format-version: 1.2
data-version: uberon/releases/2019-06-27/ext.owl
subsetdef: cumbo "CUMBO"
subsetdef: cyclostome_subset "cyclostome structures"
subsetdef: defined_by_cytoarchitecture "brain region defined by cyto-architecture"
subsetdef: defined_by_ordinal_series "classes that are defined by relative position counting from first in a series of elements along an axis in an individual organism rather than by strict homology"
subsetdef: developmental_classification "developmental_classification"
subsetdef: dubious_grouping "Indicates that subclasses in AOs may be inappropriately linked"
subsetdef: early_development "A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes."
subsetdef: efo_slim "EFO slim"
subsetdef: emapa_ehdaa2 "derived from the union of EHDAA2 and EMAPA - still to be checked"
subsetdef: feed_aligned "subset of classes that have logical defs text defs and synonyms aligned with FEED"
subsetdef: functional_classification "functional_classification"
subsetdef: grouping_class "Subset consisting of classes creating for grouping purposes"
subsetdef: homology_grouping "A grouping class that depends on an assumption of homology between subclasses"
subsetdef: inconsistent_with_fma "classes that have some inconsistency with FMA"
subsetdef: major_organ "somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord,  peripheral nerves, kidneys, ureters, bladder, urethra, gonads"
subsetdef: metazoa_core "core classes typically found across metazoa. one purpose is to create a rough set of terms that could be used to start a new metazoan AO. Note this subset is not yet fully fleshed out"
subsetdef: non_informative "abstract class brought in to group ontology classes but not informative"
subsetdef: organ_slim "organs, excluding individual muscles and skeletal elements"
subsetdef: pheno_slim "Phenotype slim"
subsetdef: phenotype_rcn "A subset specifically created for the 2012 Phenotype RCN meeting. Includes some human-specific terms that may eventually be removed when they are adequately represented with part of relationships in FMA"
subsetdef: uberon_slim "Uberon slim - subset that excludes obscure terms and deep compositional terms"
subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis"
subsetdef: unverified_taxonomic_grouping "Indicates that the class encompasses classes from other AOs that have not been verified"
subsetdef: upper_level "abstract upper-level terms not directly useful for analysis"
subsetdef: vertebrate_core "core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO"
synonymtypedef: ABBREVIATION "abbreviation"
synonymtypedef: BRAIN_NAME_ABV ""
synonymtypedef: COMPARATIVE_PREFERRED "preferred term in the context of comparative anatomy"
synonymtypedef: DEPRECATED "A historic synonym, no longer encouraged"
synonymtypedef: DEVELOPMENTAL "developmental term"
synonymtypedef: DUBIOUS "dubious or contested synonym"
synonymtypedef: HOMOLOGY "a synonym made on the basis of a possibly homologous structure in another species"
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: INCONSISTENT "indicates that a synonym is used in an inconsistent or confusing way, typically between species"
synonymtypedef: LATIN "latin term"
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
synonymtypedef: NON_AMNIOTE "synonym that is inappropriate for amniotes"
synonymtypedef: NON_MAMMAL "synonym that is inappropriate for mammals"
synonymtypedef: PENDING_REVIEW "expert consultation and attribution required"
synonymtypedef: PLURAL "plural term"
synonymtypedef: PLURAL "plurals"
synonymtypedef: SENSU "taxonomic disambiguation"
synonymtypedef: SYSTEMATIC "a systematic synonym used as the base name for design patterns"
default-namespace: uberon
treat-xrefs-as-equivalent: AEO
treat-xrefs-as-equivalent: BILA
treat-xrefs-as-equivalent: BSPO
treat-xrefs-as-equivalent: CARO
treat-xrefs-as-equivalent: EFO
treat-xrefs-as-equivalent: GO
treat-xrefs-as-equivalent: OG
treat-xrefs-as-equivalent: VSAO
treat-xrefs-as-is_a: VHOG
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remark: Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/uberon/go_import.owl>) VersionIRI(<http://purl.obolibrary.org/obo/uberon/releases/2019-06-27/go_import.owl>))) [Axioms: 6910 Logical Axioms: 4109]
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remark: Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/uberon/nbo_import.owl>) VersionIRI(<http://purl.obolibrary.org/obo/uberon/releases/2013-10-21/nbo_import.owl>))) [Axioms: 30 Logical Axioms: 9]
remark: Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/uberon/ncbitaxon_import.owl>) VersionIRI(<http://purl.obolibrary.org/obo/uberon/releases/2019-06-27/ncbitaxon_import.owl>))) [Axioms: 1637 Logical Axioms: 923]
remark: Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/uberon/pato_import.owl>) VersionIRI(<http://purl.obolibrary.org/obo/uberon/releases/2019-06-27/pato_import.owl>))) [Axioms: 330 Logical Axioms: 110]
remark: Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/uberon/pr_import.owl>) VersionIRI(<http://purl.obolibrary.org/obo/uberon/releases/2019-06-27/pr_import.owl>))) [Axioms: 42 Logical Axioms: 13]
remark: Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/uberon/reflexivity_axioms.owl>) VersionIRI(<null>))) [Axioms: 2 Logical Axioms: 2]
remark: Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/uberon/ro_import.owl>) VersionIRI(<null>))) [Axioms: 1110 Logical Axioms: 474]
ontology: uberon/ext
property_value: dc-contributor "Alan Ruttenberg" xsd:string
property_value: dc-contributor "Alexander Diehl" xsd:string
property_value: dc-contributor "Ann Maglia" xsd:string
property_value: dc-contributor "Anna Anagnostopoulos" xsd:string
property_value: dc-contributor "Bgee Project - http://bgee.unil.ch" xsd:string
property_value: dc-contributor "Bill Bug" xsd:string
property_value: dc-contributor "Brian K Hall" xsd:string
property_value: dc-contributor "Carlo Torniai" xsd:string
property_value: dc-contributor "Catherine Leroy" xsd:string
property_value: dc-contributor "Ceri Van Slyke" xsd:string
property_value: dc-contributor "Cynthia Smith" xsd:string
property_value: dc-contributor "David Hill" xsd:string
property_value: dc-contributor "David Osumi-Sutherland" xsd:string
property_value: dc-contributor "Duncan Davidson" xsd:string
property_value: dc-contributor "Frederic Bastian" xsd:string
property_value: dc-contributor "Gene Ontology Consortium" xsd:string
property_value: dc-contributor "George Gkoutos" xsd:string
property_value: dc-contributor "Hilmar Lapp" xsd:string
property_value: dc-contributor "James Balhoff" xsd:string
property_value: dc-contributor "James Malone" xsd:string
property_value: dc-contributor "Jonathan Bard" xsd:string
property_value: dc-contributor "Lydie Lane" xsd:string
property_value: dc-contributor "Marc Robinson-Rechavi" xsd:string
property_value: dc-contributor "Mark Engelstad - https://orcid.org/0000-0001-5889-4463" xsd:string
property_value: dc-contributor "Maryann Martone" xsd:string
property_value: dc-contributor "neXtProt project" xsd:string
property_value: dc-contributor "NIF Project - http://neuinfo.org/" xsd:string
property_value: dc-contributor "Onard Mejino" xsd:string
property_value: dc-contributor "PATO Project" xsd:string
property_value: dc-contributor "Paul Schofield" xsd:string
property_value: dc-contributor "Paul Sereno" xsd:string
property_value: dc-contributor "Paula Duek Roggli" xsd:string
property_value: dc-contributor "Paula Mabee" xsd:string
property_value: dc-contributor "Phenoscape Project" xsd:string
property_value: dc-contributor "Rebecca Foulger" xsd:string
property_value: dc-contributor "Robert Druzinsky" xsd:string
property_value: dc-contributor "Sarah Whitcher Kansa - https://orcid.org/0000-0001-7920-5321" xsd:string
property_value: dc-contributor "Shahim Essaid" xsd:string
property_value: dc-contributor "Suzanna Lewis" xsd:string
property_value: dc-contributor "Terry Hayamizu" xsd:string
property_value: dc-contributor "Terry Meehan" xsd:string
property_value: dc-contributor "Trish Whetzel" xsd:string
property_value: dc-contributor "Yvonne Bradford" xsd:string
property_value: dc-creator "Alex Dececchi" xsd:string
property_value: dc-creator "Anne Niknejad" xsd:string
property_value: dc-creator "Aurelie Comte" xsd:string
property_value: dc-creator "Chris Mungall - http://orcid.org/0000-0002-6601-2165    " xsd:string
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property_value: dc-creator "Melissa Haendel" xsd:string
property_value: dc-creator "Nizar Ibrahim" xsd:string
property_value: dc-creator "Wasila Dahdul" xsd:string
property_value: dc-description "Uberon is an integrated cross-species anatomy ontology representing a variety of entities classified according to traditional anatomical criteria such as structure, function and developmental lineage. The ontology includes comprehensive relationships to taxon-specific anatomical ontologies, allowing integration of functional, phenotype and expression data." xsd:string
property_value: dc-publisher http://uberon.org xsd:anyURI
property_value: dc-rights http://creativecommons.org/licenses/by/3.0/
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property_value: dc-source http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-GrossAnatomy.owl
property_value: dc-source http://palaeos.com
property_value: dc-source http://pons.incf.org/wiki/Common_Upper_Mammalian_Brain_Ontology_%28Cumbo%29
property_value: dc-source http://purl.obolibrary.org/obo/aao.owl
property_value: dc-source http://purl.obolibrary.org/obo/aba.owl
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property_value: dc-source http://purl.obolibrary.org/obo/fbbt.owl
property_value: dc-source http://purl.obolibrary.org/obo/fma.owl
property_value: dc-source http://purl.obolibrary.org/obo/go.owl
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property_value: dc-source http://purl.obolibrary.org/obo/xao.owl
property_value: dc-source http://purl.obolibrary.org/obo/zfa.owl
property_value: dc-source http://uri.neuinfo.org/nif/nifstd
property_value: dc-source http://wiki.phenotypercn.org/wg/phenotypercn/index.php?title=Neural_Crest_Workshop xsd:anyURI
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property_value: dc-source "ISBN:0226313379 Fins into Limbs: Evolution, Development, and Transformation, Hall" xsd:string
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property_value: dc-source "ISBN:1607950324 Craniofacial Embryogenetics & Development, 2nd edition, Sperber" xsd:string
property_value: dc-source "ISBN:978-0-12-369548-2 Principles of Developmental Genetics, Sally A Moody" xsd:string
property_value: dc-source "ISBN:9780120749034 The laboratory rat" xsd:string
property_value: dc-source "ISBN:9780397517251 Surgical anatomy of the hand and upper extremity. By James R. Doyle and Michael J. Botte" xsd:string
property_value: dc-source "ISBN:9780674021839 The Tree of Life - Guillaume Lecointre, Herve Le Guyader" xsd:string
property_value: dc-source "ISBN:9780878932504 Developmental Biology" xsd:string
property_value: dc-source "MESH" xsd:string
property_value: dc-source "PMID:11433360 Placental development: lessons from mouse mutants" xsd:string
property_value: dc-source "PMID:16417468 Forgotten and novel aspects in pancreas development, Pieler and Chen" xsd:string
property_value: dc-title "Uber-anatomy ontology" xsd:string
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brary.org/obo/UBERON_0034942>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0034943>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0034965>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035044>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035086>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035087>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035088>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035089>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035090>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035092>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035563>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035566>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035568>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035569>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035607>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035639>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035776>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035819>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035820>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035831>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035850>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0035962>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0036072>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0036073>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0036148>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0036150>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0036242>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_2000815>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_6000006>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000050>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000051>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000066>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000053>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0001025>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002013>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002014>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002015>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002018>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002019>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002025>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002131>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002162>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002170>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002176>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002180>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002207>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002211>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002212>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002213>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002215>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002233>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002234>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002327>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002331>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002333>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002351>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002352>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002379>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002380>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002387>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002404>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002411>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002447>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002448>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002449>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002450>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002551>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002566>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002578>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002629>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002630>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0003000>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/IAO_0000115>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/core#provenance_notes>))\nDeclaration(AnnotationProperty(<http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled>))\nDeclaration(AnnotationProperty(<http://www.geneontology.org/formats/oboInOwl#created_by>))\nDeclaration(AnnotationProperty(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespace>))\nDeclaration(AnnotationProperty(<http://www.geneontology.org/formats/oboInOwl#id>))\nDeclaration(AnnotationProperty(<http://www.geneontology.org/formats/oboInOwl#notes>))\nDeclaration(AnnotationProperty(<http://www.geneontology.org/formats/oboInOwl#source>))\n\n############################\n#   Object Properties\n############################\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0001025> (<http://purl.obolibrary.org/obo/RO_0001025>)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0001025> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/BFO_0000004> ObjectComplementOf(<http://purl.obolibrary.org/obo/BFO_0000006>)))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002170> (<http://purl.obolibrary.org/obo/RO_0002170>)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002170> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/RO_0002577>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002176> (<http://purl.obolibrary.org/obo/RO_0002176>)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002176> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/RO_0002577>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002207> (<http://purl.obolibrary.org/obo/RO_0002207>)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002207> ObjectUnionOf(<http://purl.obolibrary.org/obo/CARO_0010000> <http://purl.obolibrary.org/obo/CL_0000000>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002351> (<http://purl.obolibrary.org/obo/RO_0002351>)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0002351>)\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002380> (<http://purl.obolibrary.org/obo/RO_0002380>)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002380> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000053> <http://purl.obolibrary.org/obo/PATO_0000402>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002551> (<http://purl.obolibrary.org/obo/RO_0002551>)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0002551>)\n\n\n\n############################\n#   Classes\n############################\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000002> (<http://purl.obolibrary.org/obo/CL_0000002>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000002> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000004> (<http://purl.obolibrary.org/obo/CL_0000004>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000004> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000009> (<http://purl.obolibrary.org/obo/CL_0000009>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000009> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000012> (<http://purl.obolibrary.org/obo/CL_0000012>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000012> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000013> (<http://purl.obolibrary.org/obo/CL_0000013>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000013> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000045> (<http://purl.obolibrary.org/obo/CL_0000045>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000045> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000046> (<http://purl.obolibrary.org/obo/CL_0000046>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000046> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000063> (<http://purl.obolibrary.org/obo/CL_0000063>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000063> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000070> (<http://purl.obolibrary.org/obo/CL_0000070>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000070> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000074> (<http://purl.obolibrary.org/obo/CL_0000074>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000074> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000093> (<http://purl.obolibrary.org/obo/CL_0000093>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000093> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000108> (<http://purl.obolibrary.org/obo/CL_0000108>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/CL_0000108> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/GO_0014055>))\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000144> (<http://purl.obolibrary.org/obo/CL_0000144>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000144> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000156> (<http://purl.obolibrary.org/obo/CL_0000156>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000156> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000194> (<http://purl.obolibrary.org/obo/CL_0000194>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000194> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000195> (<http://purl.obolibrary.org/obo/CL_0000195>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000195> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000220> (<http://purl.obolibrary.org/obo/CL_0000220>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000220> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000224> (<http://purl.obolibrary.org/obo/CL_0000224>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000224> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000229> (<http://purl.obolibrary.org/obo/CL_0000229>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000229> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000230> (<http://purl.obolibrary.org/obo/CL_0000230>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000230> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000231> (<http://purl.obolibrary.org/obo/CL_0000231>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000231> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000245> (<http://purl.obolibrary.org/obo/CL_0000245>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000245> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000248> (<http://purl.obolibrary.org/obo/CL_0000248>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000248> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000250> (<http://purl.obolibrary.org/obo/CL_0000250>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000250> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000252> (<http://purl.obolibrary.org/obo/CL_0000252>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000252> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000254> (<http://purl.obolibrary.org/obo/CL_0000254>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000254> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000258> (<http://purl.obolibrary.org/obo/CL_0000258>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000258> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000259> (<http://purl.obolibrary.org/obo/CL_0000259>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000259> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000260> (<http://purl.obolibrary.org/obo/CL_0000260>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000260> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000261> (<http://purl.obolibrary.org/obo/CL_0000261>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000261> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000262> (<http://purl.obolibrary.org/obo/CL_0000262>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000262> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000263> (<http://purl.obolibrary.org/obo/CL_0000263>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000263> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000264> (<http://purl.obolibrary.org/obo/CL_0000264>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000264> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000265> (<http://purl.obolibrary.org/obo/CL_0000265>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000265> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000266> (<http://purl.obolibrary.org/obo/CL_0000266>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000266> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000267> (<http://purl.obolibrary.org/obo/CL_0000267>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000267> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000268> (<http://purl.obolibrary.org/obo/CL_0000268>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000268> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000269> (<http://purl.obolibrary.org/obo/CL_0000269>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000269> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000270> (<http://purl.obolibrary.org/obo/CL_0000270>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000270> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000271> (<http://purl.obolibrary.org/obo/CL_0000271>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000271> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000272> (<http://purl.obolibrary.org/obo/CL_0000272>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000272> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000273> (<http://purl.obolibrary.org/obo/CL_0000273>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000273> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000275> (<http://purl.obolibrary.org/obo/CL_0000275>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000275> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000276> (<http://purl.obolibrary.org/obo/CL_0000276>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000276> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000277> (<http://purl.obolibrary.org/obo/CL_0000277>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000277> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000278> (<http://purl.obolibrary.org/obo/CL_0000278>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000278> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000279> (<http://purl.obolibrary.org/obo/CL_0000279>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000279> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000280> (<http://purl.obolibrary.org/obo/CL_0000280>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000280> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000281> (<http://purl.obolibrary.org/obo/CL_0000281>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000281> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000282> (<http://purl.obolibrary.org/obo/CL_0000282>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000282> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000283> (<http://purl.obolibrary.org/obo/CL_0000283>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000283> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000284> (<http://purl.obolibrary.org/obo/CL_0000284>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000284> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000285> (<http://purl.obolibrary.org/obo/CL_0000285>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000285> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000288> (<http://purl.obolibrary.org/obo/CL_0000288>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000288> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000289> (<http://purl.obolibrary.org/obo/CL_0000289>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000289> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000290> (<http://purl.obolibrary.org/obo/CL_0000290>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000290> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000291> (<http://purl.obolibrary.org/obo/CL_0000291>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000291> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000292> (<http://purl.obolibrary.org/obo/CL_0000292>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000292> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000294> (<http://purl.obolibrary.org/obo/CL_0000294>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000294> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000296> (<http://purl.obolibrary.org/obo/CL_0000296>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000296> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000297> (<http://purl.obolibrary.org/obo/CL_0000297>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000297> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000298> (<http://purl.obolibrary.org/obo/CL_0000298>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000298> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000299> (<http://purl.obolibrary.org/obo/CL_0000299>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000299> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000302> (<http://purl.obolibrary.org/obo/CL_0000302>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000302> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000303> (<http://purl.obolibrary.org/obo/CL_0000303>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000303> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000304> (<http://purl.obolibrary.org/obo/CL_0000304>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000304> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000305> (<http://purl.obolibrary.org/obo/CL_0000305>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000305> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000316> (<http://purl.obolibrary.org/obo/CL_0000316>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000316> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000320> (<http://purl.obolibrary.org/obo/CL_0000320>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000320> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000330> (<http://purl.obolibrary.org/obo/CL_0000330>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000330> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000331> (<http://purl.obolibrary.org/obo/CL_0000331>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000331> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000332> (<http://purl.obolibrary.org/obo/CL_0000332>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000332> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000344> (<http://purl.obolibrary.org/obo/CL_0000344>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000344> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000363> (<http://purl.obolibrary.org/obo/CL_0000363>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000363> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000364> (<http://purl.obolibrary.org/obo/CL_0000364>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000364> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000366> (<http://purl.obolibrary.org/obo/CL_0000366>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000366> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000368> (<http://purl.obolibrary.org/obo/CL_0000368>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000368> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000370> (<http://purl.obolibrary.org/obo/CL_0000370>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000370> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000375> (<http://purl.obolibrary.org/obo/CL_0000375>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000375> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000399> (<http://purl.obolibrary.org/obo/CL_0000399>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000399> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000400> (<http://purl.obolibrary.org/obo/CL_0000400>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000400> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000414> (<http://purl.obolibrary.org/obo/CL_0000414>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000414> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000433> (<http://purl.obolibrary.org/obo/CL_0000433>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000433> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000455> (<http://purl.obolibrary.org/obo/CL_0000455>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000455> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000472> (<http://purl.obolibrary.org/obo/CL_0000472>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000472> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000475> (<http://purl.obolibrary.org/obo/CL_0000475>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000475> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000491> (<http://purl.obolibrary.org/obo/CL_0000491>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000491> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000493> (<http://purl.obolibrary.org/obo/CL_0000493>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000493> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000522> (<http://purl.obolibrary.org/obo/CL_0000522>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000522> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000537> (<http://purl.obolibrary.org/obo/CL_0000537>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000537> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000538> (<http://purl.obolibrary.org/obo/CL_0000538>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000538> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000539> (<http://purl.obolibrary.org/obo/CL_0000539>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000539> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000543> (<http://purl.obolibrary.org/obo/CL_0000543>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000543> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000585> (<http://purl.obolibrary.org/obo/CL_0000585>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000585> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000610> (<http://purl.obolibrary.org/obo/CL_0000610>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000610> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000616> (<http://purl.obolibrary.org/obo/CL_0000616>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000616> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000620> (<http://purl.obolibrary.org/obo/CL_0000620>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000620> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000668> (<http://purl.obolibrary.org/obo/CL_0000668>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000668> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000672> (<http://purl.obolibrary.org/obo/CL_0000672>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000672> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000685> (<http://purl.obolibrary.org/obo/CL_0000685>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000685> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000698> (<http://purl.obolibrary.org/obo/CL_0000698>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000698> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000748> (<http://purl.obolibrary.org/obo/CL_0000748>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000748> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0061535> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0098976>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_0001068> (<http://purl.obolibrary.org/obo/CL_0001068>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/CL_0001068> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CL_0001067> ObjectComplementOf(ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/GO_0001909>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002245> (<http://purl.obolibrary.org/obo/CL_0002245>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002245> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002276> (<http://purl.obolibrary.org/obo/CL_0002276>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002276> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002392> (<http://purl.obolibrary.org/obo/CL_0002392>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002392> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002590> (<http://purl.obolibrary.org/obo/CL_0002590>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/CL_0002590> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CL_0000359> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0002049> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000955>)))))\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002590> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0002049> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000955>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002646> (<http://purl.obolibrary.org/obo/CL_0002646>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002646> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002647> (<http://purl.obolibrary.org/obo/CL_0002647>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002647> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002648> (<http://purl.obolibrary.org/obo/CL_0002648>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002648> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002649> (<http://purl.obolibrary.org/obo/CL_0002649>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002649> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0002650> (<http://purl.obolibrary.org/obo/CL_0002650>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0002650> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0005016> (<http://purl.obolibrary.org/obo/CL_0005016>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0005016> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0005017> (<http://purl.obolibrary.org/obo/CL_0005017>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0005017> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0007014> (<http://purl.obolibrary.org/obo/CL_0007014>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0007014> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0007015> (<http://purl.obolibrary.org/obo/CL_0007015>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0007015> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0008023> (<http://purl.obolibrary.org/obo/CL_0008023>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0008023> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_0008029> (<http://purl.obolibrary.org/obo/CL_0008029>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/CL_0008029> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CL_0000540> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0007269> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0098977>)))))\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0008029> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0007269> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0098977>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_0008030> (<http://purl.obolibrary.org/obo/CL_0008030>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/CL_0008030> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CL_0000540> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0007269> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0098976>)))))\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0008030> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0007269> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0098976>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_0009001> (<http://purl.obolibrary.org/obo/CL_0009001>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/CL_0009001> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CL_0000000> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0005388> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000018>)))))\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0009001> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0005388> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000018>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_0011112> (<http://purl.obolibrary.org/obo/CL_0011112>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0011112> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CL_0000540> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/GO_0030103>)))\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000314> (<http://purl.obolibrary.org/obo/CL_1000314>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000314> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000483> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008859>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000316> (<http://purl.obolibrary.org/obo/CL_1000316>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000316> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000318> (<http://purl.obolibrary.org/obo/CL_1000318>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000318> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000319> (<http://purl.obolibrary.org/obo/CL_1000319>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000319> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000321> (<http://purl.obolibrary.org/obo/CL_1000321>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/CL_1000321> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CL_0000160> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0001983> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000059>)))))\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000321> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000483> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0001983> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000059>))))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000323> (<http://purl.obolibrary.org/obo/CL_1000323>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000323> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000483> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008861>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000325> (<http://purl.obolibrary.org/obo/CL_1000325>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000325> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000483> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002115>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000326> (<http://purl.obolibrary.org/obo/CL_1000326>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000326> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000483> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002116>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000328> (<http://purl.obolibrary.org/obo/CL_1000328>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000328> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_1000488> (<http://purl.obolibrary.org/obo/CL_1000488>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1000488> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0015106> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0032782>))))\n\n# Class: <http://purl.obolibrary.org/obo/CL_1001583> (<http://purl.obolibrary.org/obo/CL_1001583>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_1001583> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_2000009> (<http://purl.obolibrary.org/obo/CL_2000009>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_2000009> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_2000026> (<http://purl.obolibrary.org/obo/CL_2000026>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_2000026> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/CL_2000050> (<http://purl.obolibrary.org/obo/CL_2000050>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_2000050> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0000095> (<http://purl.obolibrary.org/obo/UBERON_0000095>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"Wikipedia\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0000095> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005428>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0000165> (<http://purl.obolibrary.org/obo/UBERON_0000165>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"exceptions in some taxa\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0000165> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001004>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0000209> (<http://purl.obolibrary.org/obo/UBERON_0000209>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000209> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001697>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0000403> (<http://purl.obolibrary.org/obo/UBERON_0000403>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000403> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001084>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000403> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006661>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0000475> (<http://purl.obolibrary.org/obo/UBERON_0000475>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000475> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001009>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000475> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001015>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000475> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001016>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000475> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001434>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000475> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002416>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0000908> (<http://purl.obolibrary.org/obo/UBERON_0000908>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000908> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004680>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0000976> (<http://purl.obolibrary.org/obo/UBERON_0000976>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000976> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001470>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001032> (<http://purl.obolibrary.org/obo/UBERON_0001032>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001032> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001016>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001172> (<http://purl.obolibrary.org/obo/UBERON_0001172>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001171>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004647>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001322> (<http://purl.obolibrary.org/obo/UBERON_0001322>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001322> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000978>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001353> (<http://purl.obolibrary.org/obo/UBERON_0001353>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001353> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006866>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001464> (<http://purl.obolibrary.org/obo/UBERON_0001464>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001464> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001271>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001467> (<http://purl.obolibrary.org/obo/UBERON_0001467>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001467> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001421>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001482> (<http://purl.obolibrary.org/obo/UBERON_0001482>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001482> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001467>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001488> (<http://purl.obolibrary.org/obo/UBERON_0001488>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001488> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002387>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001516> (<http://purl.obolibrary.org/obo/UBERON_0001516>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001516> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000916>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001533> (<http://purl.obolibrary.org/obo/UBERON_0001533>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001533> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000915>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001544> (<http://purl.obolibrary.org/obo/UBERON_0001544>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001544> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001465>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001629> (<http://purl.obolibrary.org/obo/UBERON_0001629>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001629> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001070>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001629> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001532>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001639> (<http://purl.obolibrary.org/obo/UBERON_0001639>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001639> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002107>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001676> (<http://purl.obolibrary.org/obo/UBERON_0001676>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"basi paired exo and supra occipital bones\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"MA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001676> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002241>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"interparietal (postparietal)\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001676> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003113>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001677> (<http://purl.obolibrary.org/obo/UBERON_0001677>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"orbito pre and basi sphenoid\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001677> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002241>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"pterygoid process\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001677> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003113>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"alisphenoid\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001677> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008895>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001678> (<http://purl.obolibrary.org/obo/UBERON_0001678>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"petrosal\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001678> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002241>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"squamosal plus angular\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"temporal series\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001678> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003113>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"styloid