foam cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000235 ! macrophage [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) namespace: cell def: "A phagocyte in vertebrates that is able to phagocytosis." [] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000519 name: phagocyte (sensu Nematoda and Protostomia) namespace: cell def: "A phagocyte from organisms in the Nematoda or Protostomia clades." [] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000520 name: prokaryotic cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000521 name: fungal cell namespace: cell is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000522 name: obsolete spore namespace: cell def: "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." [] is_obsolete: true [Term] id: CL:0000523 name: mononuclear cytotrophoblast cell namespace: cell def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." [] synonym: "Langhans' cell" EXACT [] xref: FMA:83042 is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000524 name: spheroplast namespace: cell def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [] synonym: "sphaeroplast" EXACT [] is_a: CL:0000371 ! protoplast [Term] id: CL:0000525 name: syncytiotrophoblast cell namespace: cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] synonym: "plasmidotrophoblast" EXACT [] synonym: "plasmidotrophoblast" RELATED [] synonym: "syncytial trophoblast" EXACT [] synonym: "syncytial trophoblast" RELATED [] synonym: "syntrophoblast" EXACT [] synonym: "syntrophoblast" RELATED [] xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000526 name: afferent neuron namespace: cell def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A.08.663.650] synonym: "input neuron" EXACT [] synonym: "input neuron" RELATED [] xref: FMA:87653 is_a: CL:0000540 ! neuron [Term] id: CL:0000527 name: efferent neuron namespace: cell def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A.08.663.655] synonym: "output neuron" EXACT [] synonym: "output neuron" RELATED [] is_a: CL:0000540 ! neuron [Term] id: CL:0000528 name: nitrergic neuron namespace: cell def: "A nerve cell where transmission is mediated by nitric oxide." [] xref: FMA:84792 is_a: CL:0000540 ! neuron [Term] id: CL:0000529 name: pigmented epithelial cell namespace: cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000710 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neurecto-epithelial cell [Term] id: CL:0000530 name: primary neuron namespace: cell is_a: CL:0000540 ! neuron relationship: existence_ends_during_or_before ZFS:0000038 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Day 6 relationship: part_of UBERON:0002346 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neurectoderm [Term] id: CL:0000531 name: primary sensory neuron namespace: cell is_a: CL:0000101 ! sensory neuron is_a: CL:0000530 ! primary neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: CL:0000530 ! primary neuron [Term] id: CL:0000532 name: CAP motoneuron namespace: cell is_a: CL:0000533 ! primary motor neuron [Term] id: CL:0000533 name: primary motor neuron namespace: cell xref: FMA:83619 is_a: CL:0000100 ! motor neuron is_a: CL:0000530 ! primary neuron relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000534 name: primary interneuron namespace: cell is_a: CL:0000099 ! interneuron is_a: CL:0000530 ! primary neuron relationship: existence_ends_during_or_before ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites [Term] id: CL:0000535 name: secondary neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000536 name: secondary motor neuron namespace: cell xref: FMA:83620 is_a: CL:0000100 ! motor neuron is_a: CL:0000535 ! secondary neuron intersection_of: CL:0000100 ! motor neuron intersection_of: CL:0000535 ! secondary neuron relationship: existence_ends_during_or_before ZFS:0000043 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Juvenile:Days 45-89 relationship: existence_starts_during_or_after ZFS:0000028 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:26+ somites [Term] id: CL:0000537 name: obsolete antipodal cell namespace: cell def: "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." [] comment: replaced_by: PO:0020093 is_obsolete: true [Term] id: CL:0000538 name: obsolete epidermal initial namespace: cell def: "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." [] comment: replaced_by: PO:0000349 is_obsolete: true [Term] id: CL:0000539 name: obsolete idioblast namespace: cell def: "OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." [] is_obsolete: true [Term] id: CL:0000540 name: neuron namespace: cell def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [MESH:A.08.663, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. synonym: "nerve cell" EXACT [] synonym: "nerve cell" RELATED [] xref: BTO:0000938 xref: CALOHA:TS-0683 xref: FBbt:00005106 xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) is_a: UBERON:0004121 ! ectoderm-derived structure relationship: capable_of GO:0019226 relationship: develops_from CL:0000031 ! neuroblast relationship: existence_starts_during_or_after ZFS:0000023 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:1-4 somites property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: CL:0000541 name: melanoblast namespace: cell def: "A cell that originates from the neural crest and differentiates into a pigment cell." [] comment: Derived from UBERON:0002342 neural crest. xref: BTO:0003217 xref: FMA:83377 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites [Term] id: CL:0000542 name: lymphocyte namespace: cell def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [] comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) xref: BTO:0000775 xref: CALOHA:TS-0583 xref: FMA:62863 xref: VHOG:0001535 is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002242 ! nucleate cell relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part CP:0000000 relationship: has_part CP:0000037 relationship: has_part GO:0000792 [Term] id: CL:0000543 name: obsolete sieve tube member namespace: cell def: "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." [] comment: replaced_by: PO:0000289 synonym: "sieve tube element" EXACT [] is_obsolete: true [Term] id: CL:0000544 name: slowly adapting mechanoreceptor cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000545 name: T-helper 1 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells. synonym: "helper T cell type 1" EXACT [] synonym: "T helper cells type 1" EXACT [] synonym: "T(H)-1 cell" EXACT [] synonym: "Th1 CD4+ T cell" EXACT [] synonym: "Th1 cell" EXACT [] synonym: "Th1 T cell" EXACT [] synonym: "Th1 T lymphocyte" EXACT [] synonym: "Th1 T-cell" EXACT [] synonym: "Th1 T-lymphocyte" EXACT [] xref: BTO:0001678 xref: FMA:84382 is_a: CL:0000492 ! CD4-positive helper T cell relationship: capable_of GO:0032609 relationship: has_part PR:000001207 relationship: has_part PR:000001835 [Term] id: CL:0000546 name: T-helper 2 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell. synonym: "helper T cell type 2" EXACT [] synonym: "T helper cells type 2" EXACT [] synonym: "T(H)-2 cell" EXACT [] synonym: "Th2 cell" EXACT [] synonym: "Th2 T cell" EXACT [] synonym: "Th2 T lymphocyte" EXACT [] synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] xref: BTO:0001679 xref: FMA:84385 is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell relationship: capable_of GO:0032633 relationship: has_part PR:000001941 [Term] id: CL:0000547 name: proerythroblast namespace: cell def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [] synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [] xref: FMA:83518 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell relationship: develops_from CL:0000038 ! erythroid progenitor cell relationship: has_part CP:0000028 relationship: has_part CP:0000037 relationship: has_part GO:0005730 relationship: has_part PR:000001945 [Term] id: CL:0000548 name: animal cell namespace: cell subset: ubprop:upper_level is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000549 name: basophilic erythroblast namespace: cell def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [] synonym: "basophilic normoblast" EXACT [] synonym: "early erythroblast" EXACT [] synonym: "early normoblast" EXACT [] synonym: "prorubricyte" EXACT [] xref: FMA:83505 is_a: CL:0000765 ! erythroblast relationship: existence_starts_during_or_after ZFS:0000030 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-15 relationship: has_part CP:0000028 relationship: has_part GO:0000792 relationship: has_part PR:000001945 [Term] id: CL:0000550 name: polychromatophilic erythroblast namespace: cell def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [] synonym: "intermediate erythroblast" EXACT [] synonym: "intermediate normoblast" EXACT [] synonym: "polychromatic erythroblast" EXACT [] synonym: "polychromatic normoblast" EXACT [] synonym: "polychromatophilic normoblast" EXACT [] synonym: "rubricyte" EXACT [] xref: FMA:83506 is_a: CL:0000765 ! erythroblast relationship: develops_from CL:0000549 ! basophilic erythroblast relationship: has_part CP:0000035 relationship: has_part GO:0000792 relationship: has_part PR:000001945 [Term] id: CL:0000551 name: unimodal nocireceptor namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000552 name: orthochromatic erythroblast namespace: cell def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [] synonym: "acidophilic erythroblast" EXACT [] synonym: "eosinophilic erythroblast" EXACT [] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [] synonym: "pyknotic eto enrythroblast" EXACT [] xref: FMA:84646 is_a: CL:0000765 ! erythroblast relationship: develops_from CL:0000550 ! polychromatophilic erythroblast relationship: has_part CP:0000027 [Term] id: CL:0000553 name: megakaryocyte progenitor cell namespace: cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [] comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. synonym: "CFU-Meg" EXACT [] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [] synonym: "MkP" EXACT [] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: capable_of GO:0007113 relationship: capable_of GO:0030219 relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000554 name: gastrin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes gastrin stimulating hormone." [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000555 name: neuronal brush cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000556 name: megakaryocyte namespace: cell def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:0000763 ! myeloid cell is_a: CL:1001610 ! bone marrow hematopoietic cell relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-C , Colony forming unit in culture" BROAD [] synonym: "CFU-GM" EXACT [] synonym: "colony forming unit granulocyte macrophage" EXACT [] synonym: "GMP" EXACT [] synonym: "granulocyte-macrophage progenitor" EXACT [] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:0011115 ! precursor cell is_a: CL:1001610 ! bone marrow hematopoietic cell relationship: capable_of GO:0030225 relationship: capable_of GO:0030851 relationship: has_part PR:000001865 relationship: has_part PR:000001944 relationship: has_part PR:000005307 [Term] id: CL:0000558 name: reticulocyte namespace: cell def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [] xref: BTO:0001173 xref: CALOHA:TS-0864 is_a: CL:0000764 ! erythroid lineage cell relationship: capable_of GO:0071971 relationship: develops_from CL:0000552 ! orthochromatic erythroblast relationship: has_part PR:000001945 [Term] id: CL:0000559 name: promonocyte namespace: cell def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [] comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. xref: BTO:0004657 xref: FMA:83551 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000040 ! monoblast relationship: has_part GO:0042582 relationship: has_part PR:000001012 [Term] id: CL:0000560 name: band form neutrophil namespace: cell def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." [] comment: Found in the Band 1 fraction. synonym: "band" BROAD [] synonym: "band cell" BROAD [] synonym: "band form" BROAD [] synonym: "rod neutrophil" EXACT [] synonym: "stab cell" BROAD [] is_a: CL:0000096 ! mature neutrophil is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000582 ! neutrophilic metamyelocyte relationship: has_part CP:0000039 relationship: has_part PR:000001337 relationship: has_part PR:000001580 relationship: has_part PR:000005307 [Term] id: CL:0000561 name: amacrine cell namespace: cell def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [] comment: Not clear if this term overlaps with retinal bipolar neuron (CL:0000748). synonym: "amacrine neuron" EXACT [] xref: BTO:0004044 xref: FBbt:00005127 xref: FMA:67766 is_a: CL:0000099 ! interneuron is_a: CL:0009004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! retinal cell is_a: FBbt:00003988 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! unilateral intrinsic neuron (Drosophila) is_a: FBbt:00007577 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! optic lobe intrinsic neuron (Drosophila) relationship: part_of UBERON:0001791 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! inner nuclear layer of retina [Term] id: CL:0000562 name: nucleate erythrocyte namespace: cell def: "An erythrocyte having a nucleus." [] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: has_part GO:0005634 ! nucleus relationship: develops_from CL:0002421 ! nucleated reticulocyte [Term] id: CL:0000563 name: endospore namespace: cell def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." [] synonym: "bacterial spore" EXACT [] xref: BTO:0002779 is_a: CL:0000520 ! prokaryotic cell [Term] id: CL:0000564 name: neutrophilic promyelocyte namespace: cell def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." [] comment: These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. synonym: "neutrophilic premyelocyte" EXACT [] synonym: "neutrophilic progranulocyte" EXACT [] xref: FMA:84196 is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000836 ! promyelocyte relationship: develops_from CL:0000042 ! neutrophilic myeloblast relationship: has_part PR:000001944 relationship: has_part PR:000005307 relationship: has_part PR:000007857 relationship: has_part PR:000010543 relationship: has_part PR:000014362 [Term] id: CL:0000565 name: fat body cell namespace: cell def: "A cell found in fat bodies whose primary function is intermediary metabolism." [] is_a: CL:0000181 ! metabolising cell [Term] id: CL:0000566 name: angioblastic mesenchymal cell namespace: cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000134 ! mesenchymal cell relationship: has_part PR:000001444 relationship: has_part PR:000002112 relationship: has_part PR:000016043 [Term] id: CL:0000567 name: polymodal nocireceptor namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000568 name: amine precursor uptake and decarboxylation cell namespace: cell def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [] synonym: "APUD cell" EXACT [] xref: BTO:0003866 xref: FMA:83114 is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000569 name: cardiac mesenchymal cell namespace: cell def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [] is_a: CL:0008019 ! mesenchymal cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure is_a: UBERON:0010313 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural crest-derived structure relationship: develops_from CL:0000011 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! migratory trunk neural crest cell relationship: develops_from CL:0000134 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesenchymal cell [Term] id: CL:0000570 name: parafollicular cell namespace: cell def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." [] synonym: "C cell" EXACT [] synonym: "C cell of thyroid gland" EXACT [] synonym: "clear cell of thyroid gland" EXACT [] synonym: "parafollicular cell of thyroid gland" EXACT [] synonym: "thyroid parafollicular cell" EXACT [] xref: FMA:68653 xref: SCTID:176770005 is_a: CL:0000443 ! calcitonin secreting cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: capable_of GO:0014046 ! dopamine secretion relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: has_part PR:000001024 relationship: part_of UBERON:0001747 ! parenchyma of thyroid gland [Term] id: CL:0000571 name: leucophore namespace: cell def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [] is_a: CL:0000147 ! pigment cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0005003 ! leucoblast relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0002199 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! integument [Term] id: CL:0000573 name: retinal cone cell namespace: cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [] xref: BTO:0001036 xref: CALOHA:TS-0866 xref: FMA:67748 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000574 name: erythrophore namespace: cell def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [] is_a: CL:0000147 ! pigment cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0005004 ! pigment erythroblast relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0002199 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! integument [Term] id: CL:0000575 name: corneal epithelial cell namespace: cell alt_id: CL:1000431 def: "An epithelial cell of the cornea." [] synonym: "epithelial cell of cornea" EXACT [] xref: BTO:0004298 xref: CALOHA:TS-0173 xref: FMA:70551 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea [Term] id: CL:0000576 name: monocyte namespace: cell def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. xref: BTO:0000876 xref: CALOHA:TS-0638 xref: FMA:62864 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000842 ! mononuclear cell is_a: CL:0011115 ! precursor cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0030225 relationship: capable_of GO:0030316 relationship: capable_of GO:0043011 relationship: develops_from CL:0000559 ! promonocyte [Term] id: CL:0000577 name: type EC enteroendocrine cell namespace: cell alt_id: CL:0002065 def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [] synonym: "argentaffin cell" EXACT [] synonym: "enterochromaffin cell" EXACT [] synonym: "Kulchitsky cell" EXACT [] xref: FMA:62934 xref: FMA:83132 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0002251 ! epithelial cell of alimentary canal relationship: part_of UBERON:0004786 ! gastrointestinal system mucosa [Term] id: CL:0000578 name: experimentally modified cell in vitro namespace: cell def: "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." [] comment: This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12 is_a: CL:0001034 ! cell in vitro [Term] id: CL:0000579 name: border follicle cell namespace: cell xref: FBbt:00004905 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000580 name: neutrophilic myelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." [] comment: These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. xref: BTO:0003455 xref: FMA:83540 is_a: CL:0000776 ! immature neutrophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte relationship: has_part CP:0000027 relationship: has_part GO:0042582 relationship: has_part PR:000001456 relationship: has_part PR:000001892 relationship: has_part PR:000001932 relationship: has_part PR:000001944 relationship: has_part PR:000002031 relationship: has_part PR:000005307 relationship: has_part PR:000005310 relationship: has_part PR:000009725 relationship: has_part PR:000009978 ! lactotransferrin relationship: has_part PR:000010543 [Term] id: CL:0000581 name: peritoneal macrophage namespace: cell def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [] comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. xref: BTO:0001034 xref: FMA:83025 is_a: CL:0000864 ! tissue-resident macrophage relationship: capable_of GO:0042742 relationship: has_part PR:000001012 relationship: has_part PR:000001807 relationship: has_part PR:000001813 relationship: has_part PR:000002062 relationship: has_part PR:000002064 relationship: has_part PR:000006172 [Term] id: CL:0000582 name: neutrophilic metamyelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." [] comment: These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. synonym: "juvenile neutrophil" EXACT [] xref: FMA:84197 is_a: CL:0000776 ! immature neutrophil is_a: CL:0002192 ! metamyelocyte relationship: develops_from CL:0000580 ! neutrophilic myelocyte relationship: has_part CP:0000027 relationship: has_part CP:0000040 relationship: has_part GO:0000792 relationship: has_part GO:0042582 relationship: has_part GO:0070820 relationship: has_part PR:000001456 relationship: has_part PR:000001483 relationship: has_part PR:000001892 relationship: has_part PR:000001932 relationship: has_part PR:000001944 relationship: has_part PR:000002031 relationship: has_part PR:000005307 relationship: has_part PR:000005310 relationship: has_part PR:000009725 relationship: has_part PR:000009978 ! lactotransferrin relationship: has_part PR:000010543 [Term] id: CL:0000583 name: alveolar macrophage namespace: cell def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [] comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. synonym: "dust cell" EXACT [] synonym: "MF.Lu" RELATED [] xref: BTO:0000802 xref: CALOHA:TS-0030 xref: FMA:83023 is_a: CL:0000864 ! tissue-resident macrophage relationship: capable_of GO:0019882 relationship: has_part PR:000001012 relationship: has_part PR:000001013 relationship: has_part PR:000001807 relationship: has_part PR:000001813 relationship: has_part PR:000001931 relationship: has_part PR:000002064 relationship: has_part PR:000002972 [Term] id: CL:0000584 name: enterocyte namespace: cell def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [] xref: BTO:0000398 xref: FMA:62122 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0000677 ! gut absorptive cell is_a: CL:0002563 ! intestinal epithelial cell [Term] id: CL:0000585 name: obsolete null cell namespace: cell def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." [] comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context. is_obsolete: true [Term] id: CL:0000586 name: germ cell namespace: cell def: "The reproductive cell in multicellular organisms." [MESH:A.05.360.490] xref: BTO:0000535 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 ! germ line cell is_a: UBERON:0000990 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! reproductive system is_a: WBbt:0005784 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! germ line (C elegans) relationship: capable_of GO:0048609 ! multicellular organismal reproductive process relationship: develops_from WBbt:0006849 {gci_relation="part_of", gci_filler="NCBITaxon:6237"} ! germline precursor cell (C elegans) [Term] id: CL:0000587 name: cold sensing thermoreceptor cell namespace: cell def: "A thermoreceptor cell that detects reduced temperatures." [] is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000588 name: odontoclast namespace: cell def: "A specialized osteoclast associated with the absorption and removal of cementum." [] xref: BTO:0002516 xref: FMA:83027 is_a: CL:0000092 ! osteoclast intersection_of: CL:0000092 ! osteoclast intersection_of: capable_of GO:0042483 relationship: capable_of GO:0042483 [Term] id: CL:0000589 name: cochlear inner hair cell namespace: cell def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [] synonym: "inner hair cell" BROAD [] xref: BTO:0003667 xref: FMA:62365 is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0000590 name: small luteal cell namespace: cell def: "A progesterone secreting cell in the corpus luteum that develops from theca cells." [] synonym: "small lutein cell" EXACT [] synonym: "theca lutein cell" EXACT [] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000175 ! luteal cell relationship: develops_from CL:0000503 ! theca cell [Term] id: CL:0000591 name: warmth sensing thermoreceptor cell namespace: cell def: "A thermoreceptor cell that detects reduced temperatures." [] is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000592 name: large luteal cell namespace: cell def: "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." [] synonym: "granulosa lutein cell" EXACT [] synonym: "granulosoluteocytus" RELATED [] xref: FMA:18689 is_a: CL:0000175 ! luteal cell is_a: CL:0000177 ! testosterone secreting cell relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000593 name: androgen secreting cell namespace: cell def: "A steroid hormone secreting cell that secretes androgen." [] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035935 relationship: capable_of GO:0035935 [Term] id: CL:0000594 name: skeletal muscle satellite cell namespace: cell def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." [] comment: Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population. is_a: CL:0000188 ! skeletal muscle cell is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000595 name: enucleate erythrocyte namespace: cell def: "An erythrocyte lacking a nucleus." [] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000232 ! erythrocyte relationship: develops_from CL:0002422 ! enucleated reticulocyte [Term] id: CL:0000596 name: sexual spore namespace: cell def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [] synonym: "meiotically-derived spore" EXACT [] xref: FAO:0000017 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000597 name: microconidium namespace: cell def: "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." [] xref: FAO:0000028 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0000598 name: pyramidal neuron namespace: cell def: "Pyramidal neurons have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [] synonym: "projection neuron" EXACT [] synonym: "pyramidal cell" EXACT [] synonym: "pyramidal neuron" EXACT [] xref: BTO:0003102 xref: FMA:67310 xref: FMA:86775 xref: NIFSTD:sao862606388 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000599 name: conidium namespace: cell def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." [] xref: BTO:0000283 xref: FAO:0000024 is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000600 name: heterokaryon namespace: cell def: "A fungal cell with two or more genetically distinct nuclei." [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000521 ! fungal cell [Term] id: CL:0000601 name: outer hair cell namespace: cell def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [] synonym: "cochlear outer hair cell" EXACT [] xref: BTO:0003666 xref: FMA:62366 is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0000602 name: pressoreceptor cell namespace: cell def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [] is_a: CL:1000082 ! stretch receptor cell [Term] id: CL:0000603 name: dikaryon namespace: cell def: "A fungal cell with two genetically distinct haploid nuclei." [] is_a: CL:0000227 ! binucleate cell is_a: CL:0000600 ! heterokaryon [Term] id: CL:0000604 name: retinal rod cell namespace: cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [] xref: BTO:0001024 xref: CALOHA:TS-0870 xref: FMA:67747 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000605 name: fungal asexual spore namespace: cell def: "A spore formed following mitosis or mitoses." [] xref: FAO:0000023 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000606 name: macroconidium namespace: cell def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." [] xref: FAO:0000038 is_a: CL:0000599 ! conidium [Term] id: CL:0000607 name: ascospore namespace: cell def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." [] xref: BTO:0000097 xref: FAO:0000020 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000608 name: zygospore namespace: cell def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." [] xref: FAO:0000040 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000609 name: vestibular hair cell namespace: cell def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [] synonym: "vestibular receptor cell" EXACT [] xref: FMA:62351 is_a: CL:0002374 ! ear hair cell [Term] id: CL:0000610 name: obsolete plant cell namespace: cell comment: This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO) is_obsolete: true consider: PO:0009002 [Term] id: CL:0000611 name: eosinophil progenitor cell namespace: cell comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76). synonym: "CFU-Eo" RELATED [] synonym: "colony forming unit eosinophil" RELATED [] synonym: "EoP" EXACT [] synonym: "eosinophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0030222 relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000001003 relationship: has_part PR:000001408 relationship: has_part PR:000001865 relationship: has_part PR:000001867 relationship: has_part PR:000001944 relationship: has_part PR:000002065 relationship: has_part PR:000005307 relationship: has_part PR:000007857 [Term] id: CL:0000612 name: eosinophilic myelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [] xref: BTO:0003454 xref: FMA:83542 is_a: CL:0000772 ! immature eosinophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte relationship: has_part GO:0042582 relationship: has_part PR:000001456 relationship: has_part PR:000001892 relationship: has_part PR:000001932 relationship: has_part PR:000002031 [Term] id: CL:0000613 name: basophil progenitor cell namespace: cell def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [] comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf). synonym: "BaP" EXACT [] synonym: "basophilic stem cell" RELATED [] synonym: "CFU-Bas" RELATED [] synonym: "colony forming unit basophil" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0030221 relationship: develops_from CL:0002028 ! basophil mast progenitor cell relationship: has_part PR:000005307 relationship: has_part PR:000007431 relationship: has_part PR:000007857 relationship: has_part PR:000007858 relationship: has_part PR:000016401 [Term] id: CL:0000614 name: basophilic myelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [] xref: BTO:0003456 xref: FMA:83543 is_a: CL:0000768 ! immature basophil is_a: CL:0002087 ! nongranular leukocyte relationship: has_part GO:0042582 relationship: has_part PR:000001456 relationship: has_part PR:000001892 relationship: has_part PR:000001932 relationship: has_part PR:000002031 [Term] id: CL:0000615 name: basidiospore namespace: cell def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." [] xref: BTO:0002166 xref: FAO:0000021 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000616 name: obsolete sporangiospore namespace: cell def: "OBSOLETE: A walled spore produced in a sporangium." [] is_obsolete: true [Term] id: CL:0000617 name: GABAergic neuron namespace: cell def: "A neuron that uses GABA as a vesicular neurotransmitter" [] synonym: "GABA-ergic neuron" EXACT [] xref: FMA:84788 xref: WBbt:0005190 is_a: CL:0000161 ! acid secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0000618 name: sheath cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000619 name: support cell (sensu Nematoda) namespace: cell is_a: CL:0000124 ! glial cell (sensu Nematoda and Protostomia) is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000620 name: obsolete zoospore namespace: cell def: "OBSOLETE: A sporangiospore that is motile, having flagella." [] xref: FAO:0000039 is_obsolete: true [Term] id: CL:0000621 name: fusion competent myoblast namespace: cell def: "A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)." [] is_a: CL:0008018 ! somatic muscle myoblast [Term] id: CL:0000622 name: acinar cell namespace: cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [] synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000154 ! protein secreting cell relationship: part_of UBERON:0009842 ! glandular acinus [Term] id: CL:0000623 name: natural killer cell namespace: cell def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [] synonym: "large granular lymphocyte" BROAD [] synonym: "NK cell" EXACT [] synonym: "null cell" BROAD [] xref: BTO:0000914 xref: BTO:0004716 xref: CALOHA:TS-0664 xref: FMA:63147 xref: FMA:83601 xref: VHOG:0001697 is_a: CL:0001067 ! group 1 innate lymphoid cell relationship: capable_of GO:0002228 relationship: capable_of GO:0050776 ! regulation of immune response relationship: develops_from CL:0000825 ! pro-NK cell [Term] id: CL:0000624 name: CD4-positive, alpha-beta T cell namespace: cell def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [] synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell relationship: has_part PR:000001004 [Term] id: CL:0000625 name: CD8-positive, alpha-beta T cell namespace: cell def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [] synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell relationship: has_part PR:000025402 [Term] id: CL:0000626 name: olfactory granule cell namespace: cell def: "Granule cell that is part of the olfactory bulb." [] is_a: CL:0000120 ! granule cell is_a: CL:0012001 ! neuron of the forebrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0002264 ! olfactory bulb relationship: part_of UBERON:0002264 ! olfactory bulb [Term] id: CL:0000627 name: transporting cell namespace: cell def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [] is_a: CL:0000003 ! native cell [Term] id: CL:0000628 name: photosynthetic cell namespace: cell def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." [] comment: see PMID:21177950, The making of a photosynthetic animal. is_a: CL:0000003 ! native cell [Term] id: CL:0000629 name: storage cell namespace: cell def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." [] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000630 name: supportive cell namespace: cell def: "A cell whose primary function is to support other cell types." [] xref: BTO:0002315 is_a: CL:0000003 ! native cell is_a: UBERON:0004121 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ectoderm-derived structure relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000038 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Day 6 relationship: part_of UBERON:0000004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! nose [Term] id: CL:0000631 name: labyrinth supporting cell namespace: cell def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." [] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000632 name: hepatic stellate cell namespace: cell def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [] comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. synonym: "fat-storing cell" RELATED [] synonym: "hepatic perisinusoidal cell" EXACT [] synonym: "Ito cell" EXACT [] synonym: "lipocyte" RELATED [] synonym: "perisinusoidal cell" EXACT [] synonym: "vitamin A-storing cells" RELATED [] xref: BTO:0002741 xref: CALOHA:TS-0452 xref: FMA:67763 is_a: CL:0000057 ! fibroblast is_a: CL:0000152 ! exocrine cell is_a: CL:0000327 ! extracellular matrix secreting cell is_a: UBERON:0000077 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004119 ! endoderm-derived structure relationship: has_part PR:000007939 relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000633 name: Hensen cell namespace: cell def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." [] synonym: "cell of Hensen" EXACT [] synonym: "external limiting cell of organ of Corti" EXACT [] synonym: "Hensen's cell" EXACT [] xref: FMA:79799 is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:0000634 name: Claudius cell namespace: cell def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." [] synonym: "cell of Claudius" EXACT [] synonym: "external supporting cell of Claudius" RELATED [] synonym: "external supporting cell of vestibular epithelium" EXACT [] xref: FMA:79802 is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:0000635 name: Deiter's cell namespace: cell def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." [] synonym: "Deiters cell" EXACT [] synonym: "outer phalangeal cell" EXACT [] xref: FMA:75725 is_a: CL:0002165 ! phalangeal cell [Term] id: CL:0000636 name: Mueller cell namespace: cell xref: BTO:0003064 is_a: CL:0000127 ! astrocyte is_a: CL:0009004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! retinal cell relationship: part_of UBERON:0001791 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! inner nuclear layer of retina [Term] id: CL:0000637 name: chromophil cell of anterior pituitary gland namespace: cell def: "A cell that stains readily in the anterior pituitary gland." [] xref: FMA:83089 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002319 ! neural cell is_a: CL:2000004 ! pituitary gland cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002196 ! adenohypophysis relationship: part_of UBERON:0002196 ! adenohypophysis [Term] id: CL:0000638 name: acidophil cell of pars distalis of adenohypophysis namespace: cell def: "An acidophilic chromophil cell that of the anterior pituitary gland." [] synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars distalis of adenohypophysis" EXACT [] synonym: "pituitary alpha cell" EXACT [] xref: FMA:83093 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis [Term] id: CL:0000639 name: basophil cell of pars distalis of adenohypophysis namespace: cell def: "A basophillic chromophil cell that of the anterior pituitary gland." [] synonym: "basophil cell of anterior lobe of hypophysis" EXACT [] synonym: "beta cell" RELATED [] synonym: "pituitary beta cell" RELATED [] xref: FMA:83094 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000641 name: chromophobe cell namespace: cell def: "A cell that is resistant to stains." [] synonym: "chromophobic cell" EXACT [] xref: FMA:83626 is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000642 name: folliculostellate cell namespace: cell def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." [] is_a: CL:0000163 ! endocrine cell is_a: CL:0000630 ! supportive cell is_a: CL:2000004 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! pituitary gland cell relationship: existence_starts_during_or_after ZFS:0000027 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:20-25 somites [Term] id: CL:0000644 name: Bergmann glial cell namespace: cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [] synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] xref: FMA:54559 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000645 name: pituicyte namespace: cell def: "A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [] xref: BTO:0003793 xref: FMA:83503 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000646 name: basal cell namespace: cell def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [] xref: BTO:0000939 xref: FMA:62516 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000647 name: multinucleated giant cell namespace: cell def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [] comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this. synonym: "foreign body giant cell" EXACT [] synonym: "Langerhans giant cell" EXACT [] synonym: "macrophage polykaryon" EXACT [] synonym: "multinucleate giant cell" EXACT [] synonym: "syncytial giant cell" EXACT [] xref: BTO:0003107 xref: FMA:83035 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000766 ! myeloid leukocyte is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000235 ! macrophage [Term] id: CL:0000648 name: kidney granular cell namespace: cell alt_id: CL:0000461 def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [] synonym: "JG cell" EXACT [] synonym: "juxtaglomerular cell" BROAD [] synonym: "renin secreting cell" EXACT [] xref: FMA:84138 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000618 ! juxtaglomerular complex cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0002001 intersection_of: part_of UBERON:0002113 ! kidney relationship: capable_of GO:0002001 [Term] id: CL:0000649 name: prickle cell namespace: cell alt_id: CL:0002186 def: "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin." [] synonym: "prickle cell of epidermis" EXACT [] xref: FMA:69059 is_a: CL:0000312 ! keratinocyte relationship: part_of UBERON:0002026 ! stratum spinosum of epidermis [Term] id: CL:0000650 name: mesangial cell namespace: cell def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [] comment: Do all of these cells really develop from some mesenchymal stem cell? synonym: "kidney mesangial cell" EXACT [] xref: BTO:0000853 xref: CALOHA:TS-0617 xref: FMA:70972 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000669 ! pericyte cell is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000651 name: mucous neck cell namespace: cell def: "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" [] synonym: "neck cell" BROAD [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell [Term] id: CL:0000652 name: pinealocyte namespace: cell def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [] xref: BTO:0001068 xref: FMA:83417 is_a: CL:0000163 ! endocrine cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell relationship: capable_of GO:0030187 ! melatonin biosynthetic process relationship: part_of UBERON:0001905 ! pineal body [Term] id: CL:0000653 name: glomerular visceral epithelial cell namespace: cell def: "A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [] comment: GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm]. synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [] synonym: "glomerular podocyte" EXACT [] synonym: "podocyte" EXACT [] xref: BTO:0002295 is_a: CL:0002522 ! renal filtration cell is_a: CL:0002523 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesonephric glomerular visceral epithelial cell is_a: CL:1000451 ! epithelial cell of visceral layer of glomerular capsule relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites [Term] id: CL:0000654 name: primary oocyte namespace: cell def: "A primary oocyte is an oocyte that has not completed female meosis I." [] synonym: "primary oogonium" RELATED [] xref: BTO:0000512 xref: FMA:18645 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000023 ! oocyte relationship: develops_from CL:0000024 ! oogonial cell [Term] id: CL:0000655 name: secondary oocyte namespace: cell def: "A secondary oocyte is an oocyte that has not completed meiosis II." [] synonym: "primary oogonium" RELATED [] xref: BTO:0003094 xref: FMA:18646 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000023 ! oocyte relationship: develops_from CL:0000654 ! primary oocyte [Term] id: CL:0000656 name: primary spermatocyte namespace: cell def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [] xref: BTO:0001115 xref: CALOHA:TS-2194 xref: FMA:72292 is_a: CL:0000017 ! spermatocyte relationship: capable_of GO:0007140 ! male meiotic nuclear division [Term] id: CL:0000657 name: secondary spermatocyte namespace: cell def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [] xref: BTO:0000709 xref: CALOHA:TS-2195 xref: FBbt:00004941 xref: FMA:72293 is_a: CL:0000017 ! spermatocyte is_a: CL:0000413 ! haploid cell relationship: capable_of GO:0007142 relationship: develops_from CL:0000656 ! primary spermatocyte relationship: develops_from FBbt:00005286 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! primary spermatocyte (Drosophila) [Term] id: CL:0000658 name: cuticle secreting cell namespace: cell def: "An epithelial cell that secretes cuticle." [GOC:tfm] is_a: CARO:0000077 ! epithelial cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000659 name: eggshell secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes eggshell." [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000500 ! follicular epithelial cell [Term] id: CL:0000660 name: glycocalyx secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes glycocalyx." [] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000661 name: distal tip cell (sensu Nematoda) namespace: cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000662 name: neuroglioblast (sensu Nematoda) namespace: cell is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000663 name: valve cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000664 name: closable valve cell namespace: cell is_a: CL:0000185 ! myoepithelial cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000665 name: permanently open valve cell namespace: cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000666 name: fenestrated cell namespace: cell synonym: "window cell" EXACT [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000667 name: collagen secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000668 name: obsolete parenchymal cell namespace: cell def: "OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." [] comment: OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074. xref: BTO:0002174 xref: FMA:84638 is_obsolete: true [Term] id: CL:0000669 name: pericyte cell namespace: cell alt_id: CL:0000184 def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [] comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. synonym: "adventitial cell" RELATED [] synonym: "adventitial reticular cell" EXACT [] synonym: "ARC" EXACT [] synonym: "cell of Rouget" EXACT [] synonym: "pericyte" EXACT [] synonym: "pericyte of Rouget" EXACT [] xref: BTO:0002441 xref: FMA:63174 is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supportive cell is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000670 name: primordial germ cell namespace: cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] synonym: "Gonocyte" EXACT [] synonym: "Gonocyte" RELATED [] synonym: "gonocyte" EXACT [] synonym: "Primitive germ cell" EXACT [] synonym: "Primitive germ cell" RELATED [] synonym: "primitive germ cell" EXACT [] xref: FMA:70567 is_a: CL:0000039 ! germ line cell is_a: CL:0000219 ! motile cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure intersection_of: CL:0000039 ! germ line cell intersection_of: capable_of GO:0048870 ! cell motility intersection_of: part_of UBERON:0000922 ! embryo relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000014 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Blastula:Sphere relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000990 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! reproductive system [Term] id: CL:0000671 name: centripetally migrating follicle cell namespace: cell xref: FBbt:00004906 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000672 name: obsolete tracheary element namespace: cell def: "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." [] comment: replaced_by: PO:0000290 is_obsolete: true [Term] id: CL:0000673 name: Kenyon cell namespace: cell is_a: CL:0000028 ! CNS neuron (sensu Nematoda and Protostomia) [Term] id: CL:0000674 name: interfollicle cell namespace: cell synonym: "fly stalk cell" EXACT [] xref: FBbt:00004910 is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000675 name: female gamete namespace: cell def: "A mature sexual reproductive cell of the female germline." [] is_a: CL:0000021 ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000676 name: cap cell namespace: cell xref: BTO:0001033 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000677 name: gut absorptive cell namespace: cell def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [] is_a: CL:0000212 ! absorptive cell is_a: UBERON:0004119 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! endoderm-derived structure relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites relationship: part_of UBERON:0001555 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! digestive tract [Term] id: CL:0000678 name: commissural neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000679 name: glutamatergic neuron namespace: cell xref: WBbt:0006829 is_a: CL:0000161 ! acid secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061535 ! glutamate secretion, neurotransmission relationship: capable_of GO:0061535 ! glutamate secretion, neurotransmission [Term] id: CL:0000680 name: muscle precursor cell namespace: cell def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000222 ! mesodermal cell relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000020 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Gastrula:75%-epiboly [Term] id: CL:0000681 name: radial glial cell namespace: cell def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [] comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life. synonym: "forebrain radial glial cell" NARROW [] is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000710 ! neurecto-epithelial cell relationship: existence_ends_during_or_before ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: existence_starts_during_or_after ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 [Term] id: CL:0000682 name: M cell of gut namespace: cell def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." [] comment: Should double check and see if M cells are particular to a specific region. synonym: "M cell" BROAD [] synonym: "M-cell" EXACT [] synonym: "microfold cell" EXACT [] xref: BTO:0003600 xref: FMA:62929 is_a: CL:0000473 ! defensive cell is_a: CL:0000627 ! transporting cell is_a: CL:0002251 ! epithelial cell of alimentary canal relationship: part_of UBERON:0003929 ! digestive tract epithelium [Term] id: CL:0000683 name: ependymoglial cell namespace: cell def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." [] synonym: "ependymal astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0000684 name: littoral cell of liver namespace: cell is_a: CL:0000077 ! mesothelial cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000685 name: obsolete meristematic cell namespace: cell def: "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." [] comment: replaced_by: PO:0004010 is_obsolete: true [Term] id: CL:0000686 name: cerebrospinal fluid secreting cell namespace: cell def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [] is_a: CL:0000151 ! secretory cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0033326 relationship: capable_of GO:0033326 relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000687 name: R1 photoreceptor cell namespace: cell synonym: "R1 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000688 name: perijunctional fibroblast namespace: cell def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." [] is_a: CL:0000057 ! fibroblast is_a: CL:0000630 ! supportive cell is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural cell [Term] id: CL:0000689 name: myoendocrine cell namespace: cell def: "A cell with both myofibrils and secretory granules." [] is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000690 name: R2 photoreceptor cell namespace: cell synonym: "R2 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000691 name: stellate interneuron namespace: cell is_a: CL:0000099 ! interneuron [Term] id: CL:0000692 name: terminal Schwann cell namespace: cell def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." [] synonym: "Schwann cell" BROAD [] is_a: CL:0000630 ! supportive cell is_a: CL:0002376 ! non-myelinating Schwann cell [Term] id: CL:0000693 name: neuroglioform cell namespace: cell def: "A stellate interneuron having 7-10 dendrites that may branch." [] synonym: "spiderweb cell" EXACT [] is_a: CL:0000691 ! stellate interneuron [Term] id: CL:0000694 name: R3 photoreceptor cell namespace: cell synonym: "R3 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000695 name: Cajal-Retzius cell namespace: cell def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000696 name: PP cell namespace: cell def: "A cell that stores and secretes pancreatic polypeptide hormone." [] synonym: "type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000697 name: R4 photoreceptor cell namespace: cell synonym: "R4 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000698 name: obsolete paraganglial cell namespace: cell is_obsolete: true [Term] id: CL:0000699 name: paraganglial type 1 cell namespace: cell def: "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." [] is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000700 name: dopaminergic neuron namespace: cell def: "A neuron that releases dopamine as a neurotransmitter." [] synonym: "dopaminergic cell" EXACT [] xref: BTO:0004032 xref: FMA:84787 xref: WBbt:0006746 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061527 ! dopamine secretion, neurotransmission relationship: capable_of GO:0061527 ! dopamine secretion, neurotransmission [Term] id: CL:0000701 name: paraganglia type 2 cell namespace: cell def: "Supports paraganglial type 1 cell." [] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000702 name: R5 photoreceptor cell namespace: cell synonym: "R5 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000703 name: sustentacular cell namespace: cell def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [] xref: BTO:0002315 is_a: CL:0000630 ! supportive cell [Term] id: CL:0000704 name: endothelial tip cell namespace: cell def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [] is_a: CL:0000071 ! blood vessel endothelial cell [Term] id: CL:0000705 name: R6 photoreceptor cell namespace: cell synonym: "R6 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000706 name: choroid plexus epithelial cell namespace: cell alt_id: CL:1000430 def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [] synonym: "epithelial cell of choroid plexus" EXACT [] xref: FMA:70549 is_a: CL:0000065 ! ependymal cell is_a: CL:0000627 ! transporting cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000065 ! ependymal cell intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus [Term] id: CL:0000707 name: R7 photoreceptor cell namespace: cell synonym: "R7 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000494 ! UV sensitive photoreceptor cell [Term] id: CL:0000708 name: leptomeningeal cell namespace: cell def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [] synonym: "leptomemingeal cell" RELATED [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000327 ! extracellular matrix secreting cell intersection_of: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier relationship: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier [Term] id: CL:0000709 name: R8 photoreceptor cell namespace: cell synonym: "R8 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000710 name: neurecto-epithelial cell namespace: cell def: "Epithelial cells derived from neural plate and neural crest." [] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell intersection_of: develops_from CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000711 name: cumulus cell namespace: cell def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." [] xref: BTO:0002236 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002174 ! follicular cell of ovary relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000712 name: stratum granulosum cell namespace: cell is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000362 ! epidermal cell intersection_of: part_of UBERON:0002069 ! stratum granulosum of epidermis relationship: part_of UBERON:0002069 ! stratum granulosum of epidermis [Term] id: CL:0000713 name: corona radiata cell namespace: cell is_a: CL:0000711 ! cumulus cell [Term] id: CL:0000715 name: embryonic crystal cell namespace: cell is_a: CL:0000392 ! crystal cell is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000716 name: lymph gland crystal cell namespace: cell is_a: CL:0000392 ! crystal cell is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000717 name: fusimotor neuron namespace: cell def: "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." [] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000718 name: compound eye cone cell namespace: cell synonym: "cone cell (sensu Endopterygota)" RELATED [] is_a: CL:0000306 ! crystallin accumulating cell relationship: part_of UBERON:0000018 ! compound eye [Term] id: CL:0000719 name: posterior cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000720 name: anterior cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000721 name: equatorial cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000722 name: cystoblast namespace: cell is_a: CL:0000586 ! germ cell [Term] id: CL:0000723 name: somatic stem cell namespace: cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000034 ! stem cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000034 ! stem cell intersection_of: capable_of GO:0048103 relationship: capable_of GO:0048103 relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000724 name: heterocyst namespace: cell def: "A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [] xref: BTO:0000600 is_a: CL:0000520 ! prokaryotic cell is_a: CL:0000725 ! nitrogen fixing cell [Term] id: CL:0000725 name: nitrogen fixing cell namespace: cell is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0009399 relationship: capable_of GO:0009399 [Term] id: CL:0000726 name: chlamydospore namespace: cell def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [] comment: Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus. is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000727 name: primary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000728 name: secondary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000729 name: tertiary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000730 name: leading edge cell namespace: cell def: "A cell at the front of a migrating epithelial sheet." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000731 name: urothelial cell namespace: cell def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [] synonym: "bladder transitional cell" NARROW [] synonym: "transitional epithelial cell of urinary bladder" NARROW [] synonym: "urinary tract transitional epithelial cell" NARROW [] xref: FMA:84127 is_a: CL:0000244 ! transitional epithelial cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000244 ! transitional epithelial cell intersection_of: part_of UBERON:0000365 ! urothelium relationship: part_of UBERON:0000365 ! urothelium [Term] id: CL:0000732 name: amoeboid cell namespace: cell is_a: CL:0000219 ! motile cell [Term] id: CL:0000733 name: lymph gland plasmatocyte namespace: cell is_a: CL:0000394 ! plasmatocyte is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000734 name: embryonic gland plasmatocyte namespace: cell is_a: CL:0000394 ! plasmatocyte is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000735 name: lymph gland hemocyte namespace: cell is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000736 name: embryonic gland hemocyte namespace: cell is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000737 name: striated muscle cell namespace: cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] xref: BTO:0002916 xref: CALOHA:TS-2157 xref: FMA:86936 is_a: CL:0000187 ! muscle cell relationship: has_part GO:0030017 [Term] id: CL:0000738 name: leukocyte namespace: cell def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [] synonym: "immune cell" EXACT [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000219 ! motile cell is_a: CL:0000988 ! hematopoietic cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration relationship: capable_of GO:0001667 ! ameboidal-type cell migration relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: part_of UBERON:0002405 ! immune system [Term] id: CL:0000740 name: retinal ganglion cell namespace: cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [] synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" EXACT [] xref: BTO:0001800 xref: FMA:67765 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:0009004 ! retinal cell relationship: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0001792 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! ganglionic layer of retina [Term] id: CL:0000741 name: spinal accessory motor neuron namespace: cell def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." [] synonym: "SACMN" EXACT [] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000742 name: periarticular chondrocyte namespace: cell def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." [] is_a: CL:1001607 ! articular chondrocyte [Term] id: CL:0000743 name: hypertrophic chondrocyte namespace: cell def: "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." [] comment: is hypertrophic pathological or normal? and can it be described using a pato term? is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000744 name: columnar chondrocyte namespace: cell def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." [] is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000745 name: retina horizontal cell namespace: cell def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [] synonym: "horizontal cell" EXACT [] xref: BTO:0004120 is_a: CL:0000099 ! interneuron is_a: CL:0009004 ! retinal cell relationship: part_of UBERON:0003902 ! retinal neural layer [Term] id: CL:0000746 name: cardiac muscle cell namespace: cell alt_id: FMA:83808 def: "A myocyte located in the heart. The contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:tfm, ISBN:0323052908] def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [] comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. synonym: "cardiac muscle fiber" EXACT [] synonym: "cardiac myocyte" EXACT [] synonym: "cardiac myocyte" RELATED [] synonym: "cardiocyte" BROAD [] synonym: "cardiocyte" RELATED [] synonym: "cardiomyocyte" EXACT [] synonym: "cardiomyocyte" RELATED [] synonym: "heart muscle cell" EXACT [] synonym: "heart muscle cell" RELATED [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: ZFA:0005784 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! striated muscle cell (Danio) relationship: develops_from CL:0000513 ! cardiac muscle myoblast relationship: part_of UBERON:0001133 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! cardiac muscle tissue relationship: part_of UBERON:0002349 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! myocardium [Term] id: CL:0000747 name: cyanophore namespace: cell def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [] synonym: "blue chromatophore" RELATED [] is_a: CL:0000147 ! pigment cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0005005 ! cyanoblast relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0002199 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! integument [Term] id: CL:0000748 name: retinal bipolar neuron def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [] is_a: CL:0000103 ! bipolar neuron is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0008028 ! visual system neuron is_a: CL:0008030 ! excitatory neuron is_a: CL:0009004 ! retinal cell intersection_of: CL:0000103 ! bipolar neuron intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina [Term] id: CL:0000749 name: ON-bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000750 name: OFF-bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells depolatize in response to light to dark transition." [] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000751 name: rod bipolar cell namespace: cell def: "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light." [] xref: FMA:67750 is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000752 name: cone retinal bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000753 name: type 1 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." [] synonym: "DB1 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000754 name: type 2 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1 (Ghosh et al., 2004). It can be differentiated from other retinal bipolar neurons by its expression of marker genes: Neto1, Lhx3 and Irx-6 (Shekhar, 2016)." [] synonym: "FMB cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000755 name: type 3 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." [] synonym: "DB2 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000756 name: type 4 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." [] synonym: "DB3 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000757 name: type 5 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." [] synonym: "DB4 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000758 name: type 6 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." [] synonym: "DB5 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000759 name: type 7 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." [] synonym: "IMB cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000760 name: type 8 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." [] synonym: "DB6 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000761 name: type 9 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." [] synonym: "BB cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000762 name: nucleated thrombocyte namespace: cell def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [] comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 ! myeloid cell relationship: capable_of GO:0007596 ! blood coagulation relationship: develops_from CL:0000828 ! thromboblast [Term] id: CL:0000763 name: myeloid cell namespace: cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [] xref: BTO:0001441 xref: CALOHA:TS-0647 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000988 ! hematopoietic cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure intersection_of: CL:0000988 ! hematopoietic cell intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell namespace: cell alt_id: CL:0002156 def: "A immature or mature cell in the lineage leading to and including erythrocytes." [] comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. synonym: "erythropoietic cell" EXACT [] xref: CALOHA:TS-0290 xref: FMA:62845 xref: FMA:83516 is_a: CL:0000763 ! myeloid cell [Term] id: CL:0000765 name: erythroblast namespace: cell def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [] synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell is_a: CL:0011115 ! precursor cell relationship: capable_of GO:0030218 relationship: develops_from CL:0000547 ! proerythroblast [Term] id: CL:0000766 name: myeloid leukocyte namespace: cell def: "A cell of the monocyte, granulocyte, or mast cell lineage." [] is_a: CL:0000738 ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000767 name: basophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [] comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. synonym: "basophilic leucocyte" EXACT [] synonym: "basophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000129 xref: CALOHA:TS-0073 xref: FMA:62862 is_a: CL:0000094 ! granulocyte relationship: has_part PR:000001255 relationship: has_part PR:000001344 relationship: has_part PR:000001865 relationship: has_part PR:000001950 relationship: has_part PR:000007431 [Term] id: CL:0000768 name: immature basophil namespace: cell def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immature basophilic leucocyte" EXACT [] synonym: "immature basophilic leukocyte" EXACT [] is_a: CL:0000767 ! basophil is_a: CL:0002242 ! nucleate cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000767 ! basophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 relationship: develops_from CL:0000830 ! basophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 [Term] id: CL:0000769 name: basophilic metamyelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [] xref: FMA:84198 is_a: CL:0000768 ! immature basophil is_a: CL:0002192 ! metamyelocyte relationship: develops_from CL:0000614 ! basophilic myelocyte relationship: has_part CP:0000040 relationship: has_part GO:0000792 relationship: has_part GO:0042582 relationship: has_part GO:0070820 relationship: has_part PR:000001456 relationship: has_part PR:000001483 relationship: has_part PR:000001892 relationship: has_part PR:000001932 relationship: has_part PR:000002031 [Term] id: CL:0000770 name: band form basophil namespace: cell def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [] is_a: CL:0000768 ! immature basophil intersection_of: CL:0000768 ! immature basophil intersection_of: has_part CP:0000039 relationship: develops_from CL:0000769 ! basophilic metamyelocyte relationship: has_part CP:0000039 [Term] id: CL:0000771 name: eosinophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [] comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. synonym: "eosinocyte" EXACT [] synonym: "eosinophilic granulocyte" EXACT [] synonym: "eosinophilic leucocyte" EXACT [] synonym: "eosinophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000399 xref: CALOHA:TS-0279 xref: FMA:62861 is_a: CL:0000094 ! granulocyte relationship: has_part PR:000001254 relationship: has_part PR:000001255 relationship: has_part PR:000001307 relationship: has_part PR:000001343 relationship: has_part PR:000005178 [Term] id: CL:0000772 name: immature eosinophil namespace: cell def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immature eosinocyte" EXACT [] synonym: "immature eosinophilic leucocyte" EXACT [] synonym: "immature eosinophilic leukocyte" EXACT [] is_a: CL:0000771 ! eosinophil is_a: CL:0002242 ! nucleate cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000771 ! eosinophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 relationship: develops_from CL:0000833 ! eosinophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 [Term] id: CL:0000773 name: eosinophilic metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [] is_a: CL:0000772 ! immature eosinophil is_a: CL:0002192 ! metamyelocyte relationship: develops_from CL:0000612 ! eosinophilic myelocyte relationship: has_part CP:0000027 relationship: has_part CP:0000040 relationship: has_part GO:0000792 relationship: has_part GO:0042582 relationship: has_part GO:0070820 relationship: has_part PR:000001456 relationship: has_part PR:000001483 relationship: has_part PR:000001892 relationship: has_part PR:000001932 relationship: has_part PR:000002031 [Term] id: CL:0000774 name: band form eosinophil namespace: cell def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [] is_a: CL:0000772 ! immature eosinophil intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part CP:0000039 relationship: develops_from CL:0000773 ! eosinophilic metamyelocyte relationship: has_part CP:0000039 [Term] id: CL:0000775 name: neutrophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [] synonym: "neutrocyte" EXACT [] synonym: "neutrophil leucocyte" EXACT [] synonym: "neutrophil leukocyte" EXACT [] synonym: "neutrophilic leucocyte" EXACT [] synonym: "neutrophilic leukocyte" EXACT [] synonym: "PMN" BROAD [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" BROAD [] synonym: "polynuclear neutrophilic leucocyte" BROAD [] synonym: "polynuclear neutrophilic leukocyte" BROAD [] xref: BTO:0000130 xref: CALOHA:TS-0688 xref: FMA:62860 is_a: CL:0000094 ! granulocyte relationship: has_part PR:000001479 relationship: has_part PR:000001879 [Term] id: CL:0000776 name: immature neutrophil namespace: cell def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immatuer neutrophilic leukocyte" EXACT [] synonym: "immature neutrocyte" EXACT [] synonym: "immature neutrophil leucocyte" EXACT [] synonym: "immature neutrophil leukocyte" EXACT [] synonym: "immature neutrophilic leucocyte" EXACT [] is_a: CL:0000775 ! neutrophil is_a: CL:0002242 ! nucleate cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000775 ! neutrophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 relationship: develops_from CL:0000564 ! neutrophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 [Term] id: CL:0000777 name: mesangial phagocyte namespace: cell def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [] synonym: "mesangial cell" BROAD [] is_a: CL:0000864 ! tissue-resident macrophage relationship: capable_of GO:0019882 relationship: capable_of GO:0048771 [Term] id: CL:0000778 name: mononuclear osteoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [] comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 ! osteoclast is_a: CL:0000226 ! single nucleate cell [Term] id: CL:0000779 name: multinuclear osteoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [] comment: Morphology: multinucleated, highly vesicular. synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 ! osteoclast is_a: CL:0000228 ! multinucleate cell relationship: develops_from CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000780 name: multinuclear odontoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [] comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth. synonym: "multinucleated odontoclast" EXACT [] is_a: CL:0000588 ! odontoclast is_a: CL:0000779 ! multinuclear osteoclast relationship: develops_from CL:0000781 ! mononuclear odontoclast [Term] id: CL:0000781 name: mononuclear odontoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [] comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth. is_a: CL:0000588 ! odontoclast is_a: CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000782 name: myeloid dendritic cell namespace: cell def: "A dendritic cell of the myeloid lineage." [] comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). synonym: "CD11c+CD123- DC" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "mDC" EXACT [] synonym: "veiled cell" BROAD [] xref: BTO:0004721 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000576 ! monocyte [Term] id: CL:0000783 name: multinucleated phagocyte namespace: cell def: "A phagocyte formed by the fusion of mononuclear phagocytes." [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 ! phagocyte (sensu Vertebrata) [Term] id: CL:0000784 name: plasmacytoid dendritic cell namespace: cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [] synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] synonym: "IPC" EXACT [] synonym: "lymphoid dendritic cell" EXACT [] synonym: "pDC" EXACT [] synonym: "plasmacytoid monocyte" EXACT [] synonym: "plasmacytoid T cell" EXACT [] synonym: "T-associated plasma cell" EXACT [] synonym: "type 2 DC" EXACT [] xref: BTO:0004625 is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: capable_of GO:0032606 relationship: capable_of GO:0032606 [Term] id: CL:0000785 name: mature B cell namespace: cell def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [] comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive. synonym: "mature B lymphocyte" EXACT [] synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] is_a: CL:0000236 ! B cell relationship: capable_of GO:0002504 relationship: capable_of GO:0042113 ! B cell activation relationship: develops_from CL:0000818 ! transitional stage B cell [Term] id: CL:0000786 name: plasma cell namespace: cell def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [] comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. synonym: "effector B cell" RELATED [] synonym: "effector B-cell" RELATED [] synonym: "plasma B cell" EXACT [] synonym: "plasma B-cell" EXACT [] synonym: "plasmacyte" EXACT [] synonym: "plasmocyte" EXACT [] xref: BTO:0000392 xref: FMA:70574 is_a: CL:0000946 ! antibody secreting cell relationship: develops_from CL:0000980 ! plasmablast relationship: has_part CP:0000043 relationship: has_part GO:0005794 relationship: has_part PR:000001935 [Term] id: CL:0000787 name: memory B cell namespace: cell def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [] comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive. synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell relationship: has_part GO:0042613 relationship: has_part PR:000001289 relationship: has_part PR:000001963 [Term] id: CL:0000788 name: naive B cell namespace: cell def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell relationship: has_part GO:0071738 relationship: has_part GO:0071753 relationship: has_part PR:000001289 [Term] id: CL:0000789 name: alpha-beta T cell namespace: cell def: "A T cell that expresses an alpha-beta T cell receptor complex." [] synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000084 ! T cell is_a: CL:0000812 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} relationship: has_part GO:0042105 [Term] id: CL:0000790 name: immature alpha-beta T cell namespace: cell def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [] synonym: "immature alpha-beta T lymphocyte" EXACT [] synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 ! alpha-beta T cell is_a: CL:0002420 ! immature T cell [Term] id: CL:0000791 name: mature alpha-beta T cell namespace: cell def: "A alpha-beta T cell that has a mature phenotype." [] synonym: "mature alpha-beta T lymphocyte" EXACT [] synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 ! alpha-beta T cell is_a: CL:0002419 ! mature T cell relationship: develops_from CL:0000790 ! immature alpha-beta T cell [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell relationship: has_part PR:000001380 relationship: has_part PR:000001869 [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [] comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] synonym: "cytotoxic T cell" BROAD [] synonym: "cytotoxic T lymphocyte" BROAD [] synonym: "cytotoxic T-cell" BROAD [] synonym: "cytotoxic T-lymphocyte" BROAD [] synonym: "killer T cell" BROAD [] synonym: "killer T lymphocyte" BROAD [] synonym: "killer T-cell" BROAD [] synonym: "killer T-lymphocyte" BROAD [] xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: capable_of GO:0033380 relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000003466 relationship: has_part PR:000003499 [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] synonym: "CD8+ regulatory T cell" EXACT [] synonym: "CD8+ T(reg)" EXACT [] synonym: "CD8+ Treg" EXACT [] synonym: "CD8-positive T(reg)" EXACT [] synonym: "CD8-positive Treg" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta Treg" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: capable_of GO:0050777 ! negative regulation of immune response [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell namespace: cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell relationship: has_part PR:000025402 [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell namespace: cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [] synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000791 ! mature alpha-beta T cell is_a: CL:0002496 ! intraepithelial lymphocyte [Term] id: CL:0000798 name: gamma-delta T cell namespace: cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] synonym: "gd T cell" RELATED [] is_a: CL:0000084 ! T cell is_a: CL:0000812 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} relationship: has_part GO:0042106 [Term] id: CL:0000799 name: immature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has an immature phenotype." [] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "immature gamma-delta T lymphocyte" EXACT [] synonym: "immature gamma-delta T-cell" EXACT [] synonym: "immature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002420 ! immature T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000807 ! DN3 thymocyte [Term] id: CL:0000800 name: mature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [] synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] synonym: "mature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002419 ! mature T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000799 ! immature gamma-delta T cell [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell namespace: cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [] synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000800 ! mature gamma-delta T cell is_a: CL:0002496 ! intraepithelial lymphocyte [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 ! gamma-delta intraepithelial T cell relationship: has_part PR:000001084 [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 ! gamma-delta intraepithelial T cell [Term] id: CL:0000805 name: immature single positive thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. synonym: "immature single positive T cell" EXACT [] synonym: "immature single positive T lymphocyte" EXACT [] synonym: "immature single positive T-lymphocyte" EXACT [] synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000808 ! DN4 thymocyte relationship: has_part GO:0043384 relationship: has_part PR:000001932 relationship: has_part PR:000025402 [Term] id: CL:0000806 name: DN2 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [] comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. synonym: "DN2 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN2 alpha-beta immature T-cell" EXACT [] synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN2 cell" EXACT [] synonym: "DN2 immature T cell" EXACT [] synonym: "double negative 2" EXACT [] synonym: "preT.DN2.Th" EXACT [] synonym: "TN2 cell" EXACT [] synonym: "TN2 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_part PR:000001307 relationship: has_part PR:000001380 [Term] id: CL:0000807 name: DN3 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [] synonym: "DN3 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN3 alpha-beta immature T-cell" EXACT [] synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN3 cell" EXACT [] synonym: "DN3 immature T cell" EXACT [] synonym: "double negative 3" EXACT [] synonym: "early cortical thymocyte" BROAD [] synonym: "preT.DN3.Th" EXACT [] synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte relationship: develops_from CL:0000806 ! DN2 thymocyte relationship: has_part GO:0043384 relationship: has_part PR:000001380 [Term] id: CL:0000808 name: DN4 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. synonym: "DN4 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN4 cell" EXACT [] synonym: "DN4 immature T cell" EXACT [] synonym: "DN4 immature T-cell" EXACT [] synonym: "double negative 4" EXACT [] synonym: "early cortical thymocyte" BROAD [] synonym: "T.DN4.th" EXACT [] is_a: CL:0002489 ! double negative thymocyte relationship: develops_from CL:0000807 ! DN3 thymocyte relationship: has_part GO:0043384 [Term] id: CL:0000809 name: double-positive, alpha-beta thymocyte namespace: cell def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [] comment: Thymocytes of this stage are undergoing positive and negative selection. synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "DP cell" EXACT [] synonym: "DP thymocyte" EXACT [] synonym: "late cortical thymocyte" BROAD [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000805 ! immature single positive thymocyte relationship: has_part PR:000001004 relationship: has_part PR:000025402 [Term] id: CL:0000810 name: CD4-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [] synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD4 cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000001004 [Term] id: CL:0000811 name: CD8-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [] synonym: "CD8-positive, alpha-beta immature T cell" RELATED [] synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD8 cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000025402 [Term] id: CL:0000813 name: memory T cell namespace: cell def: "A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [] synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] synonym: "memory T-lymphocyte" EXACT [] xref: BTO:0003435 is_a: CL:0000812 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} is_a: CL:0002419 ! mature T cell relationship: develops_from CL:0000812 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} relationship: has_part PR:000001017 relationship: has_part PR:000001869 [Term] id: CL:0000814 name: mature NK T cell namespace: cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [] synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] synonym: "mature natural killer T-cell" EXACT [] synonym: "mature natural killer T-lymphocyte" EXACT [] synonym: "mature NK T lymphocyte" EXACT [] synonym: "mature NK T-cell" EXACT [] synonym: "mature NK T-lymphocyte" EXACT [] synonym: "mature NKT cell" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: capable_of GO:0032394 relationship: develops_from CL:0002042 ! immature NK T cell stage IV relationship: has_part PR:000001874 [Term] id: CL:0000815 name: regulatory T cell namespace: cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. synonym: "regulatory T lymphocyte" EXACT [] synonym: "regulatory T-cell" EXACT [] synonym: "regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] xref: BTO:0004520 xref: FMA:84070 is_a: CL:0002419 ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: capable_of GO:0050777 ! negative regulation of immune response relationship: capable_of GO:0050777 ! negative regulation of immune response [Term] id: CL:0000816 name: immature B cell namespace: cell def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [] comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive. synonym: "immature B lymphocyte" EXACT [] synonym: "immature B-cell" EXACT [] synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B cell" EXACT [] is_a: CL:0000236 ! B cell relationship: develops_from CL:0000954 ! small pre-B-II cell relationship: has_part GO:0071753 relationship: has_part PR:000001289 [Term] id: CL:0000817 name: precursor B cell namespace: cell def: "A precursor B cell is a B cell with the phenotype CD10-positive." [] synonym: "pre-B cell" RELATED [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000236 ! B cell relationship: has_part PR:000001898 [Term] id: CL:0000818 name: transitional stage B cell namespace: cell def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'. synonym: "T1 B cell" NARROW [] synonym: "T2 B cell" NARROW [] synonym: "T3 B cell" NARROW [] synonym: "transitional B cell" EXACT [] synonym: "transitional stage B lymphocyte" EXACT [] synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] is_a: CL:0000236 ! B cell relationship: develops_from CL:0000816 ! immature B cell relationship: has_part GO:0071753 relationship: has_part PR:000001289 relationship: has_part PR:000001408 relationship: has_part PR:000001932 [Term] id: CL:0000819 name: B-1 B cell namespace: cell def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [] comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low. synonym: "B-1 B lymphocyte" EXACT [] synonym: "B-1 B-cell" EXACT [] synonym: "B-1 B-lymphocyte" EXACT [] synonym: "B-1 cell" EXACT [] synonym: "B1 B cell" EXACT [] synonym: "B1 B lymphocyte" EXACT [] synonym: "B1 B-cell" EXACT [] synonym: "B1 B-lymphocyte" EXACT [] synonym: "B1 cell" EXACT [] is_a: CL:0000785 ! mature B cell relationship: capable_of GO:0045087 relationship: has_part GO:0071753 relationship: has_part PR:000001014 relationship: has_part PR:000001289 relationship: has_part PR:000001879 [Term] id: CL:0000820 name: B-1a B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-positive." [] synonym: "B-1a B lymphocyte" EXACT [] synonym: "B-1a B-cell" EXACT [] synonym: "B-1a B-lymphocyte" EXACT [] synonym: "B1a B cell" EXACT [] synonym: "B1a B lymphocyte" EXACT [] synonym: "B1a B-cell" EXACT [] synonym: "B1a B-lymphocyte" EXACT [] synonym: "B1a cell" EXACT [] synonym: "CD5(+) B1 cell" EXACT [] synonym: "CD5+ B1 cell" EXACT [] synonym: "CD5-positive B1 cell" EXACT [] is_a: CL:0000819 ! B-1 B cell relationship: has_part PR:000001839 [Term] id: CL:0000821 name: B-1b B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [] synonym: "B-1b B lymphocyte" EXACT [] synonym: "B-1b B-cell" EXACT [] synonym: "B-1b B-lymphocyte" EXACT [] synonym: "B1b B cell" EXACT [] synonym: "B1b B lymphocyte" EXACT [] synonym: "B1b B-cell" EXACT [] synonym: "B1b B-lymphocyte" EXACT [] synonym: "B1b cell" EXACT [] is_a: CL:0000819 ! B-1 B cell [Term] id: CL:0000822 name: B-2 B cell namespace: cell def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [] comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive. synonym: "B-0 B cell" RELATED [] synonym: "B-2 B lymphocyte" EXACT [] synonym: "B-2 B-cell" EXACT [] synonym: "B-2 B-lymphocyte" EXACT [] synonym: "B2 B cell" EXACT [] synonym: "B2 B lymphocyte" EXACT [] synonym: "B2 B-cell" EXACT [] synonym: "B2 B-lymphocyte" EXACT [] synonym: "B2 cell" EXACT [] is_a: CL:0000785 ! mature B cell relationship: has_part PR:000001289 [Term] id: CL:0000823 name: immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [] comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [] is_a: CL:0000623 ! natural killer cell relationship: develops_from CL:0000937 ! pre-natural killer cell [Term] id: CL:0000824 name: mature natural killer cell namespace: cell def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [] synonym: "LAK cell" BROAD [] synonym: "lymphokine activated killer cell" BROAD [] synonym: "mature NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell relationship: develops_from CL:0000823 ! immature natural killer cell [Term] id: CL:0000825 name: pro-NK cell namespace: cell def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [] comment: Most markers only described for human pro NK cells. synonym: "natural killer cell progenitor" EXACT [] synonym: "NKP" EXACT [] synonym: "null cell" RELATED [] synonym: "preNK cell" RELATED [] synonym: "pro-natural killer cell" EXACT [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part PR:000001003 relationship: has_part PR:000001015 relationship: has_part PR:000001381 relationship: has_part PR:000001898 [Term] id: CL:0000826 name: pro-B cell namespace: cell def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [] comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [] synonym: "pre-pro B cell" BROAD [] synonym: "pro-B lymphocyte" EXACT [] synonym: "pro-B-cell" EXACT [] synonym: "pro-B-lymphocyte" EXACT [] synonym: "progenitor B cell" EXACT [] synonym: "progenitor B lymphocyte" EXACT [] synonym: "progenitor B-cell" EXACT [] synonym: "progenitor B-lymphocyte" EXACT [] xref: BTO:0003104 is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part PR:000001903 relationship: has_part PR:000006611 [Term] id: CL:0000827 name: pro-T cell namespace: cell def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [] synonym: "DN1 cell" NARROW [] synonym: "DN1 thymocyte" NARROW [] synonym: "pro-T lymphocyte" EXACT [] synonym: "progenitor T cell" EXACT [] synonym: "TN1 cell" NARROW [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell is_a: UBERON:0000078 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mixed ectoderm/mesoderm/endoderm-derived structure is_a: UBERON:0010313 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural crest-derived structure intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: capable_of GO:0030217 ! T cell differentiation relationship: capable_of GO:0030217 ! T cell differentiation relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: existence_starts_during_or_after ZFS:0000035 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Larval:Protruding-mouth relationship: part_of UBERON:0002370 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! thymus [Term] id: CL:0000828 name: thromboblast namespace: cell def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [] comment: Note that this is a non-mammalian cell type. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: capable_of GO:0002574 relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000829 name: basophilic myeloblast namespace: cell def: "A myeloblast committed to the basophil lineage." [] is_a: CL:0000835 ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: capable_of GO:0030221 relationship: capable_of GO:0030221 relationship: develops_from CL:0000613 ! basophil progenitor cell [Term] id: CL:0000830 name: basophilic promyelocyte namespace: cell def: "A promyelocyte committed to the basophil lineage." [] xref: FMA:84208 is_a: CL:0000836 ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: capable_of GO:0030221 relationship: capable_of GO:0030221 relationship: develops_from CL:0000829 ! basophilic myeloblast [Term] id: CL:0000831 name: mast cell progenitor namespace: cell def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." [] comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa. synonym: "CFU-Mast" RELATED [] synonym: "CFU-MC" RELATED [] synonym: "colony forming unit mast cell" RELATED [] synonym: "MCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0060374 relationship: develops_from CL:0002028 ! basophil mast progenitor cell relationship: has_part PR:000002065 relationship: has_part PR:000005178 relationship: has_part PR:000007431 relationship: has_part PR:000007857 relationship: has_part PR:000007858 relationship: has_part PR:000009143 relationship: has_part PR:000016401 [Term] id: CL:0000832 name: eosinophilic myeloblast namespace: cell def: "A myeloblast committed to the eosinophil lineage." [] is_a: CL:0000835 ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: capable_of GO:0030222 relationship: capable_of GO:0030222 relationship: develops_from CL:0000611 ! eosinophil progenitor cell [Term] id: CL:0000833 name: eosinophilic promyelocyte namespace: cell def: "A promyelocyte committed to the eosinophil lineage." [] xref: FMA:84199 is_a: CL:0000836 ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: capable_of GO:0030222 relationship: capable_of GO:0030222 relationship: develops_from CL:0000832 ! eosinophilic myeloblast [Term] id: CL:0000834 name: neutrophil progenitor cell namespace: cell def: "A progenitor cell of the neutrophil lineage." [] synonym: "neutrophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: capable_of GO:0030223 relationship: capable_of GO:0030223 relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000835 name: myeloblast namespace: cell def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [] xref: BTO:0000187 xref: FMA:83524 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: CL:0002242 ! nucleate cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part CP:0000028 relationship: has_part CP:0000037 relationship: has_part GO:0000791 [Term] id: CL:0000836 name: promyelocyte namespace: cell def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." [] xref: CALOHA:TS-0825 xref: FMA:83530 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: CL:0002242 ! nucleate cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000835 ! myeloblast relationship: has_part CP:0000028 relationship: has_part CP:0000037 relationship: has_part GO:0005730 relationship: has_part GO:0042582 relationship: has_part PR:000001456 relationship: has_part PR:000001892 [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell namespace: cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [] comment: Markers differ between mouse and human. synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0008001 ! hematopoietic precursor cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! mesoderm-derived structure relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: has_part PR:000001003 [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell namespace: cell def: "A progenitor cell restricted to the lymphoid lineage." [] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "lymphoid progenitor cell" BROAD [] xref: BTO:0004731 xref: CALOHA:TS-2025 xref: FMA:70338 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: capable_of GO:0030098 ! lymphocyte differentiation relationship: capable_of GO:0030098 ! lymphocyte differentiation relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell namespace: cell def: "A progenitor cell restricted to the myeloid lineage." [] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "myeloid progenitor cell" BROAD [] xref: BTO:0004730 xref: CALOHA:TS-2099 xref: FMA:70339 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: capable_of GO:0030099 relationship: capable_of GO:0030099 relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0000840 name: immature conventional dendritic cell namespace: cell def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [] synonym: "immature myeloid dendritic cell" NARROW [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_part PR:000001412 relationship: has_part PR:000001438 [Term] id: CL:0000841 name: mature conventional dendritic cell namespace: cell def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [] synonym: "mature dendritic cell" BROAD [] synonym: "mature myeloid dendritic cell" NARROW [] xref: FMA:83038 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000840 ! immature conventional dendritic cell relationship: has_part PR:000001310 relationship: has_part PR:000001412 relationship: has_part PR:000001438 [Term] id: CL:0000842 name: mononuclear cell namespace: cell def: "A leukocyte with a single non-segmented nucleus in the mature form." [] synonym: "mononuclear leukocyte" EXACT [] synonym: "peripheral blood mononuclear cell" NARROW [] xref: BTO:0000878 xref: CALOHA:TS-0768 xref: FMA:86713 is_a: CL:0000226 ! single nucleate cell is_a: CL:0002087 ! nongranular leukocyte [Term] id: CL:0000843 name: follicular B cell namespace: cell def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [] comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "Fo B cell" EXACT [] synonym: "Fo B-cell" EXACT [] synonym: "follicular B lymphocyte" EXACT [] synonym: "follicular B-cell" EXACT [] synonym: "follicular B-lymphocyte" EXACT [] is_a: CL:0000822 ! B-2 B cell relationship: has_part GO:0071738 relationship: has_part GO:0071753 relationship: has_part PR:000001014 relationship: has_part PR:000001338 [Term] id: CL:0000844 name: germinal center B cell namespace: cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [] comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. synonym: "GC B cell" EXACT [] synonym: "GC B lymphocyte" EXACT [] synonym: "GC B-cell" EXACT [] synonym: "GC B-lymphocyte" EXACT [] synonym: "germinal center B lymphocyte" EXACT [] synonym: "germinal center B-cell" EXACT [] synonym: "germinal center B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell relationship: develops_from CL:0000843 ! follicular B cell relationship: has_part PR:000001289 relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue [Term] id: CL:0000845 name: marginal zone B cell namespace: cell def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." [] comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive. synonym: "marginal zone B lymphocyte" EXACT [] synonym: "marginal zone B-cell" EXACT [] synonym: "marginal zone B-lymphocyte" EXACT [] synonym: "MZ B cell" EXACT [] synonym: "MZ B lymphocyte" EXACT [] synonym: "MZ B-cell" EXACT [] synonym: "MZ B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell is_a: CL:2000074 ! splenocyte relationship: capable_of GO:0042742 relationship: has_part GO:0071753 relationship: has_part PR:000001289 relationship: has_part PR:000001338 relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000846 name: vestibular dark cell namespace: cell def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000847 name: ciliated olfactory receptor neuron namespace: cell def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [] synonym: "ciliated olfactory sensory neuron" EXACT [] synonym: "ciliated sensory neuron" EXACT [] is_a: CL:0000064 ! ciliated cell is_a: CL:0000207 ! olfactory receptor cell intersection_of: CL:0000207 ! olfactory receptor cell intersection_of: has_part GO:0005929 ! cilium [Term] id: CL:0000848 name: microvillous olfactory receptor neuron namespace: cell def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [] synonym: "microvillous olfactory sensory neuron" EXACT [] synonym: "microvillous sensory neuron" RELATED [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000849 name: crypt olfactory receptor neuron namespace: cell def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." [] synonym: "crypt cell" EXACT [] synonym: "crypt olfactory sensory neuron" EXACT [] synonym: "crypt sensory neuron" EXACT [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000850 name: serotonergic neuron namespace: cell alt_id: CL:0000403 def: "A neuron that releases serotonin as a neurotransmitter." [] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: FBbt:00005133 xref: WBbt:0006837 is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0060096 ! serotonin secretion, neurotransmission relationship: capable_of GO:0060096 ! serotonin secretion, neurotransmission [Term] id: CL:0000851 name: neuromast mantle cell namespace: cell def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [] is_a: CL:0000151 ! secretory cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000852 name: neuromast support cell namespace: cell def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [] is_a: CL:0000630 ! supportive cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: existence_starts_during_or_after ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000853 name: olfactory epithelial support cell namespace: cell def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [] synonym: "olfactory sustentacular cell" EXACT [] synonym: "supporting cell of olfactory epithelium" EXACT [] synonym: "sustentaculocyte of olfactory epithelium" EXACT [] xref: FMA:62302 is_a: CL:0000630 ! supportive cell is_a: CL:0002169 ! basal cell of olfactory epithelium intersection_of: CL:0000630 ! supportive cell intersection_of: part_of UBERON:0001997 ! olfactory epithelium [Term] id: CL:0000854 name: interneuromast cell namespace: cell def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [] is_a: CL:0000133 ! neurectodermal cell is_a: CL:0002319 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000032 ! neuroplacodal cell relationship: existence_starts_during_or_after ZFS:0000029 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:Prim-5 relationship: part_of UBERON:0002540 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! lateral line system [Term] id: CL:0000855 name: sensory hair cell namespace: cell def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [] synonym: "hair cell" BROAD [] xref: BTO:0004744 is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000856 name: neuromast hair cell namespace: cell def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [] is_a: CL:0000855 ! sensory hair cell is_a: CL:2000032 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! peripheral nervous system neuron intersection_of: CL:0000855 ! sensory hair cell intersection_of: part_of UBERON:0008904 ! neuromast relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000857 name: slow muscle myoblast namespace: cell def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [] is_a: CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0000858 name: fast muscle myoblast namespace: cell def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [] is_a: CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0000860 name: classical monocyte namespace: cell def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [] comment: Markers: CCR2+CXCCR1 (human, mouse, rat). synonym: "inflammatory monocyte" EXACT [] is_a: CL:0000234 ! phagocyte is_a: CL:0000576 ! monocyte relationship: capable_of GO:0002548 relationship: capable_of GO:0006954 ! inflammatory response relationship: has_part PR:000001199 relationship: has_part PR:000001206 [Term] id: CL:0000861 name: elicited macrophage namespace: cell def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [] comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] xref: FMA:84643 xref: FMA:84645 is_a: CL:0000235 ! macrophage relationship: develops_from CL:0000860 ! classical monocyte relationship: has_part PR:000001012 relationship: has_part PR:000001813 relationship: has_part PR:000002064 [Term] id: CL:0000862 name: suppressor macrophage namespace: cell def: "A macrophage that suppresses immune responses." [] comment: Markers: May express: IL10, TGFbeta. is_a: CL:0000861 ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: capable_of GO:0050777 ! negative regulation of immune response relationship: capable_of GO:0050777 ! negative regulation of immune response [Term] id: CL:0000863 name: inflammatory macrophage namespace: cell def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [] comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response). synonym: "classically activated macrophage" EXACT [] synonym: "M1 macrophage" RELATED [] is_a: CL:0000861 ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: capable_of GO:0032611 intersection_of: capable_of GO:0032635 intersection_of: capable_of GO:0032640 intersection_of: capable_of GO:0042554 intersection_of: capable_of GO:0042742 intersection_of: capable_of GO:0051767 relationship: capable_of GO:0032611 relationship: capable_of GO:0032635 relationship: capable_of GO:0032640 relationship: capable_of GO:0042554 relationship: capable_of GO:0042742 relationship: capable_of GO:0051767 [Term] id: CL:0000864 name: tissue-resident macrophage namespace: cell def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [] synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] xref: FMA:84642 xref: FMA:84644 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: part_of UBERON:0000479 ! simple tissue relationship: part_of UBERON:0000479 ! simple tissue [Term] id: CL:0000865 name: gastrointestinal tract (lamina propria) macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." [] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine relationship: part_of UBERON:0001238 ! lamina propria of small intestine [Term] id: CL:0000866 name: thymic macrophage namespace: cell def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [] comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation. is_a: CL:0000864 ! tissue-resident macrophage is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: capable_of GO:0043277 intersection_of: part_of UBERON:0002370 ! thymus relationship: capable_of GO:0043277 relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000867 name: secondary lymphoid organ macrophage namespace: cell def: "A tissue-resident macrophage found in a secondary lymphoid organ." [] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000868 name: lymph node macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [] comment: Marker was observed on rat cells. synonym: "MF.LN" EXACT [] is_a: CL:0000867 ! secondary lymphoid organ macrophage relationship: has_part PR:000001012 relationship: has_part PR:000001813 relationship: has_part PR:000001931 relationship: part_of UBERON:0000029 ! lymph node [Term] id: CL:0000869 name: tonsillar macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in tonsils." [] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: capable_of GO:0002395 intersection_of: part_of UBERON:0002372 ! tonsil relationship: capable_of GO:0002395 relationship: part_of UBERON:0002372 ! tonsil [Term] id: CL:0000870 name: Peyer's patch macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: CL:0000871 name: splenic macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in the spleen." [] comment: Role or process: immune, clearance of apoptotic and senescent cells. xref: FMA:83026 is_a: CL:0000867 ! secondary lymphoid organ macrophage is_a: CL:2000074 ! splenocyte intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: capable_of GO:0034102 intersection_of: part_of UBERON:0002106 ! spleen relationship: capable_of GO:0034102 [Term] id: CL:0000872 name: splenic marginal zone macrophage namespace: cell def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [] comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. is_a: CL:0000871 ! splenic macrophage relationship: has_part PR:000001806 relationship: has_part PR:000001884 relationship: has_part PR:000001885 relationship: has_part PR:000006172 relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000873 name: splenic metallophillic macrophage namespace: cell def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [] comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+. is_a: CL:0000871 ! splenic macrophage relationship: has_part PR:000001806 relationship: has_part PR:000001931 relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000874 name: splenic red pulp macrophage namespace: cell def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [] comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes. is_a: CL:0000871 ! splenic macrophage relationship: capable_of GO:0006955 ! immune response relationship: has_part PR:000001012 relationship: has_part PR:000001806 relationship: has_part PR:000001813 relationship: has_part PR:000001931 relationship: has_part PR:000002064 relationship: has_part PR:000002972 relationship: part_of UBERON:0001250 ! red pulp of spleen [Term] id: CL:0000875 name: non-classical monocyte namespace: cell def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." [] comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-. synonym: "patrolling monocyte" EXACT [] synonym: "resident monocyte" EXACT [] is_a: CL:0000576 ! monocyte relationship: capable_of GO:0031294 relationship: develops_from CL:0002393 ! intermediate monocyte relationship: has_part PR:000001206 [Term] id: CL:0000876 name: splenic white pulp macrophage namespace: cell def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [] comment: Markers: Mouse: F4/80-, CD68+, macrosialin+. is_a: CL:0000871 ! splenic macrophage relationship: has_part PR:000002064 relationship: part_of UBERON:0001959 ! white pulp of spleen [Term] id: CL:0000877 name: splenic tingible body macrophage namespace: cell def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." [] is_a: CL:0000876 ! splenic white pulp macrophage relationship: capable_of GO:0043277 relationship: has_part PR:000010329 relationship: part_of UBERON:0001249 ! spleen lymphoid follicle [Term] id: CL:0000878 name: central nervous system macrophage namespace: cell def: "A tissue-resident macrophage found in the central nervous system." [] synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000879 name: meningeal macrophage namespace: cell def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors." [] is_a: CL:0000878 ! central nervous system macrophage is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: capable_of GO:0005044 intersection_of: part_of UBERON:0002360 ! meninx relationship: capable_of GO:0005044 relationship: part_of UBERON:0002360 ! meninx [Term] id: CL:0000880 name: choroid-plexus macrophage namespace: cell def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." [] is_a: CL:0000878 ! central nervous system macrophage relationship: capable_of GO:0005044 [Term] id: CL:0000881 name: perivascular macrophage namespace: cell def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [] comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. is_a: CL:0000878 ! central nervous system macrophage relationship: has_part PR:000001483 relationship: has_part PR:000001889 relationship: has_part PR:000001925 relationship: part_of UBERON:0001981 ! blood vessel [Term] id: CL:0000882 name: thymic medullary macrophage namespace: cell def: "A thymic macrophage found in the thymic medulla." [] is_a: CL:0000866 ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0002124 ! medulla of thymus [Term] id: CL:0000883 name: thymic cortical macrophage namespace: cell def: "A thymic macrophage found in the thymic cortex." [] is_a: CL:0000866 ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: part_of UBERON:0002123 ! cortex of thymus relationship: part_of UBERON:0002123 ! cortex of thymus [Term] id: CL:0000884 name: mucosa-associated lymphoid tissue macrophage namespace: cell def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [] is_a: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: CL:0000885 name: gut-associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [] is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: capable_of GO:0002387 intersection_of: part_of UBERON:0001962 ! gut-associated lymphoid tissue relationship: capable_of GO:0002387 relationship: part_of UBERON:0001962 ! gut-associated lymphoid tissue [Term] id: CL:0000886 name: nasal and broncial associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [] is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: capable_of GO:0002395 intersection_of: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue relationship: capable_of GO:0002395 relationship: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue [Term] id: CL:0000887 name: lymph node subcapsular sinus macrophage namespace: cell def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." [] is_a: CL:0000868 ! lymph node macrophage relationship: capable_of GO:0032816 [Term] id: CL:0000888 name: lymph node tingible body macrophage namespace: cell def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." [] is_a: CL:0000868 ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: capable_of GO:0002905 intersection_of: capable_of GO:0043277 intersection_of: part_of UBERON:0002006 ! cortex of lymph node relationship: capable_of GO:0002905 relationship: capable_of GO:0043277 relationship: part_of UBERON:0002006 ! cortex of lymph node [Term] id: CL:0000889 name: myeloid suppressor cell namespace: cell def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [] comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis. is_a: CL:0000766 ! myeloid leukocyte relationship: capable_of GO:0050777 ! negative regulation of immune response relationship: has_part PR:000001006 relationship: has_part PR:000001012 [Term] id: CL:0000890 name: alternatively activated macrophage namespace: cell def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [] comment: Role or process: tissue remodeling. synonym: "M2 macrophage" RELATED [] is_a: CL:0000861 ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: capable_of GO:0048771 intersection_of: has_part PR:000001844 relationship: capable_of GO:0048771 relationship: has_part PR:000001844 [Term] id: CL:0000891 name: foam cell namespace: cell def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [] xref: BTO:0003872 xref: FMA:83586 is_a: CL:0000003 ! native cell [Term] id: CL:0000892 name: smooth muscle cell derived foam cell namespace: cell def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [] is_a: CL:0000891 ! foam cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000192 ! smooth muscle cell [Term] id: CL:0000893 name: thymocyte namespace: cell def: "An immature T cell located in the thymus." [] synonym: "immature T cell" BROAD [] synonym: "immature T lymphocyte" BROAD [] synonym: "immature T-cell" BROAD [] synonym: "immature T-lymphocyte" BROAD [] synonym: "thymic lymphocyte" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 xref: FMA:72202 xref: XAO:0003159 is_a: CL:0002420 ! immature T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: XAO:0003155 {gci_relation="part_of", gci_filler="NCBITaxon:8353"} ! lymphocyte (Xenopus) relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000894 name: DN1 thymic pro-T cell namespace: cell def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [] synonym: "DN1 thymic pro-T lymphocyte" EXACT [] synonym: "DN1 thymic pro-T-cell" EXACT [] synonym: "DN1 thymic pro-T-lymphocyte" EXACT [] synonym: "DN1 thymic progenitor T cell" EXACT [] synonym: "DN1 thymocyte" EXACT [] synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] is_a: CL:0000827 ! pro-T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0002425 ! early T lineage precursor relationship: has_part PR:000001307 relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000895 name: naive thymus-derived CD4-positive, alpha-beta T cell namespace: cell def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [] comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells. synonym: "naive CD4+ T cell" BROAD [] synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.4Nve.Sp" EXACT [] synonym: "Th0" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0002436 ! mature CD4 single-positive thymocyte [Term] id: CL:0000896 name: activated CD4-positive, alpha-beta T cell namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [] synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell relationship: has_part PR:000001343 relationship: has_part PR:000001380 [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell namespace: cell def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [] synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T4.Mem.Sp" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001307 relationship: has_part PR:000001381 [Term] id: CL:0000898 name: naive T cell namespace: cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [] synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] synonym: "naive T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell relationship: has_part PR:000001015 relationship: has_part PR:000001203 relationship: has_part PR:000001307 relationship: has_part PR:000001318 relationship: has_part PR:000001869 [Term] id: CL:0000899 name: T-helper 17 cell namespace: cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells. synonym: "helper T cell type 17" EXACT [] synonym: "IL-17-producing CD4+ T helper" EXACT [] synonym: "T helper cells type 17" EXACT [] synonym: "T(H)-17 cell" EXACT [] synonym: "Th17 CD4+ T cell" EXACT [] synonym: "Th17 cell" EXACT [] synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell relationship: capable_of GO:0032620 relationship: has_part PR:000001202 relationship: has_part PR:000003455 [Term] id: CL:0000900 name: naive thymus-derived CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [] comment: This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells. synonym: "naive CD8+ T cell" BROAD [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.8Nve.Sp" NARROW [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0002437 ! mature CD8 single-positive thymocyte [Term] id: CL:0000901 name: Tr1 cell namespace: cell def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [] comment: These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.) synonym: "T-regulatory T cell type 1" EXACT [] synonym: "Tr1 T cell" EXACT [] synonym: "Tr1 T lymphocyte" EXACT [] synonym: "Tr1 T-cell" EXACT [] synonym: "Tr1 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: capable_of GO:0032613 intersection_of: capable_of GO:0050777 ! negative regulation of immune response relationship: capable_of GO:0032613 [Term] id: CL:0000902 name: induced T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [] synonym: "adaptive Treg" RELATED [] synonym: "aTreg" RELATED [] synonym: "induced regulatory T cell" EXACT [] synonym: "induced regulatory T lymphocyte" EXACT [] synonym: "induced regulatory T-cell" EXACT [] synonym: "induced regulatory T-lymphocyte" EXACT [] synonym: "induced Treg" EXACT [] synonym: "iTreg" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001350 relationship: has_part PR:000001852 [Term] id: CL:0000903 name: natural T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [] synonym: "natural regulatory T cell" EXACT [] synonym: "natural regulatory T lymphocyte" EXACT [] synonym: "natural regulatory T-cell" EXACT [] synonym: "natural regulatory T-lymphocyte" EXACT [] synonym: "natural Treg" EXACT [] synonym: "nTreg" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000001318 relationship: has_part PR:000001350 relationship: has_part PR:000001852 [Term] id: CL:0000904 name: central memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells. synonym: "central CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD4+ T cell" BROAD [] synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell relationship: has_part PR:000001203 [Term] id: CL:0000905 name: effector memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells. synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD4+ T cell" BROAD [] synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [] synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell relationship: has_part PR:000001343 relationship: has_part PR:000001380 [Term] id: CL:0000907 name: central memory CD8-positive, alpha-beta T cell namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells. synonym: "central CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD8+ T cell" BROAD [] synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell relationship: has_part PR:000001203 [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001343 relationship: has_part PR:000001380 [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [] synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T.8Mem.Sp" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001307 relationship: has_part PR:000001381 [Term] id: CL:0000910 name: cytotoxic T cell namespace: cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [] synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] synonym: "cytotoxic T-lymphocyte" EXACT [] xref: BTO:0000289 xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: capable_of GO:0001913 relationship: capable_of GO:0001913 [Term] id: CL:0000911 name: effector T cell namespace: cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [] synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] synonym: "effector T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell [Term] id: CL:0000912 name: helper T cell namespace: cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [] synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] xref: BTO:0002417 is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: capable_of GO:0001816 relationship: capable_of GO:0001816 [Term] id: CL:0000913 name: effector memory CD8-positive, alpha-beta T cell namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells. synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD8+ T cell" BROAD [] synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell [Term] id: CL:0000914 name: immature NK T cell namespace: cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [] synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] synonym: "immature NK T-lymphocyte" EXACT [] synonym: "immature NKT cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_part PR:000003469 relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000003469 [Term] id: CL:0000915 name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell namespace: cell def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte relationship: has_part PR:000001084 [Term] id: CL:0000916 name: dendritic epidermal T cell namespace: cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [] comment: In mice, DETC have an invariant T cell receptor. synonym: "dendritic epidermal T lymphocyte" EXACT [] synonym: "dendritic epidermal T-cell" EXACT [] synonym: "dendritic epidermal T-lymphocyte" EXACT [] synonym: "DETC" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell relationship: capable_of GO:0060054 ! positive regulation of epithelial cell proliferation involved in wound healing relationship: develops_from CL:0002401 ! mature dendritic epithelial T cell precursor [Term] id: CL:0000917 name: Tc1 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells. synonym: "T-cytotoxic T cell type 1" EXACT [] synonym: "Tc1 CD8+ T cell" EXACT [] synonym: "Tc1 T cell" EXACT [] synonym: "Tc1 T lymphocyte" EXACT [] synonym: "Tc1 T-cell" EXACT [] synonym: "Tc1 T-lymphocyte" EXACT [] xref: BTO:0004793 xref: BTO:0004888 xref: FMA:84793 is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell relationship: capable_of GO:0032609 relationship: has_part PR:000001207 relationship: has_part PR:000001835 relationship: has_part PR:000003463 [Term] id: CL:0000918 name: Tc2 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell. synonym: "T-cytotoxic T cell type 2" EXACT [] synonym: "Tc2 T cell" EXACT [] synonym: "Tc2 T lymphocyte" EXACT [] synonym: "Tc2 T-cell" EXACT [] synonym: "Tc2 T-lymphocyte" EXACT [] xref: BTO:0004794 xref: FMA:84794 is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell relationship: capable_of GO:0032633 relationship: has_part PR:000001941 [Term] id: CL:0000919 name: CD8-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [] synonym: "CD8+CD25+ T cell" EXACT [] synonym: "CD8+CD25+ T lymphocyte" EXACT [] synonym: "CD8+CD25+ T(reg)" EXACT [] synonym: "CD8+CD25+ T-cell" EXACT [] synonym: "CD8+CD25+ T-lymphocyte" EXACT [] synonym: "CD8+CD25+ Treg" EXACT [] synonym: "CD8-positive, CD25-positive Treg" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001350 relationship: has_part PR:000001380 [Term] id: CL:0000920 name: CD8-positive, CD28-negative, alpha-beta regulatory T cell namespace: cell def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [] synonym: "CD8+CD28- T cell" EXACT [] synonym: "CD8+CD28- T lymphocyte" EXACT [] synonym: "CD8+CD28- T(reg)" EXACT [] synonym: "CD8+CD28- T-cell" EXACT [] synonym: "CD8+CD28- T-lymphocyte" EXACT [] synonym: "CD8+CD28- Treg" EXACT [] synonym: "CD8-positive, CD28-negative T(reg)" EXACT [] synonym: "CD8-positive, CD28-negative Treg" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001350 [Term] id: CL:0000921 name: type I NK T cell namespace: cell def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [] comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24. synonym: "classical NK T cell" EXACT [] synonym: "invariant NK T cell" RELATED [] synonym: "type I NK T lymphocyte" EXACT [] synonym: "type I NK T-cell" EXACT [] synonym: "type I NK T-lymphocyte" EXACT [] synonym: "type I NKT cell" EXACT [] is_a: CL:0000814 ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: capable_of GO:0043208 relationship: capable_of GO:0043208 [Term] id: CL:0000922 name: type II NK T cell namespace: cell def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [] synonym: "type II NK T lymphocyte" EXACT [] synonym: "type II NK T-cell" EXACT [] synonym: "type II NK T-lymphocyte" EXACT [] synonym: "type II NKT cell" EXACT [] is_a: CL:0000814 ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: capable_of GO:0002288 relationship: capable_of GO:0002288 [Term] id: CL:0000923 name: CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-positive." [] synonym: "CD4-positive type I NK T lymphocyte" EXACT [] synonym: "CD4-positive type I NK T-cell" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "CD4-positive type I NKT cell" EXACT [] synonym: "NKT.4+.SP" NARROW [] is_a: CL:0000921 ! type I NK T cell relationship: has_part PR:000001004 [Term] id: CL:0000924 name: CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT [] synonym: "NKT.4-.Sp" NARROW [] is_a: CL:0000921 ! type I NK T cell [Term] id: CL:0000925 name: activated CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [] synonym: "activated CD4-positive type I NK T lymphocyte" EXACT [] synonym: "activated CD4-positive type I NK T-cell" EXACT [] synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-positive type I NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell relationship: capable_of GO:0032609 relationship: capable_of GO:0032633 relationship: develops_from CL:0000923 ! CD4-positive type I NK T cell relationship: has_part PR:000001343 [Term] id: CL:0000926 name: CD4-positive type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [] synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell relationship: capable_of GO:0002827 relationship: capable_of GO:0032609 relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell [Term] id: CL:0000927 name: CD4-positive type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [] synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell relationship: capable_of GO:0002830 relationship: capable_of GO:0032616 relationship: capable_of GO:0032633 relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell [Term] id: CL:0000928 name: activated CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [] synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: capable_of GO:0002369 relationship: develops_from CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: has_part PR:000001343 [Term] id: CL:0000929 name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: capable_of GO:0002827 relationship: capable_of GO:0032609 relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000930 name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: capable_of GO:0002830 relationship: capable_of GO:0032633 relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000931 name: activated type II NK T cell namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "activated type II NK T lymphocyte" EXACT [] synonym: "activated type II NK T-cell" EXACT [] synonym: "activated type II NK T-lymphocyte" EXACT [] synonym: "activated type II NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 ! type II NK T cell relationship: capable_of GO:0002369 relationship: has_part PR:000001343 [Term] id: CL:0000932 name: type II NK T cell secreting interferon-gamma namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "type II NK T cell secreting IFN-gamma" EXACT [] synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NK T-cell secreting interferon-gamma" EXACT [] synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 ! type II NK T cell relationship: capable_of GO:0032609 relationship: develops_from CL:0000931 ! activated type II NK T cell relationship: has_part PR:000001343 [Term] id: CL:0000933 name: type II NK T cell secreting interleukin-4 namespace: cell def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "type II NK T cell secreting IL-4" EXACT [] synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NK T-cell secreting interleukin-4" EXACT [] synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 ! type II NK T cell relationship: capable_of GO:0032633 relationship: develops_from CL:0000931 ! activated type II NK T cell relationship: has_part PR:000001343 [Term] id: CL:0000934 name: CD4-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [] synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000935 name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell [Term] id: CL:0000936 name: early lymphoid progenitor namespace: cell def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [] comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. synonym: "ELP" EXACT [] synonym: "GMLP" RELATED [] synonym: "LMPP" EXACT [] synonym: "lymphoid-primed multipotent progenitor" EXACT [] is_a: CL:0000837 ! hematopoietic multipotent progenitor cell is_a: CL:0011115 ! precursor cell relationship: capable_of GO:0030098 ! lymphocyte differentiation relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: has_part PR:000002001 relationship: has_part PR:000002065 relationship: has_part PR:000002979 [Term] id: CL:0000937 name: pre-natural killer cell namespace: cell def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [] comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. synonym: "pre-NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell relationship: has_part PR:000001003 relationship: has_part PR:000001381 relationship: has_part PR:000002065 [Term] id: CL:0000938 name: CD16-negative, CD56-bright natural killer cell namespace: cell def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types. synonym: "CD16-CD56bright NK cell" EXACT [] synonym: "CD16-negative, CD56-bright NK cell" EXACT [] synonym: "CD56-bright cytokine secreting natural killer cell" EXACT [] synonym: "CD56-bright cytokine secreting NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell relationship: has_part PR:000001024 relationship: has_part PR:000001319 [Term] id: CL:0000939 name: CD16-positive, CD56-dim natural killer cell namespace: cell def: "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types. synonym: "CD16+CD56+ NK cell" EXACT [] synonym: "CD16-positive, CD56-dim NK cell" EXACT [] synonym: "CD16-positive, CD56-low natural killer cell" EXACT [] synonym: "CD16-positive, CD56-low NK cell" EXACT [] synonym: "CD16-positive, CD56-positive natural killer cell" EXACT [] synonym: "CD16-positive, CD56-positive NK cell" EXACT [] synonym: "cytotoxic CD56-dim natural killer cell" EXACT [] synonym: "cytotoxic CD56-dim NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell relationship: capable_of GO:0042267 relationship: has_part PR:000001024 relationship: has_part PR:000001483 [Term] id: CL:0000940 name: mucosal invariant T cell namespace: cell def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [] synonym: "mucosal invariant T lymphocyte" EXACT [] synonym: "mucosal invariant T-cell" EXACT [] synonym: "mucosal invariant T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell relationship: capable_of GO:0002227 relationship: capable_of GO:0032394 [Term] id: CL:0000941 name: thymic conventional dendritic cell namespace: cell def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [] comment: In the mouse this cell expresses CD8-alpha-alpha. is_a: CL:0000990 ! conventional dendritic cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000942 name: thymic plasmacytoid dendritic cell namespace: cell def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [] is_a: CL:0000784 ! plasmacytoid dendritic cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_part PR:000001015 relationship: has_part PR:000001865 [Term] id: CL:0000943 name: Be1 Cell namespace: cell def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [] comment: Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 1 cell" EXACT [] synonym: "B effector cell type 1" RELATED [] is_a: CL:0000968 ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: capable_of GO:0032609 intersection_of: capable_of GO:0032623 intersection_of: capable_of GO:0032640 intersection_of: capable_of GO:0045627 relationship: capable_of GO:0032609 relationship: capable_of GO:0032623 relationship: capable_of GO:0032640 relationship: capable_of GO:0045627 [Term] id: CL:0000944 name: Be2 cell namespace: cell def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [] comment: Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 2 cell" EXACT [] synonym: "B effector cell type 2" RELATED [] is_a: CL:0000968 ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: capable_of GO:0032613 intersection_of: capable_of GO:0032623 intersection_of: capable_of GO:0032633 intersection_of: capable_of GO:0032635 intersection_of: capable_of GO:0045630 relationship: capable_of GO:0032613 relationship: capable_of GO:0032623 relationship: capable_of GO:0032633 relationship: capable_of GO:0032635 relationship: capable_of GO:0045630 [Term] id: CL:0000945 name: lymphocyte of B lineage namespace: cell def: "A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex." [] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). is_a: CL:0000542 ! lymphocyte relationship: develops_from CL:0000826 ! pro-B cell relationship: has_part PR:000001002 [Term] id: CL:0000946 name: antibody secreting cell namespace: cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [] is_a: CL:0000945 ! lymphocyte of B lineage [Term] id: CL:0000947 name: IgE plasma cell namespace: cell def: "A long lived plasma cell that secretes IgE." [] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000948 name: IgE memory B cell namespace: cell def: "A class switched memory B cell that expresses IgE on the cell surface." [] synonym: "IgE memory B lymphocyte" EXACT [] synonym: "IgE memory B-cell" EXACT [] synonym: "IgE memory B-lymphocyte" EXACT [] synonym: "memory IgE B cell" EXACT [] synonym: "memory IgE B lymphocyte" EXACT [] synonym: "memory IgE B-cell" EXACT [] synonym: "memory IgE B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell relationship: has_part GO:0071742 [Term] id: CL:0000949 name: IgD plasmablast namespace: cell def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000950 name: IgE plasmablast namespace: cell def: "A plasmablast that secretes IgE." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000951 name: IgE short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgE." [] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000952 name: preBCR-positive large pre-B-II cell namespace: cell def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [] is_a: CL:0000957 ! large pre-B-II cell relationship: has_part GO:0035369 relationship: has_part PR:000001858 relationship: has_part PR:000001859 [Term] id: CL:0000953 name: preBCR-negative large pre-B-II cell namespace: cell def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [] is_a: CL:0000957 ! large pre-B-II cell [Term] id: CL:0000954 name: small pre-B-II cell namespace: cell def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [] comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "small pre-BII cell" EXACT [] is_a: CL:0000955 ! pre-B-II cell relationship: has_part PR:000003457 relationship: has_part PR:000003460 [Term] id: CL:0000955 name: pre-B-II cell namespace: cell def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [] comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive. synonym: "pre-B-lymphocyte" EXACT [] synonym: "pre-BII cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000817 ! precursor B cell [Term] id: CL:0000956 name: pre-B-I cell namespace: cell def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [] comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive. synonym: "pre-BI cell" EXACT [] synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [] is_a: CL:0000817 ! precursor B cell relationship: has_part PR:000001003 relationship: has_part PR:000001858 relationship: has_part PR:000001859 relationship: has_part PR:000003457 relationship: has_part PR:000003460 relationship: has_part PR:000006611 [Term] id: CL:0000957 name: large pre-B-II cell namespace: cell def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [] comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "large pre-B cell" BROAD [] synonym: "large pre-BII cell" EXACT [] is_a: CL:0000955 ! pre-B-II cell [Term] id: CL:0000958 name: T1 B cell namespace: cell def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [] comment: T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T1 B lymphocyte" EXACT [] synonym: "T1 B-cell" EXACT [] synonym: "T1 B-lymphocyte" EXACT [] synonym: "transitional stage 1 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell relationship: has_part PR:000002037 [Term] id: CL:0000959 name: T2 B cell namespace: cell def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [] comment: T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T2 B lymphocyte" EXACT [] synonym: "T2 B-cell" EXACT [] synonym: "T2 B-lymphocyte" EXACT [] synonym: "transitional stage 2 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell relationship: develops_from CL:0000958 ! T1 B cell relationship: has_part GO:0071738 relationship: has_part PR:000001338 relationship: has_part PR:000001880 relationship: has_part PR:000002037 [Term] id: CL:0000960 name: T3 B cell namespace: cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [] synonym: "An1 B cell" EXACT [] synonym: "T3 B lymphocyte" EXACT [] synonym: "T3 B-cell" EXACT [] synonym: "T3 B-lymphocyte" EXACT [] synonym: "transitional stage 3 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell relationship: develops_from CL:0000959 ! T2 B cell relationship: has_part GO:0071738 relationship: has_part PR:000001318 relationship: has_part PR:000001338 relationship: has_part PR:000001880 [Term] id: CL:0000961 name: Bm1 B cell namespace: cell def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [] comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm1 B lymphocyte" EXACT [] synonym: "Bm1 B-cell" EXACT [] synonym: "Bm1 B-lymphocyte" EXACT [] is_a: CL:0000843 ! follicular B cell is_a: CL:0002056 ! Fraction F mature B cell [Term] id: CL:0000962 name: Bm2 B cell namespace: cell def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [] comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2 B lymphocyte" EXACT [] synonym: "Bm2 B-cell" EXACT [] synonym: "Bm2 B-lymphocyte" EXACT [] is_a: CL:0000843 ! follicular B cell relationship: develops_from CL:0000961 ! Bm1 B cell relationship: has_part PR:000001408 relationship: has_part PR:000001880 [Term] id: CL:0000963 name: Bm3-delta B cell namespace: cell def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [] synonym: "Bm3-delta B lymphocyte" EXACT [] synonym: "Bm3-delta B-cell" EXACT [] synonym: "Bm3-delta B-lymphocyte" EXACT [] is_a: CL:0000844 ! germinal center B cell relationship: develops_from CL:0000965 ! Bm3 B cell relationship: has_part GO:0071738 relationship: has_part PR:000001408 [Term] id: CL:0000964 name: Bm2' B cell namespace: cell def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [] comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2' B lymphocyte" EXACT [] synonym: "Bm2' B-cell" EXACT [] synonym: "Bm2-prime B cell" EXACT [] synonym: "Bm2-prime B-lymphocyte" EXACT [] synonym: "germinal center founder cell" RELATED [] is_a: CL:0000844 ! germinal center B cell relationship: capable_of GO:0002634 relationship: develops_from CL:0000962 ! Bm2 B cell relationship: has_part GO:0071738 relationship: has_part PR:000001408 [Term] id: CL:0000965 name: Bm3 B cell namespace: cell def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [] comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive. synonym: "Bm3 B lymphocyte" EXACT [] synonym: "Bm3 B-cell" EXACT [] synonym: "Bm3 B-lymphocyte" EXACT [] synonym: "centroblast" RELATED [] is_a: CL:0000844 ! germinal center B cell relationship: capable_of GO:0016446 relationship: develops_from CL:0000964 ! Bm2' B cell relationship: has_part PR:000001408 relationship: has_part PR:000003516 [Term] id: CL:0000966 name: Bm4 B cell namespace: cell def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [] comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive. synonym: "Bm4 B lymphocyte" EXACT [] synonym: "Bm4 B-cell" EXACT [] synonym: "Bm4 B-lymphocyte" EXACT [] synonym: "centrocyte" RELATED [] is_a: CL:0000844 ! germinal center B cell relationship: develops_from CL:0000963 ! Bm3-delta B cell relationship: has_part PR:000001408 [Term] id: CL:0000967 name: Bm5 B cell namespace: cell def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [] comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative. synonym: "Bm5 B lymphocyte" EXACT [] synonym: "Bm5 B-cell" EXACT [] synonym: "Bm5 B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell relationship: develops_from CL:0000966 ! Bm4 B cell [Term] id: CL:0000968 name: Be cell namespace: cell def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [] synonym: "B effector cell" EXACT [] synonym: "effector B cell" EXACT [] synonym: "effector B lymphocyte" EXACT [] synonym: "effector B-cell" EXACT [] synonym: "effector B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell relationship: capable_of GO:0001816 relationship: capable_of GO:0043370 relationship: has_part PR:000001289 [Term] id: CL:0000969 name: regulatory B cell namespace: cell def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [] comment: Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive. synonym: "B(reg)" EXACT [] synonym: "B10 cell" EXACT [] synonym: "Breg" EXACT [] synonym: "regulatory B lymphocyte" EXACT [] synonym: "regulatory B-cell" EXACT [] synonym: "regulatory B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell relationship: capable_of GO:0032613 relationship: capable_of GO:0050777 ! negative regulation of immune response relationship: has_part PR:000001289 relationship: has_part PR:000002028 [Term] id: CL:0000970 name: unswitched memory B cell namespace: cell def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "IgD+ memory B cell" BROAD [] synonym: "unswitched memory B lymphocyte" EXACT [] synonym: "unswitched memory B-cell" EXACT [] synonym: "unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000787 ! memory B cell relationship: develops_from CL:0000980 ! plasmablast relationship: has_part GO:0071738 relationship: has_part GO:0071753 [Term] id: CL:0000971 name: IgM memory B cell namespace: cell def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [] comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive. synonym: "IgM memory B lymphocyte" EXACT [] synonym: "IgM memory B-cell" EXACT [] synonym: "IgM memory B-lymphocyte" EXACT [] synonym: "memory IgM B cell" EXACT [] synonym: "memory IgM B lymphocyte" EXACT [] synonym: "memory IgM B-cell" EXACT [] synonym: "memory IgM B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell relationship: has_part GO:0071753 [Term] id: CL:0000972 name: class switched memory B cell namespace: cell def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." [] comment: Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive. synonym: "class switched memory B lymphocyte" EXACT [] synonym: "class switched memory B-cell" EXACT [] synonym: "class switched memory B-lymphocyte" EXACT [] is_a: CL:0000787 ! memory B cell relationship: develops_from CL:0000970 ! unswitched memory B cell [Term] id: CL:0000973 name: IgA memory B cell namespace: cell def: "A class switched memory B cell that expresses IgA." [] comment: IgA memory B cell are also reportedly RORalpha-positive. synonym: "IgA memory B lymphocyte" EXACT [] synonym: "IgA memory B-cell" EXACT [] synonym: "IgA memory B-lymphocyte" EXACT [] synonym: "memory IgA B cell" EXACT [] synonym: "memory IgA B lymphocyte" EXACT [] synonym: "memory IgA B-cell" EXACT [] synonym: "memory IgA B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell relationship: has_part GO:0071745 [Term] id: CL:0000974 name: long lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [] is_a: CL:0000786 ! plasma cell relationship: develops_from CL:0000975 ! short lived plasma cell relationship: has_part PR:000001208 [Term] id: CL:0000975 name: short lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for months." [] is_a: CL:0000786 ! plasma cell [Term] id: CL:0000976 name: IgA short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000977 name: IgG short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgG." [] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000978 name: IgM short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgM." [] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000979 name: IgG memory B cell namespace: cell def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [] synonym: "IgG memory B lymphocyte" EXACT [] synonym: "IgG memory B-cell" EXACT [] synonym: "IgG memory B-lymphocyte" EXACT [] synonym: "memory IgG B cell" EXACT [] synonym: "memory IgG B lymphocyte" EXACT [] synonym: "memory IgG B-cell" EXACT [] synonym: "memory IgG B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell relationship: has_part GO:0071735 [Term] id: CL:0000980 name: plasmablast namespace: cell def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative. xref: FMA:84371 is_a: CL:0000785 ! mature B cell is_a: CL:0000946 ! antibody secreting cell relationship: develops_from CL:0000785 ! mature B cell relationship: has_part PR:000001408 relationship: has_part PR:000001963 [Term] id: CL:0000981 name: double negative memory B cell namespace: cell def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [] synonym: "dn memory B cell" EXACT [] synonym: "dn memory B lymphocyte" EXACT [] synonym: "dn memory B-cell" EXACT [] synonym: "dn memory B-lymphocyte" EXACT [] synonym: "double negative memory B lymphocyte" EXACT [] synonym: "double negative memory B-cell" EXACT [] synonym: "double negative memory B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell [Term] id: CL:0000982 name: IgG plasmablast namespace: cell def: "A plasmablast that secretes IgG." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000983 name: IgM plasmablast namespace: cell def: "A plasmablast that secretes IgM." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000984 name: IgA plasmablast namespace: cell def: "A plasmablast that secretes IgA." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000985 name: IgG plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgG." [] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000986 name: IgM plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgM." [] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000987 name: IgA plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgA." [] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000988 name: hematopoietic cell namespace: cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] synonym: "haematopoietic cell" EXACT [] synonym: "haematopoietic cell" RELATED [] synonym: "haemopoietic cell" EXACT [] synonym: "haemopoietic cell" RELATED [] synonym: "hemopoietic cell" EXACT [] synonym: "hemopoietic cell" RELATED [] xref: BTO:0000574 xref: CALOHA:TS-2017 xref: FMA:70366 xref: FMA:83598 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000989 name: CD11c-low plasmacytoid dendritic cell namespace: cell def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8). is_a: CL:0000784 ! plasmacytoid dendritic cell relationship: has_part PR:000001013 relationship: has_part PR:000001014 relationship: has_part PR:000002978 [Term] id: CL:0000990 name: conventional dendritic cell namespace: cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. synonym: "cDC" EXACT [] synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "type 1 DC" EXACT [] synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 ! dendritic cell relationship: has_part PR:000001013 [Term] id: CL:0000991 name: CD11c-negative plasmacytoid dendritic cell namespace: cell def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10). synonym: "CD303-positive dendritic cell" EXACT [] is_a: CL:0000784 ! plasmacytoid dendritic cell relationship: has_part PR:000001014 relationship: has_part PR:000001292 relationship: has_part PR:000001398 relationship: has_part PR:000001865 [Term] id: CL:0000992 name: immature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_part PR:000001412 relationship: has_part PR:000001438 [Term] id: CL:0000993 name: mature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell relationship: has_part PR:000001310 relationship: has_part PR:000001412 relationship: has_part PR:000001438 [Term] id: CL:0000994 name: immature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617). is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell relationship: develops_from CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor relationship: has_part PR:000001412 [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD [] is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0000996 name: mature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617). is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell relationship: develops_from CL:0000994 ! immature CD11c-negative plasmacytoid dendritic cell relationship: has_part PR:000001310 relationship: has_part PR:000001412 relationship: has_part PR:000001438 [Term] id: CL:0000997 name: immature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000999 ! CD4-positive CD11b-positive dendritic cell [Term] id: CL:0000998 name: CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617). synonym: "DC.8-4-11b-" EXACT [] synonym: "triple negative dendritic cell" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0002474 relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_part PR:000001026 [Term] id: CL:0000999 name: CD4-positive CD11b-positive dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative." [] comment: Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617). synonym: "DC.4+" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002465 ! CD11b-positive dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0050728 ! negative regulation of inflammatory response relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_part PR:000001004 [Term] id: CL:0001000 name: CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive." [] comment: Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617). synonym: "DC.8+" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0042590 relationship: capable_of GO:0050729 ! positive regulation of inflammatory response relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_part PR:000001026 relationship: has_part PR:000001084 [Term] id: CL:0001001 name: immature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell [Term] id: CL:0001002 name: mature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell relationship: develops_from CL:0001001 ! immature CD8_alpha-negative CD11b-negative dendritic cell [Term] id: CL:0001003 name: mature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000999 ! CD4-positive CD11b-positive dendritic cell relationship: develops_from CL:0000997 ! immature CD8_alpha-negative CD11b-positive dendritic cell [Term] id: CL:0001004 name: immature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell [Term] id: CL:0001005 name: mature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell relationship: develops_from CL:0001004 ! immature CD8_alpha-positive CD11b-negative dendritic cell [Term] id: CL:0001006 name: dermal dendritic cell namespace: cell def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9). xref: BTO:0004812 is_a: CL:0002465 ! CD11b-positive dendritic cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: has_part PR:000001026 relationship: has_part PR:000001084 relationship: part_of UBERON:0002067 ! dermis [Term] id: CL:0001007 name: interstitial dendritic cell namespace: cell def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10). is_a: CL:0002465 ! CD11b-positive dendritic cell relationship: has_part PR:000001300 relationship: has_part PR:000001905 relationship: has_part PR:000002025 relationship: has_part PR:000002972 [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [] comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). synonym: "LSK stem cell" EXACT [] synonym: "Sca1-positive hematopoietic stem cell" EXACT [] is_a: CL:0000037 ! hematopoietic stem cell relationship: has_part PR:000001833 relationship: has_part PR:000002065 relationship: has_part PR:000002979 [Term] id: CL:0001009 name: immature dermal dendritic cell namespace: cell def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001006 ! dermal dendritic cell [Term] id: CL:0001010 name: mature dermal dendritic cell namespace: cell def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001006 ! dermal dendritic cell is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from CL:0001009 ! immature dermal dendritic cell [Term] id: CL:0001011 name: immature interstitial dendritic cell namespace: cell def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001007 ! interstitial dendritic cell [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001013 name: mature interstitial dendritic cell namespace: cell def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001007 ! interstitial dendritic cell relationship: develops_from CL:0001011 ! immature interstitial dendritic cell [Term] id: CL:0001014 name: CD1a-positive Langerhans cell namespace: cell def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." [] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15. synonym: "CD1a-LC" EXACT [] is_a: CL:0000453 ! Langerhans cell relationship: has_part PR:000001447 relationship: has_part PR:000002025 [Term] id: CL:0001015 name: CD8_alpha-low Langerhans cell namespace: cell def: "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9). is_a: CL:0000453 ! Langerhans cell relationship: has_part PR:000001026 relationship: has_part PR:000001084 [Term] id: CL:0001016 name: immature CD1a-positive Langerhans cell namespace: cell def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001014 ! CD1a-positive Langerhans cell [Term] id: CL:0001017 name: mature CD1a-positive Langerhans cell namespace: cell def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15. is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001014 ! CD1a-positive Langerhans cell relationship: develops_from CL:0001016 ! immature CD1a-positive Langerhans cell [Term] id: CL:0001018 name: immature CD8_alpha-low Langerhans cell namespace: cell def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001015 ! CD8_alpha-low Langerhans cell [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001020 name: mature CD8_alpha-low Langerhans cell namespace: cell def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001015 ! CD8_alpha-low Langerhans cell relationship: develops_from CL:0001018 ! immature CD8_alpha-low Langerhans cell [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor namespace: cell def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [] comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). synonym: "CD10-positive common lymphocyte precursor" EXACT [] synonym: "CD10-positive common lymphocyte progenitor" EXACT [] synonym: "CD10-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: has_part PR:000001003 relationship: has_part PR:000001015 relationship: has_part PR:000001408 relationship: has_part PR:000001898 [Term] id: CL:0001022 name: CD115-positive monocyte namespace: cell def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). is_a: CL:0000576 ! monocyte is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor relationship: has_part PR:000001012 relationship: has_part PR:000002062 [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor namespace: cell def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [] comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). synonym: "CD117-positive common myeloid precursor" BROAD [] is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: has_part GO:0033001 relationship: has_part PR:000001481 relationship: has_part PR:000002065 [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell namespace: cell def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [] comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). synonym: "CD133-positive hematopoietic stem cell" EXACT [] xref: CALOHA:TS-0448 xref: FMA:86475 is_a: CL:0000037 ! hematopoietic stem cell relationship: has_part PR:000001003 relationship: has_part PR:000001786 relationship: has_part PR:000001809 relationship: has_part PR:000001843 [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor namespace: cell def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [] comment: Markers are associated with mouse cells. synonym: "CD217-positive common lymphocyte precursor" EXACT [] synonym: "CD217-positive common lymphocyte progenitor" EXACT [] synonym: "CD217-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor relationship: develops_from CL:0000936 ! early lymphoid progenitor relationship: has_part PR:000001869 relationship: has_part PR:000001963 relationship: has_part PR:000002001 relationship: has_part PR:000002037 relationship: has_part PR:000002065 relationship: has_part PR:000002979 [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor namespace: cell def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [] comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: has_part PR:000001408 relationship: has_part PR:000001865 [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell namespace: cell def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). synonym: "CD7-negative lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor relationship: develops_from CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor relationship: has_part PR:000001003 [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell namespace: cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). synonym: "CD7-positive lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor relationship: develops_from CL:0001027 ! CD7-negative lymphoid progenitor cell relationship: has_part PR:000001003 relationship: has_part PR:000001836 [Term] id: CL:0001029 name: common dendritic progenitor namespace: cell def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [] comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). synonym: "CDP" EXACT [] synonym: "common dendritic precursor" EXACT [] synonym: "pro-DCs" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor relationship: has_part PR:000002001 relationship: has_part PR:000002062 relationship: has_part PR:000002065 [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001031 name: cerebellar granule cell namespace: cell def: "Granule cell that is part of the cerebellum." [] xref: BTO:0004278 is_a: CL:0000120 ! granule cell is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0002037 ! cerebellum [Term] id: CL:0001032 name: cortical granule cell namespace: cell def: "Granule cell that is part of the cerebral cortex." [] is_a: CL:0000120 ! granule cell is_a: CL:0002609 ! neuron of cerebral cortex intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:0001033 name: hippocampal granule cell namespace: cell def: "Granule cell that is part of the hippocampus." [] is_a: CL:0001032 ! cortical granule cell is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0001954 ! Ammon's horn [Term] id: CL:0001034 name: cell in vitro namespace: cell def: "A cell that is maintained or propagated in a controlled artificial environment for use in an investigation." [] comment: 'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells. is_a: CL:0000000 ! cell created_by: haendel creation_date: 2012-01-12T09:58:38Z [Term] id: CL:0001035 name: bone cell namespace: cell def: "A connective tissue cell found in bone." [] is_a: CL:0000548 ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0001474 ! bone element created_by: adiehl creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001039 name: terminally differentiated osteoblast namespace: cl def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." [] xref: VSAO:0000116 is_a: CL:0000062 ! osteoblast [Term] id: CL:0001040 name: non-terminally differentiated osteoblast namespace: cl def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 xref: VSAO:0000117 is_a: CL:0000062 ! osteoblast is_a: CL:0001035 ! bone cell relationship: part_of UBERON:0002481 ! bone tissue [Term] id: CL:0001041 name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." [] comment: These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction. synonym: "CD8+CXCR3+ T cell" EXACT [] synonym: "CD8+CXCR3+ T lymphocyte" EXACT [] synonym: "CD8+CXCR3+ T(reg)" EXACT [] synonym: "CD8+CXCR3+ T-cell" EXACT [] synonym: "CD8+CXCR3+ Treg" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT [] synonym: "CD8-positive, CXCR3-positive, Treg" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: capable_of GO:0032613 intersection_of: capable_of GO:0032689 intersection_of: capable_of GO:0042130 intersection_of: has_part PR:000001207 relationship: capable_of GO:0032613 relationship: capable_of GO:0032689 relationship: capable_of GO:0042130 relationship: has_part PR:000001207 [Term] id: CL:0001042 name: T-helper 22 cell namespace: cell def: "CD4-positive, alpha-beta T cell that produces IL-22." [] comment: TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13. synonym: "helper T cell type 22" EXACT [] synonym: "T(H)-22 cell" EXACT [] synonym: "Th22 cell" EXACT [] synonym: "Th22 T cell" EXACT [] synonym: "Th22 T lymphocyte" EXACT [] synonym: "Th22 T-cell" EXACT [] synonym: "Th22 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: capable_of GO:0032626 relationship: capable_of GO:0032626 [Term] id: CL:0001043 name: activated CD4-positive, alpha-beta T cell, human namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CD4+ T cell" BROAD [] synonym: "activated CD4-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001408 relationship: has_part PR:000002015 [Term] id: CL:0001044 name: effector CD4-positive, alpha-beta T cell namespace: cell def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. synonym: "effector CD4+ T cell" BROAD [] synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell relationship: has_part PR:000001015 [Term] id: CL:0001045 name: naive CCR4-positive regulatory T cell namespace: cell def: "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "naive CCR4+ Treg" EXACT [] synonym: "naive CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "naive CCR4-positive regulatory T-cell" EXACT [] synonym: "naive CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002677 ! naive regulatory T cell [Term] id: CL:0001046 name: memory CCR4-positive regulatory T cell namespace: cell def: "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "memory CCR4+ Treg" EXACT [] synonym: "memory CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "memory CCR4-positive regulatory T-cell" EXACT [] synonym: "memory CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002678 ! memory regulatory T cell [Term] id: CL:0001047 name: CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "CCR+ Treg" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell relationship: has_part PR:000001200 [Term] id: CL:0001048 name: activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human namespace: cell def: "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CCR4+ Treg" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell relationship: has_part PR:000002015 [Term] id: CL:0001049 name: activated CD8-positive, alpha-beta T cell, human namespace: cell def: "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CD8+ T cell" BROAD [] synonym: "activated CD8-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001408 relationship: has_part PR:000002015 [Term] id: CL:0001050 name: effector CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. synonym: "effector CD8+ T cell" BROAD [] synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell relationship: has_part PR:000001015 [Term] id: CL:0001051 name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells. synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Th1/Th17 CD4+ T cell" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell [Term] id: CL:0001052 name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'. Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells. synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell [Term] id: CL:0001053 name: IgD-negative memory B cell namespace: cell def: "A memory B cell that lacks expression of surface IgD." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive. synonym: "IgD- memory B cell" EXACT [] is_a: CL:0000787 ! memory B cell [Term] id: CL:0001054 name: CD14-positive monocyte namespace: cell def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. synonym: "monocyte" NARROW [] is_a: CL:0000576 ! monocyte relationship: has_part PR:000001889 [Term] id: CL:0001055 name: CD14-positive, CD16-low monocyte namespace: cell def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." [] comment: Definition is valid for human intermediate monocytes. synonym: "intermediate monocyte, human" EXACT [] is_a: CL:0002393 ! intermediate monocyte is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte [Term] id: CL:0001056 name: dendritic cell, human namespace: cell def: "A dendritic cell with the phenotype HLA-DRA-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells. synonym: "dendritic cell" BROAD [] is_a: CL:0000451 ! dendritic cell relationship: has_part PR:000002015 [Term] id: CL:0001057 name: myeloid dendritic cell, human namespace: cell def: "A myeloid dendritic cell with the phenotype HLA-DRA-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells. synonym: "myeloid dendritic cell" BROAD [] is_a: CL:0000782 ! myeloid dendritic cell is_a: CL:0001056 ! dendritic cell, human [Term] id: CL:0001058 name: plasmacytoid dendritic cell, human namespace: cell def: "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells. synonym: "plasmacytoid dendritic cell" BROAD [] is_a: CL:0000784 ! plasmacytoid dendritic cell is_a: CL:0001056 ! dendritic cell, human relationship: has_part PR:000001865 [Term] id: CL:0001059 name: common myeloid progenitor, CD34-positive namespace: cell def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [] comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-GEMM" RELATED [] synonym: "CFU-S" RELATED [] synonym: "CMP" BROAD [] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [] synonym: "common myeloid precursor, CD34-positive" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [] synonym: "myeloid stem cell" RELATED [] synonym: "pluripotent stem cell (bone marrow)" RELATED [] is_a: CL:0000049 ! common myeloid progenitor is_a: CL:0011115 ! precursor cell relationship: capable_of GO:0043011 relationship: has_part PR:000001003 relationship: has_part PR:000001944 relationship: has_part PR:000005307 relationship: has_part PR:000007857 relationship: has_part PR:000007858 [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative namespace: cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0001061 name: abnormal cell namespace: cell def: "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." [] comment: https://github.com/obophenotype/cell-ontology/issues/448 xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913 is_a: CL:0000000 ! cell relationship: dc-creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T18:53:32Z xsd:dateTime [Term] id: CL:0001062 name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated namespace: cell def: "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." [] comment: This cell type is seen human but not found in the mouse. synonym: "TEMRA" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0000913 ! effector memory CD8-positive, alpha-beta T cell relationship: has_part PR:000001015 [Term] id: CL:0001063 name: neoplastic cell namespace: cell def: "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." [] comment: https://github.com/obophenotype/cell-ontology/issues/448 synonym: "tumor cell" RELATED [] synonym: "tumour cell" RELATED [] xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922 is_a: CL:0001061 ! abnormal cell relationship: dc-creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T19:16:26Z xsd:dateTime [Term] id: CL:0001064 name: malignant cell namespace: cell def: "A neoplastic cell that is capable of entering a surrounding tissue" [] comment: https://github.com/obophenotype/cell-ontology/issues/448 synonym: "cancer cell" RELATED [] xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917 is_a: CL:0001063 ! neoplastic cell relationship: dc-creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T19:39:12Z xsd:dateTime [Term] id: CL:0001065 name: innate lymphoid cell namespace: cell def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [] is_a: CL:0000542 ! lymphocyte relationship: capable_of GO:0001816 relationship: capable_of GO:0045087 relationship: dc-creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:20:48Z xsd:dateTime [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian namespace: cell def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell relationship: capable_of GO:0030218 relationship: has_part PR:000001945 [Term] id: CL:0001067 name: group 1 innate lymphoid cell namespace: cell def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: capable_of GO:0032609 relationship: capable_of GO:0032609 relationship: dc-creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:42:44Z xsd:dateTime [Term] id: CL:0001068 name: ILC1 namespace: cell def: "A group 1 innate lymphoid cell that is non-cytotoxic." [] is_a: CL:0001067 ! group 1 innate lymphoid cell relationship: dc-creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:54:12Z xsd:dateTime [Term] id: CL:0001069 name: group 2 innate lymphoid cell namespace: cell def: "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." [] synonym: "ILC2" EXACT [] synonym: "nuocyte" EXACT [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: capable_of GO:0032634 relationship: capable_of GO:0032634 relationship: dc-creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T21:20:08Z xsd:dateTime [Term] id: CL:0001070 name: beige adipocyte namespace: cell def: "A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." [] synonym: "beige brown adipocyte" EXACT [] synonym: "beige fat cell" EXACT [] synonym: "beige/brite adipocyte" EXACT [] synonym: "brite adipocyte" EXACT [] synonym: "brite cell" EXACT [] synonym: "brite fat cell" EXACT [] is_a: CL:0000136 ! fat cell relationship: part_of UBERON:0001347 ! white adipose tissue [Term] id: CL:0001071 name: group 3 innate lymphoid cell namespace: cell def: "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." [] synonym: "ILC3" EXACT [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: has_part PR:000003455 relationship: dc-creator http://orcid.org/0000-0001-9990-8331 relationship: has_part PR:000003455 property_value: http://purl.org/dc/elements/1.1/date 2017-01-31T20:21:26Z xsd:dateTime [Term] id: CL:0001658 name: visual pigment cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004230 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia) is_a: FBbt:00100318 {gci_relation="part_of", gci_filler="NCBITaxon:7227"} ! somatic cell (Drosophila) [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell namespace: cell def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [] comment: Markers found on mouse cells. synonym: "c- Kit-positive erythroid progenitor cell" EXACT [] is_a: CL:0001066 ! erythroid progenitor cell, mammalian relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: has_part PR:000001345 relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-04-26T10:14:16Z [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 ! granulocyte monocyte progenitor cell relationship: develops_from CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: has_part PR:000001003 relationship: has_part PR:000001408 created_by: tmeehan creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [] comment: Markers are found on mouse cells. is_a: CL:0000557 ! granulocyte monocyte progenitor cell relationship: develops_from CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor relationship: has_part GO:0033001 relationship: has_part PR:000001003 relationship: has_part PR:000001479 relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-01-13T03:19:28Z [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell namespace: cell def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [] comment: Cell markers associated with human cells. xref: FMA:83517 is_a: CL:0001066 ! erythroid progenitor cell, mammalian relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell relationship: has_part PR:000001003 created_by: tmeehan creation_date: 2010-04-26T10:14:30Z [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast namespace: cell def: "A proerythoblast that is CD34-negative and GlyA-negative." [] comment: Cell surface markers are associated with human cells. is_a: CL:0000547 ! proerythroblast relationship: develops_from CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell created_by: tmeehan creation_date: 2010-04-26T10:31:50Z [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell namespace: cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [] comment: Markers are associated with human cell type. is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: has_part PR:000001003 relationship: has_part PR:000001408 created_by: tmeehan creation_date: 2010-01-13T03:43:10Z [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell namespace: cell def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [] comment: Markers are associated with mouse cells. is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: has_part GO:0033001 relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-01-13T03:43:12Z [Term] id: CL:0002007 name: Kit-low, CD34-positive eosinophil progenitor cell namespace: cell def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." [] comment: Markers are found on mouse cells. is_a: CL:0000611 ! eosinophil progenitor cell relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor created_by: tmeehan creation_date: 2010-01-14T03:25:15Z [Term] id: CL:0002008 name: CD34-positive, CD38-positive eosinophil progenitor cell namespace: cell def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." [] comment: Markers are associated with human cells. is_a: CL:0000611 ! eosinophil progenitor cell relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor relationship: has_part PR:000001015 created_by: tmeehan creation_date: 2010-01-14T03:25:17Z [Term] id: CL:0002009 name: macrophage dendritic cell progenitor namespace: cell def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [] synonym: "MDP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011115 ! precursor cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030224 intersection_of: capable_of GO:0043011 relationship: capable_of GO:0030224 relationship: capable_of GO:0043011 relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell created_by: tmeehan creation_date: 2010-01-19T02:51:58Z [Term] id: CL:0002010 name: pre-conventional dendritic cell namespace: cell def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_part PR:000001013 relationship: has_part PR:000001968 relationship: has_part PR:000002001 created_by: tmeehan creation_date: 2010-01-19T03:39:30Z [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor namespace: cell def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [] comment: Markers are associated with mouse cells. synonym: "murine MDP" EXACT [] is_a: CL:0002009 ! macrophage dendritic cell progenitor relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor relationship: has_part PR:000001206 relationship: has_part PR:000002001 relationship: has_part PR:000002062 relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-01-26T02:43:40Z [Term] id: CL:0002012 name: Kit-low proerythroblast namespace: cell def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [] comment: Markers are associated with mouse cells. is_a: CL:0000547 ! proerythroblast relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell relationship: has_part PR:000002065 relationship: has_part PR:000002981 created_by: tmeehan creation_date: 2010-04-26T10:31:56Z [Term] id: CL:0002013 name: GlyA-positive basophillic erythroblast namespace: cell def: "A basophilic erythroblast that is GlyA-positive." [] comment: Markers are associated with human cells. is_a: CL:0000549 ! basophilic erythroblast relationship: develops_from CL:0002004 ! CD34-negative, GlyA-negative proerythroblast relationship: has_part PR:000001460 created_by: tmeehan creation_date: 2010-04-26T10:41:15Z [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast namespace: cell def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [] comment: Cell surface markers are associated with mouse cells. is_a: CL:0000549 ! basophilic erythroblast relationship: develops_from CL:0002012 ! Kit-low proerythroblast relationship: has_part PR:000002981 created_by: tmeehan creation_date: 2010-04-26T10:41:22Z [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast namespace: cell def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [] synonym: "late basophilic and polychromatophilic erythroblast" BROAD [] is_a: CL:0000550 ! polychromatophilic erythroblast relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast relationship: has_part PR:000002981 created_by: tmeehan creation_date: 2010-04-26T10:53:11Z [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast namespace: cell def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [] comment: Cell surface markers are associated with human cells. is_a: CL:0000550 ! polychromatophilic erythroblast relationship: develops_from CL:0002013 ! GlyA-positive basophillic erythroblast relationship: has_part PR:000001460 created_by: tmeehan creation_date: 2010-04-26T10:53:16Z [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts namespace: cell def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [] comment: Cell surface markers associated with mouse cells. is_a: CL:0000552 ! orthochromatic erythroblast relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast relationship: has_part PR:000001945 relationship: has_part PR:000002981 created_by: tmeehan creation_date: 2010-04-26T11:04:15Z [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast namespace: cell def: "An erythroblast that is GlyA-positive and CD71-negative." [] comment: Markers associated with human cells. is_a: CL:0000552 ! orthochromatic erythroblast relationship: develops_from CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast relationship: has_part PR:000001460 created_by: tmeehan creation_date: 2010-04-26T11:04:21Z [Term] id: CL:0002019 name: Ly-76 high reticulocyte namespace: cell def: "A reticulocyte that is Ly76-high and is Kit-negative." [] comment: Marker associated with mouse cells. is_a: CL:0002422 ! enucleated reticulocyte relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts relationship: has_part PR:000002981 created_by: tmeehan creation_date: 2010-04-26T11:37:00Z [Term] id: CL:0002020 name: GlyA-positive reticulocytes namespace: cell def: "A reticulocyte that is GlyA-positive." [] comment: Markers is associated with human cells. is_a: CL:0002422 ! enucleated reticulocyte relationship: develops_from CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast relationship: has_part PR:000001460 created_by: tmeehan creation_date: 2010-04-26T11:48:25Z [Term] id: CL:0002021 name: GlyA-positive erythrocyte namespace: cell def: "An enucleate erythrocyte that is GlyA-positive." [] comment: Marker is associated with human cell types. is_a: CL:0000595 ! enucleate erythrocyte relationship: develops_from CL:0002020 ! GlyA-positive reticulocytes relationship: has_part PR:000001460 created_by: tmeehan creation_date: 2010-04-26T11:51:22Z [Term] id: CL:0002022 name: Ly-76 high positive erythrocyte namespace: cell def: "An enucleate erythrocyte that is Lyg-76-high." [] comment: Marker is associated with mouse cell types. is_a: CL:0000595 ! enucleate erythrocyte relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte relationship: has_part PR:000002981 created_by: tmeehan creation_date: 2010-04-26T11:51:27Z [Term] id: CL:0002023 name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell namespace: cell def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." [] comment: Markers are associated with human cell type. is_a: CL:0000553 ! megakaryocyte progenitor cell relationship: develops_from CL:0002025 ! CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell relationship: has_part PR:000001003 relationship: has_part PR:000001907 relationship: has_part PR:000009127 created_by: tmeehan creation_date: 2010-04-26T02:39:09Z [Term] id: CL:0002024 name: Kit-positive megakaryocyte progenitor cell namespace: cell def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [] comment: Markers are associated with mouse cells. is_a: CL:0000553 ! megakaryocyte progenitor cell relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: has_part PR:000001479 relationship: has_part PR:000001483 relationship: has_part PR:000002065 relationship: has_part PR:000005178 created_by: tmeehan creation_date: 2010-04-26T02:39:15Z [Term] id: CL:0002025 name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." [] comment: Markers are commonly associated with human cells. is_a: CL:0000553 ! megakaryocyte progenitor cell relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell relationship: has_part PR:000001003 relationship: has_part PR:000009127 created_by: tmeehan creation_date: 2010-04-26T03:52:47Z [Term] id: CL:0002026 name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [] comment: Markers are commonly associated with human cells. is_a: CL:0000556 ! megakaryocyte relationship: develops_from CL:0002023 ! CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell relationship: has_part PR:000001907 relationship: has_part PR:000009127 created_by: tmeehan creation_date: 2010-04-26T03:59:22Z [Term] id: CL:0002027 name: CD9-positive, CD41-positive megakaryocyte cell namespace: cell def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [] comment: Markers are commonly associated with mouse cells. is_a: CL:0000556 ! megakaryocyte relationship: develops_from CL:0002024 ! Kit-positive megakaryocyte progenitor cell relationship: has_part PR:000005178 relationship: has_part PR:000009127 created_by: tmeehan creation_date: 2010-04-27T10:39:07Z [Term] id: CL:0002028 name: basophil mast progenitor cell namespace: cell def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [] comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low. synonym: "BMCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of GO:0030221 relationship: capable_of GO:0060374 relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000001867 relationship: has_part PR:000002065 relationship: has_part PR:000005307 relationship: has_part PR:000007857 relationship: has_part PR:000007858 created_by: tmeehan creation_date: 2010-04-27T12:46:33Z [Term] id: CL:0002029 name: Fc-epsilon RIalpha-low mast cell progenitor namespace: cell def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." [] is_a: CL:0000831 ! mast cell progenitor relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell relationship: has_part PR:000001006 created_by: tmeehan creation_date: 2010-04-27T01:22:19Z [Term] id: CL:0002030 name: Fc-epsilon RIalpha-high basophil progenitor cell namespace: cell def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." [] comment: Markers are associated with mouse cells. is_a: CL:0000613 ! basophil progenitor cell relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell relationship: has_part PR:000001003 created_by: tmeehan creation_date: 2010-04-27T01:22:32Z [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0008001 ! hematopoietic precursor cell relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell namespace: cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [] comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0008001 ! hematopoietic precursor cell relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002033 name: short term hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [] comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. synonym: "ST stem cell" EXACT [] synonym: "ST-HSC" EXACT [] is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell relationship: develops_from CL:0002034 ! long term hematopoietic stem cell relationship: has_part PR:000001003 created_by: tmeehan creation_date: 2010-01-08T09:19:25Z [Term] id: CL:0002034 name: long term hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [] comment: Markers are associated with mouse cells. synonym: "LT stem cell" EXACT [] synonym: "LT-HSC" EXACT [] is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell relationship: has_part PR:000001843 created_by: tmeehan creation_date: 2010-01-08T09:19:28Z [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell namespace: cell def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [] comment: Markers are associated with mouse cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell relationship: develops_from CL:0002036 ! Slamf1-positive multipotent progenitor cell relationship: has_part PR:000002065 relationship: has_part PR:000002979 created_by: tmeehan creation_date: 2010-01-08T11:16:33Z [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell namespace: cell def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [] comment: Markers are associated with mouse cells. synonym: "KSL cell" EXACT [] is_a: CL:0000837 ! hematopoietic multipotent progenitor cell relationship: develops_from CL:0002033 ! short term hematopoietic stem cell relationship: has_part PR:000001833 relationship: has_part PR:000002065 relationship: has_part PR:000002979 created_by: tmeehan creation_date: 2010-01-08T11:16:35Z [Term] id: CL:0002037 name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell namespace: cell def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [] synonym: "memory alpha beta IEL" EXACT [] is_a: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell relationship: has_part PR:000001083 relationship: has_part PR:000001307 relationship: has_part PR:000001839 created_by: tmeehan creation_date: 2009-10-20T02:20:43Z [Term] id: CL:0002038 name: T follicular helper cell namespace: cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [] synonym: "follicular B helper T cell" RELATED [] synonym: "follicular helper T cell" RELATED [] synonym: "follicular helper T-cell" RELATED [] synonym: "follicular T cell" RELATED [] synonym: "follicular T-cell" RELATED [] synonym: "follicular T-helper cell" RELATED [] synonym: "T(FH)" EXACT [] synonym: "Tfh" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell relationship: capable_of GO:0045830 relationship: capable_of GO:0051024 relationship: has_part PR:000001209 relationship: has_part PR:000001860 relationship: has_part PR:000001919 relationship: has_part PR:000003450 created_by: tmeehan creation_date: 2009-10-29T04:01:27Z [Term] id: CL:0002039 name: immature NK T cell stage I namespace: cell def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [] is_a: CL:0000914 ! immature NK T cell relationship: has_part PR:000001004 relationship: has_part PR:000001932 relationship: has_part PR:000025402 created_by: tmeehan creation_date: 2009-10-29T04:09:16Z [Term] id: CL:0002040 name: immature NK T cell stage II namespace: cell def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [] comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. synonym: "NKT.44-NK1.1-.Th" EXACT [] is_a: CL:0000914 ! immature NK T cell relationship: develops_from CL:0002039 ! immature NK T cell stage I relationship: has_part PR:000001932 created_by: tmeehan creation_date: 2009-10-29T04:13:43Z [Term] id: CL:0002041 name: immature NK T cell stage III namespace: cell def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 ! immature NK T cell relationship: develops_from CL:0002040 ! immature NK T cell stage II relationship: has_part PR:000001008 relationship: has_part PR:000001307 relationship: has_part PR:000001932 created_by: tmeehan creation_date: 2009-10-29T04:14:48Z [Term] id: CL:0002042 name: immature NK T cell stage IV namespace: cell def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 ! immature NK T cell relationship: develops_from CL:0002041 ! immature NK T cell stage III relationship: has_part PR:000001008 relationship: has_part PR:000001307 relationship: has_part PR:000001932 created_by: tmeehan creation_date: 2009-10-29T04:17:38Z [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell namespace: cell def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [] comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell relationship: develops_from CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell created_by: tmeehan creation_date: 2010-01-12T11:14:15Z [Term] id: CL:0002044 name: Kit-positive, integrin beta7-high basophil mast progenitor cell namespace: cell def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." [] comment: Markers are associated with mouse cells. is_a: CL:0002028 ! basophil mast progenitor cell relationship: has_part PR:000001479 relationship: has_part PR:000001483 relationship: has_part PR:000009143 created_by: tmeehan creation_date: 2010-04-27T01:22:38Z [Term] id: CL:0002045 name: Fraction A pre-pro B cell namespace: cell def: "A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [] comment: Markers associated with mouse cells. synonym: "fraction A" EXACT [] synonym: "pre pro B cell" RELATED [] is_a: CL:0000826 ! pro-B cell relationship: has_part PR:000001015 relationship: has_part PR:000001879 relationship: has_part PR:000001932 relationship: has_part PR:000002037 relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-04-28T10:50:07Z [Term] id: CL:0002046 name: early pro-B cell namespace: cell def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [] comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000826 ! pro-B cell relationship: has_part GO:0035369 relationship: has_part PR:000001003 relationship: has_part PR:000001288 relationship: has_part PR:000001408 relationship: has_part PR:000001898 created_by: tmeehan creation_date: 2010-04-28T11:19:11Z [Term] id: CL:0002047 name: Fraction B precursor B cell namespace: cell def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [] comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive. synonym: "Fr. B" EXACT [] synonym: "Fraction B" EXACT [] is_a: CL:0002400 ! Fraction B/C precursor B cell relationship: develops_from CL:0002045 ! Fraction A pre-pro B cell relationship: has_part PR:000001014 created_by: tmeehan creation_date: 2010-04-28T11:56:21Z [Term] id: CL:0002048 name: late pro-B cell namespace: cell def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [] comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000817 ! precursor B cell relationship: develops_from CL:0002046 ! early pro-B cell relationship: has_part PR:000001003 relationship: has_part PR:000001288 relationship: has_part PR:000001408 created_by: tmeehan creation_date: 2010-04-28T12:06:06Z [Term] id: CL:0002049 name: Fraction C precursor B cell namespace: cell def: "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [] synonym: "Fraction C" RELATED [] is_a: CL:0002400 ! Fraction B/C precursor B cell relationship: develops_from CL:0002047 ! Fraction B precursor B cell relationship: has_part PR:000001014 relationship: has_part PR:000001858 relationship: has_part PR:000001859 relationship: has_part PR:000002039 relationship: has_part PR:000003457 relationship: has_part PR:000003460 created_by: tmeehan creation_date: 2010-04-28T02:04:01Z [Term] id: CL:0002050 name: Fraction C' precursor B cell namespace: cell def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [] synonym: "Fr. C'" EXACT [] synonym: "Fraction C-prime" EXACT [] is_a: CL:0000817 ! precursor B cell relationship: develops_from CL:0002049 ! Fraction C precursor B cell relationship: has_part GO:0035369 relationship: has_part PR:000001014 relationship: has_part PR:000001380 relationship: has_part PR:000001879 relationship: has_part PR:000001932 relationship: has_part PR:000002039 created_by: tmeehan creation_date: 2010-04-28T02:13:46Z [Term] id: CL:0002051 name: CD38-high pre-BCR positive cell namespace: cell def: "A pre-BCR positive T cell that is CD38-high." [] comment: Markers are associated with human cells. synonym: "large pre-B cell type I" RELATED [] is_a: CL:0000952 ! preBCR-positive large pre-B-II cell relationship: develops_from CL:0002048 ! late pro-B cell relationship: has_part PR:000001288 relationship: has_part PR:000001408 created_by: tmeehan creation_date: 2010-04-28T02:27:47Z [Term] id: CL:0002052 name: Fraction D precursor B cell namespace: cell def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [] comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative. synonym: "Fr. D" EXACT [] synonym: "Fraction D pre-B cell" EXACT [] is_a: CL:0002400 ! Fraction B/C precursor B cell relationship: develops_from CL:0002050 ! Fraction C' precursor B cell relationship: has_part PR:000001014 relationship: has_part PR:000001380 relationship: has_part PR:000002039 created_by: tmeehan creation_date: 2010-04-28T02:55:16Z [Term] id: CL:0002053 name: CD22-positive, CD38-low small pre-B cell namespace: cell def: "A small pre-B cell that is CD22-positive and CD38-low." [] comment: Markers are associated with human cell. RAG expression maybe diminishing. synonym: "small pre-B cell" EXACT [] is_a: CL:0000954 ! small pre-B-II cell relationship: develops_from CL:0002051 ! CD38-high pre-BCR positive cell relationship: has_part PR:000001288 relationship: has_part PR:000001408 created_by: tmeehan creation_date: 2010-04-28T03:04:48Z [Term] id: CL:0002054 name: Fraction E immature B cell namespace: cell def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [] comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative. is_a: CL:0000816 ! immature B cell relationship: develops_from CL:0002052 ! Fraction D precursor B cell relationship: has_part PR:000001879 relationship: has_part PR:000001932 relationship: has_part PR:000002037 created_by: tmeehan creation_date: 2010-04-28T03:13:47Z [Term] id: CL:0002055 name: CD38-negative immature B cell namespace: cell def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." [] comment: Markers are associated with human cell type. is_a: CL:0000816 ! immature B cell relationship: develops_from CL:0002053 ! CD22-positive, CD38-low small pre-B cell relationship: has_part PR:000001288 relationship: has_part PR:000001338 relationship: has_part PR:000001898 created_by: tmeehan creation_date: 2010-04-28T03:19:14Z [Term] id: CL:0002056 name: Fraction F mature B cell namespace: cell def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [] is_a: CL:0000822 ! B-2 B cell relationship: develops_from CL:0002054 ! Fraction E immature B cell relationship: has_part GO:0071738 relationship: has_part GO:0071753 relationship: has_part PR:000001014 relationship: has_part PR:000001338 created_by: tmeehan creation_date: 2010-04-30T03:01:48Z [Term] id: CL:0002057 name: CD14-positive, CD16-negative classical monocyte namespace: cell def: "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes. synonym: "CD16- monocyte" EXACT [] synonym: "CD16-negative monocyte" EXACT [] is_a: CL:0000860 ! classical monocyte is_a: CL:0001054 ! CD14-positive monocyte relationship: has_part PR:000001465 relationship: has_part PR:000001925 created_by: tmeehan creation_date: 2010-06-05T08:25:41Z [Term] id: CL:0002058 name: Gr1-low non-classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative. is_a: CL:0000875 ! non-classical monocyte is_a: CL:0002398 ! Gr1-positive, CD43-positive monocyte relationship: develops_from CL:0002398 ! Gr1-positive, CD43-positive monocyte relationship: has_part PR:000001199 created_by: tmeehan creation_date: 2010-06-05T08:25:44Z [Term] id: CL:0002059 name: CD8alpha-positive thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-positive." [] synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT [] synonym: "DC.8+.Th" EXACT [] is_a: CL:0000941 ! thymic conventional dendritic cell relationship: has_part PR:000001084 created_by: tmeehan creation_date: 2010-06-07T02:48:36Z [Term] id: CL:0002060 name: melanophage namespace: cell def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [] is_a: CL:0000864 ! tissue-resident macrophage is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_part CHEBI:25179 intersection_of: part_of UBERON:0002097 ! skin of body relationship: has_part CHEBI:25179 relationship: part_of UBERON:0002097 ! skin of body created_by: tmeehan creation_date: 2010-06-22T10:46:12Z [Term] id: CL:0002061 name: T-helper 9 cell namespace: cell def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." [] synonym: "T helper cells type 9" EXACT [] synonym: "T(H)-9 cell" EXACT [] synonym: "Th9" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell relationship: capable_of GO:0002215 relationship: capable_of GO:0032638 relationship: has_part PR:000008982 created_by: tmeehan creation_date: 2010-06-22T11:18:44Z [Term] id: CL:0002062 name: type I pneumocyte namespace: cell def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [] synonym: "AT1" EXACT [] synonym: "ATI" EXACT [] synonym: "lung type 1 cells" EXACT [] synonym: "membranous pneumocytes" EXACT [] synonym: "pulmonary alveolar type I cell" EXACT [] synonym: "small alveolar cells" EXACT [] synonym: "squamous alveolar cell" EXACT [] synonym: "squamous alveolar lining cell" EXACT [] synonym: "type 1 alveolar epithelial cells" EXACT [] synonym: "type 1 pneumocyte" EXACT [] synonym: "type I alveolar cells" EXACT [] synonym: "type I alveolar epithelial cells" EXACT [] xref: BTO:0000780 xref: FMA:62500 is_a: CL:0000322 ! pneumocyte intersection_of: CL:0000322 ! pneumocyte intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange relationship: capable_of GO:0007585 ! respiratory gaseous exchange created_by: tmeehan creation_date: 2010-06-23T04:37:54Z [Term] id: CL:0002063 name: type II pneumocyte namespace: cell def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [] synonym: "AT2" EXACT [] synonym: "ATII" EXACT [] synonym: "cuboidal type II cell" EXACT [] synonym: "granular pneumocyte" EXACT [] synonym: "great alveolar cell" EXACT [] synonym: "lung type 2 cell" EXACT [] synonym: "lung type II cell" RELATED [] synonym: "TII" EXACT [] synonym: "type 2 alveolar epithelial cell" EXACT [] synonym: "type 2 alveolocyte" EXACT [] synonym: "type 2 pneumocyte" EXACT [] synonym: "type II alveolar cell" EXACT [] synonym: "type II alveolar epithelial cell" EXACT [] synonym: "type II alveolocyte" EXACT [] xref: BTO:0000538 xref: FMA:62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pneumocyte is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000322 ! pneumocyte intersection_of: capable_of GO:0032940 ! secretion by cell intersection_of: capable_of GO:0043129 created_by: tmeehan creation_date: 2010-06-24T12:04:13Z [Term] id: CL:0002064 name: pancreatic acinar cell namespace: cell def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [] synonym: "acinar cell of pancreas" EXACT [] xref: BTO:0000028 xref: CALOHA:TS-0737 xref: FMA:63032 is_a: CL:0000622 ! acinar cell is_a: CL:1001599 ! pancreas exocrine glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: has_part GO:0042589 relationship: part_of UBERON:0001263 ! pancreatic acinus created_by: tmeehan creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002066 name: Feyrter cell namespace: cell def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [] synonym: "bronchiolar Kulchitsky cell" EXACT [] synonym: "Kultschitzky cell of bronchiole" EXACT [] synonym: "P cell" BROAD [] synonym: "respiratory enterochromaffin cell" EXACT [] xref: FMA:14118 is_a: CL:0000165 ! neuroendocrine cell created_by: tmeehan creation_date: 2010-06-28T08:24:30Z [Term] id: CL:0002067 name: type A enteroendocrine cell namespace: cell def: "An enteroendocrine cell that produces glucagon." [] xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: capable_of GO:0070091 ! glucagon secretion created_by: tmeehan creation_date: 2010-09-10T10:48:54Z [Term] id: CL:0002068 name: Purkinje myocyte namespace: cell def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [] synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: BTO:0001032 xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002069 name: type II vestibular sensory cell namespace: cell def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." [] synonym: "type 2 vestibular hair cell" EXACT [] synonym: "type 2 vestibular sensory cell" EXACT [] synonym: "type II hair cell" EXACT [] xref: FMA:67909 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:13Z [Term] id: CL:0002070 name: type I vestibular sensory cell namespace: cell def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." [] synonym: "type 1 vestibular hair cell" EXACT [] synonym: "type 1 vestibular sensory cell" EXACT [] synonym: "type I hair cell" EXACT [] xref: FMA:62352 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:19Z [Term] id: CL:0002071 name: enterocyte of epithelium of large intestine namespace: cell def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." [] synonym: "columnar cell" BROAD [] synonym: "columnar cell of the colon" EXACT [] synonym: "vacuolar absorptive cell" EXACT [] xref: BTO:0002484 xref: FMA:63638 xref: FMA:66771 is_a: CL:0000584 ! enterocyte is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0001278 ! epithelium of large intestine relationship: part_of UBERON:0001278 ! epithelium of large intestine created_by: tmeehan creation_date: 2010-06-29T11:07:25Z [Term] id: CL:0002072 name: nodal myocyte namespace: cell def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [] synonym: "cardiac pacemaker cell" EXACT [] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] xref: BTO:0004190 xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte namespace: cell def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [] xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell namespace: cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [] xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002075 name: brush cell of trachebronchial tree namespace: cell def: "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known." [] synonym: "pulmonary brush cell" RELATED [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0002204 ! brush cell intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-06-29T03:22:46Z [Term] id: CL:0002076 name: endo-epithelial cell namespace: cell def: "An epithelial cell derived from endoderm." [] xref: FMA:69075 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from CL:0000223 ! endodermal cell created_by: tmeehan creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell namespace: cell def: "An epithelial cell derived from ectoderm." [] xref: FMA:69074 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000221 ! ectodermal cell relationship: develops_from CL:0000221 ! ectodermal cell created_by: tmeehan creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell namespace: cell def: "Epithelial cell derived from mesoderm or mesenchyme." [] synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000222 ! mesodermal cell relationship: develops_from CL:0000222 ! mesodermal cell created_by: tmeehan creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002079 name: pancreatic ductal cell namespace: cell def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [] xref: FMA:63099 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: capable_of GO:0015106 intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct relationship: capable_of GO:0015106 relationship: part_of UBERON:0001064 ! ventral pancreatic duct created_by: tmeehan creation_date: 2010-06-30T08:49:43Z [Term] id: CL:0002080 name: pancreatic centro-acinar cell namespace: cell def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [] synonym: "centroacinar cell of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: capable_of GO:0015106 intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: capable_of GO:0015106 relationship: part_of UBERON:0001263 ! pancreatic acinus created_by: tmeehan creation_date: 2010-06-30T08:49:52Z [Term] id: CL:0002081 name: type II cell of carotid body namespace: cell def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [] synonym: "sheath cell of carotid body" EXACT [] xref: FMA:84187 is_a: CL:0000703 ! sustentacular cell is_a: CL:0002256 ! supporting cell of carotid body created_by: tmeehan creation_date: 2010-06-30T04:23:42Z [Term] id: CL:0002082 name: type II cell of adrenal medulla namespace: cell def: "A chromaffin cell of the adrenal medulla that produces epinephrine." [] synonym: "adremergic chromaffin cell" EXACT [] synonym: "adrenal secreting cell of the adrenal medulla" EXACT [] synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT [] xref: FMA:69322 is_a: CL:0000336 ! adrenal medulla chromaffin cell is_a: CL:0000454 ! epinephrine secreting cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: capable_of GO:0048242 intersection_of: part_of UBERON:0001236 ! adrenal medulla created_by: tmeehan creation_date: 2010-07-14T09:41:42Z [Term] id: CL:0002083 name: type I cell of adrenal medulla namespace: cell def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." [] synonym: "noradrenergic chromaffin cell" EXACT [] xref: FMA:69321 is_a: CL:0000336 ! adrenal medulla chromaffin cell is_a: CL:0000459 ! noradrenergic cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: capable_of GO:0048243 ! norepinephrine secretion intersection_of: part_of UBERON:0001236 ! adrenal medulla created_by: tmeehan creation_date: 2010-07-14T10:12:24Z [Term] id: CL:0002084 name: Boettcher cell namespace: cell def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." [] synonym: "Boettcher's cell" EXACT [] synonym: "Bottcher cell" EXACT [] synonym: "Bottcher's cell" EXACT [] is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-07-14T03:22:02Z [Term] id: CL:0002085 name: tanycyte namespace: cell alt_id: CL:0000643 def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." [] synonym: "stretch cell" EXACT [] xref: BTO:0001953 xref: FMA:54560 is_a: CL:0000683 ! ependymoglial cell created_by: tmeehan creation_date: 2010-07-15T11:21:11Z [Term] id: CL:0002086 name: specialized cardiac myocyte namespace: cell def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [] xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte namespace: cell def: "A leukocyte that lacks granules." [] synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 ! leukocyte created_by: tmeehan creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal namespace: cell def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [] comment: Some argue this cell type is of mesenchymal origin. synonym: "ICC" EXACT [] synonym: "intestinal pacemaker cell" EXACT [] xref: BTO:0003914 xref: FMA:86573 is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: capable_of GO:0043134 relationship: capable_of GO:0043134 created_by: tmeehan creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002089 name: group 2 innate lymphoid cell, mouse namespace: cell def: "A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [] synonym: "nuocyte" BROAD [] is_a: CL:0001069 ! group 2 innate lymphoid cell relationship: capable_of GO:0002830 relationship: capable_of GO:0032616 relationship: has_part PR:000001860 relationship: has_part PR:000001869 relationship: has_part PR:000008982 relationship: has_part PR:000008994 created_by: tmeehan creation_date: 2010-08-12T02:22:19Z [Term] id: CL:0002090 name: polar body namespace: cell def: "One of two small cells formed by the first and second meiotic division of oocytes." [] xref: EHDAA2:0004716 xref: FMA:85543 xref: WBbt:0008429 xref: XAO:0000262 is_a: CL:0000021 ! female germ cell is_a: UBERON:0004120 {gci_relation="part_of", gci_filler="NCBITaxon:8353"} ! mesoderm-derived structure relationship: existence_ends_during_or_before HsapDv:0000007 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! CS03 relationship: existence_ends_during_or_before XAO:1000088 {gci_relation="part_of", gci_filler="NCBITaxon:8353"} ! oocyte stage VI (Xenopus) relationship: existence_starts_during_or_after HsapDv:0000003 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! CS01 relationship: existence_starts_during_or_after XAO:1000083 {gci_relation="part_of", gci_filler="NCBITaxon:8353"} ! oocyte stage I (Xenopus) relationship: part_of XAO:0000256 {gci_relation="part_of", gci_filler="NCBITaxon:8353"} ! oocyte (Xenopus) created_by: tmeehan creation_date: 2010-08-23T09:49:53Z [Term] id: CL:0002091 name: primary polar body namespace: cell def: "A small cell formed by the first meiotic division of oocytes." [] synonym: "first polar body" EXACT [] synonym: "polocytus primarius" EXACT [] xref: EHDAA2:0000541 xref: EMAPA:16032 xref: FMA:18650 xref: VHOG:0000464 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:49:58Z [Term] id: CL:0002092 name: bone marrow cell namespace: cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. xref: BTO:0004850 xref: FMA:83621 is_a: CL:0001035 ! bone cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0001035 ! bone cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002093 name: secondary polar body namespace: cell def: "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." [] synonym: "polocytus secundarius" EXACT [] synonym: "second polar body" EXACT [] xref: EHDAA2:0001820 xref: EMAPA:16034 xref: EMAPA:16045 xref: FMA:18651 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:50:01Z [Term] id: CL:0002094 name: interstitial cell of ovary namespace: cell def: "A cell that makes up the loose connective tissue of the ovary." [] xref: FMA:18709 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:11:34Z [Term] id: CL:0002095 name: hilus cell of ovary namespace: cell def: "A cell in the hilum of the ovary that produces androgens." [] synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002096 name: internodal tract myocyte namespace: cell def: "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." [] xref: FMA:223275 is_a: CL:0002086 ! specialized cardiac myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0009966 ! internodal tract relationship: part_of UBERON:0009966 ! internodal tract created_by: tmeehan creation_date: 2010-08-23T11:24:11Z [Term] id: CL:0002097 name: cortical cell of adrenal gland namespace: cell def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." [] synonym: "adrenal cortex cell" EXACT [] synonym: "adrenocortical cell" EXACT [] xref: FMA:69545 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1001601 ! adrenal gland glandular cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: part_of UBERON:0001235 ! adrenal cortex created_by: tmeehan creation_date: 2010-08-24T01:37:44Z [Term] id: CL:0002098 name: regular cardiac myocyte namespace: cell def: "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." [] synonym: "regular cardiac muscle cell" EXACT [] synonym: "regular cardiac muscle fiber" EXACT [] xref: FMA:67967 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-08-23T11:33:10Z [Term] id: CL:0002099 name: type I cell of adrenal cortex namespace: cell alt_id: CL:1000423 def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." [] synonym: "epithelial cell of zona glomerulosa of adrenal gland" EXACT [] xref: FMA:69273 is_a: CL:0000456 ! mineralocorticoid secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland intersection_of: CL:0002097 ! cortical cell of adrenal gland intersection_of: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland relationship: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:42:02Z [Term] id: CL:0002100 name: regular interventricular cardiac myocyte namespace: cell def: "A regular cardiac myocyte of the interventricular region of the heart." [] xref: FMA:228792 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:40:52Z [Term] id: CL:0002101 name: CD38-positive naive B cell namespace: cell def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [] synonym: "CD38+ naive B cell" EXACT [] synonym: "CD38+ naive B lymphocyte" EXACT [] synonym: "CD38+ naive B-cell" EXACT [] synonym: "CD38+ naive B-lymphocyte" EXACT [] synonym: "CD38-positive naive B lymphocyte" EXACT [] synonym: "CD38-positive naive B-cell" EXACT [] synonym: "CD38-positive naive B-lymphocyte" EXACT [] is_a: CL:0000788 ! naive B cell relationship: has_part PR:000001408 [Term] id: CL:0002102 name: CD38-negative naive B cell namespace: cell def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [] synonym: "CD38- naive B cell" EXACT [] synonym: "CD38- naive B lymphocyte" EXACT [] synonym: "CD38- naive B-cell" EXACT [] synonym: "CD38- naive B-lymphocyte" EXACT [] synonym: "CD38-negative naive B lymphocyte" EXACT [] synonym: "CD38-negative naive B-cell" EXACT [] synonym: "CD38-negative naive B-lymphocyte" EXACT [] is_a: CL:0000788 ! naive B cell [Term] id: CL:0002103 name: IgG-positive double negative memory B cell namespace: cell def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [] synonym: "IgG+ dn memory B cell" EXACT [] synonym: "IgG+ dn memory B lymphocyte" EXACT [] synonym: "IgG+ dn memory B-cell" EXACT [] synonym: "IgG+ dn memory B-lymphocyte" EXACT [] synonym: "IgG+ double negative memory B cell" EXACT [] synonym: "IgG+ double negative memory B lymphocyte" EXACT [] synonym: "IgG+ double negative memory B-cell" EXACT [] synonym: "IgG+ double negative memory B-lymphocyte" EXACT [] synonym: "IgG-positive dn memory B cell" EXACT [] synonym: "IgG-positive dn memory B lymphocyte" EXACT [] synonym: "IgG-positive dn memory B-cell" EXACT [] synonym: "IgG-positive dn memory B-lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B-cell" EXACT [] synonym: "IgG-positive double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 ! double negative memory B cell relationship: has_part GO:0071735 [Term] id: CL:0002104 name: IgG-negative double negative memory B cell namespace: cell def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [] synonym: "IgG- dn memory B cell" EXACT [] synonym: "IgG- dn memory B lymphocyte" EXACT [] synonym: "IgG- dn memory B-cell" EXACT [] synonym: "IgG- dn memory B-lymphocyte" EXACT [] synonym: "IgG- double negative memory B cell" EXACT [] synonym: "IgG- double negative memory B lymphocyte" EXACT [] synonym: "IgG- double negative memory B-cell" EXACT [] synonym: "IgG- double negative memory B-lymphocyte" EXACT [] synonym: "IgG-negative dn memory B cell" EXACT [] synonym: "IgG-negative dn memory B lymphocyte" EXACT [] synonym: "IgG-negative dn memory B-cell" EXACT [] synonym: "IgG-negative dn memory B-lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B-cell" EXACT [] synonym: "IgG-negative double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 ! double negative memory B cell [Term] id: CL:0002105 name: CD38-positive IgG memory B cell namespace: cell def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [] synonym: "CD38+ IgG memory B cell" EXACT [] synonym: "CD38+ IgG memory B lymphocyte" EXACT [] synonym: "CD38+ IgG memory B-cell" EXACT [] synonym: "CD38+ IgG memory B-lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B-cell" EXACT [] synonym: "CD38-positive IgG memory B-lymphocyte" EXACT [] is_a: CL:0000979 ! IgG memory B cell relationship: has_part PR:000001408 [Term] id: CL:0002106 name: IgD-positive CD38-positive IgG memory B cell namespace: cell def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [] is_a: CL:0002105 ! CD38-positive IgG memory B cell relationship: has_part GO:0071738 [Term] id: CL:0002107 name: IgD-negative CD38-positive IgG memory B cell namespace: cell def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [] is_a: CL:0001053 ! IgD-negative memory B cell is_a: CL:0002105 ! CD38-positive IgG memory B cell [Term] id: CL:0002108 name: CD38-negative IgG memory B cell namespace: cell def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [] is_a: CL:0000979 ! IgG memory B cell is_a: CL:0001053 ! IgD-negative memory B cell [Term] id: CL:0002109 name: B220-positive CD38-positive naive B cell namespace: cell def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [] synonym: "B220+CD38+ naive B cell" EXACT [] synonym: "B220+CD38+ naive B lymphocyte" EXACT [] synonym: "B220+CD38+ naive B-cell" EXACT [] synonym: "B220+CD38+ naive B-lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B-cell" EXACT [] synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT [] synonym: "CD38+B220+ naive B cell" EXACT [] synonym: "CD38+B220+ naive B lymphocyte" EXACT [] synonym: "CD38+B220+ naive B-cell" EXACT [] synonym: "CD38+B220+ naive B-lymphocyte" EXACT [] is_a: CL:0002101 ! CD38-positive naive B cell relationship: has_part PR:000001014 [Term] id: CL:0002110 name: B220-low CD38-positive naive B cell namespace: cell def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [] is_a: CL:0002109 ! B220-positive CD38-positive naive B cell [Term] id: CL:0002111 name: CD38-negative unswitched memory B cell namespace: cell def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] synonym: "CD38- unswitched memory B cell" EXACT [] synonym: "CD38- unswitched memory B lymphocyte" EXACT [] synonym: "CD38- unswitched memory B-cell" EXACT [] synonym: "CD38- unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B-cell" EXACT [] synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 ! unswitched memory B cell [Term] id: CL:0002112 name: B220-positive CD38-negative unswitched memory B cell namespace: cell def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002111 ! CD38-negative unswitched memory B cell relationship: has_part PR:000001014 [Term] id: CL:0002113 name: B220-low CD38-negative unswitched memory B cell namespace: cell def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002112 ! B220-positive CD38-negative unswitched memory B cell [Term] id: CL:0002114 name: CD38-positive unswitched memory B cell namespace: cell def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] synonym: "CD38+ unswitched memory B cell" EXACT [] synonym: "CD38+ unswitched memory B lymphocyte" EXACT [] synonym: "CD38+ unswitched memory B-cell" EXACT [] synonym: "CD38+ unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B-cell" EXACT [] synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 ! unswitched memory B cell relationship: has_part PR:000001408 [Term] id: CL:0002115 name: B220-positive CD38-positive unswitched memory B cell namespace: cell def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002114 ! CD38-positive unswitched memory B cell relationship: has_part PR:000001014 [Term] id: CL:0002116 name: B220-low CD38-positive unswitched memory B cell namespace: cell def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002115 ! B220-positive CD38-positive unswitched memory B cell [Term] id: CL:0002117 name: IgG-negative class switched memory B cell namespace: cell def: "A class switched memory B cell that lacks IgG on the cell surface." [] synonym: "IgG- class switched memory B cell" EXACT [] synonym: "IgG- class switched memory B lymphocyte" EXACT [] synonym: "IgG- class switched memory B-cell" EXACT [] synonym: "IgG- class switched memory B-lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B-cell" EXACT [] synonym: "IgG-negative class switched memory B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0002118 name: CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [] is_a: CL:0002117 ! IgG-negative class switched memory B cell [Term] id: CL:0002119 name: CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [] is_a: CL:0002117 ! IgG-negative class switched memory B cell relationship: has_part PR:000001408 [Term] id: CL:0002120 name: CD24-positive CD38-negative IgG-negative class switched memory B cell namespace: cell def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [] is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell relationship: has_part PR:000001932 [Term] id: CL:0002121 name: CD24-negative CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [] is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell [Term] id: CL:0002122 name: B220-positive CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [] is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell relationship: has_part PR:000001014 [Term] id: CL:0002123 name: B220-low CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [] is_a: CL:0002122 ! B220-positive CD38-positive IgG-negative class switched memory B cell [Term] id: CL:0002124 name: CD27-positive gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [] synonym: "gammadelta27-positive" EXACT [] synonym: "gd27-positive" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell relationship: capable_of GO:0032609 relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell relationship: has_part PR:000001963 created_by: tmeehan creation_date: 2010-08-18T09:57:19Z [Term] id: CL:0002125 name: CD27-negative gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." [] synonym: "gammadelta-17 cells" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell relationship: capable_of GO:0032620 relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell relationship: has_part PR:000003455 created_by: tmeehan creation_date: 2010-08-18T09:57:29Z [Term] id: CL:0002126 name: CD25-positive, CD27-positive immature gamma-delta T cell namespace: cell def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [] is_a: CL:0000799 ! immature gamma-delta T cell is_a: CL:0000893 ! thymocyte relationship: has_part PR:000001083 relationship: has_part PR:000001307 relationship: has_part PR:000001318 relationship: has_part PR:000001380 relationship: has_part PR:000001839 relationship: has_part PR:000001919 relationship: has_part PR:000001932 created_by: tmeehan creation_date: 2010-08-18T10:35:37Z [Term] id: CL:0002127 name: innate effector T cell namespace: cell def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [] is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: capable_of GO:0045087 relationship: capable_of GO:0045087 created_by: tmeehan creation_date: 2010-08-20T02:14:25Z [Term] id: CL:0002128 name: Tc17 cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition). synonym: "Tc17 CD8+ T cell" EXACT [] synonym: "Tc17 T cell" EXACT [] synonym: "Tc17 T lymphocyte" EXACT [] synonym: "Tc17 T-cell" EXACT [] synonym: "Tc17 T-lymphocyte" EXACT [] is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell relationship: capable_of GO:0032620 relationship: has_part PR:000001201 relationship: has_part PR:000001202 [Term] id: CL:0002129 name: regular atrial cardiac myocyte namespace: cell def: "Regular cardiac myocyte of a cardiac atrium." [] synonym: "atrial cardiac muscle cell" EXACT [] synonym: "atrial myocyte" EXACT [] synonym: "regular atrial cardiac muscle fiber" EXACT [] synonym: "regular cardiac muscle cell of atrium" EXACT [] xref: FMA:83108 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:03Z [Term] id: CL:0002130 name: regular interatrial cardiac myocyte namespace: cell def: "A cardiac myocyte of the interatrial region of the heart." [] xref: FMA:228790 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:09Z [Term] id: CL:0002131 name: regular ventricular cardiac myocyte namespace: cell def: "Regular cardiac myocyte of a cardiac ventricle." [] synonym: "regular cardiac muscle cell of ventricle" EXACT [] synonym: "regular ventricular cardiac muscle fiber" EXACT [] synonym: "ventricular cardiac muscle cell" BROAD [] synonym: "ventricular myocyte" EXACT [] xref: FMA:83109 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:13Z [Term] id: CL:0002132 name: stromal cell of ovary namespace: cell def: "A stomal cell of the ovary" [] synonym: "ovarian stromal cell" EXACT [] xref: FMA:72299 is_a: CL:0000499 ! stromal cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary created_by: tmeehan creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002133 name: stromal cell of ovarian cortex namespace: cell def: "A stromal cell of the ovarian cortex." [] xref: FMA:256169 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T12:12:15Z [Term] id: CL:0002134 name: stromal cell of ovarian medulla namespace: cell def: "A stromal cell of the ovarian medulla." [] xref: FMA:256171 is_a: CL:0002132 ! stromal cell of ovary intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0013192 ! ovarian medulla relationship: part_of UBERON:0013192 ! ovarian medulla created_by: tmeehan creation_date: 2010-08-23T12:12:17Z [Term] id: CL:0002135 name: nonkeratinized cell of epidermis namespace: cell def: "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." [] xref: FMA:62880 is_a: CL:0000362 ! epidermal cell relationship: part_of UBERON:0001003 ! skin epidermis created_by: tmeehan creation_date: 2010-08-24T08:43:27Z [Term] id: CL:0002136 name: type II cell of adrenal cortex namespace: cell def: "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." [] synonym: "type II cortical cell of adrenal gland" EXACT [] xref: FMA:69547 is_a: CL:0000460 ! glucocorticoid secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:42Z [Term] id: CL:0002137 name: type III cell of adrenal cortex namespace: cell def: "A cell in the zona reticularis that produce sex hormones." [] xref: FMA:69564 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:44Z [Term] id: CL:0002138 name: endothelial cell of lymphatic vessel namespace: cell alt_id: CL:1000421 def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [] synonym: "LEC" EXACT [] synonym: "lymphatic endothelial cell" EXACT [] xref: BTO:0004167 xref: FMA:68458 is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: develops_from CL:0005022 ! vascular lymphangioblast intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: develops_from CL:0005022 ! vascular lymphangioblast relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2010-08-24T02:05:28Z [Term] id: CL:0002139 name: endothelial cell of vascular tree namespace: cell def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] xref: BTO:0001854 xref: CALOHA:TS-1106 xref: FMA:67755 is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002140 name: acinar cell of sebaceous gland namespace: cell alt_id: CL:0002587 def: "A sebum secreting cell of the skin that secretes sebum into the hair follicles." [] synonym: "sebocyte" BROAD [] xref: BTO:0004613 xref: FMA:70953 is_a: CL:0000317 ! sebum secreting cell is_a: CL:0000622 ! acinar cell is_a: CL:1000448 ! epithelial cell of sweat gland intersection_of: CL:0000317 ! sebum secreting cell intersection_of: part_of UBERON:0003487 ! skin sebaceous gland relationship: part_of UBERON:0003487 ! skin sebaceous gland created_by: tmeehan creation_date: 2010-08-24T09:27:52Z [Term] id: CL:0002141 name: active chief cell of parathyroid gland namespace: cell def: "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" [] xref: FMA:69082 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T09:30:15Z [Term] id: CL:0002142 name: dark cell of eccrine sweat gland namespace: cell def: "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." [] xref: FMA:70659 is_a: CL:0000152 ! exocrine cell is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell is_a: CL:1000448 ! epithelial cell of sweat gland relationship: part_of UBERON:0000423 ! eccrine sweat gland created_by: tmeehan creation_date: 2010-08-24T02:15:16Z [Term] id: CL:0002143 name: dark chief cell of parathyroid cell namespace: cell def: "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." [] xref: FMA:69080 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T02:18:36Z [Term] id: CL:0002144 name: capillary endothelial cell namespace: cell def: "An endothelial cell found in capillaries." [] xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001915 ! endothelium of capillary relationship: part_of UBERON:0001915 ! endothelium of capillary created_by: tmeehan creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002145 name: ciliated columnar cell of tracheobronchial tree namespace: cell def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [] xref: FMA:70542 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0005012 ! multi-ciliated epithelial cell relationship: develops_from CL:0002209 ! intermediate epitheliocyte created_by: tmeehan creation_date: 2010-08-24T03:38:29Z [Term] id: CL:0002146 name: clear cell of eccrine sweat gland namespace: cell def: "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." [] xref: FMA:70658 is_a: CL:0000152 ! exocrine cell is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell is_a: CL:1000448 ! epithelial cell of sweat gland relationship: part_of UBERON:0000423 ! eccrine sweat gland created_by: tmeehan creation_date: 2010-08-24T10:33:02Z [Term] id: CL:0002147 name: clear chief cell of parathyroid cell namespace: cell def: "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." [] xref: FMA:69081 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T10:39:42Z [Term] id: CL:0002148 name: dental pulp cell namespace: cell def: "A cell found within the dental pulp." [] xref: BTO:0000339 xref: CALOHA:TS-0195 xref: FMA:87170 is_a: CL:0002159 ! general ecto-epithelial cell is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: part_of UBERON:0001754 ! dental pulp relationship: part_of UBERON:0001754 ! dental pulp created_by: tmeehan creation_date: 2010-08-24T02:52:09Z [Term] id: CL:0002149 name: epithelial cell of uterus namespace: cell alt_id: CL:1000294 def: "An epithelial cell of the uterus." [] xref: FMA:256161 is_a: CL:0002076 ! endo-epithelial cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus created_by: tmeehan creation_date: 2010-08-24T10:45:54Z [Term] id: CL:0002150 name: epithelioid macrophage namespace: cell def: "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." [] synonym: "epithelioid cell" BROAD [] synonym: "epithelioid histocyte" EXACT [] synonym: "epitheloid macrophage" EXACT [] xref: FMA:83514 is_a: CL:0000235 ! macrophage relationship: develops_from CL:0000861 ! elicited macrophage created_by: tmeehan creation_date: 2010-08-24T03:48:30Z [Term] id: CL:0002151 name: late promyelocyte namespace: cell def: "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." [] xref: FMA:83534 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:50Z [Term] id: CL:0002152 name: columnar cell of endocervix namespace: cell def: "A columnar cell of the cervix uteri." [] xref: FMA:86486 is_a: CL:0002149 ! epithelial cell of uterus is_a: CL:0002535 ! epithelial cell of cervix relationship: part_of UBERON:0000458 ! endocervix created_by: tmeehan creation_date: 2010-08-24T10:47:47Z [Term] id: CL:0002153 name: corneocyte namespace: cell def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [] xref: BTO:0001943 xref: FMA:68650 is_a: CL:0000225 ! anucleate cell is_a: CL:0000311 ! keratin accumulating cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000312 ! keratinocyte relationship: part_of UBERON:0002027 ! stratum corneum of epidermis created_by: tmeehan creation_date: 2010-08-24T10:53:03Z [Term] id: CL:0002154 name: early promyelocyte namespace: cell def: "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." [] xref: FMA:83533 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:53Z [Term] id: CL:0002155 name: echinocyte namespace: cell def: "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." [] synonym: "burr cell" EXACT [] xref: FMA:81099 is_a: CL:0000595 ! enucleate erythrocyte created_by: tmeehan creation_date: 2010-08-24T03:15:21Z [Term] id: CL:0002157 name: endosteal cell namespace: cell def: "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." [] xref: FMA:86495 is_a: CL:0001035 ! bone cell is_a: CL:0002078 ! meso-epithelial cell relationship: part_of UBERON:0009859 ! endosteum created_by: tmeehan creation_date: 2010-08-24T03:33:58Z [Term] id: CL:0002158 name: external epithelial cell of tympanic membrane namespace: cell def: "Epithelial cell found on the external side of the tympanic membrane" [] xref: FMA:70558 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-25T10:25:31Z [Term] id: CL:0002159 name: general ecto-epithelial cell namespace: cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [] xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002160 name: basal external epithelial cell of tympanic membrane namespace: cell def: "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." [] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:44Z [Term] id: CL:0002161 name: superficial external epithelial cell of tympanic membrane namespace: cell def: "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." [] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:48Z [Term] id: CL:0002162 name: internal epithelial cell of tympanic membrane namespace: cell def: "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." [] xref: FMA:70626 is_a: CL:0002076 ! endo-epithelial cell is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002364 ! tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:49:46Z [Term] id: CL:0002163 name: internal pillar cell of cochlea namespace: cell def: "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." [] xref: FMA:75722 xref: FMA:75726 is_a: CL:1000191 ! pillar cell created_by: tmeehan creation_date: 2010-08-25T11:05:21Z [Term] id: CL:0002164 name: external pillar cell of cochlea namespace: cell def: "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." [] xref: FMA:75727 is_a: CL:1000191 ! pillar cell created_by: tmeehan creation_date: 2010-08-25T11:05:23Z [Term] id: CL:0002165 name: phalangeal cell namespace: cell def: "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." [] xref: FMA:79800 is_a: CL:0002490 ! organ of Corti supporting cell created_by: tmeehan creation_date: 2010-08-25T01:29:07Z [Term] id: CL:0002166 name: epithelial cell of Malassez namespace: cell def: "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." [] synonym: "epithelial cell rests of Malassez" EXACT [] synonym: "epithelial debris of Malassez" EXACT [] xref: FMA:62987 is_a: CL:0002159 ! general ecto-epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal relationship: part_of UBERON:0011595 ! jaw region created_by: tmeehan creation_date: 2010-08-26T08:51:27Z [Term] id: CL:0002167 name: olfactory epithelial cell namespace: cell def: "A specialized cell involved in sensory perception of smell." [] xref: FMA:67870 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell created_by: tmeehan creation_date: 2010-08-26T01:47:13Z [Term] id: CL:0002168 name: border cell of cochlea namespace: cell def: "A border cell is a slender columnar cell on the medial portion of the basilar membrane." [] xref: FMA:79798 is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-08-25T01:47:12Z [Term] id: CL:0002169 name: basal cell of olfactory epithelium namespace: cell alt_id: CL:1000395 def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [] synonym: "horizontal basal call" BROAD [] xref: FMA:62303 is_a: CL:0002167 ! olfactory epithelial cell is_a: CL:0002319 ! neural cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0002167 ! olfactory epithelial cell intersection_of: part_of UBERON:0001997 ! olfactory epithelium relationship: part_of UBERON:0001997 ! olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:58:54Z [Term] id: CL:0002170 name: keratinized cell of the oral mucosa namespace: cell def: "A keratinized cell located in the hard palate or gingiva." [] is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal is_a: CL:0002336 ! buccal mucosa cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0003729 ! mouth mucosa relationship: part_of UBERON:0003729 ! mouth mucosa created_by: tmeehan creation_date: 2010-08-26T02:51:30Z [Term] id: CL:0002171 name: globose cell of olfactory epithelium namespace: cell def: "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." [] synonym: "blastema cell of olfactory epithelium" EXACT [] xref: FMA:67874 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:18Z [Term] id: CL:0002172 name: interdental cell of cochlea namespace: cell def: "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." [] synonym: "interdental cell" EXACT [] xref: FMA:79797 is_a: CL:0002315 ! supporting cell of cochlea relationship: part_of UBERON:0002276 ! lamina of spiral limbus created_by: tmeehan creation_date: 2010-08-25T02:02:48Z [Term] id: CL:0002173 name: extraglomerular mesangial cell namespace: cell def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [] synonym: "Goormaghtigh cell" EXACT [] synonym: "lacis cell" RELATED [] synonym: "polar cushion cells" EXACT [] xref: FMA:84143 xref: KUPO:0001033 is_a: CL:0000650 ! mesangial cell is_a: CL:1000500 ! kidney interstitial cell is_a: CL:1000618 ! juxtaglomerular complex cell is_a: CL:1000746 ! glomerular cell is_a: CL:1001318 ! renal interstitial pericyte intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0002321 ! extraglomerular mesangium relationship: part_of UBERON:0002321 ! extraglomerular mesangium created_by: tmeehan creation_date: 2010-08-25T02:20:55Z [Term] id: CL:0002174 name: follicular cell of ovary namespace: cell def: "A cell within the follicle of an ovary." [] xref: EMAPA:31247 xref: FMA:70589 is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-08-25T03:01:27Z [Term] id: CL:0002175 name: primary follicular cell of ovary namespace: cell def: "A cell within the primary follicle of the ovary." [] xref: FMA:70590 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:42Z [Term] id: CL:0002176 name: secondary follicular cell of ovary namespace: cell def: "A cell of a secondary follicile within the ovary." [] xref: FMA:70591 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:48Z [Term] id: CL:0002177 name: folliculostellate cell of pars distalis of adenohypophysis namespace: cell def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [] synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT [] xref: FMA:83102 is_a: CL:0000642 ! folliculostellate cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell is_a: CL:2000004 ! pituitary gland cell intersection_of: CL:0000642 ! folliculostellate cell intersection_of: part_of UBERON:0006964 ! pars distalis of adenohypophysis relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-08-25T03:10:10Z [Term] id: CL:0002178 name: epithelial cell of stomach namespace: cell alt_id: CL:1000399 def: "An epithelial cell found in the lining of the stomach." [] xref: FMA:62948 is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-08-25T03:22:08Z [Term] id: CL:0002179 name: foveolar cell of stomach namespace: cell def: "An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop ." [] xref: FMA:86552 is_a: CL:0002178 ! epithelial cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:23:22Z [Term] id: CL:0002180 name: mucous cell of stomach namespace: cell alt_id: CL:1000404 def: "A mucous cell in the epithelium of the stomach." [] xref: FMA:63464 is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002178 ! epithelial cell of stomach intersection_of: part_of UBERON:0001199 ! mucosa of stomach relationship: part_of UBERON:0001199 ! mucosa of stomach created_by: tmeehan creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002181 name: mucus neck cell of gastric gland namespace: cell alt_id: CL:1000401 def: "A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach." [] xref: FMA:62954 is_a: CL:0000152 ! exocrine cell is_a: CL:0000651 ! mucous neck cell is_a: CL:0002180 ! mucous cell of stomach intersection_of: CL:0000651 ! mucous neck cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland created_by: tmeehan creation_date: 2010-08-25T03:41:30Z [Term] id: CL:0002182 name: surface mucosal cell of stomach namespace: cell def: "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [] xref: FMA:62949 is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002180 ! mucous cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:45:10Z [Term] id: CL:0002183 name: stem cell of gastric gland namespace: cell alt_id: CL:1000400 def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [] xref: FMA:62953 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000152 ! exocrine cell is_a: CL:0002180 ! mucous cell of stomach intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland created_by: tmeehan creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002184 name: basal proper cell of olfactory epithelium namespace: cell def: "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." [] synonym: "horizontal basal cells" EXACT [] xref: FMA:62304 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:22Z [Term] id: CL:0002187 name: basal cell of epidermis namespace: cell alt_id: CL:1000439 def: "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." [] xref: FMA:70571 is_a: CL:0000312 ! keratinocyte is_a: CL:0000646 ! basal cell is_a: CL:1000428 ! stem cell of epidermis intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0001003 ! skin epidermis created_by: tmeehan creation_date: 2010-08-26T03:12:49Z [Term] id: CL:0002188 name: glomerular endothelial cell namespace: cell def: "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [] xref: BTO:0004632 xref: FMA:70970 is_a: CL:0000115 ! endothelial cell is_a: CL:0000666 ! fenestrated cell is_a: CL:1000746 ! glomerular cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000074 ! renal glomerulus created_by: tmeehan creation_date: 2010-08-26T10:59:44Z [Term] id: CL:0002189 name: granular cell of epidermis namespace: cell def: "A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules." [] xref: FMA:70543 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T03:19:00Z [Term] id: CL:0002190 name: squamous cell of epidermis namespace: cell def: "A flat keratinocyte immediately below the cornified layer." [] xref: FMA:86925 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T03:37:02Z [Term] id: CL:0002191 name: granulocytopoietic cell namespace: cell def: "A cell involved in the formation of a granulocyte." [] xref: FMA:83519 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0030851 relationship: capable_of GO:0030851 created_by: tmeehan creation_date: 2010-08-30T12:54:27Z [Term] id: CL:0002192 name: metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." [] xref: FMA:83541 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002193 ! myelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:15Z [Term] id: CL:0002193 name: myelocyte namespace: cell def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." [] xref: BTO:0000734 xref: FMA:83525 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:19Z [Term] id: CL:0002194 name: monopoietic cell namespace: cell def: "A cell involved in the formation of a monocyte (monopoiesis)." [] xref: FMA:83552 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0030224 relationship: capable_of GO:0030224 created_by: tmeehan creation_date: 2010-08-30T01:27:48Z [Term] id: CL:0002195 name: hepatic stem cell namespace: cell def: "A stem cell that can give rise to the cells of the liver." [] xref: FMA:86577 is_a: CL:0000048 ! multi fate stem cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002196 name: hepatic oval stem cell namespace: cell alt_id: CL:1000036 def: "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." [] synonym: "hepatic oval cell" EXACT [] xref: BTO:0004270 xref: FMA:86576 is_a: CL:0002195 ! hepatic stem cell created_by: tmeehan creation_date: 2010-08-30T02:01:49Z [Term] id: CL:0002197 name: inactive chief cell of parathyoid gland namespace: cell def: "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." [] is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:14:01Z [Term] id: CL:0002198 name: oncocyte namespace: cell def: "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." [] synonym: "oxyphil" EXACT [] xref: FMA:67606 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T11:26:49Z [Term] id: CL:0002199 name: oxyphil cell of parathyroid gland namespace: cell def: "An oncocyte located in the parathyroid gland." [] xref: FMA:69084 is_a: CL:0002198 ! oncocyte is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:23Z [Term] id: CL:0002200 name: oxyphil cell of thyroid namespace: cell def: "An oncocyte located in the thyroid." [] synonym: "Askanazy cells" EXACT [] synonym: "Hurthle cells" EXACT [] xref: FMA:87169 is_a: CL:0002198 ! oncocyte is_a: CL:0002257 ! epithelial cell of thyroid gland intersection_of: CL:0002198 ! oncocyte intersection_of: part_of UBERON:0002046 ! thyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:26Z [Term] id: CL:0002201 name: renal beta-intercalated cell namespace: cell def: "A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance." [] is_a: CL:0005010 ! renal intercalated cell created_by: tmeehan creation_date: 2010-09-02T01:43:55Z [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree namespace: cell alt_id: CL:1000407 def: "An epithelial cell of the tracheobronchial tree." [] xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:09:14Z [Term] id: CL:0002203 name: Brush cell of epithelium proper of large intestine namespace: cell alt_id: CL:1000387 def: "Brush cell found in the epithelial layer of the colon." [] comment: Brush cells are a distinct cell type from brush border cell-types. xref: FMA:263222 is_a: CL:0002204 ! brush cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2010-09-02T02:20:50Z [Term] id: CL:0002204 name: brush cell namespace: cell def: "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known." [] synonym: "caveolated cell" EXACT [] synonym: "fibrillovesicular cell" EXACT [] synonym: "multivesicular cell" EXACT [] synonym: "tuft cell" EXACT [] xref: FMA:67978 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T02:28:53Z [Term] id: CL:0002205 name: brush cell of lobular bronchiole namespace: cell alt_id: CL:1000386 def: "A brush cell found in the epithelium of lobular bronchiole." [] xref: FMA:263220 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002208 ! brush cell of bronchus intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole relationship: part_of UBERON:0002051 ! epithelium of bronchiole created_by: tmeehan creation_date: 2010-09-02T02:38:34Z [Term] id: CL:0002206 name: brush cell of terminal bronchiole namespace: cell alt_id: CL:1000390 def: "A brush cell of the epithelium in the terminal bronchiole." [] xref: FMA:263228 is_a: CL:0002205 ! brush cell of lobular bronchiole intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium created_by: tmeehan creation_date: 2010-09-02T02:38:36Z [Term] id: CL:0002207 name: brush cell of trachea namespace: cell alt_id: CL:1000388 def: "Brush cell of the epithelium in the trachea." [] xref: FMA:263224 is_a: CL:0000307 ! tracheal epithelial cell is_a: CL:0002075 ! brush cell of trachebronchial tree intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea created_by: tmeehan creation_date: 2010-09-02T02:38:37Z [Term] id: CL:0002208 name: brush cell of bronchus namespace: cell alt_id: CL:1000389 def: "A brush cell found in the epithelium of bronchus." [] xref: FMA:263226 is_a: CL:0002075 ! brush cell of trachebronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0002031 ! epithelium of bronchus created_by: tmeehan creation_date: 2010-09-02T02:38:42Z [Term] id: CL:0002209 name: intermediate epitheliocyte namespace: cell def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [] synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:53:59Z [Term] id: CL:0002210 name: red muscle cell namespace: cell def: "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." [] synonym: "oxidative muscle fiber" EXACT [] synonym: "red muscle fiber" EXACT [] xref: FMA:84448 is_a: CL:0008002 ! skeletal muscle fiber created_by: tmeehan creation_date: 2010-09-02T03:20:03Z [Term] id: CL:0002211 name: type I muscle cell namespace: cell def: "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." [] synonym: "intermediate muscle fiber" RELATED [] synonym: "slow twitch fiber" EXACT [] synonym: "slow twitch muscle cell" EXACT [] synonym: "slow twitch muscle fiber" RELATED [] synonym: "slow-twitch muscle fiber" RELATED [] synonym: "type 1 muscle cell" EXACT [] synonym: "type 1 muscle fiber" EXACT [] synonym: "type I muscle fiber" EXACT [] xref: BTO:0001812 xref: CALOHA:TS-0940 xref: FMA:84413 xref: MESH:A02.633.565.700 is_a: CL:0000189 ! slow muscle cell is_a: CL:0002210 ! red muscle cell created_by: tmeehan creation_date: 2010-09-02T03:24:05Z [Term] id: CL:0002212 name: type II muscle cell namespace: cell def: "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." [] synonym: "type 2 muscle cell" EXACT [] synonym: "type 2 muscle fiber" EXACT [] synonym: "type II muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84414 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:45Z [Term] id: CL:0002213 name: white muscle cell namespace: cell def: "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." [] xref: FMA:84449 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:48Z [Term] id: CL:0002214 name: type IIa muscle cell namespace: cell def: "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." [] synonym: "fast twitch A" EXACT [] synonym: "fatigue resistant fast twitch muscle cell" EXACT [] synonym: "type 2a muscle cell" EXACT [] synonym: "type 2a muscle fiber" EXACT [] synonym: "type IIa muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84415 is_a: CL:0002210 ! red muscle cell is_a: CL:0002212 ! type II muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:38Z [Term] id: CL:0002215 name: type IIb muscle cell namespace: cell def: "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." [] synonym: "type 2b muscle cell" EXACT [] synonym: "type 2b muscle fiber" EXACT [] synonym: "type IIb muscle fiber" EXACT [] xref: FMA:84416 is_a: CL:0002212 ! type II muscle cell is_a: CL:0002213 ! white muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:42Z [Term] id: CL:0002216 name: intermediate muscle cell namespace: cell def: "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." [] xref: FMA:84450 is_a: CL:0008002 ! skeletal muscle fiber created_by: tmeehan creation_date: 2010-09-02T03:51:17Z [Term] id: CL:0002217 name: intermediate trophoblast cell namespace: cell def: "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." [] xref: BTO:0002366 xref: FMA:86564 is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:04:36Z [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "immature DEC precursor" EXACT [] synonym: "immature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T01:58:00Z [Term] id: CL:0002219 name: anchoring trophoblast namespace: cell def: "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." [] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:14:28Z [Term] id: CL:0002220 name: interstitial cell of pineal gland namespace: cell def: "A cell located between the pinealocytes." [] xref: FMA:86575 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-02T04:28:41Z [Term] id: CL:0002221 name: keratinized squamous cell of esophagus namespace: cell def: "A squamous cell that has keratin in the esophagus." [] xref: FMA:86549 is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2010-09-07T10:11:06Z [Term] id: CL:0002222 name: vertebrate lens cell namespace: cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [] xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000965 ! lens of camera-type eye created_by: tmeehan creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002223 name: anterior lens cell namespace: cell def: "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." [] xref: FMA:63181 is_a: CL:0002224 ! lens epithelial cell created_by: tmeehan creation_date: 2010-09-07T10:45:45Z [Term] id: CL:0002224 name: lens epithelial cell namespace: cell def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [] xref: FMA:67559 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: part_of UBERON:0001803 ! epithelium of lens relationship: part_of UBERON:0001803 ! epithelium of lens created_by: tmeehan creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002225 name: secondary lens fiber namespace: cell def: "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [] synonym: "secondary lens fibre" EXACT [] is_a: CL:0011004 ! lens fiber cell is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from CL:0002228 ! primary lens fiber created_by: tmeehan creation_date: 2010-09-07T10:53:39Z [Term] id: CL:0002226 name: non-nucleated secondary lens fiber namespace: cell def: "A secondary lens fiber cell that lacks a nucleus." [] synonym: "non-nucleated secondary lens fibre" EXACT [] xref: FMA:67561 is_a: CL:0002225 ! secondary lens fiber relationship: develops_from CL:0002227 ! nucleated secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:23Z [Term] id: CL:0002227 name: nucleated secondary lens fiber namespace: cell def: "A secondary fiber cell that contains a nucleus." [] synonym: "nucleated secondary lens fibre" EXACT [] xref: FMA:70949 is_a: CL:0002225 ! secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:26Z [Term] id: CL:0002228 name: primary lens fiber namespace: cell def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." [] synonym: "primary lens fibre" EXACT [] xref: FMA:70613 is_a: CL:0011004 ! lens fiber cell is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from CL:0002223 ! anterior lens cell created_by: tmeehan creation_date: 2010-09-07T11:19:01Z [Term] id: CL:0002229 name: light chief cell of parathyroid gland namespace: cell def: "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." [] xref: FMA:69079 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-07T11:46:54Z [Term] id: CL:0002231 name: epithelial cell of prostate namespace: cell alt_id: CL:1000295 alt_id: CL:1000408 def: "An epithelial cell of the prostate." [] synonym: "prostate epithelial cell" EXACT [] xref: FMA:256163 xref: FMA:66817 is_a: CL:0002076 ! endo-epithelial cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-07T01:49:29Z [Term] id: CL:0002232 name: epithelial cell of prostatic duct namespace: cell alt_id: CL:1000462 def: "An epithelial cell of prostatic duct." [] synonym: "ductal epithelial cell of prostate" EXACT [] xref: FMA:74224 is_a: CL:0000072 ! non-branched duct epithelial cell is_a: CL:0002231 ! epithelial cell of prostate intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:55:51Z [Term] id: CL:0002233 name: epithelial cell of prostatic acinus namespace: cell alt_id: CL:1000461 def: "An epithelial cell of the prostatic acinus." [] synonym: "acinar epithelial cell of prostate" EXACT [] xref: FMA:74223 is_a: CL:0002231 ! epithelial cell of prostate intersection_of: CL:0002231 ! epithelial cell of prostate intersection_of: part_of UBERON:0004179 ! prostate glandular acinus relationship: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:55:53Z [Term] id: CL:0002234 name: basal cell of prostatic acinus namespace: cell alt_id: CL:1000464 def: "A cell of the basal layer of the epithelium in the prostatic acinus." [] synonym: "basal epithelial cell of prostatic acinus" EXACT [] xref: FMA:74265 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:59:08Z [Term] id: CL:0002235 name: luminal cell of prostatic acinus namespace: cell def: "A cell of the luminal layer of the epithelium in the prostatic acinus." [] xref: FMA:74266 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002340 ! luminal cell of prostate epithelium intersection_of: CL:0002340 ! luminal cell of prostate epithelium intersection_of: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:59:10Z [Term] id: CL:0002236 name: basal epithelial cell of prostatic duct namespace: cell alt_id: CL:1000463 def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [] xref: FMA:74226 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:59:12Z [Term] id: CL:0002237 name: luminal epithelial cell of prostatic duct namespace: cell def: "A cell that constitutes the luminal layer of epithelium of prostatic duct." [] xref: FMA:74225 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002340 ! luminal cell of prostate epithelium intersection_of: CL:0002340 ! luminal cell of prostate epithelium intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:59:16Z [Term] id: CL:0002238 name: male gonocyte namespace: cell def: "A primordial germ cell that is destined to become a male germ cell." [] synonym: "male primordial germ cell" EXACT [] synonym: "testis primordial germ cell" EXACT [] xref: EHDAA2:0001053 xref: EMAPA:18686 xref: FMA:84771 xref: VHOG:0000662 is_a: CL:0000670 ! primordial germ cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from EHDAA2:0001536 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! indifferent gonad primordial germ cells (human) relationship: existence_starts_during_or_after HsapDv:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! CS18 relationship: part_of UBERON:0000473 ! testis created_by: tmeehan creation_date: 2010-09-07T02:11:13Z [Term] id: CL:0002239 name: ooblast namespace: cell def: "A primordial cell from which an oocyte (ovum) ultimately is developed." [] synonym: "ovary primordial germ cell" EXACT [] synonym: "ovigerm" EXACT [] xref: EHDAA2:0000505 xref: EMAPA:17965 xref: FMA:84772 xref: ISBN:0721662544 xref: VHOG:0000661 is_a: CL:0000670 ! primordial germ cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from EHDAA2:0001536 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! indifferent gonad primordial germ cells (human) relationship: existence_starts_during_or_after HsapDv:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! CS18 relationship: part_of UBERON:0000992 ! ovary created_by: tmeehan creation_date: 2010-09-07T02:11:16Z [Term] id: CL:0002240 name: marrow fibroblast namespace: cell def: "A fibroblast in the bone marrow." [] xref: FMA:84377 is_a: CL:0000057 ! fibroblast is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002241 name: pulmonary interstitial fibroblast namespace: cell def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [] synonym: "pulmonary myofibroblast" EXACT [] synonym: "pulmonary septal cell" EXACT [] xref: FMA:84467 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001004 ! respiratory system intersection_of: part_of UBERON:0005169 ! interstitial tissue relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0005169 ! interstitial tissue created_by: tmeehan creation_date: 2010-09-07T02:29:38Z [Term] id: CL:0002242 name: nucleate cell namespace: cell def: "A cell containing at least one nucleus." [GOC:tfm] xref: FMA:67513 is_a: CL:0000003 ! native cell is_a: CL:0000224 ! obsolete cell by nuclear number intersection_of: CL:0000003 ! native cell intersection_of: has_part GO:0005634 ! nucleus relationship: has_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002243 name: smooth muscle cell of sphincter of pupil namespace: cell def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [] synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] xref: FMA:70611 is_a: CL:0000358 ! sphincter associated smooth muscle cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001607 ! sphincter pupillae relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001607 ! sphincter pupillae created_by: tmeehan creation_date: 2010-09-08T08:53:42Z [Term] id: CL:0002244 name: squamous cell of ectocervix namespace: cell def: "A nonstratified squamous cell located in the ectocervix." [] synonym: "ectocervical squamous cell" EXACT [] xref: FMA:86483 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002149 ! epithelial cell of uterus created_by: tmeehan creation_date: 2010-09-08T09:12:23Z [Term] id: CL:0002245 name: obsolete null lymphocyte namespace: cell def: "OBSOLETE: A lymphocyte that lacks T or B cell surface markers." [] xref: FMA:83601 is_obsolete: true created_by: tmeehan creation_date: 2010-09-07T03:43:42Z [Term] id: CL:0002246 name: peripheral blood stem cell namespace: cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [] synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 is_a: CL:0000037 ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood created_by: tmeehan creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002247 name: pleural macrophage namespace: cell def: "A tissue macrophage that is in the pleural space." [] xref: FMA:83024 is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-09-07T04:16:43Z [Term] id: CL:0002248 name: pluripotent stem cell namespace: cell def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." [] xref: FMA:70570 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-07T04:26:06Z [Term] id: CL:0002249 name: primitive cardiac myocyte namespace: cell def: "A stem cell that can differentiate into a cardiac myocyte." [] xref: FMA:75620 is_a: CL:0000035 ! single fate stem cell is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-09-07T04:40:32Z [Term] id: CL:0002250 name: intestinal crypt stem cell namespace: cell def: "A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells." [] synonym: "stem cell of intestinal crypt of Lieberkuhn" EXACT [] xref: FMA:63379 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn created_by: tmeehan creation_date: 2010-09-08T09:21:22Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal namespace: cell def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract created_by: tmeehan creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus namespace: cell alt_id: CL:1000402 def: "An epithelial cell of the esophagus." [] xref: FMA:63071 is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002253 name: epithelial cell of large intestine namespace: cell alt_id: CL:1000292 def: "An epithelial cell of the large intestine." [] synonym: "epithelial cell of colon" RELATED [] xref: BTO:0004297 xref: FMA:256157 is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2010-09-08T09:28:22Z [Term] id: CL:0002254 name: epithelial cell of small intestine namespace: cell alt_id: CL:1000293 def: "An epithelial cell of the small intestine." [] xref: FMA:256159 is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-09-08T09:41:46Z [Term] id: CL:0002255 name: stromal cell of endometrium namespace: cell def: "An epithelial cell that regulates growth and differentiation of the overlying epithelium." [] xref: CALOHA:TS-1266 xref: FMA:86490 is_a: CL:0000499 ! stromal cell is_a: CL:0002149 ! epithelial cell of uterus intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium created_by: tmeehan creation_date: 2010-09-08T09:50:04Z [Term] id: CL:0002256 name: supporting cell of carotid body namespace: cell def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [] synonym: "carotid body sustentacular cell" EXACT [] xref: FMA:84188 is_a: CL:0000630 ! supportive cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-08T10:34:45Z [Term] id: CL:0002257 name: epithelial cell of thyroid gland namespace: cell alt_id: CL:1000297 def: "An epithelial cell of thyroid gland." [] xref: FMA:256167 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:46:51Z [Term] id: CL:0002258 name: thyroid follicular cell namespace: cell def: "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." [] synonym: "follicular cell of thyroid gland" EXACT [] synonym: "principal cell of thyroid gland" EXACT [] synonym: "thyroid gland follicular cell" EXACT [] xref: BTO:0003736 xref: CALOHA:TS-1285 xref: FMA:68782 is_a: CL:0002257 ! epithelial cell of thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:50:08Z [Term] id: CL:0002259 name: neuroepithelial stem cell namespace: cell def: "The stem cell from which glial precursor cell arises from." [] synonym: "totipotent neuroepithelial stem cell" NARROW [] xref: FMA:87171 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-08T02:14:14Z [Term] id: CL:0002260 name: epithelial cell of parathyroid gland namespace: cell alt_id: CL:1000429 def: "An epithelial cell of the parathyroid gland." [] xref: FMA:70547 is_a: CL:0002076 ! endo-epithelial cell is_a: CL:1001593 ! parathyroid glandular cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0001132 ! parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:29:38Z [Term] id: CL:0002261 name: endothelial cell of viscerocranial mucosa namespace: cell alt_id: CL:1000446 def: "An endothelial cell found in the mucosa associated with the facial skeleton." [] xref: FMA:70627 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-14T10:40:12Z [Term] id: CL:0002262 name: endothelial cell of sinusoid namespace: cell alt_id: CL:1000403 def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [] xref: FMA:63134 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0003909 ! sinusoid relationship: part_of UBERON:0003909 ! sinusoid created_by: tmeehan creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002263 name: transitional cell of parathyroid gland namespace: cell def: "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." [] xref: FMA:69324 is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:33:50Z [Term] id: CL:0002264 name: type A cell of stomach namespace: cell def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [] xref: FMA:83411 is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-09-10T10:54:42Z [Term] id: CL:0002265 name: type D cell of colon namespace: cell def: "A D cell located in the colon." [] synonym: "colon D-cell" EXACT [] synonym: "colonc delta cell" EXACT [] synonym: "delta cell of colon" EXACT [] xref: FMA:268744 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001155 ! colon created_by: tmeehan creation_date: 2010-09-10T11:37:35Z [Term] id: CL:0002266 name: type D cell of small intestine namespace: cell def: "A type D cell of the small intestine." [] synonym: "delta cell of small intestine" EXACT [] synonym: "small intestine D-cell" EXACT [] synonym: "small intestine delta cell" EXACT [] xref: FMA:268736 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-09-10T01:34:22Z [Term] id: CL:0002267 name: type D cell of stomach namespace: cell def: "A type D cell found in the stomach." [] synonym: "delta cell of stomach" EXACT [] synonym: "stomach D-cell" EXACT [] synonym: "stomach delta cell" EXACT [] xref: FMA:83410 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-09-10T01:36:03Z [Term] id: CL:0002268 name: P/D1 enteroendocrine cell namespace: cell def: "An enteroendocrine cell that stores and secretes Ghrelin." [] xref: FMA:63207 xref: FMA:63418 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002269 ! vasoactive intestinal peptide secreting cell created_by: tmeehan creation_date: 2010-09-10T01:47:45Z [Term] id: CL:0002269 name: vasoactive intestinal peptide secreting cell namespace: cell def: "An endocrine cell that secretes vasoactive intestinal peptide." [] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T01:52:20Z [Term] id: CL:0002270 name: type EC2 enteroendocrine cell namespace: cell def: "A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." [] synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:62941 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002272 ! motilin secreting cell created_by: tmeehan creation_date: 2010-09-10T02:13:47Z [Term] id: CL:0002271 name: type EC1 enteroendocrine cell namespace: cell def: "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." [] xref: FMA:62940 is_a: CL:0000505 ! substance P secreting cell is_a: CL:0000577 ! type EC enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T02:13:49Z [Term] id: CL:0002272 name: motilin secreting cell namespace: cell def: "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." [] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T02:31:13Z [Term] id: CL:0002273 name: type ECL enteroendocrine cell namespace: cell def: "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." [] xref: FMA:63208 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell created_by: tmeehan creation_date: 2010-09-10T02:35:17Z [Term] id: CL:0002274 name: histamine secreting cell namespace: cell def: "A cell type that secretes histamine." [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0001821 ! histamine secretion relationship: capable_of GO:0001821 ! histamine secretion created_by: tmeehan creation_date: 2010-09-10T03:04:42Z [Term] id: CL:0002275 name: pancreatic PP cell namespace: cell def: "A PP cell located in the islets of the pancreas." [] comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. synonym: "pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP cell of pancreatic islet" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] xref: BTO:0000805 xref: FMA:70588 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000696 ! PP cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans created_by: tmeehan creation_date: 2010-09-10T03:30:31Z [Term] id: CL:0002276 name: obsolete PP cell of pancreatic acinus namespace: cell def: "OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus." [] synonym: "type F cell of pancreatic acinus" EXACT [] xref: FMA:85400 is_obsolete: true created_by: tmeehan creation_date: 2010-09-10T03:30:33Z [Term] id: CL:0002277 name: type I enteroendocrine cell namespace: cell def: "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." [] synonym: "CCK cell" EXACT [] xref: FMA:62937 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:44:36Z [Term] id: CL:0002278 name: GIP cell namespace: cell def: "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." [] synonym: "type K enteroendocrine cell" EXACT [] xref: FMA:62942 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:51:47Z [Term] id: CL:0002279 name: type L enteroendocrine cell namespace: cell def: "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." [] xref: FMA:62944 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:59:09Z [Term] id: CL:0002280 name: type N enteroendocrine cell namespace: cell def: "An enteroendorcine cell found in the ileum and jejunum that produces neurotensin." [] synonym: "N cell" EXACT [] xref: FMA:62943 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T04:08:29Z [Term] id: CL:0002281 name: type S enteroendocrine cell namespace: cell def: "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." [] xref: FMA:62936 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000458 ! serotonin secreting cell created_by: tmeehan creation_date: 2010-09-10T04:44:46Z [Term] id: CL:0002282 name: type TG enteroendocrine cell namespace: cell def: "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." [] xref: FMA:63421 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000509 ! gastrin secreting cell created_by: tmeehan creation_date: 2010-09-13T09:48:34Z [Term] id: CL:0002283 name: ecto-epithelial cell of viscerocranial mucosa namespace: cell alt_id: CL:1000440 def: "An epithelial cell of the mucosa associated with facial skeleton." [] xref: FMA:70581 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T11:04:02Z [Term] id: CL:0002284 name: type X enteroendocrine cell namespace: cell def: "An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin." [] synonym: "A-like" EXACT [] synonym: "X/A-like" EXACT [] xref: FMA:63209 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0005018 ! ghrelin secreting cell created_by: tmeehan creation_date: 2010-09-13T10:12:12Z [Term] id: CL:0002285 name: type III taste bud cell namespace: cell def: "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." [] synonym: "taste bud basal cell" BROAD [] synonym: "type 3 taste cell" EXACT [] xref: FMA:67940 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:21Z [Term] id: CL:0002286 name: type II taste cell namespace: cell def: "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." [] synonym: "type 2 taste cell" EXACT [] xref: FMA:62381 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:26Z [Term] id: CL:0002287 name: type IV taste receptor cell namespace: cell def: "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." [] comment: There is debate about the exact lineage of these cell types from this progenitor. See PMID:15738192. synonym: "taste bud basal cell" BROAD [] synonym: "type 4 taste cell" EXACT [] xref: FMA:62380 is_a: CL:0000034 ! stem cell is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:29Z [Term] id: CL:0002288 name: type V taste receptor cell namespace: cell def: "A cell type that forms the boundary with the surrounding epithelium." [] xref: FMA:67941 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:31Z [Term] id: CL:0002289 name: type I taste bud cell namespace: cell def: "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." [] synonym: "dark tongue cell" EXACT [] synonym: "type I taste cell" EXACT [] synonym: "type taste 1 cell" EXACT [] xref: FMA:62356 is_a: CL:0000209 ! taste receptor cell is_a: CL:0000703 ! sustentacular cell created_by: tmeehan creation_date: 2010-09-13T10:57:35Z [Term] id: CL:0002290 name: Y chromosome-bearing sperm cell namespace: cell def: "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [] synonym: "Y bearing sperm" EXACT [] synonym: "Y-bearing sperm" EXACT [] xref: FMA:84058 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:24Z [Term] id: CL:0002291 name: X chromosome-bearing sperm cell namespace: cell def: "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [] synonym: "X bearing sperm" EXACT [] synonym: "X-bearing sperm" EXACT [] xref: FMA:84057 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:26Z [Term] id: CL:0002292 name: type I cell of carotid body namespace: cell def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [] synonym: "glomus cell" EXACT [] xref: FMA:84186 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-13T01:40:21Z [Term] id: CL:0002293 name: epithelial cell of thymus namespace: cell alt_id: CL:1000459 def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [] synonym: "epithelial cell of thymus gland" EXACT [] synonym: "epithelial reticular cell" EXACT [] synonym: "epithelial reticular cell of thymus" EXACT [] synonym: "thymic epithelial cell" EXACT [] xref: CALOHA:TS-1040 xref: FMA:72208 is_a: CL:0002076 ! endo-epithelial cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus created_by: tmeehan creation_date: 2010-09-13T02:34:22Z [Term] id: CL:0002294 name: type-1 epithelial cell of thymus namespace: cell def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [] synonym: "subcapsular thymic epithelial cell" EXACT [] xref: FMA:72209 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:23Z [Term] id: CL:0002295 name: type-6 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." [] synonym: "cystic thymic epithelial cells" EXACT [] synonym: "large medullary thymic epithelial cells" EXACT [] synonym: "large mTEC" EXACT [] xref: FMA:72214 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:26Z [Term] id: CL:0002296 name: type-4 epithelial cell of thymus namespace: cell def: "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." [] synonym: "dark thymic epithelial cell" EXACT [] xref: FMA:72212 is_a: CL:0002364 ! cortical thymic epithelial cell is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:45Z [Term] id: CL:0002297 name: type-3 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." [] synonym: "intermediate thymic epithelial cell" EXACT [] xref: FMA:72211 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:51Z [Term] id: CL:0002298 name: type-5 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." [] synonym: "undifferentiated medullary thymic epithelial cell" EXACT [] synonym: "undifferentiated mTEC" EXACT [] synonym: "undifferentiated thymic epithelial cell" EXACT [] xref: FMA:72213 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:54Z [Term] id: CL:0002299 name: type-2 epithelial cell of thymus namespace: cell def: "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." [] synonym: "pale thymic epithelial cell" EXACT [] xref: FMA:72210 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:58Z [Term] id: CL:0002300 name: type-7 epithelial cell of thymus namespace: cell def: "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." [] synonym: "spindle shaped medullary thymic epithelial cell" EXACT [] synonym: "spindle shaped mTEC" EXACT [] is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T03:23:25Z [Term] id: CL:0002301 name: type B synovial cell namespace: cell def: "A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid." [] xref: FMA:66788 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:14Z [Term] id: CL:0002302 name: type A synovial cell namespace: cell def: "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." [] synonym: "type A synoviocyte" EXACT [] xref: FMA:66787 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:17Z [Term] id: CL:0002303 name: pigmented ciliary epithelial cell namespace: cell def: "A ciliated epithelial cell of the retina, this cell type uptakes sodium chloride and passes it to non-pigmented ciliary epithelial cells." [] synonym: "PE" EXACT [] xref: FMA:70606 is_a: CL:0000529 ! pigmented epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:27Z [Term] id: CL:0002304 name: non-pigmented ciliary epithelial cell namespace: cell def: "A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells." [] synonym: "NPE" EXACT [] xref: FMA:70607 is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:31Z [Term] id: CL:0002305 name: epithelial cell of distal tubule namespace: cell def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [] synonym: "kidney distal tubule epithelial cell" EXACT [] xref: FMA:62125 xref: FMA:70981 xref: KUPO:0001055 is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000494 ! nephron tubule epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004135 ! distal tubule relationship: part_of UBERON:0004135 ! distal tubule [Term] id: CL:0002306 name: epithelial cell of proximal tubule namespace: cell def: "An epithelial cell of the proximal tubule of the kidney." [] synonym: "kidney proximal tubule epithelial cell" EXACT [] xref: FMA:62125 xref: FMA:70973 xref: KUPO:0001044 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000494 ! nephron tubule epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004134 ! proximal tubule relationship: part_of UBERON:0004134 ! proximal tubule [Term] id: CL:0002307 name: brush border cell of the proximal tubule namespace: cell def: "A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow." [] is_a: CL:0002306 ! epithelial cell of proximal tubule created_by: tmeehan creation_date: 2010-09-14T11:29:20Z [Term] id: CL:0002308 name: epithelial cell of skin gland namespace: cell def: "An epithelial cell of a skin gland." [] synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002419 ! skin gland relationship: part_of UBERON:0002419 ! skin gland created_by: tmeehan creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002309 name: corticotroph namespace: cell def: "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" [] xref: BTO:0002509 xref: FMA:83098 is_a: CL:0000467 ! adrenocorticotropic hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:08:23Z [Term] id: CL:0002310 name: mammosomatotroph namespace: cell def: "An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone." [] xref: FMA:83097 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:25:34Z [Term] id: CL:0002311 name: mammotroph namespace: cell def: "An acidophilic cell of the anterior pituitary that produces prolactin." [] synonym: "epsilon-acidophil" EXACT [] synonym: "lactotrope" EXACT [] synonym: "lactotroph" EXACT [] synonym: "lactotropic cell" EXACT [] synonym: "mammotrope" EXACT [] synonym: "mammotrophic cell" EXACT [] synonym: "mammotropic cell" EXACT [] xref: FMA:83096 is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:30:57Z [Term] id: CL:0002312 name: somatotroph namespace: cell def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [] synonym: "somatotrope" EXACT [] synonym: "somatotropic cell" EXACT [] synonym: "somatrophic cell" EXACT [] xref: FMA:83095 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:33:09Z [Term] id: CL:0002313 name: endocrine-paracrine cell of prostate gland namespace: cell def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [] synonym: "glandular cell of prostate" EXACT [] synonym: "neuro-epithelial cell of prostate gland" EXACT [] xref: CALOHA:TS-1280 xref: FMA:74390 xref: FMA:86774 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell is_a: UBERON:0000078 ! mixed ectoderm/mesoderm/endoderm-derived structure intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: capable_of GO:0046879 ! hormone secretion intersection_of: part_of UBERON:0002367 ! prostate gland relationship: capable_of GO:0046879 ! hormone secretion relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-14T03:01:58Z [Term] id: CL:0002314 name: external supporting cell of vestibular epithelium namespace: cell def: "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." [] xref: FMA:75809 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:20:01Z [Term] id: CL:0002315 name: supporting cell of cochlea namespace: cell def: "An epithelial supporting cell located in the cochlea." [] xref: FMA:79796 is_a: CL:0001035 ! bone cell is_a: CL:0005014 ! auditory epithelial support cell is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0001844 ! cochlea relationship: part_of UBERON:0001844 ! cochlea created_by: tmeehan creation_date: 2010-09-14T03:31:38Z [Term] id: CL:0002316 name: supporting cell of vestibular epithelium namespace: cell def: "A supporting cell of the vestibular epithelium." [] xref: FMA:75607 is_a: CL:0005014 ! auditory epithelial support cell is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0001862 ! vestibular labyrinth relationship: part_of UBERON:0001862 ! vestibular labyrinth created_by: tmeehan creation_date: 2010-09-14T03:31:44Z [Term] id: CL:0002317 name: external limiting cell of vestibular epithelium namespace: cell def: "An external limiting cell found in the vestibular epithelium." [] xref: FMA:75808 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:33:50Z [Term] id: CL:0002318 name: periperhal blood mesothelial cell namespace: cell def: "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." [] xref: FMA:86712 is_a: CL:0000081 ! blood cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000077 ! mesothelial cell created_by: tmeehan creation_date: 2010-09-15T10:47:11Z [Term] id: CL:0002319 name: neural cell namespace: cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2040 xref: FMA:70333 is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system created_by: tmeehan creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell namespace: cell alt_id: CL:1000406 def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2096 xref: FMA:63875 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: existence_ends_during_or_before ZFS:0000044 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Adult relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown relationship: part_of UBERON:0002384 ! connective tissue created_by: tmeehan creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell namespace: cell def: "A cell of the embryo." [] xref: CALOHA:TS-0263 xref: FMA:82840 xref: FMA:82841 xref: WBbt:0007028 is_a: CL:0000548 ! animal cell created_by: tmeehan creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002322 name: embryonic stem cell namespace: cell def: "A stem cell of embryonic origin." [] comment: This is an in vitro cell type and may be removed in future releases. These cells are reportedly SSEA-4-positive, CD73-negative, and CD324-positive. synonym: "ESC" EXACT [] xref: BTO:0001086 xref: CALOHA:TS-0263 xref: FMA:82841 is_a: CL:0000034 ! stem cell is_a: CL:0002321 ! embryonic cell created_by: tmeehan creation_date: 2010-09-15T03:44:35Z [Term] id: CL:0002323 name: amniocyte namespace: cell def: "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." [] xref: BTO:0000066 is_a: CL:0000349 ! extraembryonic cell created_by: tmeehan creation_date: 2010-09-20T10:13:37Z [Term] id: CL:0002324 name: myoepithelial cell of mammary gland namespace: cell def: "A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative." [] is_a: CL:1000416 ! myoepithelial cell of lactiferous gland created_by: tmeehan creation_date: 2010-09-20T11:42:14Z [Term] id: CL:0002325 name: mammary alveolar cell namespace: cell alt_id: CL:0002230 alt_id: CL:1000476 def: "The milk-producing cell of the alveolar unit that emerges during pregnancy." [] synonym: "epithelial cell of lactiferous gland" EXACT [] synonym: "luminal cell of alveolus of lactiferous gland" EXACT [] xref: FMA:74506 xref: FMA:79866 is_a: CL:0000314 ! milk secreting cell is_a: CL:0002159 ! general ecto-epithelial cell is_a: CL:1001586 ! mammary gland glandular cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0003214 ! mammary gland alveolus relationship: part_of UBERON:0003214 ! mammary gland alveolus created_by: tmeehan creation_date: 2010-09-20T01:30:57Z [Term] id: CL:0002326 name: luminal epithelial cell of mammary gland namespace: cell def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [] xref: FMA:73280 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0002327 ! mammary gland epithelial cell created_by: tmeehan creation_date: 2010-09-20T01:37:53Z [Term] id: CL:0002327 name: mammary gland epithelial cell namespace: cell def: "An epithelial cell of the mammary gland." [] synonym: "breast epithelial cell" EXACT [] synonym: "mammary epithelial cell" EXACT [] xref: BTO:0004300 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland created_by: tmeehan creation_date: 2010-09-20T01:49:37Z [Term] id: CL:0002328 name: bronchial epithelial cell namespace: cell def: "An epithelial cell of the bronchus." [] xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus created_by: tmeehan creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002329 name: basal epithelial cell of tracheobronchial tree namespace: cell def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-20T02:10:36Z [Term] id: CL:0002330 name: undifferentiated cell of bronchus epithelium namespace: cell def: "An undifferentiated columnar cell of the bronchus epithelium" [] is_a: CL:0002328 ! bronchial epithelial cell created_by: tmeehan creation_date: 2010-09-20T02:17:58Z [Term] id: CL:0002332 name: ciliated cell of the bronchus namespace: cell def: "A ciliated cell of the bronchus." [] is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2010-09-20T02:21:12Z [Term] id: CL:0002333 name: neural crest derived fat cell namespace: cell def: "A fat cell derived from a neural crest cell." [] is_a: CL:0000136 ! fat cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000136 ! fat cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000005 ! fibroblast neural crest derived created_by: tmeehan creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002334 name: preadipocyte namespace: cell def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [] xref: BTO:0001107 is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-09-20T02:31:53Z [Term] id: CL:0002335 name: brown preadipocyte namespace: cell def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [] is_a: CL:0002334 ! preadipocyte created_by: tmeehan creation_date: 2010-09-20T02:38:38Z [Term] id: CL:0002336 name: buccal mucosa cell namespace: cell def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [] is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2010-09-20T02:52:54Z [Term] id: CL:0002337 name: keratinocyte stem cell namespace: cell def: "A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair." [] synonym: "bulge keratinocyte" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-09-20T03:07:03Z [Term] id: CL:0002338 name: CD56-positive, CD161-positive immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [] is_a: CL:0000823 ! immature natural killer cell relationship: develops_from CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: has_part PR:000001024 relationship: has_part PR:000001381 relationship: has_part PR:000001874 relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-09-21T10:06:53Z [Term] id: CL:0002339 name: prostate stem cell namespace: cell def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [] synonym: "CD133-positive prostate epithelial cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-20T03:21:06Z [Term] id: CL:0002340 name: luminal cell of prostate epithelium namespace: cell def: "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." [] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:05Z [Term] id: CL:0002341 name: basal cell of prostate epithelium namespace: cell def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:10Z [Term] id: CL:0002342 name: circulating endothelial cell namespace: cell def: "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." [] is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-09-20T03:49:58Z [Term] id: CL:0002343 name: decidual natural killer cell namespace: cell def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [] synonym: "decidual NK cell" EXACT [] synonym: "dNK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell relationship: has_part PR:000001024 relationship: has_part PR:000009766 created_by: tmeehan creation_date: 2010-09-20T04:00:02Z [Term] id: CL:0002344 name: CD56-negative, CD161-positive immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [] is_a: CL:0000823 ! immature natural killer cell relationship: has_part PR:000001381 relationship: has_part PR:000001874 relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-09-20T04:33:11Z [Term] id: CL:0002345 name: CD27-low, CD11b-low immature natural killer cell namespace: cell def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [] comment: Markers are associated with mouse cells. synonym: "preNK.BM" BROAD [] is_a: CL:0000823 ! immature natural killer cell relationship: develops_from CL:0002346 ! Dx5-negative, NK1.1-positive immature natural killer cell relationship: has_part PR:000001008 relationship: has_part PR:000001012 relationship: has_part PR:000001963 relationship: has_part PR:000002977 relationship: has_part PR:000009616 created_by: tmeehan creation_date: 2010-09-20T04:41:01Z [Term] id: CL:0002346 name: Dx5-negative, NK1.1-positive immature natural killer cell namespace: cell def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [] is_a: CL:0000823 ! immature natural killer cell relationship: has_part PR:000002977 created_by: tmeehan creation_date: 2010-09-21T10:11:44Z [Term] id: CL:0002347 name: CD27-high, CD11b-high natural killer cell namespace: cell def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell relationship: develops_from CL:0002349 ! CD27-high, CD11b-low natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:19:49Z [Term] id: CL:0002348 name: CD27-low, CD11b-high natural killer cell namespace: cell def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell relationship: develops_from CL:0002347 ! CD27-high, CD11b-high natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:19:54Z [Term] id: CL:0002349 name: CD27-high, CD11b-low natural killer cell namespace: cell def: "A natural killer cell that is CD27-high and CD11b-low." [] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell relationship: develops_from CL:0002345 ! CD27-low, CD11b-low immature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:20:00Z [Term] id: CL:0002350 name: endocardial cell namespace: cell alt_id: CL:1000475 def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [] synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [] xref: FMA:75621 is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002165 ! endocardium relationship: part_of UBERON:0002165 ! endocardium created_by: tmeehan creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas namespace: cell def: "A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [] synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-09-21T04:41:06Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell that exists during embryogenesis." [] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002353 name: fetal liver hematopoietic progenitor cell namespace: cell def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [] is_a: CL:0002352 ! gestational hematopoietic stem cell is_a: UBERON:0004119 ! endoderm-derived structure relationship: has_part GO:0042611 relationship: has_part PR:000001006 relationship: has_part PR:000001833 relationship: has_part PR:000001932 relationship: has_part PR:000002037 relationship: has_part PR:000002979 relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2010-09-22T09:08:32Z [Term] id: CL:0002354 name: yolk sac hematopoietic stem cell namespace: cell def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [] synonym: "hemangioblast precursor" EXACT [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002352 ! gestational hematopoietic stem cell relationship: has_part PR:000001307 relationship: has_part PR:000001932 relationship: has_part PR:000002037 relationship: part_of UBERON:0001040 ! yolk sac created_by: tmeehan creation_date: 2010-09-22T09:08:34Z [Term] id: CL:0002355 name: primitive red blood cell namespace: cell def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [] synonym: "primitive erythroblast" EXACT [] synonym: "primitive erythrocyte" EXACT [] synonym: "primitive erythroid cell" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002361 ! primitive erythroid progenitor relationship: has_part PR:000008467 relationship: has_part PR:000008857 relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:27:05Z [Term] id: CL:0002356 name: primitive reticulocyte namespace: cell def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." [] synonym: "megalocyte" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002355 ! primitive red blood cell created_by: tmeehan creation_date: 2010-09-22T09:35:16Z [Term] id: CL:0002357 name: fetal derived definitive erythrocyte namespace: cell def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [] synonym: "macrocyte" EXACT [] is_a: CL:0000595 ! enucleate erythrocyte is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_part PR:000008857 intersection_of: part_of UBERON:0000922 ! embryo relationship: develops_from CL:0002353 ! fetal liver hematopoietic progenitor cell relationship: has_part PR:000008857 relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:38:32Z [Term] id: CL:0002358 name: pyrenocyte namespace: cell def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." [] is_a: CL:0002417 ! primitive erythroid lineage cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002355 ! primitive red blood cell created_by: tmeehan creation_date: 2010-09-22T10:02:37Z [Term] id: CL:0002359 name: placental hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [] is_a: CL:0002352 ! gestational hematopoietic stem cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2010-09-22T10:30:02Z [Term] id: CL:0002360 name: AGM hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." [] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T10:31:49Z [Term] id: CL:0002361 name: primitive erythroid progenitor namespace: cell def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [] synonym: "EryP-CFC" EXACT [] synonym: "inner blood island hemangioblast" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002418 ! hemangioblast relationship: has_part PR:000009127 created_by: tmeehan creation_date: 2010-09-22T10:47:28Z [Term] id: CL:0002362 name: granule cell precursor namespace: cell def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." [] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) created_by: tmeehan creation_date: 2010-09-22T01:40:44Z [Term] id: CL:0002363 name: keratocyte namespace: cell def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." [] synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000005 ! fibroblast neural crest derived intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001777 ! substantia propria of cornea relationship: part_of UBERON:0001777 ! substantia propria of cornea created_by: tmeehan creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002364 name: cortical thymic epithelial cell namespace: cell def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [] synonym: "cTEC" EXACT [] xref: BTO:0004562 is_a: CL:0002293 ! epithelial cell of thymus intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002123 ! cortex of thymus relationship: part_of UBERON:0002123 ! cortex of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:12Z [Term] id: CL:0002365 name: medullary thymic epithelial cell namespace: cell def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [] synonym: "mTEC" EXACT [] xref: BTO:0004563 is_a: CL:0002293 ! epithelial cell of thymus intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0002124 ! medulla of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:14Z [Term] id: CL:0002366 name: myometrial cell namespace: cell def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [] synonym: "myometrium smooth muscle cell" EXACT [] xref: BTO:0004519 is_a: CL:0002601 ! uterine smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001296 ! myometrium relationship: part_of UBERON:0001296 ! myometrium created_by: tmeehan creation_date: 2010-09-23T03:46:34Z [Term] id: CL:0002367 name: trabecular meshwork cell namespace: cell def: "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." [] synonym: "trabeculocyte" EXACT [] is_a: CL:0000115 ! endothelial cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0005969 ! eye trabecular meshwork relationship: part_of UBERON:0005969 ! eye trabecular meshwork created_by: tmeehan creation_date: 2010-09-23T04:18:50Z [Term] id: CL:0002368 name: respiratory epithelial cell namespace: cell def: "An endo-epithelial cell of the respiratory tract." [] synonym: "airway epithelial cell" EXACT [] xref: BTO:0004533 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract created_by: tmeehan creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002369 name: fungal spore namespace: cell def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2010-10-01T09:02:42Z [Term] id: CL:0002370 name: respiratory goblet cell namespace: cell def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [] synonym: "respiratory mucosa goblet cells" EXACT [] is_a: CL:0000160 ! goblet cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0004802 ! respiratory tract epithelium created_by: tmeehan creation_date: 2010-09-23T04:42:27Z [Term] id: CL:0002371 name: somatic cell namespace: cell def: "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544] subset: ubprop:upper_level xref: BTO:0001268 xref: FMA:72300 xref: WBbt:0008378 is_a: CL:0000003 ! native cell is_a: CL:0000144 ! obsolete cell by function created_by: tmeehan creation_date: 2010-09-24T09:44:42Z [Term] id: CL:0002372 name: myotube namespace: cell alt_id: CL:0000369 def: "A myotube is a multinucleated cells that is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [] synonym: "myotubule" EXACT [] synonym: "myotubule" RELATED [] synonym: "single cell sarcomere" EXACT [] synonym: "single cell sarcomere" RELATED [] synonym: "skeletal muscle fiber" RELATED [] is_a: CL:0000188 ! skeletal muscle cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell created_by: tmeehan creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002373 name: growth hormone releasing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes growth hormone releasing hormone." [] synonym: "GHRH secreting cell" EXACT [] synonym: "somatocrinin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-24T01:36:44Z [Term] id: CL:0002374 name: ear hair cell namespace: cell def: "A hair cell of the ear that contains the organs of balance and hearing." [] synonym: "ear receptor cell" EXACT [] is_a: CL:0000855 ! sensory hair cell created_by: tmeehan creation_date: 2010-09-24T01:49:31Z [Term] id: CL:0002375 name: Schwann cell precursor namespace: cell def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [] synonym: "Schwann cell precursor cell" EXACT [] is_a: CL:0000030 ! glioblast is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2010-09-24T02:06:10Z [Term] id: CL:0002376 name: non-myelinating Schwann cell namespace: cell def: "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." [] synonym: "Schwann cell" BROAD [] is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002377 ! immature Schwann cell created_by: tmeehan creation_date: 2010-09-24T02:10:26Z [Term] id: CL:0002377 name: immature Schwann cell namespace: cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [] synonym: "Schwann cell" BROAD [] xref: ZFA:0001725 is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002375 ! Schwann cell precursor relationship: existence_ends_during_or_before ZFS:0000032 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:High-pec relationship: existence_starts_during_or_after ZFS:0000025 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Segmentation:10-13 somites created_by: tmeehan creation_date: 2010-09-24T02:10:31Z [Term] id: CL:0002378 name: immature Vgamma2-positive fetal thymocyte namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive and is found in the fetal thymus." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2+ thymocyte" BROAD [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:21:07Z [Term] id: CL:0002379 name: meningothelial cell namespace: cell def: "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." [] synonym: "arachnoid cap cell" EXACT [] xref: FMA:86588 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-28T02:23:46Z [Term] id: CL:0002380 name: oospore namespace: cell def: "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." [] xref: FAO:0000039 is_a: CL:0000605 ! fungal asexual spore created_by: tmeehan creation_date: 2010-10-01T09:22:45Z [Term] id: CL:0002381 name: uninucleate conidium namespace: cell def: "A conidium that has only one nucleus." [] xref: FAO:0000025 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:26:39Z [Term] id: CL:0002382 name: multinucleate conidium namespace: cell def: "A conidium that has more than one nucleus." [] xref: FAO:0000033 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:31:28Z [Term] id: CL:0002383 name: conidium of conidiophore head namespace: cell def: "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." [] xref: FAO:0000033 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002384 name: uninucleate macroconidium namespace: cell def: "A macroconidium that has only one nucleus." [] xref: FAO:0000029 is_a: CL:0000606 ! macroconidium is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002385 name: blastoconidium namespace: cell def: "An oblong or round asexual spore formed from conidial chains." [] synonym: "blastospore" RELATED [] xref: BTO:0000127 xref: FAO:0000042 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002386 name: multinucleate macroconidium namespace: cell def: "A macroconidium that has more than one nucleus." [] xref: FAO:0000035 is_a: CL:0000606 ! macroconidium is_a: CL:0002382 ! multinucleate conidium [Term] id: CL:0002387 name: arthroconidium namespace: cell def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." [] synonym: "arthrospore" RELATED [] xref: FAO:0000041 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002388 name: multinucleate arthroconidium namespace: cell def: "An arthroconidium that has more than one nucleus." [] xref: FAO:0000037 is_a: CL:0002386 ! multinucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002389 name: uninucleate arthroconidium namespace: cell def: "An arthroconidium that has only one nucleus." [] xref: FAO:0000031 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002390 name: uninucleate blastconidium namespace: cell def: "A blastoconidium that has only one nucleus." [] xref: FAO:0000030 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002385 ! blastoconidium [Term] id: CL:0002391 name: multinucleate blastoconidium namespace: cell def: "A blastoconidium that has more than one nucleus." [] xref: FAO:0000036 is_a: CL:0002385 ! blastoconidium is_a: CL:0002386 ! multinucleate macroconidium [Term] id: CL:0002392 name: obsolete plant spore namespace: cell def: "Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte." [] comment: replaced_by: PO:0025017 is_obsolete: true [Term] id: CL:0002393 name: intermediate monocyte namespace: cell def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [] is_a: CL:0000576 ! monocyte relationship: develops_from CL:0000860 ! classical monocyte created_by: tmeehan creation_date: 2010-10-04T10:52:03Z [Term] id: CL:0002394 name: CD141-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." [] comment: Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs. is_a: CL:0000782 ! myeloid dendritic cell is_a: CL:0000784 ! plasmacytoid dendritic cell relationship: capable_of GO:0002827 relationship: capable_of GO:0042590 relationship: has_part PR:000002105 created_by: tmeehan creation_date: 2010-10-04T02:38:58Z [Term] id: CL:0002395 name: Gr1-high classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. is_a: CL:0000860 ! classical monocyte is_a: CL:0001022 ! CD115-positive monocyte relationship: has_part PR:000002980 created_by: tmeehan creation_date: 2010-10-04T11:26:18Z [Term] id: CL:0002396 name: CD14-low, CD16-positive monocyte namespace: cell def: "A patrolling monocyte that is CD14-low and CD16-positive." [] comment: Markers are associated with human monocytes. synonym: "non-classical monocyte, human" EXACT [] is_a: CL:0000875 ! non-classical monocyte is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte relationship: develops_from CL:0002397 ! CD14-positive, CD16-positive monocyte created_by: tmeehan creation_date: 2010-10-04T12:25:42Z [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte namespace: cell def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). synonym: "CD16+ monocyte" EXACT [] is_a: CL:0001054 ! CD14-positive monocyte relationship: has_part PR:000001483 created_by: tmeehan creation_date: 2010-10-04T12:49:47Z [Term] id: CL:0002398 name: Gr1-positive, CD43-positive monocyte namespace: cell def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [] is_a: CL:0001022 ! CD115-positive monocyte is_a: CL:0002393 ! intermediate monocyte relationship: develops_from CL:0002395 ! Gr1-high classical monocyte relationship: has_part PR:000001879 relationship: has_part PR:000002980 created_by: tmeehan creation_date: 2010-10-04T12:49:49Z [Term] id: CL:0002399 name: CD1c-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD1c-positive." [] comment: Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha. is_a: CL:0000782 ! myeloid dendritic cell relationship: capable_of GO:0032637 relationship: has_part PR:000002027 created_by: tmeehan creation_date: 2010-10-04T02:39:01Z [Term] id: CL:0002400 name: Fraction B/C precursor B cell namespace: cell def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [] is_a: CL:0000817 ! precursor B cell relationship: has_part PR:000001879 relationship: has_part PR:000001932 relationship: has_part PR:000002037 created_by: tmeehan creation_date: 2010-10-05T10:11:38Z [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "mature DEC precursor" EXACT [] synonym: "mature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002218 ! immature dendritic epithelial T cell precursor created_by: tmeehan creation_date: 2010-10-07T02:05:46Z [Term] id: CL:0002402 name: Peyer's patch B cell namespace: cell def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [] synonym: "Peyers patch B cell" EXACT [] is_a: CL:0000822 ! B-2 B cell relationship: has_part GO:0071753 relationship: has_part PR:000001014 relationship: has_part PR:000001338 relationship: part_of UBERON:0001211 ! Peyer's patch created_by: tmeehan creation_date: 2010-10-05T11:18:03Z [Term] id: CL:0002403 name: mature Vgamma2-positive fetal thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2-positive" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002378 ! immature Vgamma2-positive fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:24:36Z [Term] id: CL:0002404 name: fetal thymocyte namespace: cell def: "A thymocyte found in the fetal thymus." [] is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-10-07T02:28:25Z [Term] id: CL:0002405 name: gamma-delta thymocyte namespace: cell def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [] synonym: "gammadelta thymocyte" EXACT [] synonym: "gd thymocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002489 ! double negative thymocyte created_by: tmeehan creation_date: 2010-10-07T02:33:39Z [Term] id: CL:0002406 name: immature Vgamma2-positive thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:44Z [Term] id: CL:0002407 name: mature Vgamma2-positive thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002406 ! immature Vgamma2-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:48Z [Term] id: CL:0002408 name: immature Vgamma2-negative thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:05Z [Term] id: CL:0002409 name: mature Vgamma2-negative thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002408 ! immature Vgamma2-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:08Z [Term] id: CL:0002410 name: pancreatic stellate cell namespace: cell def: "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." [] synonym: "pancreas stellate cell" EXACT [] synonym: "PaSC" EXACT [] is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2010-11-10T09:40:33Z [Term] id: CL:0002411 name: Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." [] synonym: "Vg1.1-positive, Vd6.3-negative T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:07:44Z [Term] id: CL:0002412 name: Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." [] synonym: "Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:03:00Z [Term] id: CL:0002413 name: mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." [] synonym: "mature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:32Z [Term] id: CL:0002414 name: immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." [] synonym: "immature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:35Z [Term] id: CL:0002415 name: immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." [] synonym: "immature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:39Z [Term] id: CL:0002416 name: mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." [] synonym: "mature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:41Z [Term] id: CL:0002417 name: primitive erythroid lineage cell namespace: cell def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [] is_a: CL:0000764 ! erythroid lineage cell created_by: tmeehan creation_date: 2010-10-12T11:22:41Z [Term] id: CL:0002418 name: hemangioblast namespace: cell def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [] is_a: CL:0000222 ! mesodermal cell relationship: develops_from CL:0002354 ! yolk sac hematopoietic stem cell created_by: tmeehan creation_date: 2010-10-12T12:21:16Z [Term] id: CL:0002419 name: mature T cell namespace: cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [] synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] synonym: "mature T-cell" EXACT [] is_a: CL:0000084 ! T cell relationship: has_part GO:0042101 created_by: tmeehan creation_date: 2010-10-12T01:56:15Z [Term] id: CL:0002420 name: immature T cell namespace: cell def: "A T cell that has not completed T cell selection." [] synonym: "immature T-cell" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 is_a: CL:0000084 ! T cell created_by: tmeehan creation_date: 2010-10-12T01:56:17Z [Term] id: CL:0002421 name: nucleated reticulocyte namespace: cell def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [] is_a: CL:0000558 ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: has_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002422 name: enucleated reticulocyte namespace: cell def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [] xref: CALOHA:TS-0864 xref: FMA:66785 is_a: CL:0000225 ! anucleate cell is_a: CL:0000558 ! reticulocyte relationship: has_part GO:0005840 created_by: tmeehan creation_date: 2010-10-15T09:24:08Z [Term] id: CL:0002423 name: DN2a thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-hi." [] comment: Observed in mice. is_a: CL:0000806 ! DN2 thymocyte relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-10-21T10:12:05Z [Term] id: CL:0002424 name: DN2b thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-low." [] comment: Observed in mice. is_a: CL:0000806 ! DN2 thymocyte relationship: develops_from CL:0002423 ! DN2a thymocyte relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-10-21T10:12:08Z [Term] id: CL:0002425 name: early T lineage precursor namespace: cell def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [] comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative. synonym: "ETP" EXACT [] synonym: "preT.ETP.Th" EXACT [] is_a: CL:0000827 ! pro-T cell relationship: has_part PR:000001307 relationship: has_part PR:000001869 relationship: has_part PR:000002065 created_by: tmeehan creation_date: 2010-10-21T01:16:24Z [Term] id: CL:0002426 name: CD11b-positive, CD27-positive natural killer cell namespace: cell def: "A mature natural killer cell that is CD11b-positive and CD27-positive." [] comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive. is_a: CL:0002438 ! NK1.1-positive natural killer cell relationship: has_part PR:000001012 relationship: has_part PR:000001963 created_by: tmeehan creation_date: 2010-10-25T03:07:59Z [Term] id: CL:0002427 name: resting double-positive thymocyte namespace: cell def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [] synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T01:59:06Z [Term] id: CL:0002428 name: double-positive blast namespace: cell def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [] synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002427 ! resting double-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T01:59:11Z [Term] id: CL:0002429 name: CD69-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [] synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002428 ! double-positive blast relationship: has_part PR:000001343 created_by: tmeehan creation_date: 2010-10-21T02:11:52Z [Term] id: CL:0002430 name: CD4-intermediate, CD8-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [] synonym: "T.4int8+.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte relationship: has_part PR:000001343 created_by: tmeehan creation_date: 2010-10-21T02:29:19Z [Term] id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [] synonym: "T.4int8+.th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte relationship: has_part PR:000001343 created_by: tmeehan creation_date: 2010-10-21T02:29:23Z [Term] id: CL:0002432 name: CD24-positive, CD4 single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte relationship: develops_from CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte relationship: has_part PR:000001932 created_by: tmeehan creation_date: 2010-10-21T02:43:52Z [Term] id: CL:0002433 name: CD69-positive, CD4-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [] synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte relationship: develops_from CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte relationship: has_part PR:000001343 created_by: tmeehan creation_date: 2010-10-21T02:46:02Z [Term] id: CL:0002434 name: CD24-positive, CD8 single-positive thymocyte namespace: cell def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte relationship: develops_from CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte relationship: has_part PR:000001932 created_by: tmeehan creation_date: 2010-10-21T02:59:10Z [Term] id: CL:0002435 name: CD69-positive, CD8-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [] synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte relationship: develops_from CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte relationship: has_part PR:000001343 created_by: tmeehan creation_date: 2010-10-21T02:59:14Z [Term] id: CL:0002436 name: mature CD4 single-positive thymocyte namespace: cell def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [] synonym: "T.4SP24-.Th" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0002432 ! CD24-positive, CD4 single-positive thymocyte relationship: has_part PR:000001932 created_by: tmeehan creation_date: 2010-10-21T03:31:19Z [Term] id: CL:0002437 name: mature CD8 single-positive thymocyte namespace: cell def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [] synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure relationship: develops_from CL:0002434 ! CD24-positive, CD8 single-positive thymocyte relationship: has_part PR:000001932 created_by: tmeehan creation_date: 2010-10-21T03:51:50Z [Term] id: CL:0002438 name: NK1.1-positive natural killer cell namespace: cell def: "A mature NK cell that is NK1.1-positive." [] comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice. synonym: "NK.sp" EXACT [] synonym: "NK1.1-positive NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell relationship: has_part PR:000002977 created_by: tmeehan creation_date: 2010-10-25T03:18:04Z [Term] id: CL:0002439 name: NKGA2-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is NKGA2-positive." [] synonym: "NK.G2A+.SP" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell relationship: has_part PR:000002023 created_by: tmeehan creation_date: 2010-10-25T03:31:09Z [Term] id: CL:0002440 name: Ly49D-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49D-positive." [] synonym: "NK.49D+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell relationship: has_part PR:000009619 created_by: tmeehan creation_date: 2010-10-25T03:36:19Z [Term] id: CL:0002441 name: CD94-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-positive." [] synonym: "NK.94+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell relationship: has_part PR:000001402 created_by: tmeehan creation_date: 2010-10-25T03:36:28Z [Term] id: CL:0002442 name: CD94-negative, Ly49CI-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." [] synonym: "CD94- Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-94-.Sp" EXACT [] is_a: CL:0002446 ! Ly49CI-negative natural killer cell is_a: CL:0002447 ! CD94-negative natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:56:21Z [Term] id: CL:0002443 name: Ly49CI-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-positive." [] synonym: "Ly49I-positive NK cell" EXACT [] synonym: "NK.49Cl+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell relationship: has_part PR:000009618 created_by: tmeehan creation_date: 2010-10-25T03:36:38Z [Term] id: CL:0002444 name: Ly49H-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49H-positive." [] synonym: "LyH49H-positive" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell relationship: has_part PR:000009623 created_by: tmeehan creation_date: 2010-10-25T03:36:43Z [Term] id: CL:0002445 name: Ly49D-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49D-negative." [] synonym: "NK.49D-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:39:02Z [Term] id: CL:0002446 name: Ly49CI-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-negative." [] synonym: "Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:52:04Z [Term] id: CL:0002447 name: CD94-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-negative." [] synonym: "NK.94-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:54:18Z [Term] id: CL:0002448 name: Ly49H-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49H-negative." [] synonym: "LyH49H-negative" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:42:42Z [Term] id: CL:0002449 name: CD94-positive Ly49CI-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." [] synonym: "NK.49Cl+94+.Sp" EXACT [] is_a: CL:0002441 ! CD94-positive natural killer cell is_a: CL:0002443 ! Ly49CI-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:56:27Z [Term] id: CL:0002450 name: tether cell namespace: cell def: "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." [] is_a: CL:0002374 ! ear hair cell created_by: tmeehan creation_date: 2010-11-10T01:41:00Z [Term] id: CL:0002451 name: mammary stem cell namespace: cell def: "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi." [] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-11-10T01:46:51Z [Term] id: CL:0002453 name: oligodendrocyte precursor cell namespace: cell def: "The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [] is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) intersection_of: CL:0000123 ! neuron associated cell (sensu Vertebrata) intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) relationship: part_of UBERON:0001017 ! central nervous system created_by: tmeehan creation_date: 2010-11-10T02:51:34Z [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell namespace: cell def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [] synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] is_a: CL:0002465 ! CD11b-positive dendritic cell created_by: tmeehan creation_date: 2010-11-22T01:10:28Z [Term] id: CL:0002455 name: CD8_alpha-negative plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive." [] synonym: "DC.pDC.8-" EXACT [] is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell relationship: has_part PR:000001004 created_by: tmeehan creation_date: 2010-11-22T01:27:37Z [Term] id: CL:0002456 name: CD8_alpha-positive plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." [] synonym: "DC.pDC.8+" EXACT [] is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell relationship: has_part PR:000001004 relationship: has_part PR:000001084 created_by: tmeehan creation_date: 2010-11-22T01:23:07Z [Term] id: CL:0002457 name: epidermal Langerhans cell namespace: cell def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [] is_a: CL:0000453 ! Langerhans cell is_a: CL:0002465 ! CD11b-positive dendritic cell relationship: has_part PR:000001014 created_by: tmeehan creation_date: 2010-11-22T03:57:57Z [Term] id: CL:0002458 name: langerin-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-positive, CD103-positive, and CD11b-negative." [] is_a: CL:0001006 ! dermal dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell created_by: tmeehan creation_date: 2010-11-22T04:06:22Z [Term] id: CL:0002459 name: langerin-negative dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." [] is_a: CL:0001006 ! dermal dendritic cell created_by: tmeehan creation_date: 2010-11-22T04:09:44Z [Term] id: CL:0002460 name: CD8alpha-negative thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-negative." [] synonym: "DC.8-.Th" EXACT [] is_a: CL:0000941 ! thymic conventional dendritic cell created_by: tmeehan creation_date: 2010-11-23T10:58:53Z [Term] id: CL:0002461 name: CD103-positive dendritic cell namespace: cell def: "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_part PR:000001010 created_by: tmeehan creation_date: 2010-11-23T01:32:43Z [Term] id: CL:0002462 name: adipose dendritic cell namespace: cell def: "A F4/80-negative dendritic cell located in adipose tissue." [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: part_of UBERON:0001013 ! adipose tissue created_by: tmeehan creation_date: 2010-11-23T01:38:21Z [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-positive." [] synonym: "DC.SIRPa+.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell relationship: has_part PR:000001968 created_by: tmeehan creation_date: 2010-11-23T01:40:44Z [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-negative." [] synonym: "DC.SIRPa-.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell created_by: tmeehan creation_date: 2010-11-23T01:40:46Z [Term] id: CL:0002465 name: CD11b-positive dendritic cell namespace: cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [] is_a: CL:0000990 ! conventional dendritic cell relationship: has_part PR:000001012 created_by: tmeehan creation_date: 2010-11-23T01:50:05Z [Term] id: CL:0002466 name: small intestine serosal dendritic cell namespace: cell def: "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." [] synonym: "DC.11cloSer.SI" EXACT [] is_a: CL:0002465 ! CD11b-positive dendritic cell relationship: has_part PR:000001006 created_by: tmeehan creation_date: 2010-11-23T02:00:21Z [Term] id: CL:0002467 name: Gr1-high myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [] synonym: "MDS.Gr1hi" EXACT [] is_a: CL:0000889 ! myeloid suppressor cell relationship: has_part PR:000002980 created_by: tmeehan creation_date: 2010-11-23T02:15:12Z [Term] id: CL:0002468 name: Gr1-low myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [] synonym: "MDS.Gr1lo" EXACT [] is_a: CL:0000889 ! myeloid suppressor cell relationship: has_part PR:000001013 relationship: has_part PR:000002980 created_by: tmeehan creation_date: 2010-11-23T02:19:43Z [Term] id: CL:0002469 name: MHC-II-negative classical monocyte namespace: cell def: "Gr1-high monocyte that lacks MHC-II receptor complex." [] synonym: "Mo.6C+II-" EXACT [] is_a: CL:0002395 ! Gr1-high classical monocyte created_by: tmeehan creation_date: 2010-11-23T03:27:12Z [Term] id: CL:0002470 name: MHC-II-positive classical monocyte namespace: cell def: "Gr1-high monocyte that has a MHC-II receptor complex." [] synonym: "Mo.6c+II" EXACT [] is_a: CL:0002395 ! Gr1-high classical monocyte relationship: has_part GO:0042613 created_by: tmeehan creation_date: 2010-11-23T03:30:21Z [Term] id: CL:0002471 name: MHC-II-negative non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." [] synonym: "Mo.6C-II-" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte created_by: tmeehan creation_date: 2010-11-23T03:38:15Z [Term] id: CL:0002472 name: MHC-II-low non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." [] synonym: "Mo.6C-IIint" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte relationship: has_part GO:0042613 created_by: tmeehan creation_date: 2010-11-23T03:47:53Z [Term] id: CL:0002473 name: MHC-II-high non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." [] synonym: "Mo.6C-II+" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte relationship: has_part GO:0042613 created_by: tmeehan creation_date: 2010-11-23T03:47:55Z [Term] id: CL:0002474 name: lymphoid MHC-II-negative classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." [] is_a: CL:0002469 ! MHC-II-negative classical monocyte relationship: has_part PR:000001813 created_by: tmeehan creation_date: 2010-11-23T04:00:52Z [Term] id: CL:0002475 name: lymphoid MHC-II-negative non-classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." [] is_a: CL:0002469 ! MHC-II-negative classical monocyte is_a: CL:0002471 ! MHC-II-negative non-classical monocyte relationship: has_part PR:000001013 relationship: has_part PR:000001813 created_by: tmeehan creation_date: 2010-11-23T04:09:09Z [Term] id: CL:0002476 name: bone marrow macrophage namespace: cell def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [] synonym: "MF.BM" RELATED [] xref: BTO:0004732 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1001610 ! bone marrow hematopoietic cell relationship: has_part PR:000001813 relationship: has_part PR:000002062 created_by: tmeehan creation_date: 2010-11-23T04:19:25Z [Term] id: CL:0002477 name: adipose macrophage namespace: cell def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [] is_a: CL:0000864 ! tissue-resident macrophage relationship: has_part PR:000001006 relationship: has_part PR:000001013 relationship: has_part PR:000001968 created_by: tmeehan creation_date: 2010-11-23T04:31:28Z [Term] id: CL:0002478 name: F4/80-negative adipose macrophage namespace: cell def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [] synonym: "MF.Autofl.Ad" EXACT [] is_a: CL:0002477 ! adipose macrophage relationship: has_part GO:0042613 created_by: tmeehan creation_date: 2010-11-23T04:40:50Z [Term] id: CL:0002479 name: F4/80-positive adipose macrophage namespace: cell def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [] synonym: "MF.F480+.Ad" EXACT [] is_a: CL:0002477 ! adipose macrophage relationship: has_part PR:000001813 created_by: tmeehan creation_date: 2010-11-23T04:35:53Z [Term] id: CL:0002480 name: nasal mucosa goblet cell namespace: cell def: "A goblet cell located in the nasal epithelium." [] xref: MP:0002262 is_a: CL:0002370 ! respiratory goblet cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa relationship: part_of UBERON:0005384 ! nasal cavity epithelium created_by: tmeehan creation_date: 2010-12-03T03:03:02Z [Term] id: CL:0002481 name: peritubular myoid cell namespace: cell def: "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." [] is_a: CL:0000185 ! myoepithelial cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis created_by: tmeehan creation_date: 2010-12-03T03:11:48Z [Term] id: CL:0002482 name: dermal melanocyte namespace: cell def: "A melanocyte that produces pigment in the dermis." [] is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2010-12-03T03:17:05Z [Term] id: CL:0002483 name: hair follicle melanocyte namespace: cell def: "A melanocyte that produces pigment within the hair follicle." [] is_a: CL:0002559 ! hair follicle cell is_a: CL:2000000 ! epidermal melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002073 ! hair follicle created_by: tmeehan creation_date: 2010-12-03T03:17:09Z [Term] id: CL:0002484 name: epithelial melanocyte namespace: cell def: "A melanocyte that produces pigment in the epithelium." [] comment: The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium. is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0000483 ! epithelium relationship: part_of UBERON:0000483 ! epithelium created_by: tmeehan creation_date: 2010-12-03T03:17:14Z [Term] id: CL:0002485 name: retinal melanocyte namespace: cell def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." [] is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina created_by: tmeehan creation_date: 2010-12-03T03:25:32Z [Term] id: CL:0002486 name: strial intermediate cell namespace: cell def: "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." [] is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002484 ! epithelial melanocyte is_a: CL:0002491 ! auditory epithelial cell intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002282 ! stria vascularis of cochlear duct relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct created_by: tmeehan creation_date: 2010-12-03T03:29:15Z [Term] id: CL:0002487 name: cutaneous/subcutaneous mechanoreceptor cell namespace: cell def: "A neuronal receptor that respond to mechanical pressure or distortion in the skin." [] is_a: CL:0000199 ! mechanoreceptor cell created_by: tmeehan creation_date: 2010-12-06T02:53:30Z [Term] id: CL:0002488 name: trophoblast giant cell namespace: cell def: "A trophoblast cell that has a large volume of cytoplasm, is polyploidy and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." [] synonym: "giant trophoblast cell" EXACT [] is_a: CL:0000351 ! trophoblast cell relationship: capable_of GO:0001974 created_by: tmeehan creation_date: 2010-12-06T02:55:24Z [Term] id: CL:0002489 name: double negative thymocyte namespace: cell def: "A thymocyte that lacks expression of CD4 and CD8." [] synonym: "double negative T cell" BROAD [] is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-12-06T03:03:38Z [Term] id: CL:0002490 name: organ of Corti supporting cell namespace: cell def: "A supporting cell of the organ of Corti." [] is_a: CL:0002315 ! supporting cell of cochlea intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0002227 ! spiral organ of cochlea relationship: part_of UBERON:0002227 ! spiral organ of cochlea created_by: tmeehan creation_date: 2010-12-06T03:09:01Z [Term] id: CL:0002491 name: auditory epithelial cell namespace: cell def: "A specialized cell involved in auditory sensory perception." [] is_a: CL:0000098 ! sensory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound created_by: tmeehan creation_date: 2010-12-06T03:18:43Z [Term] id: CL:0002492 name: strial marginal cell namespace: cell def: "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." [] is_a: CL:0002491 ! auditory epithelial cell created_by: tmeehan creation_date: 2010-12-06T03:20:41Z [Term] id: CL:0002493 name: strial basal cell namespace: cell def: "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." [] comment: Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863] is_a: CL:0002491 ! auditory epithelial cell is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct created_by: tmeehan creation_date: 2010-12-06T03:26:53Z [Term] id: CL:0002494 name: cardiocyte namespace: cell def: "A cell located in the heart, including both muscle and non muscle cells." [] comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. synonym: "heart cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0007100 ! primary circulatory organ relationship: part_of UBERON:0007100 ! primary circulatory organ created_by: tmeehan creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002495 name: fetal cardiomyocyte namespace: cell def: "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." [] synonym: "embryonic cardiomyocyte" EXACT [] synonym: "neonatal cardiomyocyte" EXACT [] is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-12-07T09:50:41Z [Term] id: CL:0002496 name: intraepithelial lymphocyte namespace: cell def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [] synonym: "IEL" EXACT [] synonym: "intraepithelial T cell" EXACT [] synonym: "intraepithelial T-cell" EXACT [] is_a: CL:0002419 ! mature T cell relationship: capable_of GO:0002385 created_by: tmeehan creation_date: 2010-12-07T09:54:50Z [Term] id: CL:0002497 name: primary trophoblast giant cell namespace: cell def: "A trophoblast giant cell derived from the mural trophectoderm." [] xref: EMAPA:16066 is_a: CL:0002488 ! trophoblast giant cell created_by: tmeehan creation_date: 2010-12-07T10:07:47Z [Term] id: CL:0002498 name: secondary trophoblast giant cell namespace: cell def: "A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast." [] is_a: CL:0002488 ! trophoblast giant cell created_by: tmeehan creation_date: 2010-12-07T10:07:52Z [Term] id: CL:0002499 name: spongiotrophoblast cell namespace: cell def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-12-07T12:56:56Z [Term] id: CL:0002500 name: P enteroendocrine cell namespace: cell def: "A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide." [] is_a: CL:0002268 ! P/D1 enteroendocrine cell created_by: tmeehan creation_date: 2010-12-07T03:42:06Z [Term] id: CL:0002501 name: type D1 enteroendocrine cell namespace: cell def: "A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide." [] xref: FMA:63207 is_a: CL:0002268 ! P/D1 enteroendocrine cell created_by: tmeehan creation_date: 2010-12-07T03:42:09Z [Term] id: CL:0002502 name: type M enteroendocrine cell namespace: cell def: "An enteroendocrine cell of the small intestine that secretes motilin." [] synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:63420 is_a: CL:0002272 ! motilin secreting cell is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001598 ! small intestine glandular cell created_by: tmeehan creation_date: 2010-12-07T03:55:49Z [Term] id: CL:0002503 name: adventitial cell namespace: cell def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [] xref: BTO:0002441 xref: FMA:84639 is_a: CL:0000630 ! supportive cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0005742 ! adventitia relationship: part_of UBERON:0005742 ! adventitia created_by: tmeehan creation_date: 2010-12-07T04:03:56Z [Term] id: CL:0002504 name: enteric smooth muscle cell namespace: cell def: "A smooth muscle cell of the intestine." [] synonym: "intestinal smooth muscle cell" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine created_by: tmeehan creation_date: 2011-01-17T03:39:38Z [Term] id: CL:0002505 name: liver CD103-negative dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." [] synonym: "DC.103-11b+.Lv" EXACT [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell relationship: has_part PR:000001006 created_by: tmeehan creation_date: 2011-01-21T01:27:41Z [Term] id: CL:0002506 name: liver CD103-positive dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." [] synonym: "DC.103+11b-.Lv" EXACT [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell relationship: has_part PR:000001006 created_by: tmeehan creation_date: 2011-01-21T01:27:45Z [Term] id: CL:0002507 name: langerin-positive lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [] is_a: CL:0000990 ! conventional dendritic cell relationship: has_part PR:000001293 created_by: tmeehan creation_date: 2011-01-21T01:57:00Z [Term] id: CL:0002508 name: langerin-negative, CD103-negative lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." [] is_a: CL:0000990 ! conventional dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:13:58Z [Term] id: CL:0002509 name: CD103-positive, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell is_a: CL:0002507 ! langerin-positive lymph node dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:07:54Z [Term] id: CL:0002510 name: CD103-negative, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002507 ! langerin-positive lymph node dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:11:14Z [Term] id: CL:0002511 name: CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:22:15Z [Term] id: CL:0002512 name: CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:16:21Z [Term] id: CL:0002513 name: Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." [] synonym: "tgd.vg5+.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:22:18Z [Term] id: CL:0002514 name: Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." [] synonym: "tgd.vg5-.