process\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001678> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008895>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001680> (<http://purl.obolibrary.org/obo/UBERON_0001680>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001680> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001697>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001683> (<http://purl.obolibrary.org/obo/UBERON_0001683>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ISBN:0073040584\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001683> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001697>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001708> (<http://purl.obolibrary.org/obo/UBERON_0001708>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001708> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008895>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001776> (<http://purl.obolibrary.org/obo/UBERON_0001776>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"Wikipedia\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001776> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001802>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001789> (<http://purl.obolibrary.org/obo/UBERON_0001789>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"soma\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001789> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/CL_0000287>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001793> (<http://purl.obolibrary.org/obo/UBERON_0001793>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001793> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000941>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001794> (<http://purl.obolibrary.org/obo/UBERON_0001794>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001794> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/CL_0000636>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001795> (<http://purl.obolibrary.org/obo/UBERON_0001795>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001795> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/CL_0000740>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001795> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/CL_0000748>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001819> (<http://purl.obolibrary.org/obo/UBERON_0001819>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001819> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005611>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001819> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006726>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001875> (<http://purl.obolibrary.org/obo/UBERON_0001875>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"BTO-weakened\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001875> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002263>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001888> (<http://purl.obolibrary.org/obo/UBERON_0001888>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0001888> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0002265> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002894>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001888> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002894>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001944> (<http://purl.obolibrary.org/obo/UBERON_0001944>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001944> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001891>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001944> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001894>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001961> (<http://purl.obolibrary.org/obo/UBERON_0001961>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001961> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000344>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001963> (<http://purl.obolibrary.org/obo/UBERON_0001963>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ISBN:0123813611\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0001963> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001957>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002013> (<http://purl.obolibrary.org/obo/UBERON_0002013>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002013> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005303>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002014> (<http://purl.obolibrary.org/obo/UBERON_0002014>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002014> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005303>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002028> (<http://purl.obolibrary.org/obo/UBERON_0002028>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"modified-source-relation\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ABA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002028> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002298>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002073> (<http://purl.obolibrary.org/obo/UBERON_0002073>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002073> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001037>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002091> (<http://purl.obolibrary.org/obo/UBERON_0002091>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002091> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000026>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002107> (<http://purl.obolibrary.org/obo/UBERON_0002107>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA-weakened\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002107> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002405>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002138> (<http://purl.obolibrary.org/obo/UBERON_0002138>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002138> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001891>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002138> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001894>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002144> (<http://purl.obolibrary.org/obo/UBERON_0002144>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"MA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002144> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001900>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002241> (<http://purl.obolibrary.org/obo/UBERON_0002241>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002241> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001703>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002252> (<http://purl.obolibrary.org/obo/UBERON_0002252>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002252> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0012477>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002265> (<http://purl.obolibrary.org/obo/UBERON_0002265>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0002265> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0007702> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002264>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002265> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002264>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002267> (<http://purl.obolibrary.org/obo/UBERON_0002267>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"MA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002267> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000988>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002317> (<http://purl.obolibrary.org/obo/UBERON_0002317>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA-weakened\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"MA-weakened\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002317> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002037>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002321> (<http://purl.obolibrary.org/obo/UBERON_0002321>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002321> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000074>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002540> (<http://purl.obolibrary.org/obo/UBERON_0002540>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002540> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000010>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002717> (<http://purl.obolibrary.org/obo/UBERON_0002717>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002717> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002660>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002728> (<http://purl.obolibrary.org/obo/UBERON_0002728>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002728> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0013559>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002760> (<http://purl.obolibrary.org/obo/UBERON_0002760>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"modified part_of to overlaps\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"NIFSTD\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002760> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002240>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002768> (<http://purl.obolibrary.org/obo/UBERON_0002768>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"weakened\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"NIFSTD\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002768> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001896>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"weakened\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"NIFSTD\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002768> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002240>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0002949> (<http://purl.obolibrary.org/obo/UBERON_0002949>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"weakened\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002949> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001896>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"weakened\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"NIFSTD\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0002949> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002240>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003052> (<http://purl.obolibrary.org/obo/UBERON_0003052>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0003052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0007651> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001891>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002028>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003052> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001891>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003052> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002028>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003102> (<http://purl.obolibrary.org/obo/UBERON_0003102>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003102> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007376>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003278> (<http://purl.obolibrary.org/obo/UBERON_0003278>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"VHOG-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0003278> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008895>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003461> (<http://purl.obolibrary.org/obo/UBERON_0003461>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0003461> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0001474> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0016884>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003461> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0016884>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003665> (<http://purl.obolibrary.org/obo/UBERON_0003665>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003665> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007812>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003709> (<http://purl.obolibrary.org/obo/UBERON_0003709>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0003709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007142>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0003709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007143>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003974> (<http://purl.obolibrary.org/obo/UBERON_0003974>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003974> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002355>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003988> (<http://purl.obolibrary.org/obo/UBERON_0003988>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0003988> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0007651> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002123>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002124>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003988> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002123>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003988> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002124>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0003993> (<http://purl.obolibrary.org/obo/UBERON_0003993>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0003993> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002285>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"MP\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0003993> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002286>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004117> (<http://purl.obolibrary.org/obo/UBERON_0004117>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004117> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002539>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004172> (<http://purl.obolibrary.org/obo/UBERON_0004172>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000988>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002240>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004173> (<http://purl.obolibrary.org/obo/UBERON_0004173>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004173> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001896>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004173> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002240>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004220> (<http://purl.obolibrary.org/obo/UBERON_0004220>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"consider merging\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0004220> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0011198>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004221> (<http://purl.obolibrary.org/obo/UBERON_0004221>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"consider merging\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0004221> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0012367>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004239> (<http://purl.obolibrary.org/obo/UBERON_0004239>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"consider merging\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0004239> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0011201>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004339> (<http://purl.obolibrary.org/obo/UBERON_0004339>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"small pharyngeal arch and sclerotomal contribution\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0004339> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003113>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004340> (<http://purl.obolibrary.org/obo/UBERON_0004340>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"EHDAA2-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0004340> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001008>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004456> (<http://purl.obolibrary.org/obo/UBERON_0004456>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004456> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001016>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004467> (<http://purl.obolibrary.org/obo/UBERON_0004467>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004467> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001042>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004475> (<http://purl.obolibrary.org/obo/UBERON_0004475>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004475> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001464>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004476> (<http://purl.obolibrary.org/obo/UBERON_0004476>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004476> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001467>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004744> (<http://purl.obolibrary.org/obo/UBERON_0004744>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA-modifed\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"cjm\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0004744> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003113>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004745> (<http://purl.obolibrary.org/obo/UBERON_0004745>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0004745> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001697>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004866> (<http://purl.obolibrary.org/obo/UBERON_0004866>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0004866> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001697>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004873> (<http://purl.obolibrary.org/obo/UBERON_0004873>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004873> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000925>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0004874> (<http://purl.obolibrary.org/obo/UBERON_0004874>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004874> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000924>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005051> (<http://purl.obolibrary.org/obo/UBERON_0005051>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003728>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005283> (<http://purl.obolibrary.org/obo/UBERON_0005283>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005283> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001886>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005283> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0010743>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005304> (<http://purl.obolibrary.org/obo/UBERON_0005304>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0005304> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001205>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0005304> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001974>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005336> (<http://purl.obolibrary.org/obo/UBERON_0005336>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#notes> \"overlaps via basement membrane. consider also adjacency\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> <http://en.wikipedia.org/wiki/Bruch's_membrane>) <http://purl.obolibrary.org/obo/UBERON_0005336> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003957>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005381> (<http://purl.obolibrary.org/obo/UBERON_0005381>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005381> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/CL_0000118>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005872> (<http://purl.obolibrary.org/obo/UBERON_0005872>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0005872> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0005879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003066>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004362>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005872> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003066>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005872> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004362>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005873> (<http://purl.obolibrary.org/obo/UBERON_0005873>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0005873> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0005879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003066>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003114>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005873> 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<http://purl.obolibrary.org/obo/UBERON_0003115>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005874> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003114>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005874> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003115>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005875> (<http://purl.obolibrary.org/obo/UBERON_0005875>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0005875> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0005879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003115>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003116>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005875> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003115>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005875> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003116>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005879> (<http://purl.obolibrary.org/obo/UBERON_0005879>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002539>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0005969> (<http://purl.obolibrary.org/obo/UBERON_0005969>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005969> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006206>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0006086> (<http://purl.obolibrary.org/obo/UBERON_0006086>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0006086> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001904>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0006211> (<http://purl.obolibrary.org/obo/UBERON_0006211>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0006211> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> 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<http://purl.obolibrary.org/obo/UBERON_0001045>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0006235> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001041>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0006235> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001045>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0006264> (<http://purl.obolibrary.org/obo/UBERON_0006264>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0006264> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0007651> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000165>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001041>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0006264> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000165>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0006264> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001041>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0006801> (<http://purl.obolibrary.org/obo/UBERON_0006801>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0006801> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001470>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0007122> (<http://purl.obolibrary.org/obo/UBERON_0007122>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0007122> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0004117> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003066>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004362>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007122> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003066>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007122> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004362>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0007123> (<http://purl.obolibrary.org/obo/UBERON_0007123>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0007123> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0004117> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003066>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003114>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007123> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003066>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007123> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003114>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0007124> (<http://purl.obolibrary.org/obo/UBERON_0007124>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0007124> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0004117> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003114>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003115>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007124> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003114>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007124> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003115>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0007125> (<http://purl.obolibrary.org/obo/UBERON_0007125>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0007125> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0004117> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003115>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003116>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007125> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003115>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007125> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003116>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0007268> (<http://purl.obolibrary.org/obo/UBERON_0007268>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007268> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0013472>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0007414> (<http://purl.obolibrary.org/obo/UBERON_0007414>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0007414> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000125> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001943>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007414> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001943>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0007641> (<http://purl.obolibrary.org/obo/UBERON_0007641>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"FMA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0007641> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003023>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0007805> (<http://purl.obolibrary.org/obo/UBERON_0007805>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007805> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006075>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0008202> (<http://purl.obolibrary.org/obo/UBERON_0008202>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"MA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0008202> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001464>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0008286> (<http://purl.obolibrary.org/obo/UBERON_0008286>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0008286> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0011783>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0008881> (<http://purl.obolibrary.org/obo/UBERON_0008881>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"BTO-modified\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0008881> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002285>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009210> (<http://purl.obolibrary.org/obo/UBERON_0009210>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009210> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004117>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009210> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005879>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009213> (<http://purl.obolibrary.org/obo/UBERON_0009213>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009213> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005872>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009213> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007122>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009215> (<http://purl.obolibrary.org/obo/UBERON_0009215>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009215> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005873>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009215> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007123>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009216> (<http://purl.obolibrary.org/obo/UBERON_0009216>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009216> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005874>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009216> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007124>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009217> (<http://purl.obolibrary.org/obo/UBERON_0009217>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009217> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005875>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009217> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007125>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009551> (<http://purl.obolibrary.org/obo/UBERON_0009551>)\n\nEquivalentClasses(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"cjm\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009551> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0002529> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002544>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/UBERON_0004300>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0009768>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009551> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0009768>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009635> (<http://purl.obolibrary.org/obo/UBERON_0009635>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009635> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003110>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009635> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005902>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009643> (<http://purl.obolibrary.org/obo/UBERON_0009643>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"NIFSTD\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009643> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001943>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"NIFSTD\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009643> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0003023>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009738> (<http://purl.obolibrary.org/obo/UBERON_0009738>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0009738> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0009740> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008922>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008923>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009738> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008922>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009738> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008923>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009739> (<http://purl.obolibrary.org/obo/UBERON_0009739>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0009739> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0009740> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008924>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008925>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009739> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008924>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009739> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008925>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009740> (<http://purl.obolibrary.org/obo/UBERON_0009740>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009740> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008921>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009834> (<http://purl.obolibrary.org/obo/UBERON_0009834>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009834> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006483>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009840> (<http://purl.obolibrary.org/obo/UBERON_0009840>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009840> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005507>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009840> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005511>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009840> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005515>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009840> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005519>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009840> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005523>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009840> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005527>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ZFA\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0009840> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005569>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009851> (<http://purl.obolibrary.org/obo/UBERON_0009851>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0009851> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0009740> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008925>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008926>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009851> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008925>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009851> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008926>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009852> (<http://purl.obolibrary.org/obo/UBERON_0009852>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0009852> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0009740> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008923>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008924>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009852> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008923>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009852> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008924>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0009883> (<http://purl.obolibrary.org/obo/UBERON_0009883>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009883> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001231>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0010011> (<http://purl.obolibrary.org/obo/UBERON_0010011>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010011> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001891>)))\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"MA\"^^xsd:string) Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"NIF\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0010011> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001893>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0010175> (<http://purl.obolibrary.org/obo/UBERON_0010175>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010175> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001474>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0010176> (<http://purl.obolibrary.org/obo/UBERON_0010176>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010176> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001474>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0010260> (<http://purl.obolibrary.org/obo/UBERON_0010260>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010260> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0001981> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002331>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010260> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002331>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0010406> (<http://purl.obolibrary.org/obo/UBERON_0010406>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010406> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/CL_0000108>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0010750> (<http://purl.obolibrary.org/obo/UBERON_0010750>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"ISBN:0073040584\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0010750> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001697>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0010892> (<http://purl.obolibrary.org/obo/UBERON_0010892>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"TAO\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0010892> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> 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(<http://purl.obolibrary.org/obo/UBERON_0012101>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0012101> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000068>)))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0012101> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000092>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0012330> (<http://purl.obolibrary.org/obo/UBERON_0012330>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0012330> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0005022>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0013201> 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ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001157>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0034730> (<http://purl.obolibrary.org/obo/UBERON_0034730>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0034730> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0002265> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000203>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0034730> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000203>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0034771> (<http://purl.obolibrary.org/obo/UBERON_0034771>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0034771> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0016579>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0034965> (<http://purl.obolibrary.org/obo/UBERON_0034965>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0034965> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001586>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0035044> (<http://purl.obolibrary.org/obo/UBERON_0035044>)\n\nSubClassOf(Annotation(<http://www.geneontology.org/formats/oboInOwl#source> \"NIFSTD\"^^xsd:string) <http://purl.obolibrary.org/obo/UBERON_0035044> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0014283>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0035087> (<http://purl.obolibrary.org/obo/UBERON_0035087>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0035087> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0035086> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001474>))))\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0035087> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001474>)))\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0035088> (<http://purl.obolibrary.org/obo/UBERON_0035088>)\n\nEquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0035088> 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<http://purl.obolibrary.org/obo/NCBITaxon_32524>)))\nEquivalentClasses(owl:Nothing ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000351> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9596>)))\nEquivalentClasses(owl:Nothing ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000359> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9606>)))\nEquivalentClasses(owl:Nothing ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000382> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9822>)))\nEquivalentClasses(owl:Nothing ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000383> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_6040>)))\nEquivalentClasses(owl:Nothing 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Variable(<urn:swrl#z>))))\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#a1>) Variable(<urn:swrl#a2>)) ClassAtom(<http://purl.obolibrary.org/obo/GO_0016301> Variable(<urn:swrl#a1>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#a1>) Variable(<urn:swrl#g1>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#a2>) Variable(<urn:swrl#g2>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002447> Variable(<urn:swrl#g1>) Variable(<urn:swrl#g2>))))\nDLSafeRule(Annotation(rdfs:label \"From ligand activity to has_ligand\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002327> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#z>) Variable(<urn:swrl#x>)) ClassAtom(<http://purl.obolibrary.org/obo/GO_0048018> Variable(<urn:swrl#z>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002019> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>))))\nDLSafeRule(Annotation(rdfs:comment \"This rule is dubious: added as a quick fix for expected inference in GO-CAM.  The problem is most acute for transmembrane proteins, such as receptors or cell adhesion molecules, which have some subfunctions inside the cell (e.g. kinase activity) and some subfunctions outside (e.g. ligand binding).  Correct annotation of where these functions occurs leads to incorrect inference about the location of the whole protein.  This should probably be weakened to \\\"... -> overlaps\\\"\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/BFO_0000066> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002327> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/BFO_0000050> Variable(<urn:swrl#x>) Variable(<urn:swrl#z>))))\nDLSafeRule(Annotation(rdfs:comment \"If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X.  Note:  this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this.\") Annotation(rdfs:label \"inferring direct reg edge from input to regulatory subfunction\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002352> Variable(<urn:swrl#B>) Variable(<urn:swrl#C>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#A>) Variable(<urn:swrl#B>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002013> Variable(<urn:swrl#D>) Variable(<urn:swrl#C>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#A>) Variable(<urn:swrl#D>))))\nDLSafeRule(Annotation(rdfs:label \"inferring direct neg reg edge from input to regulatory subfunction\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002352> Variable(<urn:swrl#B>) Variable(<urn:swrl#C>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#A>) Variable(<urn:swrl#B>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002014> Variable(<urn:swrl#D>) Variable(<urn:swrl#C>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002630> Variable(<urn:swrl#A>) Variable(<urn:swrl#D>))))\nDLSafeRule(Annotation(rdfs:label \"inferring direct positive reg edge from input to regulatory subfunction\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002352> Variable(<urn:swrl#B>) Variable(<urn:swrl#C>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#A>) Variable(<urn:swrl#B>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002015> Variable(<urn:swrl#D>) Variable(<urn:swrl#C>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002629> Variable(<urn:swrl#A>) Variable(<urn:swrl#D>))))\nDLSafeRule(Annotation(rdfs:label \"From has_ligand to ligand activity\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002327> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002019> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ClassAtom(<http://purl.obolibrary.org/obo/GO_0048018> Variable(<urn:swrl#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#z>) Variable(<urn:swrl#x>))))\nDLSafeRule(Annotation(rdfs:label \"effector input is compound function input\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<urn:swrl#eff>) Variable(<urn:swrl#in>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<urn:swrl#mf>) Variable(<urn:swrl#in>))))\nDLSafeRule(Annotation(rdfs:label \"Input of effector is input of its parent MF\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<urn:swrl#mf>) Variable(<urn:swrl#in>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<urn:swrl#eff>) Variable(<urn:swrl#in>))))\nDLSafeRule(Annotation(rdfs:comment \"if effector directly regulates X,  its parent MF directly regulates X\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#mf>) Variable(<urn:swrl#mf2>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#eff>) Variable(<urn:swrl#mf2>))))\nDLSafeRule(Annotation(rdfs:comment \"if effector directly positively regulates X,  its parent MF directly positively regulates X\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002629> Variable(<urn:swrl#mf>) Variable(<urn:swrl#mf2>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002629> Variable(<urn:swrl#eff>) Variable(<urn:swrl#mf2>))))\nDLSafeRule(Annotation(rdfs:label \"if effector directly negatively regulates X,  its parent MF directly negatively regulates X\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002630> Variable(<urn:swrl#mf>) Variable(<urn:swrl#mf2>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002630> Variable(<urn:swrl#eff>) Variable(<urn:swrl#mf2>))))\nDLSafeRule(Annotation(rdfs:label \"'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002404> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002131> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ClassAtom(owl:Nothing Variable(<urn:swrl#x>)) ClassAtom(owl:Nothing Variable(<urn:swrl#y>))))\nDLSafeRule(Annotation(rdfs:label \"'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002411> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002131> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ClassAtom(owl:Nothing Variable(<urn:swrl#x>)) ClassAtom(owl:Nothing Variable(<urn:swrl#y>))))\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002213> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl#x>) Variable(<urn:swrl#z>))))\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002213> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl#x>) Variable(<urn:swrl#z>))))\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/RO_0002473> \"RO:0002473\"^^xsd:string)\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/RO_0002488> \"RO:0002488\"^^xsd:string)\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/RO_0002492> \"RO:0002492\"^^xsd:string)\nAnnotationAssertion(<http://purl.obolibrary.org/obo/core#provenance_notes> <http://purl.obolibrary.org/obo/UBERON_3010717> \"This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon\"^^xsd:string)\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#created_by> <http://purl.obolibrary.org/obo/UBERON_3010717> \"amphibian_anatomy_curators\"^^xsd:string)\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespace> <http://purl.obolibrary.org/obo/UBERON_3010717> \"uberon/phenoscape-anatomy\"^^xsd:string)\nAnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_3010717> \"obsolete diverticulum\"^^xsd:string)\nAnnotationAssertion(<http://purl.obolibrary.org/obo/core#provenance_notes> <http://purl.obolibrary.org/obo/UBERON_3010730> \"This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon\"^^xsd:string)\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#created_by> <http://purl.obolibrary.org/obo/UBERON_3010730> \"amphibian_anatomy_curators\"^^xsd:string)\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespace> <http://purl.obolibrary.org/obo/UBERON_3010730> \"uberon/phenoscape-anatomy\"^^xsd:string)\nAnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_3010730> \"pterygoideus\"^^xsd:string)\nAnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/UBERON_4300122> \"Posteriorly projecting processes allowing de facto contact between consecutive vertebrae (some soft tissues are also present) via articular facets. [PHENOSCAPE:NI]\"^^xsd:string)\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#created_by> <http://purl.obolibrary.org/obo/UBERON_4300122> \"WD\"^^xsd:string)\nAnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_4300122> \"obsolete postzygapophysis\"^^xsd:string)\n)
treat-xrefs-as-has-subclass: EHDAA
treat-xrefs-as-has-subclass: EV
treat-xrefs-as-has-subclass: NCIT
treat-xrefs-as-has-subclass: OGES
treat-xrefs-as-has-subclass: SCTID
treat-xrefs-as-reverse-genus-differentia: AAO part_of NCBITaxon:8292
treat-xrefs-as-reverse-genus-differentia: DHBA part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: DMBA part_of NCBITaxon:10090
treat-xrefs-as-reverse-genus-differentia: EHDAA2 part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: EMAPA part_of NCBITaxon:10090
treat-xrefs-as-reverse-genus-differentia: FBbt part_of NCBITaxon:7227
treat-xrefs-as-reverse-genus-differentia: FBdv part_of NCBITaxon:7227
treat-xrefs-as-reverse-genus-differentia: FMA part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: HAO part_of NCBITaxon:7399
treat-xrefs-as-reverse-genus-differentia: HBA part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: HsapDv part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: MA part_of NCBITaxon:10090
treat-xrefs-as-reverse-genus-differentia: MBA part_of NCBITaxon:10090
treat-xrefs-as-reverse-genus-differentia: MFO part_of NCBITaxon:8089
treat-xrefs-as-reverse-genus-differentia: MmusDv part_of NCBITaxon:10090
treat-xrefs-as-reverse-genus-differentia: OlatDv part_of NCBITaxon:8089
treat-xrefs-as-reverse-genus-differentia: PBA part_of NCBITaxon:9443
treat-xrefs-as-reverse-genus-differentia: SPD part_of NCBITaxon:6893
treat-xrefs-as-reverse-genus-differentia: TADS part_of NCBITaxon:6939
treat-xrefs-as-reverse-genus-differentia: TAO part_of NCBITaxon:32443
treat-xrefs-as-reverse-genus-differentia: TGMA part_of NCBITaxon:44484
treat-xrefs-as-reverse-genus-differentia: WBbt part_of NCBITaxon:6237
treat-xrefs-as-reverse-genus-differentia: WBls part_of NCBITaxon:6237
treat-xrefs-as-reverse-genus-differentia: XAO part_of NCBITaxon:8353
treat-xrefs-as-reverse-genus-differentia: ZFA part_of NCBITaxon:7954
treat-xrefs-as-reverse-genus-differentia: ZFS part_of NCBITaxon:7954

[Term]
id: BFO:0000004
is_a: BFO:0000002

[Term]
id: BFO:0000015
is_a: BFO:0000003

[Term]
id: BFO:0000030
name: object
is_a: BFO:0000040 ! material entity

[Term]
id: BFO:0000040
name: material entity
is_a: BFO:0000004

[Term]
id: BFO:0000141
is_a: BFO:0000004

[Term]
id: CHEBI:10545
name: electron
is_a: CHEBI:36338 ! lepton

[Term]
id: CHEBI:131927
name: dicarboxylic acids and O-substituted derivatives
is_a: CHEBI:36586 ! carbonyl compound

[Term]
id: CHEBI:13850
name: apoprotein
is_a: CHEBI:38560 ! simple protein

[Term]
id: CHEBI:138675
name: gas molecular entity
is_a: CHEBI:33579 ! main group molecular entity

[Term]
id: CHEBI:140325
name: secondary carboxamide
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:142163
name: 24G7 epitope
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:15440
name: squalene
is_a: CHEBI:35191 ! triterpene

[Term]
id: CHEBI:15841
name: polypeptide
is_a: CHEBI:16670 ! peptide
is_a: CHEBI:33839 ! macromolecule

[Term]
id: CHEBI:16247
name: phospholipid
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester

[Term]
id: CHEBI:16336
name: hyaluronic acid
is_a: CHEBI:37395 ! mucopolysaccharide
is_a: CHEBI:72813 ! exopolysaccharide

[Term]
id: CHEBI:16526
name: carbon dioxide
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:23014 ! carbon oxide
is_a: CHEBI:64708 ! one-carbon compound

[Term]
id: CHEBI:16541
name: protein polypeptide chain
is_a: CHEBI:15841 ! polypeptide
relationship: has_part CHEBI:33700 ! proteinogenic amino-acid residue

[Term]
id: CHEBI:16646
name: carbohydrate
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives

[Term]
id: CHEBI:16670
name: peptide
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:50047 ! organic amino compound
relationship: has_part CHEBI:33708 ! amino-acid residue

[Term]
id: CHEBI:16990
name: bilirubin IXalpha
is_a: CHEBI:35692 ! dicarboxylic acid
is_a: CHEBI:36735 ! biladienes
relationship: has_part CHEBI:142163 ! 24G7 epitope

[Term]
id: CHEBI:17029
name: chitin
is_a: CHEBI:21638 ! N-acylglucosamine
is_a: CHEBI:22506 ! aminoglycan

[Term]
id: CHEBI:17089
name: glycoprotein
is_a: CHEBI:33837 ! conjugated protein
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:17761
name: ceramide
is_a: CHEBI:26739 ! sphingolipid
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:18059
name: lipid
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:18085
name: glycosaminoglycan
is_a: CHEBI:22506 ! aminoglycan

[Term]
id: CHEBI:18154
name: polysaccharide
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:18246
name: (1->4)-beta-D-glucan
is_a: CHEBI:28793 ! beta-D-glucan

[Term]
id: CHEBI:21638
name: N-acylglucosamine
is_a: CHEBI:21656 ! N-acyl-hexosamine
is_a: CHEBI:24271 ! glucosamines

[Term]
id: CHEBI:21656
name: N-acyl-hexosamine
is_a: CHEBI:24586 ! hexosamine

[Term]
id: CHEBI:22221
name: acyl group
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:22313
name: alkaline earth metal atom
is_a: CHEBI:33318 ! main group element atom
is_a: CHEBI:33521 ! metal atom
is_a: CHEBI:33559 ! s-block element atom

[Term]
id: CHEBI:22314
name: alkali metal atom
is_a: CHEBI:33318 ! main group element atom
is_a: CHEBI:33521 ! metal atom
is_a: CHEBI:33559 ! s-block element atom

[Term]
id: CHEBI:22506
name: aminoglycan
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:65212 ! polysaccharide derivative

[Term]
id: CHEBI:22563
name: anion
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:22868
name: bile salt
is_a: CHEBI:36078 ! cholanoid
is_a: CHEBI:38700 ! organic sodium salt

[Term]
id: CHEBI:22984
name: calcium atom
is_a: CHEBI:22313 ! alkaline earth metal atom

[Term]
id: CHEBI:22985
name: calcium molecular entity
is_a: CHEBI:33299 ! alkaline earth molecular entity
relationship: has_part CHEBI:22984 ! calcium atom

[Term]
id: CHEBI:23004
name: carbamoyl group
is_a: CHEBI:27207 ! univalent carboacyl group

[Term]
id: CHEBI:23014
name: carbon oxide
is_a: CHEBI:25701 ! organic oxide
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:23016
name: carbonates
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:23019
name: carbonyl group
is_a: CHEBI:51422 ! organodiyl group

[Term]
id: CHEBI:23044
name: carotenoid
is_a: CHEBI:26935 ! tetraterpenoid

[Term]
id: CHEBI:23045
name: carotenol
is_a: CHEBI:27325 ! xanthophyll

[Term]
id: CHEBI:23079
name: cerebroside
is_a: CHEBI:17761 ! ceramide
is_a: CHEBI:25513 ! neutral glycosphingolipid

[Term]
id: CHEBI:23213
name: choline ester
is_a: CHEBI:35701 ! ester

[Term]
id: CHEBI:23217
name: cholines
is_a: CHEBI:35267 ! quaternary ammonium ion

[Term]
id: CHEBI:23367
name: molecular entity
is_a: BFO:0000030 ! object
is_a: CHEBI:24431 ! chemical entity

[Term]
id: CHEBI:23906
name: monoatomic cation
is_a: CHEBI:24867 ! monoatomic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:24271
name: glucosamines
is_a: CHEBI:24586 ! hexosamine

[Term]
id: CHEBI:24402
name: glycosphingolipid
is_a: CHEBI:26739 ! sphingolipid
is_a: CHEBI:33563 ! glycolipid

[Term]
id: CHEBI:24431
name: chemical entity

[Term]
id: CHEBI:24433
name: group
is_a: CHEBI:24431 ! chemical entity
relationship: has_part CHEBI:33250 ! atom

[Term]
id: CHEBI:24532
name: organic heterocyclic compound
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33832 ! organic cyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:24586
name: hexosamine
is_a: CHEBI:60926 ! amino monosaccharide

[Term]
id: CHEBI:24632
name: hydrocarbon
is_a: CHEBI:33245 ! organic fundamental parent

[Term]
id: CHEBI:24651
name: hydroxides
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: has_part CHEBI:43176 ! hydroxy group

[Term]
id: CHEBI:24833
name: oxoacid
is_a: CHEBI:24651 ! hydroxides

[Term]
id: CHEBI:24835
name: inorganic molecular entity
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:24866
name: salt
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: has_part CHEBI:22563 ! anion
relationship: has_part CHEBI:36916 ! cation

[Term]
id: CHEBI:24867
name: monoatomic ion
is_a: CHEBI:24870 ! ion
is_a: CHEBI:33238 ! monoatomic entity

[Term]
id: CHEBI:24868
name: organic salt
is_a: CHEBI:24866 ! salt

[Term]
id: CHEBI:24870
name: ion
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:24913
name: isoprenoid
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:25046
name: linear tetrapyrrole
is_a: CHEBI:26932 ! tetrapyrrole

[Term]
id: CHEBI:25213
name: metal cation
is_a: CHEBI:23906 ! monoatomic cation
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:25367
name: molecule
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:25414
name: monoatomic monocation
is_a: CHEBI:23906 ! monoatomic cation

[Term]
id: CHEBI:25513
name: neutral glycosphingolipid
is_a: CHEBI:24402 ! glycosphingolipid

[Term]
id: CHEBI:25555
name: nitrogen atom
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen

[Term]
id: CHEBI:25585
name: nonmetal atom
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:25696
name: organic anion
is_a: CHEBI:22563 ! anion
is_a: CHEBI:25699 ! organic ion

[Term]
id: CHEBI:25697
name: organic cation
is_a: CHEBI:25699 ! organic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:25699
name: organic ion
is_a: CHEBI:24870 ! ion
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:25701
name: organic oxide
is_a: CHEBI:25741 ! oxide
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:25703
name: organic phosphate
is_a: CHEBI:25710 ! organophosphorus compound
is_a: CHEBI:26020 ! phosphate
is_a: CHEBI:26079 ! phosphoric acid derivative

[Term]
id: CHEBI:25704
name: organic sulfate
is_a: CHEBI:26820 ! sulfates
is_a: CHEBI:37826 ! sulfuric acid derivative

[Term]
id: CHEBI:25710
name: organophosphorus compound
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:33285 ! heteroorganic entity

[Term]
id: CHEBI:25741
name: oxide
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:25805
name: oxygen atom
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen

[Term]
id: CHEBI:25806
name: oxygen molecular entity
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: has_part CHEBI:25805 ! oxygen atom

[Term]
id: CHEBI:26020
name: phosphate
is_a: CHEBI:26079 ! phosphoric acid derivative

[Term]
id: CHEBI:26079
name: phosphoric acid derivative
is_a: CHEBI:36359 ! phosphorus oxoacid derivative

[Term]
id: CHEBI:26082
name: phosphorus molecular entity
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: has_part CHEBI:28659 ! phosphorus atom

[Term]
id: CHEBI:26214
name: porphyrins
is_a: CHEBI:36309 ! cyclic tetrapyrrole

[Term]
id: CHEBI:26469
name: quaternary nitrogen compound
is_a: CHEBI:35352 ! organonitrogen compound
relationship: has_part CHEBI:35267 ! quaternary ammonium ion

[Term]
id: CHEBI:26708
name: sodium atom
is_a: CHEBI:22314 ! alkali metal atom

[Term]
id: CHEBI:26712
name: sodium molecular entity
is_a: CHEBI:33296 ! alkali metal molecular entity
relationship: has_part CHEBI:26708 ! sodium atom

[Term]
id: CHEBI:26714
name: sodium salt
is_a: CHEBI:26712 ! sodium molecular entity
is_a: CHEBI:35479 ! alkali metal salt
relationship: has_part CHEBI:29101 ! sodium(1+)

[Term]
id: CHEBI:26739
name: sphingolipid
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:26819
name: sulfuric ester
is_a: CHEBI:35701 ! ester
is_a: CHEBI:37826 ! sulfuric acid derivative

[Term]
id: CHEBI:26820
name: sulfates
is_a: CHEBI:37826 ! sulfuric acid derivative

[Term]
id: CHEBI:26833
name: sulfur atom
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen

[Term]
id: CHEBI:26835
name: sulfur molecular entity
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: has_part CHEBI:26833 ! sulfur atom

[Term]
id: CHEBI:26873
name: terpenoid
is_a: CHEBI:24913 ! isoprenoid

[Term]
id: CHEBI:26932
name: tetrapyrrole
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38077 ! polypyrrole

[Term]
id: CHEBI:26935
name: tetraterpenoid
is_a: CHEBI:26873 ! terpenoid

[Term]
id: CHEBI:27207
name: univalent carboacyl group
is_a: CHEBI:37838 ! carboacyl group

[Term]
id: CHEBI:27325
name: xanthophyll
is_a: CHEBI:23044 ! carotenoid

[Term]
id: CHEBI:27369
name: zwitterion
is_a: CHEBI:51151 ! dipolar compound

[Term]
id: CHEBI:27547
name: zeaxanthin
is_a: CHEBI:23045 ! carotenol

[Term]
id: CHEBI:27594
name: carbon atom
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33306 ! carbon group element atom

[Term]
id: CHEBI:28659
name: phosphorus atom
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen

[Term]
id: CHEBI:28793
name: beta-D-glucan
is_a: CHEBI:37163 ! glucan

[Term]
id: CHEBI:28838
name: lutein
is_a: CHEBI:23045 ! carotenol

[Term]
id: CHEBI:28963
name: amino sugar
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:29101
name: sodium(1+)
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33504 ! alkali metal cation
is_a: CHEBI:37246 ! elemental sodium
is_a: CHEBI:60242 ! monovalent inorganic cation

[Term]
id: CHEBI:29108
name: calcium(2+)
is_a: CHEBI:30412 ! monoatomic dication
is_a: CHEBI:39123 ! calcium cation
is_a: CHEBI:60240 ! divalent metal cation

[Term]
id: CHEBI:30412
name: monoatomic dication
is_a: CHEBI:23906 ! monoatomic cation

[Term]
id: CHEBI:32988
name: amide
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:3311
name: calcium carbonate
is_a: CHEBI:35156 ! calcium salt
is_a: CHEBI:46721 ! carbonate salt
is_a: CHEBI:64708 ! one-carbon compound

[Term]
id: CHEBI:33233
name: fundamental particle
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:33238
name: monoatomic entity
is_a: CHEBI:33259 ! elemental molecular entity

[Term]
id: CHEBI:33241
name: oxoacid derivative
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:33245
name: organic fundamental parent
is_a: CHEBI:37175 ! organic hydride
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33246
name: inorganic group
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:33247
name: organic group
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:33249
name: organyl group
is_a: CHEBI:51447 ! organic univalent group

[Term]
id: CHEBI:33250
name: atom
is_a: CHEBI:24431 ! chemical entity
relationship: has_part CHEBI:10545 ! electron
relationship: has_part CHEBI:33252 ! atomic nucleus

[Term]
id: CHEBI:33252
name: atomic nucleus
is_a: CHEBI:36347 ! nuclear particle
relationship: has_part CHEBI:33253 ! nucleon

[Term]
id: CHEBI:33253
name: nucleon
is_a: CHEBI:36339 ! baryon
is_a: CHEBI:36347 ! nuclear particle

[Term]
id: CHEBI:33256
name: primary amide
is_a: CHEBI:32988 ! amide

[Term]
id: CHEBI:33259
name: elemental molecular entity
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:33273
name: polyatomic anion
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36358 ! polyatomic ion

[Term]
id: CHEBI:33285
name: heteroorganic entity
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33296
name: alkali metal molecular entity
is_a: CHEBI:33674 ! s-block molecular entity
relationship: has_part CHEBI:22314 ! alkali metal atom

[Term]
id: CHEBI:33299
name: alkaline earth molecular entity
is_a: CHEBI:33674 ! s-block molecular entity
relationship: has_part CHEBI:22313 ! alkaline earth metal atom

[Term]
id: CHEBI:33300
name: pnictogen
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33302
name: pnictogen molecular entity
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33300 ! pnictogen

[Term]
id: CHEBI:33303
name: chalcogen
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33304
name: chalcogen molecular entity
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33303 ! chalcogen

[Term]
id: CHEBI:33306
name: carbon group element atom
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33318
name: main group element atom
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33424
name: sulfur oxoacid derivative
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33241 ! oxoacid derivative

[Term]
id: CHEBI:33504
name: alkali metal cation
is_a: CHEBI:25213 ! metal cation

[Term]
id: CHEBI:33513
name: alkaline earth cation
is_a: CHEBI:25213 ! metal cation
is_a: CHEBI:33299 ! alkaline earth molecular entity

[Term]
id: CHEBI:33521
name: metal atom
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33559
name: s-block element atom
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33560
name: p-block element atom
is_a: CHEBI:33318 ! main group element atom

[Term]
id: CHEBI:33563
name: glycolipid
is_a: CHEBI:35740 ! liposaccharide

[Term]
id: CHEBI:33575
name: carboxylic acid
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36586 ! carbonyl compound
is_a: CHEBI:64709 ! organic acid
relationship: has_part CHEBI:46883 ! carboxy group

[Term]
id: CHEBI:33579
name: main group molecular entity
is_a: CHEBI:23367 ! molecular entity
relationship: has_part CHEBI:33318 ! main group element atom

[Term]
id: CHEBI:33582
name: carbon group molecular entity
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33306 ! carbon group element atom

[Term]
id: CHEBI:33595
name: cyclic compound
is_a: CHEBI:25367 ! molecule

[Term]
id: CHEBI:33608
name: hydrogen molecular entity
is_a: CHEBI:33674 ! s-block molecular entity
relationship: has_part CHEBI:49637 ! hydrogen atom

[Term]
id: CHEBI:33635
name: polycyclic compound
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33655
name: aromatic compound
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33659
name: organic aromatic compound
is_a: CHEBI:33655 ! aromatic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:33674
name: s-block molecular entity
is_a: CHEBI:33579 ! main group molecular entity
relationship: has_part CHEBI:33559 ! s-block element atom

[Term]
id: CHEBI:33675
name: p-block molecular entity
is_a: CHEBI:33579 ! main group molecular entity
relationship: has_part CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33692
name: hydrides
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:33694
name: biomacromolecule
is_a: CHEBI:33839 ! macromolecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33695
name: information biomacromolecule
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:33700
name: proteinogenic amino-acid residue
is_a: CHEBI:33710 ! alpha-amino-acid residue

[Term]
id: CHEBI:33702
name: polyatomic cation
is_a: CHEBI:36358 ! polyatomic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:33708
name: amino-acid residue
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:33710
name: alpha-amino-acid residue
is_a: CHEBI:33708 ! amino-acid residue

[Term]
id: CHEBI:33832
name: organic cyclic compound
is_a: CHEBI:33595 ! cyclic compound
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:33833
name: heteroarene
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:33837
name: conjugated protein
is_a: CHEBI:36080 ! protein

[Term]
id: CHEBI:33839
name: macromolecule
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:35155
name: elemental calcium
is_a: CHEBI:22985 ! calcium molecular entity

[Term]
id: CHEBI:35156
name: calcium salt
is_a: CHEBI:22985 ! calcium molecular entity
is_a: CHEBI:36364 ! alkaline earth salt
relationship: has_part CHEBI:29108 ! calcium(2+)

[Term]
id: CHEBI:35186
name: terpene
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:24913 ! isoprenoid

[Term]
id: CHEBI:35191
name: triterpene
is_a: CHEBI:35186 ! terpene

[Term]
id: CHEBI:35267
name: quaternary ammonium ion
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion

[Term]
id: CHEBI:35274
name: ammonium ion
is_a: CHEBI:33702 ! polyatomic cation
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35281
name: onium betaine
is_a: CHEBI:27369 ! zwitterion

[Term]
id: CHEBI:35284
name: ammonium betaine
is_a: CHEBI:26469 ! quaternary nitrogen compound
is_a: CHEBI:35281 ! onium betaine

[Term]
id: CHEBI:35341
name: steroid
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:51958 ! organic polycyclic compound

[Term]
id: CHEBI:35352
name: organonitrogen compound
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35406
name: oxoanion
is_a: CHEBI:25741 ! oxide
is_a: CHEBI:33273 ! polyatomic anion

[Term]
id: CHEBI:35479
name: alkali metal salt
is_a: CHEBI:24866 ! salt
is_a: CHEBI:33296 ! alkali metal molecular entity

[Term]
id: CHEBI:35507
name: natural product fundamental parent
is_a: CHEBI:33245 ! organic fundamental parent

[Term]
id: CHEBI:35604
name: carbon oxoanion
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35605
name: carbon oxoacid
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35692
name: dicarboxylic acid
is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives
is_a: CHEBI:33575 ! carboxylic acid

[Term]
id: CHEBI:35701
name: ester
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35722
name: sulfated glycosaminoglycan
is_a: CHEBI:18085 ! glycosaminoglycan
is_a: CHEBI:35724 ! carbohydrate sulfate

[Term]
id: CHEBI:35724
name: carbohydrate sulfate
is_a: CHEBI:25704 ! organic sulfate
is_a: CHEBI:26819 ! sulfuric ester
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:35740
name: liposaccharide
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:35786
name: phosphosphingolipid
is_a: CHEBI:16247 ! phospholipid
is_a: CHEBI:26739 ! sphingolipid

[Term]
id: CHEBI:35794
name: tetrapyrrole fundamental parent
is_a: CHEBI:26932 ! tetrapyrrole
is_a: CHEBI:35507 ! natural product fundamental parent

[Term]
id: CHEBI:36078
name: cholanoid
is_a: CHEBI:35341 ! steroid

[Term]
id: CHEBI:36080
name: protein
is_a: CHEBI:33695 ! information biomacromolecule
relationship: has_part CHEBI:16541 ! protein polypeptide chain

[Term]
id: CHEBI:36277
name: bile acid salt
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:36078 ! cholanoid

[Term]
id: CHEBI:36309
name: cyclic tetrapyrrole
is_a: CHEBI:26932 ! tetrapyrrole
is_a: CHEBI:47882 ! cyclic polypyrrole

[Term]
id: CHEBI:36338
name: lepton
is_a: CHEBI:33233 ! fundamental particle
is_a: CHEBI:36340 ! fermion

[Term]
id: CHEBI:36339
name: baryon
is_a: CHEBI:36340 ! fermion
is_a: CHEBI:36344 ! hadron

[Term]
id: CHEBI:36340
name: fermion
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36342
name: subatomic particle

[Term]
id: CHEBI:36343
name: composite particle
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36344
name: hadron
is_a: CHEBI:36343 ! composite particle

[Term]
id: CHEBI:36347
name: nuclear particle
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36357
name: polyatomic entity
is_a: CHEBI:23367 ! molecular entity
relationship: has_part CHEBI:24433 ! group

[Term]
id: CHEBI:36358
name: polyatomic ion
is_a: CHEBI:24870 ! ion
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:36359
name: phosphorus oxoacid derivative
is_a: CHEBI:33241 ! oxoacid derivative
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives

[Term]
id: CHEBI:36360
name: phosphorus oxoacids and derivatives
is_a: CHEBI:26082 ! phosphorus molecular entity

[Term]
id: CHEBI:36364
name: alkaline earth salt
is_a: CHEBI:24866 ! salt
is_a: CHEBI:33299 ! alkaline earth molecular entity

[Term]
id: CHEBI:36498
name: galactosylceramide
is_a: CHEBI:23079 ! cerebroside
is_a: CHEBI:5254 ! galactolipid
is_a: CHEBI:62941 ! glycosylceramide

[Term]
id: CHEBI:36586
name: carbonyl compound
is_a: CHEBI:36587 ! organic oxo compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: has_part CHEBI:23019 ! carbonyl group

[Term]
id: CHEBI:36587
name: organic oxo compound
is_a: CHEBI:72695 ! organic molecule
relationship: has_part CHEBI:46629 ! oxo group

[Term]
id: CHEBI:36700
name: phosphocholines
is_a: CHEBI:23213 ! choline ester
is_a: CHEBI:23217 ! cholines
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester

[Term]
id: CHEBI:36735
name: biladienes
is_a: CHEBI:25046 ! linear tetrapyrrole

[Term]
id: CHEBI:36914
name: inorganic ion
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:36915
name: inorganic cation
is_a: CHEBI:36914 ! inorganic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:36916
name: cation
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:36962
name: organochalcogen compound
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33304 ! chalcogen molecular entity

[Term]
id: CHEBI:36963
name: organooxygen compound
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:37163
name: glucan
is_a: CHEBI:37164 ! homopolysaccharide

[Term]
id: CHEBI:37164
name: homopolysaccharide
is_a: CHEBI:18154 ! polysaccharide

[Term]
id: CHEBI:37175
name: organic hydride
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:37246
name: elemental sodium
is_a: CHEBI:26712 ! sodium molecular entity

[Term]
id: CHEBI:37395
name: mucopolysaccharide
is_a: CHEBI:18085 ! glycosaminoglycan

[Term]
id: CHEBI:37397
name: chondroitin sulfate
is_a: CHEBI:35722 ! sulfated glycosaminoglycan
is_a: CHEBI:37395 ! mucopolysaccharide

[Term]
id: CHEBI:37577
name: heteroatomic molecular entity
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:37622
name: carboxamide
is_a: CHEBI:33256 ! primary amide
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: has_part CHEBI:23004 ! carbamoyl group

[Term]
id: CHEBI:37734
name: phosphoric ester
is_a: CHEBI:26079 ! phosphoric acid derivative
is_a: CHEBI:35701 ! ester

[Term]
id: CHEBI:37826
name: sulfuric acid derivative
is_a: CHEBI:33424 ! sulfur oxoacid derivative

[Term]
id: CHEBI:37838
name: carboacyl group
is_a: CHEBI:22221 ! acyl group

[Term]
id: CHEBI:38077
name: polypyrrole
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:38101
name: organonitrogen heterocyclic compound
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:38560
name: simple protein
is_a: CHEBI:36080 ! protein

[Term]
id: CHEBI:38700
name: organic sodium salt
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:26714 ! sodium salt

[Term]
id: CHEBI:39015
name: apolipoprotein
is_a: CHEBI:13850 ! apoprotein

[Term]
id: CHEBI:39022
name: inclusion compound
is_a: CHEBI:50967 ! non-covalently-bound molecular entity

[Term]
id: CHEBI:39024
name: clathrate compound
is_a: CHEBI:39022 ! inclusion compound

[Term]
id: CHEBI:39123
name: calcium cation
is_a: CHEBI:33513 ! alkaline earth cation
is_a: CHEBI:39124 ! calcium ion

[Term]
id: CHEBI:39124
name: calcium ion
is_a: CHEBI:25213 ! metal cation
is_a: CHEBI:35155 ! elemental calcium

[Term]
id: CHEBI:41609
name: carbonate
is_a: CHEBI:35604 ! carbon oxoanion

[Term]
id: CHEBI:43176
name: hydroxy group
is_a: CHEBI:33246 ! inorganic group

[Term]
id: CHEBI:46629
name: oxo group
is_a: CHEBI:33246 ! inorganic group

[Term]
id: CHEBI:46662
name: mineral
is_a: CHEBI:59999 ! chemical substance

[Term]
id: CHEBI:46721
name: carbonate salt
is_a: CHEBI:23016 ! carbonates
relationship: has_part CHEBI:41609 ! carbonate

[Term]
id: CHEBI:46723
name: phosphate mineral
is_a: CHEBI:46662 ! mineral

[Term]
id: CHEBI:46883
name: carboxy group
is_a: CHEBI:33249 ! organyl group

[Term]
id: CHEBI:47882
name: cyclic polypyrrole
is_a: CHEBI:38077 ! polypyrrole

[Term]
id: CHEBI:49637
name: hydrogen atom
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33559 ! s-block element atom

[Term]
id: CHEBI:50047
name: organic amino compound
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:50860
name: organic molecular entity
is_a: CHEBI:33582 ! carbon group molecular entity
relationship: has_part CHEBI:27594 ! carbon atom

[Term]
id: CHEBI:50967
name: non-covalently-bound molecular entity
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:51143
name: nitrogen molecular entity
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: has_part CHEBI:25555 ! nitrogen atom

[Term]
id: CHEBI:51151
name: dipolar compound
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:51422
name: organodiyl group
is_a: CHEBI:51446 ! organic divalent group

[Term]
id: CHEBI:51446
name: organic divalent group
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:51447
name: organic univalent group
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:51958
name: organic polycyclic compound
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:52254
name: apatite
is_a: CHEBI:46723 ! phosphate mineral