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:25:44Z [Term] id: CL:0002515 name: interrenal norepinephrine type cell namespace: cell def: "An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane." [] synonym: "interrenal noradrenaline type cell" EXACT [] synonym: "type n interrenal cell" EXACT [] is_a: CL:0000459 ! noradrenergic cell is_a: CL:0002516 ! interrenal chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:11:55Z [Term] id: CL:0002516 name: interrenal chromaffin cell namespace: cell def: "A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish." [] is_a: CL:0000166 ! chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:21:35Z [Term] id: CL:0002517 name: interrenal epinephrin secreting cell namespace: cell def: "An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo." [] synonym: "interrenal adrenaline secreting cell" RELATED [] synonym: "type a interrenal cell" EXACT [] is_a: CL:0000454 ! epinephrine secreting cell is_a: CL:0002516 ! interrenal chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:27:05Z [Term] id: CL:0002518 name: kidney epithelial cell namespace: cell def: "An epithelial cell of the kidney." [] xref: KUPO:0001019 is_a: CL:0000066 ! epithelial cell is_a: CL:1000497 ! kidney cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002113 ! kidney created_by: tmeehan creation_date: 2011-02-08T10:46:34Z [Term] id: CL:0002519 name: interrenal epithelial cell namespace: cell def: "An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type." [] is_a: CL:0002518 ! kidney epithelial cell created_by: tmeehan creation_date: 2011-02-08T11:03:32Z [Term] id: CL:0002520 name: nephrocyte namespace: cell def: "An insect excretory cell that regulates haemolymph composition by filtration and filtrate endocytosis." [] xref: BTO:0004597 xref: FMA:83807 is_a: CL:0002522 ! renal filtration cell created_by: tmeehan creation_date: 2011-02-08T01:34:56Z [Term] id: CL:0002521 name: subcutaneous fat cell namespace: cell def: "A fat cell that is part of subcutaneous adipose tissue." [] synonym: "subcutaneous adipocyte" EXACT [] is_a: CL:0000136 ! fat cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue created_by: tmeehan creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002522 name: renal filtration cell namespace: cell def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [] is_a: CL:0000424 ! excretory cell relationship: part_of UBERON:0001008 ! renal system created_by: tmeehan creation_date: 2011-02-08T01:37:59Z [Term] id: CL:0002523 name: mesonephric glomerular visceral epithelial cell namespace: cell def: "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros" [] is_a: CL:0000653 ! glomerular visceral epithelial cell intersection_of: CL:0000653 ! glomerular visceral epithelial cell intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros created_by: tmeehan creation_date: 2011-02-08T01:58:30Z [Term] id: CL:0002524 name: disseminated nephrocyte namespace: cell def: "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." [] is_a: CL:0002520 ! nephrocyte created_by: tmeehan creation_date: 2011-02-08T02:07:33Z [Term] id: CL:0002525 name: metanephric glomerular visceral epithelial cell namespace: cell def: "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [] is_a: CL:0000653 ! glomerular visceral epithelial cell intersection_of: CL:0000653 ! glomerular visceral epithelial cell intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros created_by: tmeehan creation_date: 2011-02-08T02:02:13Z [Term] id: CL:0002526 name: CD14-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-negative and CD14-positive." [] comment: They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis. synonym: "CD14+ dermal DC" EXACT [] is_a: CL:0001006 ! dermal dendritic cell relationship: capable_of GO:0045191 relationship: has_part PR:000001889 [Term] id: CL:0002527 name: immature CD14-positive dermal dendritic cell namespace: cell def: "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002526 ! CD14-positive dermal dendritic cell [Term] id: CL:0002528 name: mature CD14-positive dermal dendritic cell namespace: cell def: "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002526 ! CD14-positive dermal dendritic cell relationship: develops_from CL:0002527 ! immature CD14-positive dermal dendritic cell [Term] id: CL:0002529 name: CD1a-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-positive and CD14-negative." [] comment: Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse. synonym: "CD1a+ dermal DC" EXACT [] is_a: CL:0001006 ! dermal dendritic cell relationship: has_part PR:000002025 [Term] id: CL:0002530 name: immature CD1a-positive dermal dendritic cell namespace: cell def: "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002529 ! CD1a-positive dermal dendritic cell [Term] id: CL:0002531 name: mature CD1a-positive dermal dendritic cell namespace: cell def: "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002529 ! CD1a-positive dermal dendritic cell relationship: develops_from CL:0002530 ! immature CD1a-positive dermal dendritic cell [Term] id: CL:0002532 name: CD16-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD16-positive." [] comment: Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8). synonym: "CD16+ mDC" EXACT [] synonym: "CD16-mDC" EXACT [] is_a: CL:0000782 ! myeloid dendritic cell relationship: capable_of GO:0032640 relationship: has_part PR:000001483 [Term] id: CL:0002533 name: immature CD16-positive myeloid dendritic cell namespace: cell def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." [] is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0002532 ! CD16-positive myeloid dendritic cell [Term] id: CL:0002534 name: mature CD16-positive myeloid dendritic cell namespace: cell def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [] is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0002532 ! CD16-positive myeloid dendritic cell relationship: develops_from CL:0002533 ! immature CD16-positive myeloid dendritic cell [Term] id: CL:0002535 name: epithelial cell of cervix namespace: cell def: "An epithelial cell of the cervix." [] synonym: "cervical canal epithelial cell" EXACT [] synonym: "cervical canal of uterus epithelial cell" EXACT [] synonym: "cervix epithelial cell" EXACT [] synonym: "cervix of uterus epithelial cell" EXACT [] synonym: "epithelial cell of cervical canal" EXACT [] synonym: "epithelial cell of cervical canal of uterus" EXACT [] synonym: "epithelial cell of cervix of uterus" EXACT [] synonym: "epithelial cell of neck of uterus" EXACT [] synonym: "epithelial cell of uterine cervix" EXACT [] synonym: "neck of uterus epithelial cell" EXACT [] synonym: "uterine cervix epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0004801 ! cervix epithelium created_by: tmeehan creation_date: 2011-02-24T08:20:08Z [Term] id: CL:0002536 name: epithelial cell of amnion namespace: cell def: "An epithelial cell that is part of the amnion." [] synonym: "amniotic epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000305 ! amnion relationship: part_of UBERON:0000305 ! amnion created_by: tmeehan creation_date: 2011-02-28T12:38:01Z [Term] id: CL:0002537 name: amnion mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the amnion membrane." [] synonym: "amniotic membrane stem cell" EXACT [] is_a: CL:0000134 ! mesenchymal cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0000305 ! amnion relationship: part_of UBERON:0000305 ! amnion created_by: tmeehan creation_date: 2011-02-28T12:44:24Z [Term] id: CL:0002538 name: intrahepatic bile duct epithelial cell namespace: cell def: "An epithelial cell of the intrahepatic portion of the bile duct." [] is_a: CL:0000069 ! branched duct epithelial cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium created_by: tmeehan creation_date: 2011-02-28T01:20:20Z [Term] id: CL:0002539 name: aortic smooth muscle cell namespace: cell def: "A smooth muscle cell of the aorta." [] xref: BTO:0004577 is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue created_by: tmeehan creation_date: 2011-02-28T01:42:12Z [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow namespace: cell def: "A mesenchymal stem cell that is part of the bone marrow." [] is_a: CL:0000134 ! mesenchymal cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002541 name: chorionic membrane mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the chorionic membrane." [] is_a: CL:0000134 ! mesenchymal cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0003124 ! chorion relationship: part_of UBERON:0003124 ! chorion created_by: tmeehan creation_date: 2011-02-28T03:04:35Z [Term] id: CL:0002543 name: vein endothelial cell namespace: cell alt_id: CL:1000393 def: "An endothelial cell that is part of the vein." [] synonym: "endothelial cell of vein" EXACT [] synonym: "venous endothelial cell" EXACT [] xref: FMA:62104 xref: KUPO:0001099 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein created_by: tmeehan creation_date: 2011-02-28T03:48:11Z [Term] id: CL:0002544 name: aortic endothelial cell namespace: cell def: "An arterial endothelial cell that is part of the aorta endothelium." [] xref: BTO:0003245 xref: CALOHA:TS-0047 is_a: CL:1000413 ! endothelial cell of artery created_by: tmeehan creation_date: 2011-02-28T03:54:42Z [Term] id: CL:0002545 name: thoracic aorta endothelial cell namespace: cell def: "An endothelial cell that is part of the thoracic endothelium." [] is_a: CL:0002544 ! aortic endothelial cell intersection_of: CL:0002544 ! aortic endothelial cell intersection_of: part_of UBERON:0001515 ! thoracic aorta relationship: part_of UBERON:0001515 ! thoracic aorta created_by: tmeehan creation_date: 2011-02-28T03:59:09Z [Term] id: CL:0002546 name: embryonic blood vessel endothelial progenitor cell namespace: cell def: "An endothelial progenitor cell that participates in angiogenesis during development." [] comment: See CL:0002619. is_a: CL:0000222 ! mesodermal cell is_a: CL:0002371 ! somatic cell created_by: tmeehan creation_date: 2011-02-28T04:20:39Z [Term] id: CL:0002547 name: fibroblast of the aortic adventitia namespace: cell def: "A fibroblast of the aortic adventitia." [] is_a: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia relationship: part_of UBERON:0004664 ! aorta tunica adventitia created_by: tmeehan creation_date: 2011-02-28T04:43:41Z [Term] id: CL:0002548 name: fibroblast of cardiac tissue namespace: cell def: "A fibroblast that is part of the heart." [] synonym: "cardiac fibroblast" EXACT [] is_a: CL:0000057 ! fibroblast is_a: CL:0002494 ! cardiocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart created_by: tmeehan creation_date: 2011-02-28T04:57:44Z [Term] id: CL:0002549 name: fibroblast of choroid plexus namespace: cell def: "A fibroblast that is part of the choroid plexus." [] is_a: CL:0000057 ! fibroblast is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus created_by: tmeehan creation_date: 2011-02-28T05:01:39Z [Term] id: CL:0002550 name: fibroblast of the conjunctiva namespace: cell def: "A fibroblast that is part of the conjuctiva of the eye." [] is_a: CL:0000057 ! fibroblast is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva created_by: tmeehan creation_date: 2011-02-28T05:03:44Z [Term] id: CL:0002551 name: fibroblast of dermis namespace: cell is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2011-02-28T05:05:33Z [Term] id: CL:0002552 name: fibroblast of gingiva namespace: cell is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001828 ! gingiva relationship: part_of UBERON:0001828 ! gingiva created_by: tmeehan creation_date: 2011-02-28T05:09:12Z [Term] id: CL:0002553 name: fibroblast of lung namespace: cell def: "A fibroblast that is part of lung." [] xref: BTO:0000764 xref: CALOHA:TS-0575 is_a: CL:0000057 ! fibroblast is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung created_by: tmeehan creation_date: 2011-02-28T05:11:03Z [Term] id: CL:0002554 name: fibroblast of lymphatic vessel namespace: cell def: "A fibroblast of the lymphatic system." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2011-02-28T05:16:18Z [Term] id: CL:0002555 name: fibroblast of mammary gland namespace: cell def: "A fibroblast that is part of the mammary gland." [] is_a: CL:0000057 ! fibroblast is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland created_by: tmeehan creation_date: 2011-02-28T05:18:38Z [Term] id: CL:0002556 name: fibroblast of periodontium namespace: cell def: "A fibroblast of the periodontium." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001758 ! periodontium relationship: part_of UBERON:0001758 ! periodontium created_by: tmeehan creation_date: 2011-02-28T05:19:48Z [Term] id: CL:0002557 name: fibroblast of pulmonary artery namespace: cell def: "A fibroblast of pulmonary artery." [] is_a: CL:0000057 ! fibroblast is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery created_by: tmeehan creation_date: 2011-02-28T05:22:27Z [Term] id: CL:0002558 name: fibroblast of villous mesenchyme namespace: cell def: "A fibroblast that is part of villous mesenchyme." [] is_a: CL:0000057 ! fibroblast is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2011-02-28T05:24:28Z [Term] id: CL:0002559 name: hair follicle cell namespace: cell def: "An animal cell that is part of a hair follicle." [] is_a: CL:0002371 ! somatic cell is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0002073 ! hair follicle relationship: part_of UBERON:0002073 ! hair follicle created_by: tmeehan creation_date: 2011-03-01T04:11:01Z [Term] id: CL:0002560 name: inner root sheath cell namespace: cell def: "An epithelial cell that resides in the inner root sheath of the hair follicle." [] is_a: CL:0000362 ! epidermal cell is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0002559 ! hair follicle cell intersection_of: part_of UBERON:0005941 ! hair inner root sheath relationship: part_of UBERON:0005941 ! hair inner root sheath created_by: tmeehan creation_date: 2011-03-01T04:27:51Z [Term] id: CL:0002561 name: outer root sheath cell namespace: cell def: "An epithelial cell that is part of the outer root sheath." [] is_a: CL:0000362 ! epidermal cell is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005942 ! hair outer root sheath relationship: part_of UBERON:0005942 ! hair outer root sheath created_by: tmeehan creation_date: 2011-03-01T04:29:47Z [Term] id: CL:0002562 name: hair germinal matrix cell namespace: cell def: "An epidermal cell that is part of the germinal matrix." [] synonym: "trichocyte" EXACT [] is_a: CL:0000362 ! epidermal cell is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000362 ! epidermal cell intersection_of: part_of UBERON:0006004 ! hair follicle matrix region relationship: part_of UBERON:0006004 ! hair follicle matrix region created_by: tmeehan creation_date: 2011-03-01T04:31:06Z [Term] id: CL:0002563 name: intestinal epithelial cell namespace: cell def: "An epithelial cell of the intestine." [] is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001277 ! intestinal epithelium created_by: tmeehan creation_date: 2011-03-01T05:18:31Z [Term] id: CL:0002564 name: nucleus pulposus cell of intervertebral disc namespace: cell def: "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." [] is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0002242 ! nucleus pulposus relationship: part_of UBERON:0002242 ! nucleus pulposus created_by: tmeehan creation_date: 2011-03-02T02:12:23Z [Term] id: CL:0002565 name: iris pigment epithelial cell namespace: cell def: "A pigment cell located in the epithelium of the iris." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0000342 ! pigment cell (sensu Vertebrata) is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: part_of UBERON:0002506 ! iris epithelium relationship: part_of UBERON:0002506 ! iris epithelium created_by: tmeehan creation_date: 2011-03-01T05:28:52Z [Term] id: CL:0002566 name: dark melanocyte namespace: cell def: "A melanocyte that appears darker due to content or amount of melanin granules." [] is_a: CL:0000148 ! melanocyte created_by: tmeehan creation_date: 2011-03-01T05:57:11Z [Term] id: CL:0002567 name: light melanocyte namespace: cell def: "A melanocyte that appears lighter in color." [] is_a: CL:0000148 ! melanocyte created_by: tmeehan creation_date: 2011-03-01T05:58:23Z [Term] id: CL:0002568 name: mesenchymal stem cell of Wharton's jelly namespace: cell def: "A mesenchymal stem cell that is part of Wharton's jelly." [] is_a: CL:0002569 ! mesenchymal stem cell of umbilical cord created_by: tmeehan creation_date: 2011-03-01T09:51:18Z [Term] id: CL:0002569 name: mesenchymal stem cell of umbilical cord namespace: cell def: "A mesenchymal stem cell of the umbilical cord." [] is_a: CL:0000134 ! mesenchymal cell is_a: CL:0000349 ! extraembryonic cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0003422 ! mesenchyme of umbilical cord relationship: part_of UBERON:0003422 ! mesenchyme of umbilical cord created_by: tmeehan creation_date: 2011-03-01T09:55:12Z [Term] id: CL:0002570 name: mesenchymal stem cell of adipose namespace: cell def: "A mesenchymal stem cell of adipose tissue." [] is_a: CL:0000134 ! mesenchymal cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: part_of UBERON:0001013 ! adipose tissue created_by: tmeehan creation_date: 2011-03-01T09:57:17Z [Term] id: CL:0002571 name: hepatic mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of liver." [] is_a: CL:0000134 ! mesenchymal cell is_a: CL:0002195 ! hepatic stem cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2011-03-01T09:58:51Z [Term] id: CL:0002572 name: vertebral mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the vertebrae." [] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0000134 ! mesenchymal cell is_a: CL:0001035 ! bone cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0002412 ! vertebra relationship: part_of UBERON:0002412 ! vertebra created_by: tmeehan creation_date: 2011-03-01T10:40:27Z [Term] id: CL:0002573 name: Schwann cell namespace: cell def: "A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function." [GOC:tfm] xref: BTO:0001220 xref: CALOHA:TS-0898 is_a: CL:0000243 ! glial cell (sensu Vertebrata) intersection_of: CL:0000243 ! glial cell (sensu Vertebrata) intersection_of: part_of UBERON:0000010 ! peripheral nervous system relationship: part_of UBERON:0000010 ! peripheral nervous system created_by: tmeehan creation_date: 2011-03-02T01:19:27Z [Term] id: CL:0002574 name: stromal cell of pancreas namespace: cell def: "A stromal cell of the pancreas." [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2011-03-02T02:40:41Z [Term] id: CL:0002575 name: central nervous system pericyte namespace: cell def: "A pericyte of the central nervous system." [] is_a: CL:0000669 ! pericyte cell is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000669 ! pericyte cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system created_by: tmeehan creation_date: 2011-03-02T02:54:18Z [Term] id: CL:0002576 name: perineural cell namespace: cell def: "A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement." [] is_a: CL:0000186 ! myofibroblast cell is_a: CL:0002319 ! neural cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000186 ! myofibroblast cell intersection_of: part_of UBERON:0000121 ! perineurium relationship: part_of UBERON:0000121 ! perineurium created_by: tmeehan creation_date: 2011-03-02T03:03:58Z [Term] id: CL:0002577 name: placental epithelial cell namespace: cell def: "An epithelial cell of the placenta." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0000349 ! extraembryonic cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2011-03-02T03:21:30Z [Term] id: CL:0002578 name: mesenteric preadipocyte namespace: cell def: "A preadipocyte found in mesenteric tissue." [] is_a: CL:0002334 ! preadipocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0002095 ! mesentery relationship: part_of UBERON:0002095 ! mesentery created_by: tmeehan creation_date: 2011-03-03T04:19:40Z [Term] id: CL:0002579 name: omentum preadipocyte namespace: cell is_a: CL:0002334 ! preadipocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0003688 ! omentum relationship: part_of UBERON:0003688 ! omentum created_by: tmeehan creation_date: 2011-03-03T04:19:42Z [Term] id: CL:0002580 name: preadipocyte of the breast namespace: cell def: "A preadipocyte that is part of the breast." [] is_a: CL:0002334 ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000310 ! breast created_by: tmeehan creation_date: 2011-03-03T04:19:46Z [Term] id: CL:0002581 name: perirenal preadipocyte namespace: cell is_a: CL:0002334 ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0005406 ! perirenal fat relationship: part_of UBERON:0005406 ! perirenal fat created_by: tmeehan creation_date: 2011-03-03T04:20:04Z [Term] id: CL:0002582 name: visceral preadipocyte namespace: cell def: "A preadipocyte that is part of visceral tissue." [] is_a: CL:0002334 ! preadipocyte created_by: tmeehan creation_date: 2011-03-03T04:32:56Z [Term] id: CL:0002583 name: subcutaneous preadipocyte namespace: cell def: "A preadipocyte that is part of subcutaneous tissue." [] is_a: CL:0002334 ! preadipocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0002072 ! hypodermis created_by: tmeehan creation_date: 2011-03-03T04:33:01Z [Term] id: CL:0002584 name: renal cortical epithelial cell namespace: cell def: "An epithelial cell of the kidney cortex." [] xref: KUPO:0001016 is_a: CL:0002518 ! kidney epithelial cell is_a: CL:0002681 ! kidney cortical cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: part_of UBERON:0001225 ! cortex of kidney [Term] id: CL:0002585 name: retinal blood vessel endothelial cell namespace: cell def: "A blood vessel endothelial cell that is part of the retina." [] is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina created_by: tmeehan creation_date: 2011-03-06T03:28:27Z [Term] id: CL:0002586 name: retinal pigment epithelial cell namespace: cell def: "An epithelial cell of the retinal pigmented epithelium." [] xref: BTO:0004910 xref: FMA:75802 is_a: CL:0000066 ! epithelial cell is_a: CL:0000149 ! visual pigment cell is_a: CL:0009004 ! retinal cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001782 ! pigmented layer of retina relationship: has_part GO:0042470 relationship: part_of UBERON:0001782 ! pigmented layer of retina created_by: tmeehan creation_date: 2011-03-06T03:37:09Z [Term] id: CL:0002588 name: smooth muscle cell of the umbilical vein namespace: cell def: "A smooth muscle cell of the umbilical vein." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002066 ! umbilical vein relationship: part_of UBERON:0002066 ! umbilical vein created_by: tmeehan creation_date: 2011-03-06T05:00:51Z [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature namespace: cell def: "A smooth muscle cell of the bachiocephalic vasculature." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001529 ! brachiocephalic artery relationship: part_of UBERON:0001529 ! brachiocephalic artery created_by: tmeehan creation_date: 2011-03-06T05:00:58Z [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature namespace: cell def: "A vascular associated smooth muscle cell of the brain vasculature." [] is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure created_by: tmeehan creation_date: 2011-03-06T05:01:20Z [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery namespace: cell def: "A smooth muscle of the pulmonary artery." [] xref: BTO:0003336 is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery created_by: tmeehan creation_date: 2011-03-06T05:01:28Z [Term] id: CL:0002592 name: smooth muscle cell of the coronary artery namespace: cell def: "A smooth muscle cell of the coronary artery." [] is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001621 ! coronary artery relationship: part_of UBERON:0001621 ! coronary artery created_by: tmeehan creation_date: 2011-03-06T05:01:34Z [Term] id: CL:0002593 name: smooth muscle cell of the internal thoracic artery namespace: cell def: "A smooth muscle of the internal thoracic artery." [] is_a: CL:0002595 ! smooth muscle cell of the subclavian artery intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002456 ! internal thoracic artery relationship: part_of UBERON:0002456 ! internal thoracic artery created_by: tmeehan creation_date: 2011-03-06T05:01:41Z [Term] id: CL:0002594 name: smooth muscle cell of the umbilical artery namespace: cell def: "A smooth muscle cell of the umbilical artery." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001310 ! umbilical artery relationship: part_of UBERON:0001310 ! umbilical artery created_by: tmeehan creation_date: 2011-03-06T05:01:48Z [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery namespace: cell def: "A smooth muscle cell of the subclavian artery." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001533 ! subclavian artery relationship: part_of UBERON:0001533 ! subclavian artery created_by: tmeehan creation_date: 2011-03-06T05:01:52Z [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery namespace: cell def: "Smooth muscle cell of the carotid artery." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0005396 ! carotid artery segment relationship: part_of UBERON:0005396 ! carotid artery segment created_by: tmeehan creation_date: 2011-03-06T05:01:56Z [Term] id: CL:0002597 name: smooth muscle cell of bladder namespace: cell def: "A smooth muscle cell of the bladder." [] xref: KUPO:0001122 is_a: CL:0000192 ! smooth muscle cell is_a: CL:1001319 ! bladder cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001255 ! urinary bladder created_by: tmeehan creation_date: 2011-03-06T05:43:24Z [Term] id: CL:0002598 name: bronchial smooth muscle cell namespace: cell xref: BTO:0004402 is_a: CL:0000192 ! smooth muscle cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2011-03-06T05:46:39Z [Term] id: CL:0002599 name: smooth muscle cell of the esophagus namespace: cell def: "A smooth muscle cell of the esophagus." [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2011-03-06T05:48:17Z [Term] id: CL:0002600 name: smooth muscle cell of trachea namespace: cell def: "A smooth muscle cell of the trachea." [] is_a: CL:0000192 ! smooth muscle cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea created_by: tmeehan creation_date: 2011-03-06T05:50:28Z [Term] id: CL:0002601 name: uterine smooth muscle cell namespace: cell def: "A smooth muscle cell of the uterus." [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus created_by: tmeehan creation_date: 2011-03-06T05:53:28Z [Term] id: CL:0002602 name: annulus pulposus cell namespace: cell synonym: "anulus pulposus cell" EXACT [] is_a: CARO:0000000 is_a: CARO:0000003 ! anatomical structure is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis relationship: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis created_by: tmeehan creation_date: 2011-03-06T06:50:53Z [Term] id: CL:0002603 name: astrocyte of the cerebellum namespace: cell def: "An astrocyte of the cerebellum." [] is_a: CL:0000127 ! astrocyte is_a: CL:2000005 ! brain macroglial cell intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum created_by: tmeehan creation_date: 2011-03-06T06:57:27Z [Term] id: CL:0002604 name: astrocyte of the hippocampus namespace: cell is_a: CL:0002605 ! astrocyte of the cerebral cortex is_a: CL:1001580 ! hippocampus glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0001954 ! Ammon's horn created_by: tmeehan creation_date: 2011-03-06T06:57:33Z [Term] id: CL:0002605 name: astrocyte of the cerebral cortex namespace: cell def: "An astrocyte of the cerebral cortex." [] is_a: CL:0012000 ! astrocyte of the forebrain is_a: CL:1001579 ! cerebral cortex glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0000956 ! cerebral cortex created_by: tmeehan creation_date: 2011-03-06T06:57:36Z [Term] id: CL:0002606 name: astrocyte of the spinal cord namespace: cell def: "An astrocyte of the spinal cord." [] is_a: CL:0000127 ! astrocyte is_a: CL:2000025 ! spinal cord oligodendrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0002240 ! spinal cord created_by: tmeehan creation_date: 2011-03-06T07:11:26Z [Term] id: CL:0002607 name: migratory enteric neural crest cell namespace: cell def: "A neural crest cell that gives rise to cells of the enteric nervous system." [] is_a: CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2011-03-06T07:24:35Z [Term] id: CL:0002608 name: hippocampal neuron namespace: cell def: "A neuron of the hippocampus." [] is_a: CL:0002609 ! neuron of cerebral cortex intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn created_by: tmeehan creation_date: 2011-03-06T07:31:49Z [Term] id: CL:0002609 name: neuron of cerebral cortex namespace: cell def: "A CNS neuron of the cerebral cortex." [] synonym: "cortical neuron" EXACT [] xref: BTO:0004102 xref: FMA:84104 is_a: CL:0010012 ! cerebral cortex neuron is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0000956 ! cerebral cortex created_by: tmeehan creation_date: 2011-03-06T07:37:08Z [Term] id: CL:0002610 name: raphe nuclei neuron namespace: cell def: "A neuron of the raphe nuclei." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0004684 ! raphe nuclei relationship: part_of UBERON:0004684 ! raphe nuclei created_by: tmeehan creation_date: 2011-03-06T07:42:06Z [Term] id: CL:0002611 name: neuron of the dorsal spinal cord namespace: cell def: "A CNS neuron of the dorsal spinal cord." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002256 ! dorsal horn of spinal cord relationship: part_of UBERON:0002256 ! dorsal horn of spinal cord created_by: tmeehan creation_date: 2011-03-06T07:43:34Z [Term] id: CL:0002612 name: neuron of the ventral spinal cord namespace: cell def: "A neuron of the ventral spinal cord." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002257 ! ventral horn of spinal cord relationship: part_of UBERON:0002257 ! ventral horn of spinal cord created_by: tmeehan creation_date: 2011-03-06T07:46:03Z [Term] id: CL:0002613 name: striatum neuron namespace: cell def: "A neuron of the striatum." [] is_a: CL:0012001 ! neuron of the forebrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002435 ! striatum relationship: part_of UBERON:0002435 ! striatum created_by: tmeehan creation_date: 2011-03-06T07:47:12Z [Term] id: CL:0002614 name: neuron of the substantia nigra namespace: cell def: "A neuron of the substantia nigra." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002038 ! substantia nigra relationship: part_of UBERON:0002038 ! substantia nigra created_by: tmeehan creation_date: 2011-03-06T07:48:42Z [Term] id: CL:0002615 name: adipocyte of omentum tissue namespace: cell def: "A fat cell that is part of omentum tissue." [] synonym: "omental adipocyte" EXACT [] synonym: "omental fat cell" EXACT [] is_a: CL:0000136 ! fat cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0003688 ! omentum relationship: part_of UBERON:0003688 ! omentum created_by: tmeehan creation_date: 2011-03-14T10:17:00Z [Term] id: CL:0002616 name: perirenal adipocyte cell namespace: cell def: "A fat cell of perirenal fat tissue." [] synonym: "perirenal fat cell" EXACT [] is_a: CL:0000136 ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0005406 ! perirenal fat relationship: part_of UBERON:0005406 ! perirenal fat created_by: tmeehan creation_date: 2011-03-14T10:17:05Z [Term] id: CL:0002617 name: adipocyte of breast namespace: cell def: "A fat cell that is part of the breast." [] comment: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA] synonym: "breast adipocyte" EXACT [] synonym: "fat cell of breast" EXACT [] xref: CALOHA:TS-2377 is_a: CL:0000136 ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000310 ! breast created_by: tmeehan creation_date: 2011-03-14T10:17:07Z [Term] id: CL:0002618 name: endothelial cell of umbilical vein namespace: cell def: "An endothelial cell of the umbilical vein." [] xref: BTO:0004296 is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002066 ! umbilical vein relationship: part_of UBERON:0002066 ! umbilical vein created_by: tmeehan creation_date: 2011-03-14T11:36:51Z [Term] id: CL:0002619 name: adult endothelial progenitor cell namespace: cell def: "An adult angioblastic cell released from the bone marrow, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells. Their existence is controversial." [] synonym: "EPC" EXACT [] is_a: CL:0000566 ! angioblastic mesenchymal cell created_by: tmeehan creation_date: 2011-03-14T12:11:18Z [Term] id: CL:0002620 name: skin fibroblast namespace: cell def: "A fibroblast of skin." [] xref: BTO:0001255 xref: CALOHA:TS-0935 is_a: CL:0000057 ! fibroblast is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body created_by: tmeehan creation_date: 2011-03-14T12:31:49Z [Term] id: CL:0002621 name: gingival epithelial cell namespace: cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001949 ! gingival epithelium relationship: part_of UBERON:0001949 ! gingival epithelium created_by: tmeehan creation_date: 2011-03-14T12:46:28Z [Term] id: CL:0002622 name: prostate stromal cell namespace: cell def: "A stromal cell of the prostate." [] xref: BTO:0003972 is_a: CL:0000499 ! stromal cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2011-03-14T02:11:10Z [Term] id: CL:0002623 name: acinar cell of salivary gland namespace: cell def: "An acinar cell of salivary gland." [] is_a: CL:0000622 ! acinar cell is_a: CL:1001596 ! salivary gland glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001044 ! saliva-secreting gland created_by: tmeehan creation_date: 2011-03-14T02:22:22Z [Term] id: CL:0002624 name: paneth cell of the appendix namespace: cell def: "A paneth cell of the appendix." [] is_a: CL:0000510 ! paneth cell is_a: CL:1001585 ! appendix glandular cell intersection_of: CL:0000510 ! paneth cell intersection_of: part_of UBERON:0001154 ! vermiform appendix created_by: tmeehan creation_date: 2011-03-15T09:38:18Z [Term] id: CL:0002625 name: seminiferous tubule epithelial cell namespace: cell def: "A cell of the seminiferous tubule epithelium." [] is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0004813 ! seminiferous tubule epithelium created_by: tmeehan creation_date: 2011-03-15T11:59:23Z [Term] id: CL:0002626 name: immature astrocyte namespace: cell def: "An immature astrocyte." [] synonym: "immature astrocytic glia" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0002627 name: mature astrocyte namespace: cell def: "A mature astrocyte that is capable of producing cytokines." [] comment: Mature astrocytes are reportedly able to produce aspartate, ATP, BDNF, BMP-2a, BMP-3, CCL2, CCL3, CCL4, CCL5, CCL19, CCL20,CD40L, CNTF, CTGF, CXCL1, CXCL2, CXCL8, edn-1, aFGF, bFGF, G-CSF, glutamate, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, IGF-1, IL-1alpha, IL-1beta, IL-2, Il-4, IL-6, IL-10, IL-12, LIF, MIP-2, NGF, nitric oxide, NT3, taurine, TGF-beta, TNF-alpha, TNF-beta. synonym: "activated astrocyte" EXACT [] synonym: "mature astrocytic glia" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0002628 name: immature microglial cell namespace: cell def: "An immature microglial cell with a ramified morphology." [] comment: Immature microglia are reportedly CD34-positive, CD163-negative, MHCI-negative, MHCII-negative. synonym: "immature microglia" EXACT [] synonym: "quiescent microglia" EXACT [] synonym: "resting microglia" EXACT [] is_a: CL:0000129 ! microglial cell [Term] id: CL:0002629 name: mature microglial cell namespace: cell def: "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." [] comment: Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha. synonym: "activated microglia" EXACT [] synonym: "mature microglia" EXACT [] synonym: "reactive microglia" EXACT [] is_a: CL:0000129 ! microglial cell intersection_of: CL:0000129 ! microglial cell intersection_of: capable_of GO:0001816 intersection_of: capable_of GO:0002536 intersection_of: capable_of GO:0002537 intersection_of: capable_of GO:0006909 ! phagocytosis intersection_of: capable_of GO:0019882 relationship: capable_of GO:0001816 relationship: capable_of GO:0002536 relationship: capable_of GO:0002537 relationship: capable_of GO:0019882 [Term] id: CL:0002630 name: actinomycete-type spore namespace: cell def: "A spore formed from bacteria in the order Actinomycetales." [] is_a: CL:0000520 ! prokaryotic cell created_by: tmeehan creation_date: 2011-06-16T01:01:41Z [Term] id: CL:0002631 name: epithelial cell of upper respiratory tract namespace: cell is_a: CL:0002368 ! respiratory epithelial cell intersection_of: CL:0002368 ! respiratory epithelial cell intersection_of: part_of UBERON:0001557 ! upper respiratory tract relationship: part_of UBERON:0001557 ! upper respiratory tract created_by: tmeehan creation_date: 2011-06-21T12:28:55Z [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract namespace: cell is_a: CL:0002368 ! respiratory epithelial cell intersection_of: CL:0002368 ! respiratory epithelial cell intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract created_by: tmeehan creation_date: 2011-06-21T12:29:31Z [Term] id: CL:0002633 name: respiratory basal cell namespace: cell def: "A basal cell in the respiratory tract." [] synonym: "airway basal cell" EXACT [] synonym: "airway basal stem cell" EXACT [] is_a: CL:0000646 ! basal cell is_a: CL:0002368 ! respiratory epithelial cell created_by: tmeehan creation_date: 2011-06-21T03:11:10Z [Term] id: CL:0002634 name: epithelial cell of anal column namespace: cell def: "An epithelial cell of the anal column." [] is_a: CL:0002253 ! epithelial cell of large intestine is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0009882 ! anal column relationship: part_of UBERON:0009882 ! anal column created_by: tmeehan creation_date: 2011-07-08T12:11:38Z [Term] id: CL:0002635 name: nonkeratinized epithelial cell of anal column namespace: cell def: "A nonkeratinized epithelial cell of the anal canal." [] xref: FMA:263146 is_a: CL:0002634 ! epithelial cell of anal column created_by: tmeehan creation_date: 2011-07-08T02:05:33Z [Term] id: CL:0002636 name: nonkeratinized epithelial cell of inferior part of anal canal namespace: cell def: "A nonkeratinized cell epithleial cell of the inferior part of the anal canal." [] xref: FMA:263144 is_a: CL:0002635 ! nonkeratinized epithelial cell of anal column is_a: CL:1000438 ! epithelial cell of wall of inferior part of anal canal created_by: tmeehan creation_date: 2011-07-08T02:06:53Z [Term] id: CL:0002637 name: keratinized epithelial cell of the anal canal namespace: cell def: "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." [] is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002634 ! epithelial cell of anal column intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0000159 ! anal canal created_by: tmeehan creation_date: 2011-07-08T02:08:40Z [Term] id: CL:0002638 name: bronchioalveolar stem cell namespace: cell def: "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc." [] synonym: "basal epithelial cell of bronchioalveolar duct junction" EXACT [] synonym: "BASC" EXACT [] is_a: CL:1000350 ! basal cell of epithelium of terminal bronchiole is_a: CL:1000351 ! basal cell of epithelium of respiratory bronchiole intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001955 ! epithelium of respiratory bronchiole intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium created_by: tmeehan creation_date: 2011-06-21T03:26:08Z [Term] id: CL:0002639 name: amniotic stem cell namespace: cell def: "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" [] comment: Not clear to me if amniotic stem cell is a different cell type from amnion mesenchymal stem cells. They are treated as distinct in the literature as isolations methods are different, so I will keep them as separate terms for now. is_a: CL:0000134 ! mesenchymal cell is_a: CL:0002323 ! amniocyte created_by: tmeehan creation_date: 2011-06-21T03:55:39Z [Term] id: CL:0002640 name: amniotic epithelial stem cell namespace: cell def: "An epithelial fate stem cell derived form the amnion membrane." [] is_a: CL:0000036 ! epithelial fate stem cell created_by: tmeehan creation_date: 2011-06-21T04:06:17Z [Term] id: CL:0002641 name: epithelial cell of esophageal gland proper namespace: cell def: "An epithelial cell of the esophageal gland proper." [] xref: FMA:256141 is_a: CL:0002657 ! glandular cell of esophagus created_by: tmeehan creation_date: 2011-07-08T02:16:51Z [Term] id: CL:0002642 name: epithelial cell of esophageal cardiac gland namespace: cell def: "An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia." [] xref: FMA:256143 is_a: CL:0002657 ! glandular cell of esophagus created_by: tmeehan creation_date: 2011-07-08T02:16:54Z [Term] id: CL:0002643 name: nonkeratinized cell of stratum corneum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin." [] xref: FMA:263148 is_a: CL:0002654 ! epithelial cell of stratum corneum of esophageal epithelium created_by: tmeehan creation_date: 2011-07-08T02:22:09Z [Term] id: CL:0002644 name: endo-epithelial cell of tympanic part of viscerocranial mucosa namespace: cell def: "An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa." [] xref: FMA:70628 is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:25:44Z [Term] id: CL:0002645 name: endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa namespace: cell def: "An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa." [] xref: FMA:70629 is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:25:46Z [Term] id: CL:0002646 name: obsolete epithelial cell of buccal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the buccal region of the viscerocranial mucosa." [] xref: FMA:70577 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:34:12Z [Term] id: CL:0002647 name: obsolete epithelial cell of anterior palatal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the palatal region of the viscerocranial mucosa." [] xref: FMA:70580 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:34:14Z [Term] id: CL:0002648 name: obsolete epithelial cell of nasal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the nasal region of the viscerocranial mucosa." [] xref: FMA:70554 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:36:06Z [Term] id: CL:0002649 name: obsolete epithelial cell of gingival part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the gingival region of the viscerocranial mucosa." [] xref: FMA:70579 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:36:11Z [Term] id: CL:0002650 name: obsolete epithelial cell of paranasal sinus part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa." [] xref: FMA:70578 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:38:18Z [Term] id: CL:0002651 name: endothelial cell of venous sinus of spleen namespace: cell def: "An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits." [] synonym: "stave cell" EXACT [] xref: FMA:72140 is_a: CL:0002262 ! endothelial cell of sinusoid created_by: tmeehan creation_date: 2011-07-08T03:06:49Z [Term] id: CL:0002652 name: endothelial cell of high endothelial venule namespace: cell def: "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [] comment: Markers expressed on HEV include: MAdCAM-1,PNAd (sulfated and glycosylated molecules, i.e. GlyCAM-1, CD34, endomucin, nepmucin), ICAM-1, ICAM-2,Fuc-TVII, beta 3GlcNAcT-3, GlcNAc6ST2,CCL21, CCL19, CXCL13, CXCL12, Autotaxin, DARC, angiomodulin, LRHG. synonym: "endothelial cell of postcapillary venule of lymph node" EXACT [] synonym: "HEV cell" EXACT [] xref: FMA:67759 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:1000414 ! endothelial cell of venule created_by: tmeehan creation_date: 2011-07-08T03:14:10Z [Term] id: CL:0002653 name: squamous endothelial cell namespace: cell def: "A endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells." [] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:1000414 ! endothelial cell of venule created_by: tmeehan creation_date: 2011-07-08T03:31:25Z [Term] id: CL:0002654 name: epithelial cell of stratum corneum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum corneum of esophageal epithelium." [] xref: FMA:70733 is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2011-07-08T03:46:35Z [Term] id: CL:0002655 name: epithelial cell of stratum spinosum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum spinosum of esophageal epithelium." [] xref: FMA:70732 is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2011-07-08T03:48:26Z [Term] id: CL:0002656 name: glandular cell of endometrium namespace: cell def: "A glandular epithelial cell of the endometrium." [] xref: FMA:86489 is_a: CL:1001591 ! oviduct glandular cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium created_by: tmeehan creation_date: 2011-07-08T03:54:08Z [Term] id: CL:0002657 name: glandular cell of esophagus namespace: cell def: "A glandular epithelial cell of the esophagus." [] xref: FMA:86548 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2011-07-08T03:55:57Z [Term] id: CL:0002658 name: glandular cell of the large intestine namespace: cell def: "A glandular epithelial cell of the large intestine." [] xref: FMA:87194 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2011-07-08T04:03:01Z [Term] id: CL:0002659 name: glandular cell of stomach namespace: cell def: "A glandular epithelial cell that is part of the stomach." [] xref: CALOHA:TS-1284 xref: FMA:86554 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2011-07-11T01:20:35Z [Term] id: CL:0002660 name: luminal cell of acinus of lactiferous gland namespace: cell def: "A luminal epithelial cell of mammary gland located in acinus of structure." [] comment: Consider if synonymous with mammary alveolar cell CL:0002325. Some use this term to refer to the non-lactating cell type that gives rise to the lactating cell type. xref: FMA:74505 is_a: CL:0002326 ! luminal epithelial cell of mammary gland created_by: tmeehan creation_date: 2011-07-11T01:44:31Z [Term] id: CL:0002661 name: luminal cell of lactiferous terminal ductal lobular unit namespace: cell def: "A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into." [] xref: FMA:87168 is_a: CL:0002662 ! luminal cell of lactiferous duct created_by: tmeehan creation_date: 2011-07-11T01:44:33Z [Term] id: CL:0002662 name: luminal cell of lactiferous duct namespace: cell def: "A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive." [] xref: FMA:74504 xref: FMA:74505 is_a: CL:0002326 ! luminal epithelial cell of mammary gland created_by: tmeehan creation_date: 2011-07-11T01:44:48Z [Term] id: CL:0002663 name: myocardial endocrine cell of atrium namespace: cell def: "A myocardial endocrine cell that is part of the atrium." [] xref: FMA:83389 is_a: CL:0002074 ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium created_by: tmeehan creation_date: 2011-07-11T02:45:39Z [Term] id: CL:0002664 name: cardioblast namespace: cell def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2011-07-11T03:15:38Z [Term] id: CL:0002665 name: otic fibrocyte namespace: cell def: "A fibrocyte of the cochlea that has specialized structural and molecular adaptions." [] is_a: CL:0000135 ! fibrocyte is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0006725 ! spiral ligament created_by: tmeehan creation_date: 2011-07-11T03:35:01Z [Term] id: CL:0002666 name: type 2 otic fibrocyte namespace: cell def: "An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [] synonym: "type II otic fibrocyte" EXACT [] synonym: "type II spiral ligament fibrocyte" EXACT [] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:40Z [Term] id: CL:0002667 name: type 5 otic fibrocyte namespace: cell def: "An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [] synonym: "type V otic fibrocyte" EXACT [] synonym: "type V spiral ligament fibrocyte" EXACT [] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:42Z [Term] id: CL:0002668 name: type 4 otic fibrocyte namespace: cell def: "An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall." [] synonym: "type IV otic fibrocyte" EXACT [] synonym: "type IV spiral ligament fibrocyte" EXACT [] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:46Z [Term] id: CL:0002669 name: type 3 otic fibrocyte namespace: cell def: "An otic fibrocyte that lines the otic capsule." [] synonym: "type III otic fibrocyte" EXACT [] synonym: "type III spiral ligament fibrocyte" EXACT [] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:50Z [Term] id: CL:0002670 name: type 1 otic fibrocyte namespace: cell def: "An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [] synonym: "type I otic fibrocyte" EXACT [] synonym: "type I spiral ligament fibrocyte" EXACT [] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:39:27Z [Term] id: CL:0002671 name: endothelial stalk cell namespace: cell def: "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." [] is_a: CL:0000071 ! blood vessel endothelial cell created_by: tmeehan creation_date: 2011-08-16T01:49:32Z [Term] id: CL:0002672 name: retinal progenitor cell namespace: cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [] is_a: CL:0000048 ! multi fate stem cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000133 ! neurectodermal cell created_by: tmeehan creation_date: 2011-08-16T02:38:01Z [Term] id: CL:0002673 name: tongue muscle cell namespace: cell def: "A skeletal muscle cell that is part of the tongue." [] is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: part_of UBERON:0000378 ! tongue muscle relationship: part_of UBERON:0000378 ! tongue muscle created_by: tmeehan creation_date: 2011-08-16T03:10:02Z [Term] id: CL:0002674 name: H minus namespace: cell def: "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." [] synonym: "H- cell" EXACT [] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2011-08-16T03:20:53Z [Term] id: CL:0002675 name: H plus namespace: cell def: "A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus." [] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2011-08-16T03:20:58Z [Term] id: CL:0002676 name: neural crest derived neuroblast namespace: cell def: "A neuroblast derived from a neural crest cell." [] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2011-08-22T09:24:15Z [Term] id: CL:0002677 name: naive regulatory T cell namespace: cell def: "A regulatory T cell that has not encountered antigen." [] comment: This cell type has been described as CD45RA-negative, but this doesn't fit with our current definition of naive T cell. synonym: "naive regulatory T lymphocyte" EXACT [] synonym: "naive regulatory T-cell" EXACT [] synonym: "naive regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000898 ! naive T cell created_by: tmeehan creation_date: 2011-08-25T03:17:21Z [Term] id: CL:0002678 name: memory regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." [] comment: Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell. is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000813 ! memory T cell created_by: tmeehan creation_date: 2011-08-25T03:17:34Z [Term] id: CL:0002679 name: natural helper lymphocyte namespace: cell def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [] is_a: CL:0000542 ! lymphocyte relationship: has_part PR:000002065 relationship: has_part PR:000002979 created_by: tmeehan creation_date: 2011-08-29T10:08:02Z [Term] id: CL:0002680 name: PP cell of intestine namespace: cell def: "A PP cell found in intestine." [] is_a: CL:0000696 ! PP cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000160 ! intestine created_by: tmeehan creation_date: 2011-09-27T11:59:01Z [Term] id: CL:0002681 name: kidney cortical cell namespace: cell is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney created_by: terryh creation_date: 2011-10-25T03:49:41Z [Term] id: CL:0005000 name: spinal cord interneuron namespace: cell def: "A CNS interneuron located in the spinal cord." [] comment: Is_a interneuron, part_of UBERON:0002240. is_a: CL:0000402 ! CNS interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: CL:0005001 name: iridoblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [] comment: Derived from UBERON:0002342 neural crest. is_a: CL:0000055 ! non-terminally differentiated cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: existence_ends_during_or_before ZFS:0000032 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:High-pec relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0005002 name: xanthoblast namespace: cell def: "A non-terminally differentiated cell that differentiates into a xanthophore." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: existence_ends_during_or_before ZFS:0000032 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Pharyngula:High-pec relationship: existence_starts_during_or_after ZFS:0000000 {gci_relation="part_of", gci_filler="NCBITaxon:7954"} ! Unknown [Term] id: CL:0005003 name: leucoblast namespace: cell def: "A non-term