[Term]
id: CHEBI:52255
name: hydroxylapatite
is_a: CHEBI:52254 ! apatite

[Term]
id: CHEBI:5254
name: galactolipid
is_a: CHEBI:33563 ! glycolipid

[Term]
id: CHEBI:5686
name: heterocyclic compound
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:59999
name: chemical substance
is_a: CHEBI:24431 ! chemical entity

[Term]
id: CHEBI:60240
name: divalent metal cation
is_a: CHEBI:25213 ! metal cation
is_a: CHEBI:64641 ! divalent inorganic cation

[Term]
id: CHEBI:60242
name: monovalent inorganic cation
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:60924
name: keratan sulfate
is_a: CHEBI:35722 ! sulfated glycosaminoglycan
is_a: CHEBI:37395 ! mucopolysaccharide

[Term]
id: CHEBI:60926
name: amino monosaccharide
is_a: CHEBI:28963 ! amino sugar

[Term]
id: CHEBI:62941
name: glycosylceramide
is_a: CHEBI:17761 ! ceramide
is_a: CHEBI:24402 ! glycosphingolipid

[Term]
id: CHEBI:63299
name: carbohydrate derivative
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives

[Term]
id: CHEBI:64583
name: sphingomyelin
is_a: CHEBI:140325 ! secondary carboxamide
is_a: CHEBI:35284 ! ammonium betaine
is_a: CHEBI:35786 ! phosphosphingolipid
is_a: CHEBI:36700 ! phosphocholines

[Term]
id: CHEBI:64641
name: divalent inorganic cation
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:64708
name: one-carbon compound
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:64709
name: organic acid
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:6495
name: lipoprotein
is_a: CHEBI:33837 ! conjugated protein
is_a: CHEBI:39024 ! clathrate compound
relationship: has_part CHEBI:39015 ! apolipoprotein

[Term]
id: CHEBI:65212
name: polysaccharide derivative
is_a: CHEBI:33694 ! biomacromolecule
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:72695
name: organic molecule
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:72813
name: exopolysaccharide
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:78616
name: carbohydrates and carbohydrate derivatives
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:8337
name: porphyrin
is_a: CHEBI:26214 ! porphyrins
is_a: CHEBI:35794 ! tetrapyrrole fundamental parent

[Term]
id: CL:0000000
name: cell
namespace: cell
def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." []
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
subset: ubprop:upper_level
xref: CALOHA:TS-2035
xref: FMA:68646
xref: GO:0005623
xref: KUPO:0000002
xref: VHOG:0001533
xref: WBbt:0004017
xref: XAO:0003012
is_a: GO:0005623 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000001
name: primary cultured cell
namespace: cell
def: "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." []
comment: Covers cells actively being cultured or stored in a quiescent state for future use.
synonym: "primary cell culture cell" EXACT []
synonym: "primary cell line cell" RELATED []
synonym: "unpassaged cultured cell" EXACT []
xref: BTO:0002290
is_a: CL:0000010 ! cultured cell

[Term]
id: CL:0000002
name: obsolete immortal cell line cell
namespace: cell
def: "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." []
comment: Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use.
synonym: "continuous cell line cell" EXACT []
synonym: "permanent cell line cell" EXACT []
is_obsolete: true
replaced_by: CLO:0000019

[Term]
id: CL:0000003
name: native cell
namespace: cell
def: "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." []
comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12).
subset: ubprop:upper_level
synonym: "cell in vivo" NARROW []
xref: CARO:0000013
is_a: CL:0000000 ! cell
is_a: GO:0005623 ! cell

[Term]
id: CL:0000004
name: obsolete cell by organism
namespace: cell
def: "OBSOLETE: A classification of cells by the organisms within which they are contained." []
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000005
name: fibroblast neural crest derived
namespace: cell
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell

[Term]
id: CL:0000006
name: neuronal receptor cell
namespace: cell
synonym: "neuronal receptor cell (sensu Animalia)" EXACT []
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000197 ! receptor cell
intersection_of: CL:0000197 ! receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000007
name: early embryonic cell
namespace: cell
def: "A cell found in the embryo before the formation of all the gem layers is complete." []
is_a: CL:0002321 ! embryonic cell

[Term]
id: CL:0000008
name: migratory cranial neural crest cell
namespace: cell
is_a: CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000009
name: obsolete fusiform initial
namespace: cell
alt_id: CL:0000274
def: "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." []
comment: replaced_by: PO:0000079
synonym: "xylem initial" RELATED []
synonym: "xylem mother cell" RELATED []
is_obsolete: true

[Term]
id: CL:0000010
name: cultured cell
namespace: cell
def: "A cell in vitro that is or has been maintained or propagated as part of a cell culture." []
comment: Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture.
is_a: CL:0000578 ! experimentally modified cell in vitro

[Term]
id: CL:0000011
name: migratory trunk neural crest cell
namespace: cell
is_a: CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000012
name: obsolete cell by class
namespace: cell
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000013
name: obsolete dentine secreting cell
namespace: cell
is_obsolete: true
consider: CL:0000140

[Term]
id: CL:0000014
name: germ line stem cell
namespace: cell
synonym: "germline stem cell" EXACT []
is_a: CL:0000034 ! stem cell
is_a: CL:0000039 ! germ line cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000015
name: male germ cell
namespace: cell
xref: FMA:72290
xref: MA:0002765
xref: ncithesaurus:Spermatogenic_Cell
xref: VHOG:0001531
is_a: CL:0000586 ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: capable_of GO:0007283 ! spermatogenesis
relationship: capable_of GO:0007283 ! spermatogenesis

[Term]
id: CL:0000016
name: male germ line stem cell
namespace: cell
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000015 ! male germ cell

[Term]
id: CL:0000017
name: spermatocyte
namespace: cell
def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." []
xref: BTO:0001275
xref: CALOHA:TS-0951
xref: EMAPA:31484
xref: FBbt:00004936
xref: FMA:84049
xref: WBbt:0006799
is_a: CARO:0000000
is_a: CL:0000015 ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: capable_of GO:0048137
relationship: capable_of GO:0048137
relationship: develops_from CL:0000020 ! spermatogonium

[Term]
id: CL:0000018
name: spermatid
namespace: cell
def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." []
synonym: "nematoblast" EXACT []
xref: BTO:0001274
xref: CALOHA:TS-0950
xref: EMAPA:31486
xref: FBbt:00004942
xref: FMA:72294
xref: WBbt:0006800
is_a: CARO:0000000
is_a: CL:0000015 ! male germ cell
is_a: CL:0000413 ! haploid cell
relationship: capable_of GO:0001675
relationship: capable_of GO:0007288
relationship: capable_of GO:0007289
relationship: develops_from CL:0000657 ! secondary spermatocyte

[Term]
id: CL:0000019
name: sperm
namespace: cell
def: "A mature male germ cell that develops from a spermatid." []
synonym: "sperm cell" EXACT []
synonym: "spermatozoid" EXACT []
synonym: "spermatozoon" EXACT []
xref: BTO:0001277
xref: BTO:0002046
xref: CALOHA:TS-0949
xref: FBbt:00004954
xref: FMA:67338
xref: WBbt:0006798
is_a: CARO:0000000
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000219 ! motile cell
is_a: CL:0000408 ! male gamete
intersection_of: CL:0000408 ! male gamete
intersection_of: capable_of GO:0030317 ! flagellated sperm motility
intersection_of: capable_of GO:0048240 ! sperm capacitation
relationship: capable_of GO:0030317 ! flagellated sperm motility
relationship: capable_of GO:0048240 ! sperm capacitation
relationship: develops_from CL:0000018 ! spermatid

[Term]
id: CL:0000020
name: spermatogonium
namespace: cell
def: "An euploid male germ cell of an early stage of spermatogenesis." []
xref: BTO:0000958
xref: CALOHA:TS-2193
xref: EMAPA:31482
xref: FBbt:00004935
xref: FMA:72291
is_a: CL:0000015 ! male germ cell

[Term]
id: CL:0000021
name: female germ cell
namespace: cell
def: "Female germ cell is a germ cell that supports female gamete production." []
xref: MA:0000388
xref: ncithesaurus:Egg
xref: VHOG:0001530
is_a: CL:0000586 ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: capable_of GO:0048477 ! oogenesis
relationship: capable_of GO:0048477 ! oogenesis

[Term]
id: CL:0000022
name: female germ line stem cell
namespace: cell
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000021 ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000023
name: oocyte
namespace: cell
def: "A female germ cell that has entered meiosis." []
synonym: "oogonium" RELATED []
xref: BTO:0000964
xref: CALOHA:TS-0711
xref: FBbt:00004886
xref: FMA:18644
xref: WBbt:0006797
is_a: CL:0000021 ! female germ cell

[Term]
id: CL:0000024
name: oogonial cell
namespace: cell
def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." []
xref: FMA:83673
is_a: CARO:0000000
is_a: CL:0000021 ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: capable_of GO:0000278
relationship: capable_of GO:0000278
relationship: develops_from CL:0000670 ! primordial germ cell

[Term]
id: CL:0000025
name: egg cell
namespace: cell
def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." []
synonym: "mature oocyte" EXACT []
synonym: "ovum" EXACT []
xref: BTO:0000369
xref: BTO:0003801
xref: CALOHA:TS-2191
xref: FBbt:00057012
xref: FMA:67343
xref: MA:0000388
is_a: CARO:0000000
is_a: CL:0000675 ! female gamete
relationship: develops_from CL:0000023 ! oocyte

[Term]
id: CL:0000026
name: invertebrate nurse cell
namespace: cell
def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." []
synonym: "nurse cell" RELATED []
xref: BTO:0000953
xref: FBbt:00004878
is_a: CARO:0000000
is_a: CL:0000039 ! germ line cell
is_a: CL:0000412 ! polyploid cell
relationship: develops_from CL:0000722 ! cystoblast

[Term]
id: CL:0000027
name: smooth muscle cell neural crest derived
namespace: cell
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell

[Term]
id: CL:0000028
name: CNS neuron (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:2000029 ! central nervous system neuron
relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)

[Term]
id: CL:0000029
name: neuron neural crest derived
namespace: cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0002676 ! neural crest derived neuroblast

[Term]
id: CL:0000030
name: glioblast
namespace: cell
xref: FBbt:00005145
is_a: CARO:0000000
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000031
name: neuroblast
namespace: cell
def: "A cell that will develop into a neuron often after a migration phase." []
xref: BTO:0000930
xref: FBbt:00005146
xref: FMA:70563
is_a: CL:0000047 ! neuronal stem cell
is_a: CL:0000055 ! non-terminally differentiated cell

[Term]
id: CL:0000032
name: neuroplacodal cell
namespace: cell
def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." []
synonym: "neural placode cell" EXACT []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0002321 ! embryonic cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000033
name: apocrine cell
namespace: cell
def: "An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance." []
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000034
name: stem cell
namespace: cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." []
xref: CALOHA:TS-2086
xref: FMA:63368
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000035
name: single fate stem cell
namespace: cell
def: "A stem cell that self-renews as well as give rise to a single mature cell type." []
synonym: "unipotent stem cell" EXACT []
synonym: "unipotential stem cell" EXACT []
xref: FMA:70569
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000036
name: epithelial fate stem cell
namespace: cell
is_a: CL:0000035 ! single fate stem cell

[Term]
id: CL:0000037
name: hematopoietic stem cell
namespace: cell
def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." []
comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
synonym: "HSC" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
xref: FMA:86475
xref: VHOG:0001485
is_a: CARO:0000000
is_a: CL:0000723 ! somatic stem cell
is_a: CL:0008001 ! hematopoietic precursor cell
relationship: capable_of GO:0002244
relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell

[Term]
id: CL:0000038
name: erythroid progenitor cell
namespace: cell
def: "A progenitor cell committed to the erythroid lineage." []
synonym: "BFU-E" RELATED []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell

[Term]
id: CL:0000039
name: germ line cell
namespace: cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." []
comment: Originally this term had some plant germ line cell children.
subset: ubprop:upper_level
is_a: BFO:0000040 ! material entity
is_a: CL:0000548 ! animal cell
disjoint_from: CL:0002371 ! somatic cell
relationship: capable_of GO:0022414 ! reproductive process

[Term]
id: CL:0000040
name: monoblast
namespace: cell
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." []
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
synonym: "CFU-M" RELATED []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
xref: CALOHA:TS-1195
xref: FMA:83553
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 ! monopoietic cell
relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor
relationship: has_part CP:0000028
relationship: has_part GO:0000791
relationship: has_part GO:0005730
relationship: has_part PR:000001012

[Term]
id: CL:0000041
name: mature eosinophil
namespace: cell
def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." []
comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP.
synonym: "mature eosinocyte" EXACT []
synonym: "mature eosinophil leucocyte" EXACT []
synonym: "mature eosinophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000771 ! eosinophil
is_a: CL:0002242 ! nucleate cell
relationship: capable_of GO:0002495
relationship: capable_of GO:0002540
relationship: capable_of GO:0045730
relationship: develops_from CL:0000774 ! band form eosinophil
relationship: has_part CP:0000025
relationship: has_part PR:000007152
relationship: has_part PR:000007857
relationship: has_part PR:000007858
relationship: has_part PR:000009129
relationship: has_part PR:000014046
relationship: has_part PR:000014047
relationship: has_part PR:000022006

[Term]
id: CL:0000042
name: neutrophilic myeloblast
namespace: cell
def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." []
comment: These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction.
synonym: "neutrophilic granuloblast" RELATED []
is_a: CL:0000834 ! neutrophil progenitor cell
is_a: CL:0000835 ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: capable_of GO:0030223
intersection_of: has_part PR:000001944
intersection_of: has_part PR:000005307
intersection_of: has_part PR:000007857
intersection_of: has_part PR:000010799
intersection_of: has_part PR:000014362
relationship: develops_from CL:0000834 ! neutrophil progenitor cell
relationship: has_part PR:000001944
relationship: has_part PR:000005307
relationship: has_part PR:000007857
relationship: has_part PR:000010799
relationship: has_part PR:000014362

[Term]
id: CL:0000043
name: mature basophil
namespace: cell
alt_id: CL:0000739
def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." []
comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4.
synonym: "mature basophil leucocyte" EXACT []
synonym: "mature basophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
xref: BTO:0001026
xref: CALOHA:TS-0688
is_a: CL:0000767 ! basophil
is_a: CL:0002242 ! nucleate cell
is_a: CL:0002274 ! histamine secreting cell
intersection_of: CL:0000767 ! basophil
intersection_of: capable_of GO:0002349
intersection_of: capable_of GO:0002351 ! serotonin production involved in inflammatory response
intersection_of: capable_of GO:0002830
intersection_of: capable_of GO:0008015 ! blood circulation
intersection_of: capable_of GO:0032616
intersection_of: capable_of GO:0032633
intersection_of: capable_of GO:0048295
intersection_of: has_part CP:0000025
relationship: capable_of GO:0002349
relationship: capable_of GO:0002351 ! serotonin production involved in inflammatory response
relationship: capable_of GO:0002830
relationship: capable_of GO:0032616
relationship: capable_of GO:0032633
relationship: capable_of GO:0048295
relationship: develops_from CL:0000770 ! band form basophil
relationship: has_part CP:0000025

[Term]
id: CL:0000045
name: obsolete thymus processed stem cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000046
name: obsolete bursa processed stem cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000047
name: neuronal stem cell
namespace: cell
def: "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." []
synonym: "neural stem cell" EXACT []
synonym: "NSC" EXACT []
xref: BTO:0002881
xref: CALOHA:TS-2360
xref: FMA:86684
is_a: CARO:0000000
is_a: CL:0000048 ! multi fate stem cell
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: develops_from CL:0000133 ! neurectodermal cell
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000048
name: multi fate stem cell
namespace: cell
def: "A stem cell that can give rise to multiple lineages of cells." []
synonym: "multi-fate stem cell" EXACT []
synonym: "multifate stem cell" EXACT []
synonym: "multipotent cell" EXACT []
synonym: "multipotent stem cell" EXACT []
xref: FMA:84789
is_a: CL:0000034 ! stem cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000049
name: common myeloid progenitor
namespace: cell
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." []
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor.  For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
synonym: "CFU-GEMM" RELATED []
synonym: "CFU-S" RELATED []
synonym: "CMP" EXACT []
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED []
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED []
synonym: "myeloid stem cell" RELATED []
synonym: "pluripotent stem cell (bone marrow)" RELATED []
xref: BTO:0004730
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell
disjoint_from: CL:0000051 ! common lymphoid progenitor
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000050
name: megakaryocyte-erythroid progenitor cell
namespace: cell
def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." []
comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.
synonym: "CFU-EM" EXACT []
synonym: "CFU-MegE" EXACT []
synonym: "colony forming unit erythroid megakaryocyte" EXACT []
synonym: "Meg/E progenitor" EXACT []
synonym: "megakaryocyte/erythrocyte progenitor" EXACT []
synonym: "megakaryocyte/erythroid progenitor cell" EXACT []
synonym: "MEP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030218
intersection_of: capable_of GO:0030219
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell
disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor
relationship: capable_of GO:0030218
relationship: capable_of GO:0030219

[Term]
id: CL:0000051
name: common lymphoid progenitor
namespace: cell
alt_id: CL:0000044
def: "A oligopotent progenitor cell committed to the lymphoid lineage." []
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
synonym: "CLP" EXACT []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
synonym: "ELP" RELATED []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
relationship: capable_of GO:0030098 ! lymphocyte differentiation

[Term]
id: CL:0000052
name: totipotent stem cell
namespace: cell
def: "A stem cell from which all cells of the body can form." []
synonym: "totipotential stem cell" EXACT []
xref: FMA:84790
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000054
name: bone matrix secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000055
name: non-terminally differentiated cell
namespace: cell
def: "A precursor cell with a limited number of potential fates." []
comment: define using PATO mulit-potent or oligopotent?
synonym: "blast cell" EXACT []
xref: BTO:0000125
xref: FMA:84782
is_a: CL:0011115 ! precursor cell

[Term]
id: CL:0000056
name: myoblast
namespace: cell
def: "A cell that is commited to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair." []
xref: BTO:0000222
xref: CALOHA:TS-0650
xref: FBbt:00005083
xref: FMA:70335
xref: VHOG:0001529
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000057
name: fibroblast
namespace: cell
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." []
comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
xref: BTO:0000452
xref: CALOHA:TS-0362
xref: FMA:63877
xref: VHOG:0001482
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000058
name: chondroblast
namespace: cell
def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." []
synonym: "chrondoplast" EXACT []
xref: BTO:0003607
xref: FMA:66783
is_a: CARO:0000000
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0007009 ! prechondroblast

[Term]
id: CL:0000059
name: ameloblast
namespace: cell
alt_id: CL:0000053
alt_id: CL:0000139
def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." []
comment: non-encoded relationship from VSAO produces VSAO:0000066
synonym: "amelocyte" EXACT []
synonym: "enamel secreting cell" EXACT []
xref: BTO:0001663
xref: FMA:70576
is_a: CL:0000146 ! simple columnar epithelial cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0002077 ! ecto-epithelial cell
relationship: capable_of GO:0097186
relationship: develops_from CL:0007000 ! preameloblast
relationship: part_of UBERON:0005176 ! tooth enamel organ

[Term]
id: CL:0000060
name: odontoblast
namespace: cell
def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." []
comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin.
xref: BTO:0001769
xref: CALOHA:TS-0696
xref: FMA:62999
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
relationship: develops_from CL:0007003 ! preodontoblast
relationship: part_of UBERON:0005176 ! tooth enamel organ

[Term]
id: CL:0000061
name: cementoblast
namespace: cell
alt_id: CL:0000859
def: "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." []
comment: Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth.
synonym: "cementum secreting cell" EXACT []
xref: CALOHA:TS-1164
xref: FMA:63002
is_a: CL:0000062 ! osteoblast
is_a: CL:0000151 ! secretory cell
relationship: develops_from CL:0007002 ! precementoblast
relationship: part_of UBERON:0005176 ! tooth enamel organ

[Term]
id: CL:0000062
name: osteoblast
namespace: cell
def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." []
comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020
xref: BTO:0001593
xref: CALOHA:TS-0720
xref: FMA:66780
is_a: CARO:0000000
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0007010 ! preosteoblast

[Term]
id: CL:0000063
name: obsolete cell by histology
namespace: cell
def: "OBSOLETE: A classification of cells by their microscopic appearance." []
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000064
name: ciliated cell
namespace: cell
def: "A cell that has a filiform extrusion of the cell surface." []
xref: VHOG:0001532
xref: XAO:0000031
is_a: CL:0000003 ! native cell
relationship: has_part GO:0005929 ! cilium

[Term]
id: CL:0000065
name: ependymal cell
namespace: cell
def: "A neurectoderm derived cell that lines the neural lumen." []
synonym: "ependymocyte" EXACT []
xref: BTO:0001724
xref: FMA:70550
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000066
name: epithelial cell
namespace: cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." []
synonym: "epitheliocyte" EXACT []
xref: BTO:0000414
xref: CALOHA:TS-2026
xref: CARO:0000077
xref: FBbt:00000124
xref: FMA:66768
xref: WBbt:0003672
is_a: BFO:0000002
is_a: CL:0000548 ! animal cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0000483 ! epithelium
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium

[Term]
id: CL:0000067
name: ciliated epithelial cell
namespace: cell
def: "An epithelial cell that has a cillia." []
xref: FMA:70605
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000068
name: duct epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000058 ! duct
relationship: part_of UBERON:0000058 ! duct

[Term]
id: CL:0000069
name: branched duct epithelial cell
namespace: cell
is_a: CL:0000068 ! duct epithelial cell

[Term]
id: CL:0000070
name: obsolete epithelial cell of gland
namespace: cell
is_obsolete: true

[Term]
id: CL:0000071
name: blood vessel endothelial cell
namespace: cell
def: "An endothelial cell that lines the vasculature." []
synonym: "cuboidal endothelial cell of vascular tree" EXACT []
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0004638 ! blood vessel endothelium
relationship: develops_from CL:0002546 ! embryonic blood vessel endothelial progenitor cell
relationship: part_of UBERON:0004638 ! blood vessel endothelium

[Term]
id: CL:0000072
name: non-branched duct epithelial cell
namespace: cell
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002078 ! meso-epithelial cell

[Term]
id: CL:0000073
name: barrier epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000074
name: obsolete epithem cell
namespace: cell
def: "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." []
comment: replaced_by: PO:0000066
is_obsolete: true

[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000076
name: squamous epithelial cell
namespace: cell
xref: CALOHA:TS-1249
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000077
name: mesothelial cell
namespace: cell
def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." []
synonym: "mesotheliocyte" EXACT []
xref: FMA:66773
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell

[Term]
id: CL:0000078
name: peridermal cell
namespace: cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000079
name: stratified epithelial cell
namespace: cell
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000357 ! stratified epithelial stem cell

[Term]
id: CL:0000080
name: circulating cell
namespace: cell
def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." []
is_a: BFO:0000002
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0000179 ! haemolymphatic fluid

[Term]
id: CL:0000081
name: blood cell
namespace: cell
def: "A cell found predominately in the blood." []
xref: FMA:62844
is_a: BFO:0000040 ! material entity
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0008015 ! blood circulation
relationship: capable_of GO:0008015 ! blood circulation

[Term]
id: CL:0000082
name: epithelial cell of lung
namespace: cell
synonym: "lung epithelial cell" EXACT []
xref: BTO:0004299
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0000115 ! lung epithelium

[Term]
id: CL:0000083
name: epithelial cell of pancreas
namespace: cell
def: "An epithelial cell of the pancreas." []
synonym: "pancreas epithelial cell" EXACT []
synonym: "pancreatic epithelial cell" EXACT []
xref: BTO:0000028
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0000223 ! endodermal cell
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: CL:0000084
name: T cell
namespace: cell
alt_id: CL:0000804
alt_id: CL:0000812
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." []
synonym: "immature T cell" RELATED []
synonym: "mature T cell" RELATED []
synonym: "T lymphocyte" EXACT []
synonym: "T-cell" EXACT []
synonym: "T-lymphocyte" EXACT []
xref: BTO:0000782
xref: CALOHA:TS-1001
xref: FMA:62870
xref: VHOG:0001479
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: capable_of GO:0002456
disjoint_from: CL:0000623 ! natural killer cell
disjoint_from: CL:0000945 ! lymphocyte of B lineage
relationship: capable_of GO:0002456
relationship: develops_from CL:0000827 ! pro-T cell

[Term]
id: CL:0000085
name: germ line stem cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000014 ! germ line stem cell

[Term]
id: CL:0000086
name: germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004861
is_a: CL:0000014 ! germ line stem cell

[Term]
id: CL:0000087
name: male germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004929
is_a: CL:0000016 ! male germ line stem cell
is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000088
name: female germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004873
is_a: CL:0000022 ! female germ line stem cell
is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000089
name: male germ line stem cell (sensu Vertebrata)
namespace: cell
synonym: "spermatogonial stem cell" EXACT []
is_a: CL:0000016 ! male germ line stem cell
is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata)

[Term]
id: CL:0000090
name: female germ line stem cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000022 ! female germ line stem cell
is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata)

[Term]
id: CL:0000091
name: Kupffer cell
namespace: cell
def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." []
comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.
synonym: "hepatic macrophage" EXACT []
synonym: "littoral cell of hepatic sinusoid" EXACT []
synonym: "liver macrophage" EXACT []
synonym: "macrophagocytus stellatus" EXACT []
synonym: "stellate cell of von Kupffer" EXACT []
synonym: "von Kupffer cell" EXACT []
xref: BTO:0000685
xref: FMA:14656
is_a: CL:0000864 ! tissue-resident macrophage
relationship: capable_of GO:0034102
relationship: has_part PR:000001012
relationship: has_part PR:000001813
relationship: has_part PR:000001925
relationship: has_part PR:000002064

[Term]
id: CL:0000092
name: osteoclast
namespace: cell
def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." []
comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
synonym: "chondroclast" RELATED []
xref: BTO:0000968
xref: CALOHA:TS-0721
xref: FMA:66781
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0001035 ! bone cell
relationship: capable_of GO:0045453
relationship: develops_from CL:0000576 ! monocyte
relationship: has_part PR:000001850
relationship: has_part PR:000001937
relationship: has_part PR:000001944
relationship: has_part PR:000001954
relationship: has_part PR:000002062
relationship: has_part PR:000007597
relationship: has_part PR:000011178

[Term]
id: CL:0000093
name: obsolete osteochondroclast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using 'osteoclast ; CL:0000092' instead.
is_obsolete: true

[Term]
id: CL:0000094
name: granulocyte
namespace: cell
def: "A leukocyte with abundant granules in the cytoplasm." []
synonym: "granular leucocyte" EXACT []
synonym: "granular leukocyte" EXACT []
synonym: "polymorphonuclear leukocyte" EXACT []
xref: BTO:0000539
xref: BTO:0001026
xref: CALOHA:TS-0422
xref: FMA:62854
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 ! myeloid leukocyte
relationship: has_part GO:0030141
relationship: has_part PR:000001012
relationship: has_part PR:000001332
relationship: has_part PR:000001969

[Term]
id: CL:0000095
name: neuron associated cell
namespace: cell
is_a: CL:0002319 ! neural cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000096
name: mature neutrophil
namespace: cell
def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." []
comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)).
synonym: "mature neutrocyte" EXACT []
synonym: "mature neutrophil leucocyte" EXACT []
synonym: "mature neutrophil leukocyte" EXACT []
synonym: "mature neutrophilic leucocyte" EXACT []
synonym: "mature neutrophilic leukocyte" EXACT []
synonym: "PMN" EXACT []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" EXACT []
synonym: "polynuclear neutrophilic leucocyte" EXACT []
synonym: "polynuclear neutrophilic leukocyte" EXACT []
xref: BTO:0003473
is_a: CL:0000234 ! phagocyte
is_a: CL:0000775 ! neutrophil
is_a: CL:0002242 ! nucleate cell
relationship: capable_of GO:0002536
relationship: capable_of GO:0002690
relationship: capable_of GO:0032637
relationship: has_part CP:0000000
relationship: has_part CP:0000025
relationship: has_part GO:0070820
relationship: has_part PR:000001256
relationship: has_part PR:000001257
relationship: has_part PR:000001456
relationship: has_part PR:000001483
relationship: has_part PR:000001944
relationship: has_part PR:000007597

[Term]
id: CL:0000097
name: mast cell
namespace: cell
def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." []
comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
synonym: "histaminocyte" EXACT []
synonym: "labrocyte" EXACT []
synonym: "mastocyte" EXACT []
synonym: "tissue basophil" RELATED []
xref: BTO:0000830
xref: CALOHA:TS-0603
xref: FMA:66784
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0002274 ! histamine secreting cell
relationship: capable_of GO:0002349
relationship: capable_of GO:0002539
relationship: capable_of GO:0002660
relationship: capable_of GO:0002690
relationship: capable_of GO:0002830
relationship: capable_of GO:0030210
relationship: develops_from CL:0000831 ! mast cell progenitor
relationship: has_part GO:0030141
relationship: has_part PR:000001255
relationship: has_part PR:000002065
relationship: has_part PR:000006169
relationship: has_part PR:000007431

[Term]
id: CL:0000098
name: sensory epithelial cell
namespace: cell
def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." []
comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
is_a: BFO:0000040 ! material entity
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000197 ! receptor cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000099
name: interneuron
namespace: cell
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." []
xref: BTO:0003811
xref: FBbt:00005125
xref: FMA:67313
xref: WBbt:0005113
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000100
name: motor neuron
namespace: cell
def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." []
synonym: "anterior horn cell" NARROW []
synonym: "motoneuron" EXACT []
xref: BTO:0000312
xref: FMA:83617
xref: WBbt:0005409
is_a: CL:0000527 ! efferent neuron

[Term]
id: CL:0000101
name: sensory neuron
namespace: cell
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." []
xref: BTO:0001037
xref: FBbt:00005124
xref: FMA:84649
xref: WBbt:0005759
is_a: CL:0000526 ! afferent neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000102
name: polymodal neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000103
name: bipolar neuron
namespace: cell
def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." []
xref: FMA:67282
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000104
name: multipolar neuron
namespace: cell
def: "Neuron with an axon and two or more dendrites." []
xref: FMA:67287
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000105
name: pseudounipolar neuron
namespace: cell
def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." []
xref: FMA:67305
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000106
name: unipolar neuron
namespace: cell
def: "Neuron with one neurite that extends from the cell body." []
xref: FMA:67278
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000107
name: autonomic neuron
namespace: cell
def: "A neruon whose cell body is within an autonomic ganglion." []
xref: FMA:80121
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0002410 ! autonomic nervous system
relationship: part_of UBERON:0002410 ! autonomic nervous system

[Term]
id: CL:0000108
name: cholinergic neuron
namespace: cell
def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." []
xref: BTO:0004902
xref: FMA:84796
xref: WBbt:0006840
is_a: CL:0000381 ! neurosecretory neuron
relationship: capable_of GO:0014055

[Term]
id: CL:0000109
name: adrenergic neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000110
name: peptidergic neuron
namespace: cell
is_a: CL:0000540 ! neuron
relationship: capable_of GO:0002790 ! peptide secretion

[Term]
id: CL:0000111
name: peripheral neuron
namespace: cell
def: "A neuron that is part of nerve found outside the central nervous system." []
xref: FMA:84664
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000112
name: columnar neuron
namespace: cell
synonym: "columnar neuron" RELATED []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000113
name: mononuclear phagocyte
namespace: cell
def: "A vertebrate phagocyte with a single nucleus." []
xref: BTO:0001433
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)

[Term]
id: CL:0000114
name: surface ectodermal cell
namespace: cell
synonym: "cell of surface ectoderm" EXACT []
synonym: "surface ectoderm cell" EXACT []
xref: FMA:72552
is_a: CL:0000221 ! ectodermal cell

[Term]
id: CL:0000115
name: endothelial cell
namespace: cell
def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." []
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
synonym: "endotheliocyte" EXACT []
xref: BTO:0001176
xref: CALOHA:TS-0278
xref: FMA:66772
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell

[Term]
id: CL:0000116
name: pioneer neuron
namespace: cell
def: "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." []
xref: FBbt:00005128
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000117
name: CNS neuron (sensu Vertebrata)
namespace: cell
is_a: CL:2000029 ! central nervous system neuron
relationship: develops_from CL:0000337 ! neuroblast (sensu Vertebrata)

[Term]
id: CL:0000118
name: basket cell
namespace: cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000119
name: cerebellar Golgi cell
namespace: cell
def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." []
synonym: "cerebellar Golgi neuron" EXACT []
synonym: "cerebellum Golgi cell" EXACT []
synonym: "Golgi cell" EXACT []
synonym: "Golgi neuron" EXACT []
is_a: CL:0000402 ! CNS interneuron
is_a: CL:0011005 ! GABAergic interneuron
is_a: CL:1001611 ! cerebellar neuron
relationship: part_of UBERON:0002129 ! cerebellar cortex

[Term]
id: CL:0000120
name: granule cell
namespace: cell
xref: BTO:0003393
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000121
name: Purkinje cell
namespace: cell
def: "The output neuron of the cerebellar cortex." []
synonym: "cerebellar Purkinje cell" EXACT []
synonym: "cerebellum Purkinje cell" EXACT []
synonym: "Purkinje neuron" EXACT []
synonym: "Purkinje's cell" EXACT []
xref: BTO:0001011
xref: CALOHA:TS-0845
xref: FMA:67969
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
is_a: CL:0000527 ! efferent neuron
is_a: CL:1001611 ! cerebellar neuron
relationship: part_of UBERON:0002129 ! cerebellar cortex

[Term]
id: CL:0000122
name: stellate neuron
namespace: cell
xref: BTO:0002316
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000123
name: neuron associated cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000095 ! neuron associated cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000124
name: glial cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005144
is_a: CL:0000125 ! glial cell
relationship: develops_from CL:0000340 ! glioblast (sensu Nematoda and Protostomia)

[Term]
id: CL:0000125
name: glial cell
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." []
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
xref: CALOHA:TS-0415
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell
relationship: develops_from CL:0000030 ! glioblast

[Term]
id: CL:0000126
name: macroglial cell
namespace: cell
def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." []
synonym: "macrogliocyte" EXACT []
xref: BTO:0000771
xref: CALOHA:TS-2027
xref: FMA:54538
is_a: CL:0000243 ! glial cell (sensu Vertebrata)

[Term]
id: CL:0000127
name: astrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." []
comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.
synonym: "astrocytic glia" EXACT []
xref: BTO:0000099
xref: CALOHA:TS-0060
xref: FMA:54537
is_a: CL:0000126 ! macroglial cell

[Term]
id: CL:0000128
name: oligodendrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." []
comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative.
synonym: "oligodendroglia" RELATED []
synonym: "OLs" EXACT []
xref: BTO:0000962
xref: CALOHA:TS-0709
xref: FMA:54540
is_a: CL:0000126 ! macroglial cell
relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000129
name: microglial cell
namespace: cell
def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." []
comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
synonym: "brain macrophage" BROAD []
synonym: "brain-resident macrophage" EXACT []
synonym: "hortega cells" EXACT []
synonym: "MF.microglia.CNS" RELATED []
synonym: "microglia" EXACT []
synonym: "microgliocyte" EXACT []
xref: BTO:0000078
xref: BTO:0000962
xref: FMA:54539
xref: FMA:54540
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
is_a: CL:0000878 ! central nervous system macrophage
relationship: capable_of GO:0045087
relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell
relationship: has_part PR:000001012
relationship: has_part PR:000001813
relationship: has_part PR:000002064

[Term]
id: CL:0000130
name: neuron associated cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000095 ! neuron associated cell

[Term]
id: CL:0000131
name: gut endothelial cell
namespace: cell
is_a: CL:0000115 ! endothelial cell
relationship: develops_from CL:0000223 ! endodermal cell

[Term]
id: CL:0000132
name: corneal endothelial cell
namespace: cell
def: "Cell of the single layer of large flattened cells covering the surface of the cornea." []
xref: CALOHA:TS-0172
xref: FMA:70614
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell

[Term]
id: CL:0000133
name: neurectodermal cell
namespace: cell
def: "Ectoderm destined to be nervous tissue." []
synonym: "neurectoderm cell" EXACT []
is_a: CL:0000221 ! ectodermal cell

[Term]
id: CL:0000134
name: mesenchymal stem cell
namespace: cell
alt_id: CL:0002452
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." []
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
synonym: "BMSC" NARROW []
synonym: "bone marrow stromal cells" NARROW []
synonym: "CFU-F" RELATED []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW []
synonym: "mesenchymal precursor cell" RELATED []
synonym: "mesenchymal progenitor cells" RELATED []
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED []
synonym: "MSC" RELATED []
synonym: "stem cells, mesenchymal" RELATED []
xref: BTO:0002625
xref: BTO:0003298
xref: FMA:70546
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000219 ! motile cell
is_a: CL:0002320 ! connective tissue cell
relationship: capable_of GO:0001649
relationship: capable_of GO:0016477 ! cell migration
relationship: capable_of GO:0030182
relationship: capable_of GO:0030855 ! epithelial cell differentiation
relationship: capable_of GO:0045444
relationship: capable_of GO:0055007
relationship: capable_of GO:0060591
relationship: has_part PR:000001345
relationship: has_part PR:000001800
relationship: has_part PR:000001843

[Term]
id: CL:0000135
name: fibrocyte
namespace: cell
def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." []
comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A.
xref: FMA:63879
is_a: BFO:0000040 ! material entity
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: capable_of GO:0002495
intersection_of: capable_of GO:0045766 ! positive regulation of angiogenesis
relationship: capable_of GO:0002495
relationship: capable_of GO:0045766 ! positive regulation of angiogenesis
relationship: develops_from CL:0000057 ! fibroblast

[Term]
id: CL:0000136
name: fat cell
namespace: cell
alt_id: CL:0000450
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." []
synonym: "adipocyte" EXACT []
synonym: "adipose cell" EXACT []
xref: BTO:0000443
xref: CALOHA:TS-0012
xref: FMA:63880
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000137
name: osteocyte
namespace: cell
def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." []
comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118
synonym: "bone cell" BROAD []
xref: BTO:0002038
xref: CALOHA:TS-1167
xref: FMA:66779
xref: VSAO:0000124
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0001035 ! bone cell
relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast
relationship: part_of UBERON:0002481 ! bone tissue

[Term]
id: CL:0000138
name: chondrocyte
namespace: cell
def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." []
synonym: "cartilage cell" EXACT []
xref: BTO:0000249
xref: CALOHA:TS-0138
xref: FMA:66782
is_a: CL:0000153 ! glycosaminoglycan secreting cell
is_a: CL:0000667 ! collagen secreting cell
relationship: develops_from CL:0000058 ! chondroblast

[Term]
id: CL:0000140
name: odontocyte
namespace: cell
def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000060 ! odontoblast
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000141
name: cementocyte
namespace: cell
def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." []
comment: CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def).
xref: FMA:63003
is_a: CL:0000137 ! osteocyte
relationship: develops_from CL:0000061 ! cementoblast
relationship: part_of UBERON:0005176 ! tooth enamel organ

[Term]
id: CL:0000142
name: hyalocyte
namespace: cell
def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." []
synonym: "vitreous cell" RELATED []
xref: BTO:0004271
xref: FMA:70620
is_a: CL:0000499 ! stromal cell

[Term]
id: CL:0000143
name: guidepost cell
namespace: cell
is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000144
name: obsolete cell by function
namespace: cell
def: "OBSOLETE: A classification of cells by their primary end goal or behavior." []
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000145
name: professional antigen presenting cell
namespace: cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." []
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
synonym: "APC" BROAD []
is_a: BFO:0000040 ! material entity
is_a: CL:0000473 ! defensive cell
relationship: capable_of GO:0002504

[Term]
id: CL:0000146
name: simple columnar epithelial cell
namespace: cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000147
name: pigment cell
namespace: cell
def: "A pigment cell is a cell that contains pigment granules." []
synonym: "chromatocyte" EXACT []
synonym: "chromatophore" EXACT []
xref: VHOG:0001678
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000148
name: melanocyte
namespace: cell
alt_id: CL:0000572
def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." []
synonym: "melanophore" NARROW []
xref: BTO:0000847
xref: CALOHA:TS-0613
xref: FMA:70545
xref: VHOG:0001679
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000147 ! pigment cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000147 ! pigment cell
intersection_of: develops_from CL:0000541 ! melanoblast
intersection_of: has_part GO:0042470
relationship: develops_from CL:0000541 ! melanoblast
relationship: has_part GO:0042470

[Term]
id: CL:0000149
name: visual pigment cell
namespace: cell
synonym: "pigment cell" BROAD []
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000150
name: glandular epithelial cell
namespace: cell
def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." []
xref: CALOHA:TS-2085
xref: FMA:86494
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0002371 ! somatic cell
relationship: part_of UBERON:0006799 ! glandular epithelium

[Term]
id: CL:0000151
name: secretory cell
namespace: cell
def: "A cell that specializes in controlled release of one or more substances." []
xref: BTO:0003659
xref: FMA:86916
is_a: BFO:0000040 ! material entity
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell

[Term]
id: CL:0000152
name: exocrine cell
namespace: cell
def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." []
xref: FMA:16014
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002365 ! exocrine gland
relationship: part_of UBERON:0002365 ! exocrine gland

[Term]
id: CL:0000153
name: glycosaminoglycan secreting cell
namespace: cell
def: "A cell that secretes glycosaminoglycans." []
synonym: "GAG secreting cell" EXACT []
synonym: "hyaluronic acid secreting cell" NARROW []
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000447 ! carbohydrate secreting cell

[Term]
id: CL:0000154
name: protein secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0009306 ! protein secretion
relationship: capable_of GO:0009306 ! protein secretion

[Term]
id: CL:0000155
name: peptic cell
namespace: cell
def: "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen." []
synonym: "chief cell of stomach" EXACT []
synonym: "gastric chief cell" EXACT []
synonym: "pepsinogen secreting cell" EXACT []
synonym: "zymogenic cell" EXACT []
xref: FMA:62902
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0002659 ! glandular cell of stomach

[Term]
id: CL:0000156
name: obsolete antibody secreting cell
namespace: cell
def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." []
comment: Consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000157
name: surfactant secreting cell
namespace: cell
def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." []
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0043129
relationship: capable_of GO:0043129

[Term]
id: CL:0000158
name: Clara cell
namespace: cell
def: "Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." []
synonym: "bronchiolar non-ciliated cell" EXACT []
synonym: "Clara cell of bronchiole" EXACT []
xref: BTO:0004811
xref: FMA:14119
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0002328 ! bronchial epithelial cell
relationship: has_part GO:0005902 ! microvillus

[Term]
id: CL:0000159
name: seromucus secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000160
name: goblet cell
namespace: cell
def: "A cell of the epithelial lining that produce and secrete mucins." []
synonym: "chalice cell" EXACT []
xref: BTO:0001540
xref: FMA:13148
xref: http://en.wikipedia.org/wiki/Goblet_cell
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000319 ! mucus secreting cell

[Term]
id: CL:0000161
name: acid secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0046717 ! acid secretion
relationship: capable_of GO:0046717 ! acid secretion

[Term]
id: CL:0000162
name: parietal cell
namespace: cell
def: "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." []
synonym: "oxyntic cell" EXACT []
xref: BTO:0001780
xref: FMA:62901
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0002659 ! glandular cell of stomach

[Term]
id: CL:0000163
name: endocrine cell
namespace: cell
def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." []
synonym: "endocrinocyte" EXACT []
xref: FMA:83809
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0060986 ! endocrine hormone secretion
relationship: capable_of GO:0060986 ! endocrine hormone secretion
relationship: part_of UBERON:0002368 ! endocrine gland

[Term]
id: CL:0000164
name: enteroendocrine cell
namespace: cell
def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." []
xref: BTO:0003865
xref: FMA:62930
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000165
name: neuroendocrine cell
namespace: cell
def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." []
synonym: "neurosecretory cell" EXACT []
xref: BTO:0002691
xref: FMA:83810
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000166
name: chromaffin cell
namespace: cell
def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." []
synonym: "phaeochromocyte" EXACT []
xref: BTO:0000259
xref: FMA:69263
is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000167
name: peptide hormone secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030072 ! peptide hormone secretion
relationship: capable_of GO:0030072 ! peptide hormone secretion

[Term]
id: CL:0000168
name: insulin secreting cell
namespace: cell
xref: BTO:0000783
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030073 ! insulin secretion
relationship: capable_of GO:0030073 ! insulin secretion

[Term]
id: CL:0000169
name: type B pancreatic cell
namespace: cell
def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." []
comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression.
synonym: "B-cell of pancreatic islet" EXACT []
synonym: "beta cell" BROAD []
synonym: "beta cell islet" RELATED []
synonym: "beta cell of pancreatic islet" EXACT []
synonym: "insulin-secreting cell" EXACT []
synonym: "pancreatic B cell" EXACT []
synonym: "pancreatic B-cell" EXACT []
synonym: "pancreatic beta cell" EXACT []
synonym: "pancreatic islet core" EXACT []
synonym: "type B enteroendocrine cell" EXACT []
xref: BTO:0000783
xref: EV:0200009
xref: FMA:70586
xref: MA:0002419
xref: ncithesaurus:Beta_Cell
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000168 ! insulin secreting cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: capable_of GO:0030073 ! insulin secretion
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans

[Term]
id: CL:0000170
name: glucagon secreting cell
namespace: cell
def: "A cell that secretes glucagon." []
synonym: "glucagon-secreting cell" EXACT []
xref: FMA:84045
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070091 ! glucagon secretion
relationship: capable_of GO:0070091 ! glucagon secretion

[Term]
id: CL:0000171
name: pancreatic A cell
namespace: cell
def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." []
synonym: "alpha cell of iselt of Langerhans" EXACT []
synonym: "pancreatic alpha cell" EXACT []
xref: BTO:0000990
xref: FMA:70585
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0002067 ! type A enterocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0002067 ! type A enterocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans

[Term]
id: CL:0000172
name: somatostatin secreting cell
namespace: cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070253 ! somatostatin secretion
relationship: capable_of GO:0070253 ! somatostatin secretion

[Term]
id: CL:0000173
name: pancreatic D cell
namespace: cell
def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." []
synonym: "D-cell of pancreatic islet" EXACT []
synonym: "delta cell of islet" EXACT []
synonym: "delta cell of pancreatic islet" EXACT []
synonym: "pancreatic D-cell" EXACT []
synonym: "pancreatic delta cell" EXACT []
synonym: "somatostatin-secreting pancreatic cell" EXACT []
xref: BTO:0000803
xref: FMA:70587
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans

[Term]
id: CL:0000174
name: steroid hormone secreting cell
namespace: cell
is_a: CL:0000163 ! endocrine cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035929 ! steroid hormone secretion
relationship: capable_of GO:0035929 ! steroid hormone secretion

[Term]
id: CL:0000175
name: luteal cell
namespace: cell
def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." []
synonym: "lutein cell" EXACT []
xref: BTO:0003939
xref: FMA:18688
is_a: CL:0000179 ! progesterone secreting cell
is_a: CL:0002132 ! stromal cell of ovary
relationship: part_of UBERON:0002512 ! corpus luteum

[Term]
id: CL:0000176
name: ecdysteroid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0045457
relationship: capable_of GO:0045457

[Term]
id: CL:0000177
name: testosterone secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035936
relationship: capable_of GO:0035936

[Term]
id: CL:0000178
name: Leydig cell
namespace: cell
def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." []
comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated
synonym: "interstitial cell" BROAD []
synonym: "interstitial cell of Leydig" EXACT []
xref: BTO:0000755
xref: CALOHA:TS-1150
xref: EMAPA:29655
xref: FMA:72297
is_a: CARO:0000000
is_a: CL:0000177 ! testosterone secreting cell
relationship: part_of UBERON:0005212 ! Leydig cell region of testis

[Term]
id: CL:0000179
name: progesterone secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0042701 ! progesterone secretion
relationship: capable_of GO:0042701 ! progesterone secretion

[Term]
id: CL:0000180
name: estradiol secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035938
relationship: capable_of GO:0035938

[Term]
id: CL:0000181
name: metabolising cell
namespace: cell
def: "A cell whose primary function is intermediary metabolism." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000182
name: hepatocyte
namespace: cell
def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." []
comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive.
xref: BTO:0000575
xref: CALOHA:TS-0454
xref: FMA:14515
is_a: BFO:0000040 ! material entity
is_a: CARO:0000000
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000181 ! metabolising cell
is_a: CL:0000417 ! endopolyploid cell
is_a: CL:0002371 ! somatic cell
relationship: capable_of GO:0006699 ! bile acid biosynthetic process
relationship: capable_of GO:0098754
relationship: develops_from CL:0005026 ! hepatoblast
relationship: part_of UBERON:0002107 ! liver

[Term]
id: CL:0000183
name: contractile cell
namespace: cell
def: "A cell whose primary function is to shorten." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000185
name: myoepithelial cell
namespace: cell
def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." []
synonym: "basket epithelial cell" EXACT []
synonym: "myoepitheliocyte" EXACT []
xref: BTO:0002309
xref: CALOHA:TS-2379
xref: FMA:67799
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000183 ! contractile cell
is_a: CL:0002078 ! meso-epithelial cell

[Term]
id: CL:0000186
name: myofibroblast cell
namespace: cell
def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." []
comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha.
synonym: "MFB" EXACT []
is_a: CL:0000183 ! contractile cell
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000187
name: muscle cell
namespace: cell
def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." []
synonym: "muscle fiber" EXACT []
synonym: "myocyte" EXACT []
xref: BTO:0000888
xref: BTO:0000902
xref: CALOHA:TS-2032
xref: FBbt:00005074
xref: FMA:67328
xref: WBbt:0003675
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000056 ! myoblast

[Term]
id: CL:0000188
name: cell of skeletal muscle
namespace: cell
def: "A somatic cell located in skeletal muscle." []
synonym: "skeletal muscle cell" EXACT []
xref: BTO:0004392
xref: CALOHA:TS-2158
xref: FMA:9727
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0002371 ! somatic cell
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0000189
name: slow muscle cell
namespace: cell
def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." []
synonym: "slow muscle fiber" RELATED []
xref: FMA:84448
is_a: CL:0008002 ! skeletal muscle fiber
relationship: develops_from CL:0000857 ! slow muscle myoblast

[Term]
id: CL:0000190
name: fast muscle cell
namespace: cell
def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." []
synonym: "glycolytic muscle fiber" EXACT []
is_a: CL:0008002 ! skeletal muscle fiber
relationship: develops_from CL:0000858 ! fast muscle myoblast

[Term]
id: CL:0000192
name: smooth muscle cell
namespace: cell
alt_id: CL:0000191
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." []
synonym: "myocytes, smooth muscle" EXACT []
synonym: "non-striated muscle cell" NARROW []
synonym: "SMCs" EXACT []
synonym: "smooth muscle fiber" EXACT []
xref: BTO:0004576
xref: CALOHA:TS-2159
xref: FMA:14072
is_a: CL:0008000 ! non-striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
relationship: develops_from CL:0000514 ! smooth muscle myoblast

[Term]
id: CL:0000193
name: cardiac muscle cell (sensu Arthopoda)
namespace: cell
alt_id: CL:0000466
def: "A striated muscle cell of an arthropod heart that participates in heart contraction." []
is_a: CL:0000746 ! cardiac muscle cell
intersection_of: CL:0000746 ! cardiac muscle cell
intersection_of: develops_from CL:0000465 ! cardioblast (sensu Arthropoda)
relationship: develops_from CL:0000465 ! cardioblast (sensu Arthropoda)

[Term]
id: CL:0000194
name: obsolete nodal cardiac cell
namespace: cell
comment: Consider CL:0002072.
is_obsolete: true

[Term]
id: CL:0000195
name: obsolete Purkinje fiber
namespace: cell
is_obsolete: true

[Term]
id: CL:0000196
name: flight muscle cell
namespace: cell
is_a: CL:0008003 ! somatic muscle myotube

[Term]
id: CL:0000197
name: receptor cell
namespace: cell
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000198
name: pain receptor cell
namespace: cell
def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." []
comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship
synonym: "nociceptor" EXACT []
synonym: "nocireceptor" EXACT []
is_a: CL:0000006 ! neuronal receptor cell

[Term]
id: CL:0000199
name: mechanoreceptor cell
namespace: cell
def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." []
synonym: "mechanoreceptor" RELATED []
is_a: CL:0000101 ! sensory neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception

[Term]
id: CL:0000200
name: touch receptor cell
namespace: cell
is_a: CL:0000199 ! mechanoreceptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch
relationship: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch

[Term]
id: CL:0000202
name: auditory hair cell
namespace: cell
alt_id: CL:0000201
def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." []
comment: In mammals these cells are located in the organ of Corti.
synonym: "auditory receptor cell" EXACT []
synonym: "cochlear hair cell" EXACT []
synonym: "inner ear hair cell" RELATED []
synonym: "inner ear receptor cell" RELATED []
xref: FMA:62364
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002374 ! ear hair cell
is_a: CL:0002491 ! auditory epithelial cell
relationship: part_of UBERON:0002227 ! spiral organ of cochlea

[Term]
id: CL:0000203
name: gravity sensitive cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000199 ! mechanoreceptor cell
intersection_of: CL:0000006 ! neuronal receptor cell
intersection_of: capable_of GO:0070999
relationship: capable_of GO:0070999

[Term]
id: CL:0000204
name: acceleration receptive cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell

[Term]
id: CL:0000205
name: thermoreceptor cell
namespace: cell
def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." []
is_a: CL:0000006 ! neuronal receptor cell
intersection_of: CL:0000006 ! neuronal receptor cell
intersection_of: capable_of GO:0050960
relationship: capable_of GO:0050960

[Term]
id: CL:0000206
name: chemoreceptor cell
namespace: cell
def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." []
is_a: CL:0000101 ! sensory neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception

[Term]
id: CL:0000207
name: olfactory receptor cell
namespace: cell
synonym: "odorant receptor cell" EXACT []
synonym: "olfactory receptor neuron" EXACT []
synonym: "olfactory sensory neuron" EXACT []
synonym: "Schultze's cell" EXACT []
xref: BTO:0004185
xref: FMA:67860
xref: Wikipedia:Olfactory_receptor_neuron
is_a: CL:0000206 ! chemoreceptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
relationship: part_of UBERON:0005725 ! olfactory system

[Term]
id: CL:0000208
name: pH receptor cell
namespace: cell
is_a: CL:0000206 ! chemoreceptor cell

[Term]
id: CL:0000209
name: taste receptor cell
namespace: cell
def: "A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste." []
synonym: "taste bud cell" EXACT []
xref: FMA:67910
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of UBERON:0002025 ! stratum basale of epidermis

[Term]
id: CL:0000210
name: photoreceptor cell
namespace: cell
def: "A cell specialized to detect and transduce light." []
xref: BTO:0001060
xref: CALOHA:TS-0868
xref: FBbt:00004211
xref: FMA:86740
is_a: CL:0000006 ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception

[Term]
id: CL:0000211
name: electrically active cell
namespace: cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000212
name: absorptive cell
namespace: cell
def: "A cell that takes up and metabolizes substances." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000213
name: lining cell
namespace: cell
def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." []
synonym: "boundary cell" EXACT []
is_a: CL:0000215 ! barrier cell

[Term]
id: CL:0000214
name: synovial cell
namespace: cell
def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." []
synonym: "hyaluronic acid secreting cell" NARROW []
synonym: "synoviocyte" EXACT []
xref: BTO:0003652
xref: CALOHA:TS-0995
xref: FMA:66786
is_a: CL:0000153 ! glycosaminoglycan secreting cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
intersection_of: CL:0002078 ! meso-epithelial cell
intersection_of: part_of UBERON:0002018 ! synovial membrane of synovial joint
relationship: part_of UBERON:0002018 ! synovial membrane of synovial joint

[Term]
id: CL:0000215
name: barrier cell
namespace: cell
def: "A cell whose primary function is to prevent the transport of stuff across compartments." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000216
name: Sertoli cell
namespace: cell
def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." []
xref: BTO:0001238
xref: CALOHA:TS-0922
xref: FMA:72298
xref: VHOG:0001348
is_a: CL:0000511 ! androgen binding protein secreting cell
is_a: CL:0000630 ! supportive cell
is_a: CL:0002625 ! seminiferous tubule epithelial cell
intersection_of: CL:0000630 ! supportive cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis

[Term]
id: CL:0000217
name: insulating cell
namespace: cell
is_a: CL:0000215 ! barrier cell

[Term]
id: CL:0000218
name: myelinating Schwann cell
namespace: cell
def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." []
synonym: "neurilemmal cell" EXACT []
synonym: "peripheral neuroglial cell" BROAD []
synonym: "Schwann cell" BROAD []
xref: CALOHA:TS-0898
xref: FMA:62121
is_a: CL:0000217 ! insulating cell
is_a: CL:0000328 ! myelin accumulating cell
is_a: CL:0002573 ! Schwann cell
relationship: develops_from CL:0002377 ! immature Schwann cell

[Term]
id: CL:0000219
name: motile cell
namespace: cell
def: "A cell that moves by its own activities." []
is_a: BFO:0000040 ! material entity
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0048870 ! cell motility
relationship: capable_of GO:0048870 ! cell motility

[Term]
id: CL:0000220
name: obsolete cell by lineage
namespace: cell
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000221
name: ectodermal cell
namespace: cell
def: "A cell of the outer of the three germ layers of the embryo." []
synonym: "ectoderm cell" EXACT []
xref: FMA:72549
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0002321 ! embryonic cell
relationship: part_of UBERON:0000924 ! ectoderm

[Term]
id: CL:0000222
name: mesodermal cell
namespace: cell
def: "A cell of the middle germ layer of the embryo." []
synonym: "mesoblast" EXACT []
synonym: "mesoderm cell" EXACT []
xref: FMA:72554
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0002321 ! embryonic cell
relationship: part_of UBERON:0000926 ! mesoderm

[Term]
id: CL:0000223
name: endodermal cell
namespace: cell
def: "A cell of the inner of the three germ layers of the embryo." []
synonym: "endoderm cell" EXACT []
xref: FMA:72555
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0002321 ! embryonic cell
relationship: part_of UBERON:0000925 ! endoderm

[Term]
id: CL:0000224
name: obsolete cell by nuclear number
namespace: cell
def: "OBSOLETE: A classification of cells by the number of their nuclei." []
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000225
name: anucleate cell
namespace: cell
def: "A cell that lacks a nucleus." []
synonym: "non-nucleated cell" EXACT []
xref: FMA:68647
is_a: CL:0000003 ! native cell
disjoint_from: CL:0002242 ! nucleate cell

[Term]
id: CL:0000226
name: single nucleate cell
namespace: cell
def: "A cell with a single nucleus." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000227
name: binucleate cell
namespace: cell
is_a: CL:0000228 ! multinucleate cell

[Term]
id: CL:0000228
name: multinucleate cell
namespace: cell
def: "A cell with more than one nucleus." []
synonym: "syncitium" EXACT []
synonym: "syncytial cell" EXACT []
synonym: "syncytium" EXACT []
xref: AEO:0000203
xref: WBbt:0008074
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000229
name: obsolete lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000230
name: obsolete T lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000231
name: obsolete B lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000232
name: erythrocyte
namespace: cell
def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." []
synonym: "RBC" EXACT []
synonym: "red blood cell" EXACT []
xref: BTO:0000424
xref: CALOHA:TS-0290
xref: FMA:81100
is_a: CL:0000081 ! blood cell
is_a: CL:0000329 ! oxygen accumulating cell
is_a: CL:0000764 ! erythroid lineage cell
relationship: develops_from CL:0000558 ! reticulocyte

[Term]
id: CL:0000233
name: platelet
namespace: cell
def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." []
comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.
synonym: "anucleate thrombocyte" EXACT []
synonym: "blood platelet" EXACT []
synonym: "enucleate thrombocyte" EXACT []
xref: BTO:0000132
xref: CALOHA:TS-0803
xref: FMA:62851
is_a: CL:0000081 ! blood cell
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000763 ! myeloid cell
relationship: capable_of GO:0007596 ! blood coagulation
relationship: develops_from CL:0000556 ! megakaryocyte

[Term]
id: CL:0000234
name: phagocyte
namespace: cell
def: "Any cell capable of ingesting particulate matter via phagocytosis." []
xref: BTO:0001044
xref: FMA:83806
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000473 ! defensive cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0006909
relationship: capable_of GO:0006909

[Term]
id: CL:0000235
name: macrophage
namespace: cell
def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." []
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
synonym: "histiocyte" EXACT []
xref: BTO:0000801
xref: CALOHA:TS-0587
xref: FMA:63261
xref: FMA:83585
is_a: CL:0000234 ! phagocyte
is_a: CL:0000766 ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0006909
intersection_of: capable_of GO:0031268
relationship: capable_of GO:0031268
relationship: develops_from CL:0000576 ! monocyte

[Term]
id: CL:0000236
name: B cell
namespace: cell
def: "A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity." []
synonym: "B lymphocyte" EXACT []
synonym: "B-cell" EXACT []
synonym: "B-lymphocyte" EXACT []
xref: BTO:0000776
xref: CALOHA:TS-0068
xref: FMA:62869
xref: VHOG:0001480
is_a: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: capable_of GO:0019724
relationship: capable_of GO:0019724

[Term]
id: CL:0000237
name: keratinizing barrier epithelial cell
namespace: cell
is_a: CL:0000240 ! stratified squamous epithelial cell
is_a: CL:0000311 ! keratin accumulating cell
is_a: CL:0002077 ! ecto-epithelial cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000238
name: non keratinizing barrier epithelial cell
namespace: cell
is_a: CL:0000240 ! stratified squamous epithelial cell

[Term]
id: CL:0000239
name: brush border epithelial cell
namespace: cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000240
name: stratified squamous epithelial cell
namespace: cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000079 ! stratified epithelial cell

[Term]
id: CL:0000241
name: stratified cuboidal epithelial cell
namespace: cell
is_a: CL:0000079 ! stratified epithelial cell

[Term]
id: CL:0000242
name: Merkel cell
namespace: cell
def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." []
synonym: "Merkel's cell" EXACT []
xref: FMA:70548
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000312 ! keratinocyte
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: part_of UBERON:0002025 ! stratum basale of epidermis

[Term]
id: CL:0000243
name: glial cell (sensu Vertebrata)
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." []
is_a: CL:0000125 ! glial cell
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)

[Term]
id: CL:0000244
name: transitional epithelial cell
namespace: cell
def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." []
xref: FMA:66778
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000245
name: obsolete passage cell
namespace: cell
def: "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." []
comment: replaced_by: PO:0000353
is_obsolete: true

[Term]
id: CL:0000246
name: Mauthner neuron
namespace: cell
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000247
name: Rohon-Beard neuron
namespace: cell
def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." []
synonym: "RB neuron" RELATED []
synonym: "Rohon Beard cell" EXACT []
synonym: "Rohon-Beard cell" EXACT []
xref: AAO:0010316
xref: EFO:0003711
xref: VHOG:0001484
is_a: CL:0000531 ! primary sensory neuron

[Term]
id: CL:0000248
name: obsolete microsporocyte
namespace: cell
def: "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." []
comment: replaced_by: PO:0020047
synonym: "pollen mother cell" EXACT []
synonym: "primary sporogenous cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000249
name: hatching gland cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000250
name: obsolete megaspore
namespace: cell
def: "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." []
comment: replaced_by: PO:0020019
is_obsolete: true

[Term]
id: CL:0000251
name: extramedullary cell
namespace: cell
is_a: CL:0000101 ! sensory neuron

[Term]
id: CL:0000252
name: obsolete microspore
namespace: cell
def: "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." []
comment: replaced_by: PO:0020048
is_obsolete: true

[Term]
id: CL:0000253
name: eurydendroid cell
namespace: cell
is_a: CL:0000527 ! efferent neuron

[Term]
id: CL:0000254
name: obsolete egg cell
namespace: cell
def: "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." []
comment: replaced_by: PO:0020094
synonym: "female gametophyte egg cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000255
name: eukaryotic cell
namespace: cell
is_a: CL:0000003 ! native cell
disjoint_from: CL:0000520 ! prokaryotic cell

[Term]
id: CL:0000256
name: uric acid accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000257
name: Mycetozoan cell
namespace: cell
is_a: CL:0000255 ! eukaryotic cell

[Term]
id: CL:0000258
name: obsolete fiber tracheid
namespace: cell
def: "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." []
comment: replaced_by: PO:0000355
is_obsolete: true

[Term]
id: CL:0000259
name: obsolete aggregate cell
is_obsolete: true
replaced_by: DDANAT:0000403

[Term]
id: CL:0000260
name: obsolete mucilage cell
namespace: cell
def: "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." []
comment: replaced_by: PO:0000373
is_obsolete: true

[Term]
id: CL:0000261
name: anterior cell
namespace: cell
comment: Obsoleted becuase this term has an overly general name, no definition, and by it's classification appears to refer to a very specific cell type in dictystelium.  If needed, the term should be in DDANAT - probably as a subclass of http://purl.obolibrary.org/obo/DDANAT_0000002
is_obsolete: true
consider: false
consider: http://purl.obolibrary.org/obo/DDANAT_0000002

[Term]
id: CL:0000262
name: obsolete guard mother cell
namespace: cell
def: "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." []
comment: replaced_by: PO:0000351
is_obsolete: true

[Term]
id: CL:0000263
name: obsolete vegetative cell (sensu Mycetozoa)
is_obsolete: true
replaced_by: DDANAT:0000002

[Term]
id: CL:0000264
name: obsolete phloem initial
namespace: cell
def: "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." []
comment: replaced_by: PO:0000400
synonym: "phloem mother cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000265
name: obsolete anterior like cell
is_obsolete: true
replaced_by: DDANAT:0000404

[Term]
id: CL:0000266
name: obsolete meristemoid
namespace: cell
def: "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." []
comment: replaced_by: PO:0004011
is_obsolete: true

[Term]
id: CL:0000267
name: obsolete prespore cell
is_obsolete: true
replaced_by: DDANAT:0000405

[Term]
id: CL:0000268
name: obsolete sieve element
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." []
is_obsolete: true

[Term]
id: CL:0000269
name: obsolete prestalk cell
is_obsolete: true
replaced_by: DDANAT:0000406

[Term]
id: CL:0000270
name: obsolete subsidiary cell
namespace: cell
def: "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." []
comment: replaced_by: PO:0000284
is_obsolete: true

[Term]
id: CL:0000271
name: obsolete prestalk A cell
is_obsolete: true
replaced_by: DDANAT:0000408

[Term]
id: CL:0000272
name: obsolete cambial initial
namespace: cell
def: "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." []
comment: replaced_by PO:0000295
is_obsolete: true

[Term]
id: CL:0000273
name: obsolete prestalk AB cell
is_obsolete: true
replaced_by: DDANAT:0000410

[Term]
id: CL:0000275
name: obsolete prestalk B cell
is_obsolete: true
replaced_by: DDANAT:0000409

[Term]
id: CL:0000276
name: obsolete sclerenchyma cell
namespace: cell
def: "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." []
comment: replaced_by: PO:0000077
is_obsolete: true

[Term]
id: CL:0000277
name: obsolete prestalk I cell
namespace: cell
def: "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." []
comment: This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology.
is_obsolete: true
replaced_by: DDANAT:0000406

[Term]
id: CL:0000278
name: obsolete central cell
namespace: cell
def: "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." []
comment: replaced_by: PO:0020090
is_obsolete: true

[Term]
id: CL:0000279
name: obsolete prestalk 0 cell
is_obsolete: true
replaced_by: DDANAT:0000407

[Term]
id: CL:0000280
name: obsolete generative cell
namespace: cell
def: "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." []
comment: replaced_by: PO:0020097
is_obsolete: true

[Term]
id: CL:0000281
name: obsolete pstAB/ALC
is_obsolete: true
replaced_by: DDANAT:0000411

[Term]
id: CL:0000282
name: obsolete trichome
namespace: cell
def: "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." []
comment: replaced_by: PO:0000282
is_obsolete: true

[Term]
id: CL:0000283
name: obsolete pstO/ALC
is_obsolete: true
replaced_by: DDANAT:0000412

[Term]
id: CL:0000284
name: obsolete companion cell
namespace: cell
def: "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." []
comment: replaced_by: PO:0000071
is_obsolete: true

[Term]
id: CL:0000285
name: obsolete stalk cell
is_obsolete: true
replaced_by: DDANAT:0000413

[Term]
id: CL:0000286
name: hyphal cell
namespace: cell
def: "A cell of a filament of a fungal mycelium." []
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000287
name: eye photoreceptor cell
namespace: cell
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000970 ! eye
relationship: part_of UBERON:0000970 ! eye

[Term]
id: CL:0000288
name: obsolete synergid
namespace: cell
def: "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." []
comment: replaced_by: PO:0000191
is_obsolete: true

[Term]
id: CL:0000289
name: obsolete chemotactic amoeboid cell (sensu Mycetozoa)
is_obsolete: true
replaced_by: DDANAT:0000402

[Term]
id: CL:0000290
name: obsolete xylem fiber cell
namespace: cell
def: "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." []
comment: replaced_by: PO:0000274
is_obsolete: true

[Term]
id: CL:0000291
name: obsolete spore (sensu Mycetozoa)
is_obsolete: true
replaced_by: DDANAT:0000414

[Term]
id: CL:0000292
name: obsolete guard cell
namespace: cell
def: "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." []
comment: replaced_by: PO:0000293
synonym: "stomatal guard cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000293
name: structural cell
namespace: cell
def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000294
name: obsolete sieve cell
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." []
is_obsolete: true

[Term]
id: CL:0000295
name: somatotropin secreting cell
namespace: cell
alt_id: CL:0000471
def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." []
synonym: "growth hormone secreting cell" EXACT []
synonym: "somatotrophin secreting cell" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030252
relationship: capable_of GO:0030252

[Term]
id: CL:0000296
name: obsolete vegetative cell
namespace: cell
def: "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." []
comment: replaced_by: PO:0020099
is_obsolete: true

[Term]
id: CL:0000297
name: obsolete socket cell
namespace: cell
def: "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." []
comment: replaced_by: PO:0000115
is_obsolete: true

[Term]
id: CL:0000298
name: obsolete xylem element
namespace: cell
def: "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." []
comment: replaced_by: PO:0000273
is_obsolete: true

[Term]
id: CL:0000299
name: obsolete trichoblast
namespace: cell
def: "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." []
comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262).
is_obsolete: true

[Term]
id: CL:0000300
name: gamete
namespace: cell
def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." []
synonym: "haploid germ cell" RELATED []
synonym: "haploid nucleated cell" EXACT []
xref: CALOHA:TS-0395
xref: FBbt:00005412
xref: FMA:18649
is_a: CL:0000413 ! haploid cell
is_a: CL:0000586 ! germ cell
relationship: capable_of GO:0009566

[Term]
id: CL:0000301
name: pole cell
namespace: cell
xref: FBbt:00000092
is_a: CL:0000670 ! primordial germ cell

[Term]
id: CL:0000302
name: obsolete IgM B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000303
name: obsolete IgG B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000304
name: obsolete IgA B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000305
name: obsolete IgE B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000306
name: crystallin accumulating cell
namespace: cell
synonym: "lens cell" EXACT []
xref: FBbt:00004193
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000307
name: tracheal epithelial cell
namespace: cell
alt_id: CL:1000474
def: "An epithelial cell found in the trachea." []
comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'
synonym: "tracheocyte" EXACT []
xref: FMA:74793
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from CL:0000377 ! tracheoblast
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: CL:0000308
name: metal ion accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000309
name: copper accumulating cell
namespace: cell
synonym: "cuprophilic cell" EXACT []
is_a: CL:0000308 ! metal ion accumulating cell

[Term]
id: CL:0000310
name: iron accumulating cell
namespace: cell
is_a: CL:0000308 ! metal ion accumulating cell

[Term]
id: CL:0000311
name: keratin accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000312
name: keratinocyte
namespace: cell
alt_id: CL:0002185
def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." []
comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.
synonym: "keratinized cell of epidermis" EXACT []
synonym: "malpighian cell" EXACT []
xref: BTO:0000667
xref: CALOHA:TS-0500
xref: FMA:62879
is_a: BFO:0000040 ! material entity
is_a: CL:0000237 ! keratinizing barrier epithelial cell
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000237 ! keratinizing barrier epithelial cell
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: capable_of GO:0002775
relationship: capable_of GO:0002776
relationship: capable_of GO:0090023
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: CL:0000313
name: serous secreting cell
namespace: cell
def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." []
synonym: "serous cell" EXACT []
xref: BTO:0003687
xref: FMA:62511
is_a: CL:0000159 ! seromucus secreting cell

[Term]
id: CL:0000314
name: milk secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000315
name: tears secreting cell
namespace: cell
def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." []
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000316
name: obsolete ray initial
namespace: cell
def: "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." []
comment: replaced_by: PO:0000082
is_obsolete: true

[Term]
id: CL:0000317
name: sebum secreting cell
namespace: cell
def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." []
synonym: "sebocyte" EXACT []
is_a: CL:0000152 ! exocrine cell
is_a: CL:2000021 ! sebaceous gland native cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0001821 ! sebaceous gland

[Term]
id: CL:0000318
name: sweat secreting cell
namespace: cell
def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." []
is_a: CL:0000150 ! glandular epithelial cell

[Term]
id: CL:0000319
name: mucus secreting cell
namespace: cell
synonym: "mucous cell" EXACT []
xref: BTO:0003689
is_a: CL:0000159 ! seromucus secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070254 ! mucus secretion
relationship: capable_of GO:0070254 ! mucus secretion

[Term]
id: CL:0000320
name: obsolete megasporocyte
namespace: cell
def: "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." []
comment: replaced_by: PO:0000431
synonym: "archesporial cell" EXACT []
synonym: "megaspore mother cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000321
name: seminal fluid secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000322
name: pneumocyte
namespace: cell
def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." []
synonym: "alveolar epithelial cell" EXACT []
synonym: "pneumonocyte" EXACT []
xref: BTO:0000395
xref: CALOHA:TS-2168
xref: FMA:62499
is_a: CL:0010003 ! epithelial cell of alveolus of lung
relationship: part_of UBERON:0004821 ! pulmonary alveolus epithelium

[Term]
id: CL:0000323
name: lysozyme secreting cell
namespace: cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000324
name: metanephric mesenchyme stem cell
namespace: cell
is_a: CARO:0000000
is_a: CL:0000134 ! mesenchymal stem cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000325
name: stuff accumulating cell
namespace: cell
def: "A cell that is specialised to accumulate a particular substance(s)." []
subset: ubprop:upper_level
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000326
name: glycogen accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000327
name: extracellular matrix secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070278 ! extracellular matrix constituent secretion
relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: CL:0000328
name: myelin accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000329
name: oxygen accumulating cell
namespace: cell
is_a: BFO:0000040 ! material entity
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0015671
relationship: capable_of GO:0015671

[Term]
id: CL:0000330
name: obsolete collenchymal cell
namespace: cell
def: "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." []
comment: replaced_by: PO:0000075
is_obsolete: true

[Term]
id: CL:0000331
name: obsolete tracheid
namespace: cell
def: "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." []
comment: replaced_by: PO:0000301
is_obsolete: true

[Term]
id: CL:0000332
name: obsolete atrichoblast
namespace: cell
def: "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." []
comment: replaced_by: PO:0020090
synonym: "non-hair cell" RELATED []
is_obsolete: true

[Term]
id: CL:0000333
name: migratory neural crest cell
namespace: cell
def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." []
xref: FMA:86667
is_a: CARO:0000000
is_a: CL:0000219 ! motile cell
is_a: CL:0011012 ! neural crest cell
relationship: develops_from CL:0007004 ! premigratory neural crest cell

[Term]
id: CL:0000334
name: vegetative cell (sensu Fungi)
namespace: cell
synonym: "yeast-form" RELATED []
xref: BTO:0002307
xref: FAO:0000032
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000335
name: mesenchyme condensation cell
namespace: cell
def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." []
is_a: CL:0008019 ! mesenchymal cell

[Term]
id: CL:0000336
name: adrenal medulla chromaffin cell
namespace: cell
alt_id: CL:1000422
def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." []
synonym: "medullary chromaffin cell of adrenal gland" EXACT []
xref: FMA:69262
is_a: CL:0000457 ! biogenic amine secreting cell
is_a: CL:1000426 ! chromaffin cell of adrenal gland
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0001236 ! adrenal medulla
relationship: develops_from CL:0000011 ! migratory trunk neural crest cell
relationship: part_of UBERON:0001236 ! adrenal medulla

[Term]
id: CL:0000337
name: neuroblast (sensu Vertebrata)
namespace: cell
def: "An embryonic cell that develops into a nerve cell or neuron." []
is_a: CL:0000031 ! neuroblast

[Term]
id: CL:0000338
name: neuroblast (sensu Nematoda and Protostomia)
namespace: cell
synonym: "neuroblast" BROAD []
is_a: CL:0000031 ! neuroblast

[Term]
id: CL:0000339
name: glioblast (sensu Vertebrata)
namespace: cell
def: "An early neural cell developing from the early ependymal cell of the neural tube." []
synonym: "spongioblast" EXACT []
xref: FMA:70564
is_a: CL:0000030 ! glioblast
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)

[Term]
id: CL:0000340
name: glioblast (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000030 ! glioblast
is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000341
name: pigment cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000342
name: pigment cell (sensu Vertebrata)
namespace: cell
def: "Any animal cell containing pigment granules." []
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000343
name: visual pigment cell (sensu Vertebrata)
namespace: cell
def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." []
xref: FMA:63846
is_a: BFO:0000040 ! material entity
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0000342 ! pigment cell (sensu Vertebrata)
intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata)
intersection_of: capable_of GO:0050908 ! detection of light stimulus involved in visual perception
relationship: capable_of GO:0050908 ! detection of light stimulus involved in visual perception

[Term]
id: CL:0000344
name: obsolete non-visual cell (sensu Vertebrata)
namespace: cell
is_obsolete: true

[Term]
id: CL:0000345
name: dental papilla cell
namespace: cell
def: "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." []
comment: Merge with odontoblast?
is_a: CARO:0000000
is_a: CL:0008019 ! mesenchymal cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001763 ! odontogenic papilla

[Term]
id: CL:0000346
name: hair follicle dermal papilla cell
namespace: cell
def: "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." []
comment: Are these really all stem cells?
is_a: CARO:0000000
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0000412 ! dermal papilla
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: part_of UBERON:0000412 ! dermal papilla

[Term]
id: CL:0000347
name: scleral cell
namespace: cell
def: "A cell of the sclera of the eye." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000293 ! structural cell
intersection_of: CL:0000293 ! structural cell
intersection_of: part_of UBERON:0001773 ! sclera
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001773 ! sclera

[Term]
id: CL:0000348
name: choroidal cell of the eye
namespace: cell
def: "A cell of the choroid of the eye." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000293 ! structural cell
intersection_of: CL:0000293 ! structural cell
intersection_of: part_of UBERON:0001776 ! optic choroid
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001776 ! optic choroid

[Term]
id: CL:0000349
name: extraembryonic cell
namespace: cell
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0000478 ! extraembryonic structure
relationship: part_of UBERON:0000478 ! extraembryonic structure

[Term]
id: CL:0000350
name: amnioserosal cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: part_of UBERON:0010302 ! amnioserosa
relationship: part_of UBERON:0010302 ! amnioserosa

[Term]
id: CL:0000351
name: trophoblast cell
namespace: cell
def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." []
synonym: "trophoblastic cell" EXACT []
xref: FMA:83028
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: part_of UBERON:0000358 ! blastocyst
relationship: part_of UBERON:0000358 ! blastocyst

[Term]
id: CL:0000352
name: epiblast cell
namespace: cell
def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." []
is_a: CL:0000052 ! totipotent stem cell

[Term]
id: CL:0000353
name: blastoderm cell
namespace: cell
def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." []
synonym: "blastomere" EXACT []
xref: BTO:0001473
xref: FMA:72551
is_a: CL:0000007 ! early embryonic cell

[Term]
id: CL:0000354
name: blastemal cell
namespace: cell
synonym: "blastema cell" EXACT []
xref: ncithesaurus:Blastemal_Cell
is_a: CL:0000048 ! multi fate stem cell

[Term]
id: CL:0000355
name: multi-potent skeletal muscle stem cell
namespace: cell
def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." []
comment: Multi-potency demonstrated ex vivo.  At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.
xref: FMA:86767
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000188 ! cell of skeletal muscle
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0000356
name: hair matrix stem cell
namespace: cell
is_a: CL:0000035 ! single fate stem cell

[Term]
id: CL:0000357
name: stratified epithelial stem cell
namespace: cell
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000358
name: sphincter associated smooth muscle cell
namespace: cell
def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004590 ! sphincter muscle
relationship: part_of UBERON:0004590 ! sphincter muscle

[Term]
id: CL:0000359
name: vascular associated smooth muscle cell
namespace: cell
def: "A smooth muscle cell assocatiated with the vasculature." []
synonym: "vascular smooth muscle cell" EXACT []
synonym: "VSMC" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002049 ! vasculature
relationship: part_of UBERON:0002049 ! vasculature

[Term]
id: CL:0000360
name: morula cell
namespace: cell
def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000007 ! early embryonic cell
relationship: part_of UBERON:0000085 ! morula

[Term]
id: CL:0000361
name: gastrula cell
namespace: cell
def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000007 ! early embryonic cell
relationship: part_of UBERON:0004734 ! gastrula

[Term]
id: CL:0000362
name: epidermal cell
namespace: cell
alt_id: CL:1000396
def: "An epithelial cell of the integument (the outer layer of an organism)." []
synonym: "cell of epidermis" EXACT []
synonym: "epithelial cell of skin" NARROW []
xref: BTO:0001470
xref: CALOHA:TS-0283
xref: FMA:62411
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0007376 ! outer epithelium
relationship: part_of UBERON:0007376 ! outer epithelium

[Term]
id: CL:0000363
name: obsolete axial cell
namespace: cell
def: "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." []
comment: replaced_by: PO:0000081
is_obsolete: true

[Term]
id: CL:0000364
name: obsolete ray cell
namespace: cell
def: "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." []
is_obsolete: true

[Term]
id: CL:0000365
name: animal zygote
namespace: cell
def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." []
synonym: "zygote" BROAD []
xref: BTO:0000854
xref: EHDAA2:0004546
xref: FMA:72395
is_a: CL:0000007 ! early embryonic cell

[Term]
id: CL:0000366
name: obsolete sperm cell (sensu Viridiplantae)
namespace: cell
def: "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." []
comment: replaced_by: PO:0000084
synonym: "gametophyte sperm cell" RELATED []
synonym: "male gametophyte sperm cell" RELATED []
synonym: "pollen germ cell" RELATED []
is_obsolete: true

[Term]
id: CL:0000367
name: sheath cell (sensu Nematoda)
namespace: cell
synonym: "glial cell (sensu Nematoda)" RELATED []
is_a: CL:0000619 ! support cell (sensu Nematoda)

[Term]
id: CL:0000368
name: obsolete myrosin cell
namespace: cell
def: "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." []
comment: replaced_by: PO:0000352
is_obsolete: true

[Term]
id: CL:0000370
name: obsolete transfer cell
namespace: cell
def: "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." []
comment: replaced_by: PO:0000078
synonym: "intermediary cell" RELATED []
is_obsolete: true

[Term]
id: CL:0000371
name: protoplast
namespace: cell
def: "The cell protoplasm after removal of the cell wall." []
is_a: CL:0000578 ! experimentally modified cell in vitro

[Term]
id: CL:0000372
name: tormogen cell
namespace: cell
def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." []
synonym: "socket cell" BROAD []
xref: FBbt:00005171
is_a: CL:0000463 ! epidermal cell (sensu arthropoda)

[Term]
id: CL:0000373
name: histoblast
namespace: cell
xref: FBbt:00001789
is_a: CL:0000146 ! simple columnar epithelial cell

[Term]
id: CL:0000374
name: trichogen cell
namespace: cell
def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." []
synonym: "hair cell" BROAD []
xref: BTO:0004744
xref: FBbt:00005169
is_a: CL:0000463 ! epidermal cell (sensu arthropoda)

[Term]
id: CL:0000375
name: obsolete osteoprogenitor cell
namespace: cell
xref: BTO:0002051
is_obsolete: true
replaced_by: CL:0007010

[Term]
id: CL:0000376
name: humidity receptor cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell

[Term]
id: CL:0000377
name: tracheoblast
namespace: cell
is_a: CL:0000069 ! branched duct epithelial cell

[Term]
id: CL:0000378
name: support cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000379
name: sensory processing neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000380
name: thecogen cell
namespace: cell
def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." []
synonym: "fly sheath cell" EXACT []
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000381
name: neurosecretory neuron
namespace: cell
xref: FBbt:00005130
is_a: CL:0000151 ! secretory cell
is_a: CL:0000527 ! efferent neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0046879 ! hormone secretion
relationship: capable_of GO:0046879 ! hormone secretion

[Term]
id: CL:0000382
name: scolopale cell
namespace: cell
xref: FBbt:00005219
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000383
name: nephrogenic mesenchyme stem cell
namespace: cell
is_a: CARO:0000000
is_a: CL:0000134 ! mesenchymal stem cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000384
name: ligament cell
namespace: cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000385
name: prohemocyte (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005062
is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000386
name: attachment cell
namespace: cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000387
name: hemocyte (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005063
is_a: CARO:0000000
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
relationship: capable_of GO:0035010
relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000388
name: tendon cell
namespace: cell
def: "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." []
synonym: "muscle attachment cell" EXACT []
synonym: "tenocyte" RELATED []
is_a: CL:0000135 ! fibrocyte
is_a: CL:0000386 ! attachment cell
intersection_of: CL:0000135 ! fibrocyte
intersection_of: part_of UBERON:0000043 ! tendon
relationship: part_of UBERON:0000043 ! tendon

[Term]
id: CL:0000389
name: socket cell (sensu Nematoda)
namespace: cell
is_a: CL:0000619 ! support cell (sensu Nematoda)
is_a: CL:0000658 ! cuticle secreting cell
is_a: CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000390
name: blood cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000081 ! blood cell

[Term]
id: CL:0000391
name: podocyte (sensu Diptera)
namespace: cell
def: "An insect immune cell that develops from plasmatocyte." []
xref: FBbt:00001688
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)
relationship: develops_from CL:0000394 ! plasmatocyte

[Term]
id: CL:0000392
name: crystal cell
namespace: cell
xref: FMA:63847
is_a: CL:0000391 ! podocyte (sensu Diptera)

[Term]
id: CL:0000393
name: electrically responsive cell
namespace: cell
def: "A cell whose function is determined by its response to an electric signal." []
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000394
name: plasmatocyte
namespace: cell
xref: FBbt:00001685
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000395
name: procrystal cell
namespace: cell
xref: FBbt:00001689
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000396
name: lamellocyte
namespace: cell
xref: FBbt:00001687
is_a: CL:0000394 ! plasmatocyte

[Term]
id: CL:0000397
name: ganglion interneuron
namespace: cell
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0000045 ! ganglion
relationship: part_of UBERON:0000045 ! ganglion

[Term]
id: CL:0000398
name: polygonal cell
namespace: cell
xref: FBbt:00001691
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000399
name: obsolete phloem element
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." []
is_obsolete: true

[Term]
id: CL:0000400
name: obsolete pavement cell
namespace: cell
def: "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." []
comment: replaced_by: PO:0000332
is_obsolete: true

[Term]
id: CL:0000401
name: macrophage (sensu Diptera)
namespace: cell
xref: FBbt:00001686
is_a: CL:0000394 ! plasmatocyte

[Term]
id: CL:0000402
name: CNS interneuron
namespace: cell
is_a: CL:0000099 ! interneuron
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000404
name: electrically signaling cell
namespace: cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." []
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000405
name: neuroepidermoblast
namespace: cell
xref: FBbt:00005148
is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)

[Term]
id: CL:0000406
name: CNS short range interneuron
namespace: cell
is_a: CL:0000402 ! CNS interneuron

[Term]
id: CL:0000407
name: scolopidial ligament cell
namespace: cell
xref: FBbt:00005221
is_a: CL:0000384 ! ligament cell

[Term]
id: CL:0000408
name: male gamete
namespace: cell
xref: BTO:0001277
xref: CALOHA:TS-0949
is_a: CL:0000015 ! male germ cell
is_a: CL:0000300 ! gamete

[Term]
id: CL:0000409
name: scolopidial sheath cell
namespace: cell
xref: FBbt:00005219
is_a: CL:0000618 ! sheath cell

[Term]
id: CL:0000410
name: CNS long range interneuron
namespace: cell
is_a: CL:0000402 ! CNS interneuron

[Term]
id: CL:0000411
name: flatworm hypodermal cell
namespace: cell
def: "An epithelial cell of the hypodermis of flatworms." []
xref: WBbt:0007846
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000412
name: polyploid cell
namespace: cell
def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000413
name: haploid cell
namespace: cell
def: "A cell whose nucleus contains a single haploid genome." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000414
name: obsolete cell by ploidy
namespace: cell
def: "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." []
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0000255
consider: CL:0001034

[Term]
id: CL:0000415
name: diploid cell
namespace: cell
def: "A cell whose nucleus has two haploid genomes." []
xref: FMA:72300
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000416
name: polytene cell
namespace: cell
is_a: CL:0000412 ! polyploid cell

[Term]
id: CL:0000417
name: endopolyploid cell
namespace: cell
is_a: CL:0000412 ! polyploid cell

[Term]
id: CL:0000418
name: arcade cell
namespace: cell
def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." []
xref: WBbt:0005793
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000419
name: seam cell
namespace: cell
def: "An epithelial fate stem cell found in flatworms." []
xref: BTO:0003039
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000420
name: syncytial epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000421
name: coelomocyte
namespace: cell
def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." []
xref: BTO:0002856
xref: WBbt:0005751
is_a: CL:0000080 ! circulating cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000422
name: mitogenic signaling cell
namespace: cell
def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000423
name: tip cell
namespace: cell
is_a: CL:0000422 ! mitogenic signaling cell

[Term]
id: CL:0000424
name: excretory cell
namespace: cell
def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." []
xref: WBbt:0005812
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000425
name: pore cell
namespace: cell
def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." []
is_a: CL:0000658 ! cuticle secreting cell

[Term]
id: CL:0000426
name: scaffold cell
namespace: cell
is_a: CL:0000445 ! apoptosis fated cell

[Term]
id: CL:0000427
name: GLR cell
namespace: cell
def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." []
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000428
name: yolk cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000349 ! extraembryonic cell

[Term]
id: CL:0000429
name: imaginal disc cell
namespace: cell
is_a: CL:0000146 ! simple columnar epithelial cell

[Term]
id: CL:0000430
name: xanthophore cell
namespace: cell
def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." []
synonym: "xanthophore" RELATED []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005002 ! xanthoblast

[Term]
id: CL:0000431
name: iridophore
namespace: cell
def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." []
synonym: "guanophore" RELATED []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005001 ! iridoblast

[Term]
id: CL:0000432
name: reticular cell
namespace: cell
def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." []
synonym: "reticulum cell" EXACT []
xref: FMA:62877
is_a: CL:0000057 ! fibroblast

[Term]
id: CL:0000433
name: obsolete functional megaspore
namespace: cell
def: "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." []
comment: replaced_by: PO:0000244
is_obsolete: true

[Term]
id: CL:0000434
name: eccrine cell
namespace: cell
def: "A secretory cell that discharges its product without loss of cytoplasm." []
is_a: CL:0000150 ! glandular epithelial cell

[Term]
id: CL:0000435
name: alkali secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000436
name: vaginal lubricant secreting cell
namespace: cell
is_a: CARO:0000000
is_a: CL:0000151 ! secretory cell
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: CL:0000437
name: gonadtroph
namespace: cell
def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." []
synonym: "delta basophil" EXACT []
synonym: "follicle stimulating hormone secreting cell" EXACT []
synonym: "gonadotrope" EXACT []
synonym: "gonadotrope cell" EXACT []
synonym: "gonadotroph" EXACT []
synonym: "gonadotropic cell" EXACT []
synonym: "pituitary delta cell" EXACT []
xref: BTO:0002482
xref: FMA:83100
is_a: CL:0000438 ! luteinizing hormone secreting cell
is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis

[Term]
id: CL:0000438
name: luteinizing hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." []
is_a: CL:0000163 ! endocrine cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0032275
relationship: capable_of GO:0032275

[Term]
id: CL:0000439
name: prolactin secreting cell
namespace: cell
def: "A peptide hormone cell that secretes prolactin." []
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070459
relationship: capable_of GO:0070459

[Term]
id: CL:0000440
name: melanocyte stimulating hormone secreting cell
namespace: cell
def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." []
synonym: "melanotrope" EXACT []
synonym: "melanotroph" EXACT []
xref: BTO:0002277
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0036160
relationship: capable_of GO:0036160

[Term]
id: CL:0000441
name: follicle stem cell
namespace: cell
xref: FBbt:00004903
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000442
name: follicular dendritic cell
namespace: cell
def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." []
comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451.
xref: BTO:0004267
xref: FMA:83037
is_a: CL:0000473 ! defensive cell

[Term]
id: CL:0000443
name: calcitonin secreting cell
namespace: cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0036161 ! calcitonin secretion
relationship: capable_of GO:0036161 ! calcitonin secretion

[Term]
id: CL:0000444
name: obliquely striated muscle cell
namespace: cell
def: "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." []
comment: Examples include the somatic muscles of nemotodes and cephalopods.
is_a: CL:0000737 ! striated muscle cell

[Term]
id: CL:0000445
name: apoptosis fated cell
namespace: cell
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000446
name: chief cell of parathyroid gland
namespace: cell
def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." []
synonym: "parathyroid chief cell" EXACT []
synonym: "parathyroid gland chief cell" EXACT []
synonym: "parathyroid hormone secreting cell" EXACT []
synonym: "principal cell of parathyroid gland" EXACT []
xref: BTO:0004712
xref: CALOHA:TS-2140
xref: FMA:69078
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0002260 ! epithelial cell of parathyroid gland

[Term]
id: CL:0000447
name: carbohydrate secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000448
name: white fat cell
namespace: cell
def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." []
synonym: "white adipocyte" RELATED []
synonym: "white adipose cell" EXACT []
synonym: "white fat cell" EXACT []
xref: CALOHA:TS-1119
xref: FMA:83434
is_a: CL:0000136 ! fat cell
relationship: develops_from CL:0002334 ! preadipocyte
relationship: part_of UBERON:0001347 ! white adipose tissue

[Term]
id: CL:0000449
name: brown fat cell
namespace: cell
def: "A cell from the thermogenic form of adipose tissue found in many species,  particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." []
synonym: "brown adipocyte" EXACT []
synonym: "brown adipose cell" EXACT []
xref: CALOHA:TS-0099
xref: FMA:83435
is_a: CL:0000136 ! fat cell
relationship: develops_from CL:0002335 ! brown preadipocyte
relationship: part_of UBERON:0001348 ! brown adipose tissue

[Term]
id: CL:0000451
name: dendritic cell
namespace: cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." []
synonym: "interdigitating cell" RELATED []
synonym: "veiled cell" RELATED []
xref: BTO:0002042
xref: CALOHA:TS-0194
xref: FMA:83036
is_a: CL:0000738 ! leukocyte
disjoint_from: CL:0000542 ! lymphocyte
relationship: capable_of GO:0001816
relationship: capable_of GO:0019882
relationship: capable_of GO:0045580 ! regulation of T cell differentiation
relationship: has_part GO:0042613

[Term]
id: CL:0000452
name: thyroid hormone secreting cell
namespace: cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000453
name: Langerhans cell
namespace: cell
def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
synonym: "Langerhans' cell" EXACT []
synonym: "LC" EXACT []
xref: BTO:0000705
xref: CALOHA:TS-2375
xref: FMA:63072
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
relationship: capable_of GO:0002828
relationship: develops_from CL:0000763 ! myeloid cell
relationship: has_part PR:000001293

[Term]
id: CL:0000454
name: epinephrine secreting cell
namespace: cell
def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." []
synonym: "adrenaline secreting cell" EXACT []
synonym: "epinephrin secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0048242
relationship: capable_of GO:0048242

[Term]
id: CL:0000455
name: obsolete starch sheath cell
namespace: cell
def: "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." []
comment: replaced_by: PO:0004531
is_obsolete: true

[Term]
id: CL:0000456
name: mineralocorticoid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035931 ! mineralocorticoid secretion
relationship: capable_of GO:0035931 ! mineralocorticoid secretion

[Term]
id: CL:0000457
name: biogenic amine secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000458
name: serotonin secreting cell
namespace: cell
def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." []
synonym: "5-HT secreting cell" EXACT []
synonym: "5-Hydroxytryptamine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0001820 ! serotonin secretion
relationship: capable_of GO:0001820 ! serotonin secretion

[Term]
id: CL:0000459
name: noradrenergic cell
namespace: cell
def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." []
synonym: "noradrenaline secreting cell" EXACT []
synonym: "norepinephrin secreting cell" EXACT []
synonym: "norepinephrine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0048243 ! norepinephrine secretion
relationship: capable_of GO:0048243 ! norepinephrine secretion

[Term]
id: CL:0000460
name: glucocorticoid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035933
relationship: capable_of GO:0035933

[Term]
id: CL:0000462
name: adepithelial cell
namespace: cell
xref: FBbt:00003219
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000463
name: epidermal cell (sensu arthropoda)
namespace: cell
def: "An epidermal cell that secretes chitinous cuticle from its apical side." []
comment: While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ.
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: develops_from CL:0000464 ! epidermoblast

[Term]
id: CL:0000464
name: epidermoblast
namespace: cell
def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." []
xref: FBbt:00004994
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000465
name: cardioblast (sensu Arthropoda)
namespace: cell
xref: FBbt:00001666
is_a: CL:0010021 ! cardiac myoblast

[Term]
id: CL:0000467
name: adrenocorticotropic hormone secreting cell
namespace: cell
alt_id: CL:0000640
def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." []
synonym: "ACTH secreting cell" EXACT []
synonym: "adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "corticotrophin hormone secreting cell" EXACT []
synonym: "corticotropin hormone secreting cell" EXACT []
synonym: "corticotropin secreting cell" EXACT []
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0051458
relationship: capable_of GO:0051458

[Term]
id: CL:0000468
name: neuroglioblast
namespace: cell
xref: FBbt:00005147
is_a: CL:0000047 ! neuronal stem cell
is_a: CL:0000055 ! non-terminally differentiated cell

[Term]
id: CL:0000469
name: ganglion mother cell
namespace: cell
xref: FBbt:00005149
is_a: CL:0000468 ! neuroglioblast

[Term]
id: CL:0000470
name: digestive enzyme secreting cell
namespace: cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000472
name: obsolete chlorenchyma cell
namespace: cell
def: "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." []
comment: replaced_by: PO:0000076
is_obsolete: true

[Term]
id: CL:0000473
name: defensive cell
namespace: cell
def: "A cell whose primary function is to protect the organism." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000474
name: pericardial nephrocyte
namespace: cell
def: "an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." []
synonym: "pericardial cell" NARROW []
xref: FBbt:00005058
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0002520 ! nephrocyte

[Term]
id: CL:0000475
name: obsolete degenerate megaspore
namespace: cell
def: "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." []
comment: replaced_by: PO:0000245
is_obsolete: true

[Term]
id: CL:0000476
name: thyrotroph
namespace: cell
def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." []
synonym: "beta-basophil" EXACT []
synonym: "thyroid stimulating hormone secreting cell" EXACT []
synonym: "thyrotrope" EXACT []
xref: FMA:83099
is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis
relationship: capable_of GO:0070460

[Term]
id: CL:0000477
name: follicle cell
namespace: cell
comment: Editors note: check this. Currently used in goxp
synonym: "ovarian follicle cell" EXACT []
xref: FBbt:00004904
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
relationship: develops_from CL:0000441 ! follicle stem cell

[Term]
id: CL:0000478
name: oxytocin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000479
name: vasopressin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000480
name: secretin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes secretin stimulating hormone" []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000481
name: cholecystokin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000482
name: juvenile hormone secreting cell
namespace: cell
def: "An endocrine cell that secretes juvenile hormone." []
is_a: CL:0000163 ! endocrine cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0045443
relationship: capable_of GO:0045443

[Term]
id: CL:0000483
name: bombesin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000484
name: connective tissue type mast cell
namespace: cell
def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." []
comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.
synonym: "MC(TC)" EXACT []
synonym: "MCTC" EXACT []
synonym: "TC mast cells" EXACT []
is_a: CL:0000097 ! mast cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000097 ! mast cell
intersection_of: part_of UBERON:0002384 ! connective tissue

[Term]
id: CL:0000485
name: mucosal type mast cell
namespace: cell
def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." []
comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.
synonym: "MC(T)" EXACT []
synonym: "MCT" EXACT []
synonym: "T mast cells" EXACT []
is_a: CL:0000097 ! mast cell
intersection_of: CL:0000097 ! mast cell
intersection_of: capable_of GO:0002540
intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue
relationship: capable_of GO:0002540
relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue

[Term]
id: CL:0000486
name: garland cell
namespace: cell
def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." []
synonym: "garland nephrocyte" BROAD []
xref: BTO:0004596
xref: FBbt:00005059
is_a: CL:0000227 ! binucleate cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0002520 ! nephrocyte

[Term]
id: CL:0000487
name: oenocyte
namespace: cell
def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." []
xref: FBbt:00004995
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000488
name: visible light photoreceptor cell
namespace: cell
def: "A photoreceptor cell that detects visible light." []
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: capable_of GO:0009584 ! detection of visible light
relationship: capable_of GO:0009584 ! detection of visible light

[Term]
id: CL:0000489
name: scotopic photoreceptor cell
namespace: cell
is_a: CL:0000210 ! photoreceptor cell

[Term]
id: CL:0000490
name: photopic photoreceptor cell
namespace: cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000491
name: obsolete cytotoxic T cell
namespace: cell
def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." []
comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation.
is_obsolete: true

[Term]
id: CL:0000492
name: CD4-positive helper T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." []
synonym: "CD4-positive helper T lymphocyte" EXACT []
synonym: "CD4-positive helper T-cell" EXACT []
synonym: "CD4-positive helper T-lymphocyte" EXACT []
synonym: "CD4-positive T-helper cell" EXACT []
xref: CALOHA:TS-1146
xref: FMA:70572
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000912 ! helper T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: capable_of GO:0001816
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000493
name: obsolete regulatory T cell
namespace: cell
def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." []
comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead.
is_obsolete: true

[Term]
id: CL:0000494
name: UV sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that detects ultraviolet light." []
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: capable_of GO:0009589
relationship: capable_of GO:0009589

[Term]
id: CL:0000495
name: blue sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to blue light." []
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000496
name: green sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to green light." []
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000497
name: red sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to red light." []
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000498
name: inhibitory interneuron
namespace: cell
def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." []
xref: FMA:84776
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000499
name: stromal cell
namespace: cell
def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." []
xref: BTO:0002064
xref: FMA:83624
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000500
name: follicular epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000501
name: granulosa cell
namespace: cell
def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." []
synonym: "granulosa cell of ovary" EXACT []
xref: BTO:0000542
xref: CALOHA:TS-0729
xref: FMA:18718
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002174 ! follicular cell of ovary

[Term]
id: CL:0000502
name: type D enteroendocrine cell
namespace: cell
def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." []
synonym: "D cell" EXACT []
xref: FMA:62935
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000172 ! somatostatin secreting cell

[Term]
id: CL:0000503
name: theca cell
namespace: cell
def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." []
xref: BTO:0002850
xref: FMA:18690
is_a: CL:0000499 ! stromal cell
is_a: CL:0000593 ! androgen secreting cell

[Term]
id: CL:0000504
name: enterochromaffin-like cell
namespace: cell
def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." []
comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell.
synonym: "ECL" EXACT []
xref: BTO:0002692
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002274 ! histamine secreting cell

[Term]
id: CL:0000505
name: substance P secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes substance P." []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000506
name: enkephalin secreting cell
namespace: cell
def: "An endorphine cell that secretes enkephalin." []
is_a: CL:0000507 ! endorphin secreting cell

[Term]
id: CL:0000507
name: endorphin secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes endorphin." []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000508
name: type G enteroendocrine cell
namespace: cell
def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." []
synonym: "G cell" EXACT []
xref: BTO:0004108
xref: FMA:67609
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000506 ! enkephalin secreting cell
is_a: CL:0000509 ! gastrin secreting cell
is_a: CL:0002180 ! mucous cell of stomach
relationship: part_of UBERON:0004997 ! mucosa of pyloric antrum

[Term]
id: CL:0000509
name: gastrin secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes gastrin." []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000510
name: paneth cell
namespace: cell
def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." []
xref: BTO:0000993
xref: FMA:62897
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000323 ! lysozyme secreting cell
is_a: CL:0002563 ! intestinal epithelial cell

[Term]
id: CL:0000511
name: androgen binding protein secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes androgen binding protein." []
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000512
name: paracrine cell
namespace: cell
def: "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." []
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000513
name: cardiac muscle myoblast
namespace: cell
alt_id: CL:0000714
def: "A precursor cell destined to differentiate into cardiac muscle cell." []
synonym: "cardiac muscle progenitor cell" EXACT []
synonym: "cardiomyocyte progenitor cell" EXACT []
xref: FMA:84797
is_a: CL:0002494 ! cardiocyte
is_a: CL:0010021 ! cardiac myoblast
relationship: part_of UBERON:0001133 ! cardiac muscle tissue

[Term]
id: CL:0000514
name: smooth muscle myoblast
namespace: cell
def: "A precursor cell destined to differentiate into smooth muscle myocytes." []
synonym: "myoblast, smooth muscle" EXACT []
synonym: "satellite cell" RELATED []
xref: FMA:84798
is_a: CL:0000056 ! myoblast

[Term]
id: CL:0000515
name: skeletal muscle myoblast
namespace: cell
def: "A myoblast that differentiates into skeletal muscle fibers." []
synonym: "skeletal myoblast" EXACT []
xref: FMA:84799
is_a: CL:0000056 ! myoblast
relationship: develops_from CL:0000355 ! multi-potent skeletal muscle stem cell

[Term]
id: CL:0000516
name: perineuronal satellite cell
namespace: cell
def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." []
synonym: "perineural satellite cell" EXACT []
synonym: "perineuronal satellite oligodendroglial cell" EXACT []
synonym: "satellite oligodendrocyte" EXACT []
xref: FMA:54550
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000243 ! glial cell (sensu Vertebrata)

[Term]
id: CL:0000517
name: macrophage derived foam cell
namespace: cell
def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000891 ! foam cell
relationship: develops_from CL:0000235 ! macrophage

[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
namespace: cell
def: "A phagocyte in vertebrates that is able to phagocytosis." []
is_a: CL:0000234 ! phagocyte

[Term]
id: CL:0000519
name: phagocyte (sensu Nematoda and Protostomia)
namespace: cell
def: "A phagocyte from organisms in the Nematoda or Protostomia clades." []
is_a: CL:0000234 ! phagocyte

[Term]
id: CL:0000520
name: prokaryotic cell
namespace: cell
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000521
name: fungal cell
namespace: cell
is_a: CL:0000255 ! eukaryotic cell
disjoint_from: CL:0000548 ! animal cell

[Term]
id: CL:0000522
name: obsolete spore
namespace: cell
def: "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." []
is_obsolete: true

[Term]
id: CL:0000523
name: mononuclear cytotrophoblast cell
namespace: cell
def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." []
synonym: "Langhans' cell" EXACT []
xref: FMA:83042
is_a: CL:0000351 ! trophoblast cell

[Term]
id: CL:0000524
name: spheroplast
namespace: cell
def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." []
synonym: "sphaeroplast" EXACT []
is_a: CL:0000371 ! protoplast

[Term]
id: CL:0000525
name: syncytiotrophoblast cell
namespace: cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." []
synonym: "plasmidotrophoblast" EXACT []
synonym: "syncytial trophoblast" EXACT []
synonym: "syntrophoblast" EXACT []
xref: FMA:83043
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000351 ! trophoblast cell

[Term]
id: CL:0000526
name: afferent neuron
namespace: cell
def: "A neuron which conveys sensory information centrally from the periphery." []
synonym: "input neuron" EXACT []
xref: FMA:87653
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000527
name: efferent neuron
namespace: cell
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." []
synonym: "output neuron" EXACT []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000528
name: nitrergic neuron
namespace: cell
def: "A nerve cell where transmission is mediated by nitric oxide." []
xref: FMA:84792
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000529
name: pigmented epithelial cell
namespace: cell
is_a: CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000530
name: primary neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000531
name: primary sensory neuron
namespace: cell
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000530 ! primary neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: CL:0000530 ! primary neuron

[Term]
id: CL:0000532
name: CAP motoneuron
namespace: cell
is_a: CL:0000533 ! primary motor neuron

[Term]
id: CL:0000533
name: primary motor neuron
namespace: cell
xref: FMA:83619
is_a: CL:0000100 ! motor neuron
is_a: CL:0000530 ! primary neuron

[Term]
id: CL:0000534
name: primary interneuron
namespace: cell
is_a: CL:0000099 ! interneuron
is_a: CL:0000530 ! primary neuron

[Term]
id: CL:0000535
name: secondary neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000536
name: secondary motor neuron
namespace: cell
xref: FMA:83620
is_a: CL:0000100 ! motor neuron
is_a: CL:0000535 ! secondary neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: CL:0000535 ! secondary neuron

[Term]
id: CL:0000537
name: obsolete antipodal cell
namespace: cell
def: "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." []
comment: replaced_by: PO:0020093
is_obsolete: true

[Term]
id: CL:0000538
name: obsolete epidermal initial
namespace: cell
def: "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." []
comment: replaced_by: PO:0000349
is_obsolete: true

[Term]
id: CL:0000539
name: obsolete idioblast
namespace: cell
def: "OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." []
is_obsolete: true

[Term]
id: CL:0000540
name: neuron
namespace: cell
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." []
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
synonym: "nerve cell" EXACT []
xref: BTO:0000938
xref: CALOHA:TS-0683
xref: FBbt:00005106
xref: FMA:54527
xref: VHOG:0001483
xref: WBbt:0003679
is_a: BFO:0000040 ! material entity
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226
relationship: develops_from CL:0000031 ! neuroblast
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000541
name: melanoblast
namespace: cell
def: "A cell that originates from the neural crest and differentiates into a pigment cell." []
comment: Derived from UBERON:0002342 neural crest.
xref: BTO:0003217
xref: FMA:83377
is_a: CARO:0000000
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000542
name: lymphocyte
namespace: cell
def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." []
comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)
xref: BTO:0000775
xref: CALOHA:TS-0583
xref: FMA:62863
xref: VHOG:0001535
is_a: CL:0002087 ! nongranular leukocyte
is_a: CL:0002242 ! nucleate cell
disjoint_from: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_part CP:0000000
relationship: has_part CP:0000037
relationship: has_part GO:0000792

[Term]
id: CL:0000543
name: obsolete sieve tube member
namespace: cell
def: "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." []
comment: replaced_by: PO:0000289
synonym: "sieve tube element" EXACT []
is_obsolete: true

[Term]
id: CL:0000544
name: slowly adapting mechanoreceptor cell
namespace: cell
is_a: CL:0000199 ! mechanoreceptor cell

[Term]
id: CL:0000545
name: T-helper 1 cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells.
synonym: "helper T cell type 1" EXACT []
synonym: "T helper cells type 1" EXACT []
synonym: "T(H)-1 cell" EXACT []
synonym: "Th1 CD4+ T cell" EXACT []
synonym: "Th1 cell" EXACT []
synonym: "Th1 T cell" EXACT []
synonym: "Th1 T lymphocyte" EXACT []
synonym: "Th1 T-cell" EXACT []
synonym: "Th1 T-lymphocyte" EXACT []
xref: BTO:0001678
xref: FMA:84382
is_a: CL:0000492 ! CD4-positive helper T cell
relationship: capable_of GO:0032609
relationship: has_part PR:000001207
relationship: has_part PR:000001835

[Term]
id: CL:0000546
name: T-helper 2 cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell.
synonym: "helper T cell type 2" EXACT []
synonym: "T helper cells type 2" EXACT []
synonym: "T(H)-2 cell" EXACT []
synonym: "Th2 cell" EXACT []
synonym: "Th2 T cell" EXACT []
synonym: "Th2 T lymphocyte" EXACT []
synonym: "Th2 T-cell" EXACT []
synonym: "Th2 T-lymphocyte" EXACT []
xref: BTO:0001679
xref: FMA:84385
is_a: CL:0000492 ! CD4-positive helper T cell
is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
relationship: capable_of GO:0032633
relationship: has_part PR:000001941

[Term]
id: CL:0000547
name: proerythroblast
namespace: cell
def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." []
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT []
xref: FMA:83518
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
relationship: develops_from CL:0000038 ! erythroid progenitor cell
relationship: has_part CP:0000028
relationship: has_part CP:0000037
relationship: has_part GO:0005730
relationship: has_part PR:000001945

[Term]
id: CL:0000548
name: animal cell
namespace: cell
subset: ubprop:upper_level
is_a: CL:0000255 ! eukaryotic cell

[Term]
id: CL:0000549
name: basophilic erythroblast
namespace: cell
def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." []
synonym: "basophilic normoblast" EXACT []
synonym: "early erythroblast" EXACT []
synonym: "early normoblast" EXACT []
synonym: "prorubricyte" EXACT []
xref: FMA:83505
is_a: CL:0000765 ! erythroblast
relationship: has_part CP:0000028
relationship: has_part GO:0000792
relationship: has_part PR:000001945

[Term]
id: CL:0000550
name: polychromatophilic erythroblast
namespace: cell
def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." []
synonym: "intermediate erythroblast" EXACT []
synonym: "intermediate normoblast" EXACT []
synonym: "polychromatic erythroblast" EXACT []
synonym: "polychromatic normoblast" EXACT []
synonym: "polychromatophilic normoblast" EXACT []
synonym: "rubricyte" EXACT []
xref: FMA:83506
is_a: CL:0000765 ! erythroblast
relationship: develops_from CL:0000549 ! basophilic erythroblast
relationship: has_part CP:0000035
relationship: has_part GO:0000792
relationship: has_part PR:000001945

[Term]
id: CL:0000551
name: unimodal nocireceptor
namespace: cell
is_a: CL:0000198 ! pain receptor cell

[Term]
id: CL:0000552
name: orthochromatic erythroblast
namespace: cell
def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." []
synonym: "acidophilic erythroblast" EXACT []
synonym: "eosinophilic erythroblast" EXACT []
synonym: "late erythoblast" EXACT []
synonym: "orthochromatic normoblast" EXACT []
synonym: "pyknotic eto enrythroblast" EXACT []
xref: FMA:84646
is_a: CL:0000765 ! erythroblast
relationship: develops_from CL:0000550 ! polychromatophilic erythroblast
relationship: has_part CP:0000027

[Term]
id: CL:0000553
name: megakaryocyte progenitor cell
namespace: cell
def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." []
comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
synonym: "CFU-Meg" EXACT []
synonym: "colony-forming unit-megakaryocyte" EXACT []
synonym: "Meg-CFC" EXACT []
synonym: "megacaryoblast" EXACT []
synonym: "megacaryocyte progenitor cell" EXACT []
synonym: "megakaryoblast" EXACT []
synonym: "megakaryocytic progenitor cell" EXACT []
synonym: "MkP" EXACT []
synonym: "promegacaryocyte" RELATED []
synonym: "promegakaryocyte" RELATED []
xref: BTO:0001164
xref: CALOHA:TS-0610
xref: FMA:84235
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: capable_of GO:0007113
relationship: capable_of GO:0030219
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell

[Term]
id: CL:0000554
name: gastrin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes gastrin stimulating hormone." []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000555
name: neuronal brush cell
namespace: cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000556
name: megakaryocyte
namespace: cell
def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." []
comment: Megakaryocytes are reportedly CD181-positive and CD182-positive.
synonym: "megacaryocyte" EXACT []
synonym: "megalocaryocyte" EXACT []
synonym: "megalokaryocyte" EXACT []
xref: BTO:0000843
xref: CALOHA:TS-0611
xref: FMA:83555
is_a: CL:0000763 ! myeloid cell
is_a: CL:1001610 ! bone marrow hematopoietic cell
disjoint_from: CL:0000764 ! erythroid lineage cell
relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell

[Term]
id: CL:0000557
name: granulocyte monocyte progenitor cell
namespace: cell
def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
synonym: "CFU-C , Colony forming unit in culture" BROAD []
synonym: "CFU-GM" EXACT []
synonym: "colony forming unit granulocyte macrophage" EXACT []
synonym: "GMP" EXACT []
synonym: "granulocyte-macrophage progenitor" EXACT []
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:0011115 ! precursor cell
is_a: CL:1001610 ! bone marrow hematopoietic cell
relationship: capable_of GO:0030225
relationship: capable_of GO:0030851
relationship: has_part PR:000001865
relationship: has_part PR:000001944
relationship: has_part PR:000005307

[Term]
id: CL:0000558
name: reticulocyte
namespace: cell
def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." []
xref: BTO:0001173
xref: CALOHA:TS-0864
is_a: BFO:0000040 ! material entity
is_a: CL:0000764 ! erythroid lineage cell
relationship: capable_of GO:0071971
relationship: develops_from CL:0000552 ! orthochromatic erythroblast
relationship: has_part PR:000001945

[Term]
id: CL:0000559
name: promonocyte
namespace: cell
def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." []
comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
xref: BTO:0004657
xref: FMA:83551
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 ! monopoietic cell
relationship: develops_from CL:0000040 ! monoblast
relationship: has_part GO:0042582
relationship: has_part PR:000001012

[Term]
id: CL:0000560
name: band form neutrophil
namespace: cell
def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." []
comment: Found in the Band 1 fraction.
synonym: "band" BROAD []
synonym: "band cell" BROAD []
synonym: "band form" BROAD []
synonym: "rod neutrophil" EXACT []
synonym: "stab cell" BROAD []
is_a: CL:0000096 ! mature neutrophil
relationship: develops_from CL:0000582 ! neutrophilic metamyelocyte
relationship: has_part CP:0000039
relationship: has_part PR:000001337
relationship: has_part PR:000001580
relationship: has_part PR:000001944
relationship: has_part PR:000005307
relationship: has_part PR:000007597

[Term]
id: CL:0000561
name: amacrine cell
namespace: cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." []
comment: Not clear if this term overlaps with retinal bipolar neuron (CL:0000748).
synonym: "amacrine neuron" EXACT []
xref: BTO:0004044
xref: FBbt:00005127
xref: FMA:67766
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000562
name: nucleate erythrocyte
namespace: cell
def: "An erythrocyte having a nucleus." []
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000232 ! erythrocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000232 ! erythrocyte
intersection_of: has_part GO:0005634 ! nucleus
relationship: develops_from CL:0002421 ! nucleated reticulocyte

[Term]
id: CL:0000563
name: endospore
namespace: cell
def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." []
synonym: "bacterial spore" EXACT []
xref: BTO:0002779
is_a: CL:0000520 ! prokaryotic cell

[Term]
id: CL:0000564
name: neutrophilic promyelocyte
namespace: cell
def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." []
comment: These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction.
synonym: "neutrophilic premyelocyte" EXACT []
synonym: "neutrophilic progranulocyte" EXACT []
xref: FMA:84196
is_a: CL:0000834 ! neutrophil progenitor cell
is_a: CL:0000836 ! promyelocyte
relationship: develops_from CL:0000042 ! neutrophilic myeloblast
relationship: has_part PR:000001944
relationship: has_part PR:000005307
relationship: has_part PR:000007857
relationship: has_part PR:000010543
relationship: has_part PR:000014362

[Term]
id: CL:0000565
name: fat body cell
namespace: cell
def: "A cell found in fat bodies whose primary function is intermediary metabolism." []
is_a: CL:0000181 ! metabolising cell

[Term]
id: CL:0000566
name: angioblastic mesenchymal cell
namespace: cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." []
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CARO:0000000
is_a: CL:0000134 ! mesenchymal stem cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: has_part PR:000001444
relationship: has_part PR:000002112
relationship: has_part PR:000016043

[Term]
id: CL:0000567
name: polymodal nocireceptor
namespace: cell
is_a: CL:0000198 ! pain receptor cell

[Term]
id: CL:0000568
name: amine precursor uptake and decarboxylation cell
namespace: cell
def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." []
synonym: "APUD cell" EXACT []
xref: BTO:0003866
xref: FMA:83114
is_a: CL:0000165 ! neuroendocrine cell

[Term]
id: CL:0000569
name: cardiac mesenchymal cell
namespace: cell
def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." []
is_a: CL:0008019 ! mesenchymal cell

[Term]
id: CL:0000570
name: parafollicular cell
namespace: cell
def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." []
synonym: "C cell" EXACT []
synonym: "C cell of thyroid gland" EXACT []
synonym: "clear cell of thyroid gland" EXACT []
synonym: "parafollicular cell of thyroid gland" EXACT []
synonym: "thyroid parafollicular cell" EXACT []
xref: FMA:68653
xref: SCTID:176770005
is_a: CL:0000443 ! calcitonin secreting cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: capable_of GO:0014046
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: has_part PR:000001024
relationship: part_of UBERON:0001747 ! parenchyma of thyroid gland

[Term]
id: CL:0000571
name: leucophore
namespace: cell
def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005003 ! leucoblast

[Term]
id: CL:0000573
name: retinal cone cell
namespace: cell
def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." []
xref: BTO:0001036
xref: CALOHA:TS-0866
xref: FMA:67748
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: develops_from CL:0002672 ! retinal progenitor cell

[Term]
id: CL:0000574
name: erythrophore
namespace: cell
def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005004 ! pigment erythroblast

[Term]
id: CL:0000575
name: corneal epithelial cell
namespace: cell
alt_id: CL:1000431
def: "An epithelial cell of the cornea." []
synonym: "epithelial cell of cornea" EXACT []
xref: BTO:0004298
xref: CALOHA:TS-0173
xref: FMA:70551
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0000964 ! cornea
relationship: part_of UBERON:0000964 ! cornea

[Term]
id: CL:0000576
name: monocyte
namespace: cell
def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." []
comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.
xref: BTO:0000876
xref: CALOHA:TS-0638
xref: FMA:62864
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000842 ! mononuclear cell
is_a: CL:0011115 ! precursor cell
relationship: capable_of GO:0030225
relationship: capable_of GO:0030316
relationship: capable_of GO:0043011
relationship: develops_from CL:0000559 ! promonocyte

[Term]
id: CL:0000577
name: type EC enteroendocrine cell
namespace: cell
alt_id: CL:0002065
def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." []
synonym: "argentaffin cell" EXACT []
synonym: "enterochromaffin cell" EXACT []
synonym: "Kulchitsky cell" EXACT []
xref: FMA:62934
xref: FMA:83132
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000166 ! chromaffin cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000506 ! enkephalin secreting cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
relationship: part_of UBERON:0004786 ! gastrointestinal system mucosa

[Term]
id: CL:0000578
name: experimentally modified cell in vitro
namespace: cell
def: "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." []
comment: This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12
is_a: CL:0001034 ! cell in vitro

[Term]
id: CL:0000579
name: border follicle cell
namespace: cell
xref: FBbt:00004905
is_a: CL:0000477 ! follicle cell

[Term]
id: CL:0000580
name: neutrophilic myelocyte
namespace: cell
def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." []
comment: These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.
xref: BTO:0003455
xref: FMA:83540
is_a: CL:0000776 ! immature neutrophil
is_a: CL:0002087 ! nongranular leukocyte
is_a: CL:0002193 ! myelocyte
relationship: has_part CP:0000027
relationship: has_part GO:0042582
relationship: has_part PR:000001456
relationship: has_part PR:000001892
relationship: has_part PR:000001932
relationship: has_part PR:000001944
relationship: has_part PR:000002031
relationship: has_part PR:000005307
relationship: has_part PR:000005310
relationship: has_part PR:000009725
relationship: has_part PR:000009978 ! lactotransferrin
relationship: has_part PR:000010543

[Term]
id: CL:0000581
name: peritoneal macrophage
namespace: cell
def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." []
comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+.
xref: BTO:0001034
xref: FMA:83025
is_a: CL:0000864 ! tissue-resident macrophage
relationship: capable_of GO:0042742
relationship: has_part PR:000001012
relationship: has_part PR:000001807
relationship: has_part PR:000001813
relationship: has_part PR:000002062
relationship: has_part PR:000002064
relationship: has_part PR:000006172

[Term]
id: CL:0000582
name: neutrophilic metamyelocyte
namespace: cell
def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." []
comment: These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.
synonym: "juvenile neutrophil" EXACT []
xref: FMA:84197
is_a: CL:0000776 ! immature neutrophil
is_a: CL:0002192 ! metamyelocyte
relationship: develops_from CL:0000580 ! neutrophilic myelocyte
relationship: has_part CP:0000027
relationship: has_part CP:0000040
relationship: has_part GO:0000792
relationship: has_part GO:0042582
relationship: has_part GO:0070820
relationship: has_part PR:000001456
relationship: has_part PR:000001483
relationship: has_part PR:000001892
relationship: has_part PR:000001932
relationship: has_part PR:000001944
relationship: has_part PR:000002031
relationship: has_part PR:000005307
relationship: has_part PR:000005310
relationship: has_part PR:000009725
relationship: has_part PR:000009978 ! lactotransferrin
relationship: has_part PR:000010543

[Term]
id: CL:0000583
name: alveolar macrophage
namespace: cell
def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." []
comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-.
synonym: "dust cell" EXACT []
synonym: "MF.Lu" RELATED []
xref: BTO:0000802
xref: CALOHA:TS-0030
xref: FMA:83023
is_a: CL:0000864 ! tissue-resident macrophage
relationship: capable_of GO:0019882
relationship: has_part PR:000001012
relationship: has_part PR:000001013
relationship: has_part PR:000001807
relationship: has_part PR:000001813
relationship: has_part PR:000001931
relationship: has_part PR:000002064
relationship: has_part PR:000002972

[Term]
id: CL:0000584
name: enterocyte
namespace: cell
def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." []
xref: BTO:0000398
xref: FMA:62122
is_a: CL:0000239 ! brush border epithelial cell
is_a: CL:0000677 ! gut absorptive cell
is_a: CL:0002563 ! intestinal epithelial cell

[Term]
id: CL:0000585
name: obsolete null cell
namespace: cell
def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." []
comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context.
is_obsolete: true

[Term]
id: CL:0000586
name: germ cell
namespace: cell
def: "The reproductive cell in multicellular organisms." []
xref: BTO:0000535
xref: VHOG:0001534
xref: WBbt:0006796
is_a: CL:0000039 ! germ line cell
relationship: capable_of GO:0048609 ! multicellular organismal reproductive process

[Term]
id: CL:0000587
name: cold sensing thermoreceptor cell
namespace: cell
def: "A thermoreceptor cell that detects reduced temperatures." []
is_a: CL:0000205 ! thermoreceptor cell

[Term]
id: CL:0000588
name: odontoclast
namespace: cell
def: "A specialized osteoclast associated with the absorption and removal of cementum." []
xref: BTO:0002516
xref: FMA:83027
is_a: CL:0000092 ! osteoclast
intersection_of: CL:0000092 ! osteoclast
intersection_of: capable_of GO:0042483
relationship: capable_of GO:0042483

[Term]
id: CL:0000589
name: cochlear inner hair cell
namespace: cell
def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." []
synonym: "inner hair cell" BROAD []
xref: BTO:0003667
xref: FMA:62365
is_a: CL:0000202 ! auditory hair cell

[Term]
id: CL:0000590
name: small luteal cell
namespace: cell
def: "A progesterone secreting cell in the corpus luteum that develops from theca cells." []
synonym: "small lutein cell" EXACT []
synonym: "theca lutein cell" EXACT []
xref: BTO:0002850
xref: FMA:18690
is_a: CL:0000175 ! luteal cell
relationship: develops_from CL:0000503 ! theca cell

[Term]
id: CL:0000591
name: warmth sensing thermoreceptor cell
namespace: cell
def: "A thermoreceptor cell that detects reduced temperatures." []
is_a: CL:0000205 ! thermoreceptor cell

[Term]
id: CL:0000592
name: large luteal cell
namespace: cell
def: "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." []
synonym: "granulosa lutein cell" EXACT []
synonym: "granulosoluteocytus" RELATED []
xref: FMA:18689
is_a: CL:0000175 ! luteal cell
is_a: CL:0000177 ! testosterone secreting cell
relationship: develops_from CL:0000501 ! granulosa cell

[Term]
id: CL:0000593
name: androgen secreting cell
namespace: cell
def: "A steroid hormone secreting cell that secretes androgen." []
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035935
relationship: capable_of GO:0035935

[Term]
id: CL:0000594
name: skeletal muscle satellite cell
namespace: cell
def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." []
comment: Skeletal muscle satellite cells are not traditionally referred to as myoblasts.  They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population.
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000595
name: enucleate erythrocyte
namespace: cell
def: "An erythrocyte lacking a nucleus." []
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000232 ! erythrocyte
relationship: develops_from CL:0002422 ! enucleated reticulocyte

[Term]
id: CL:0000596
name: sexual spore
namespace: cell
def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." []
synonym: "meiotically-derived spore" EXACT []
xref: FAO:0000017
is_a: CL:0002369 ! fungal spore

[Term]
id: CL:0000597
name: microconidium
namespace: cell
def: "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." []
xref: FAO:0000028
is_a: CL:0002381 ! uninucleate conidium

[Term]
id: CL:0000598
name: pyramidal neuron
namespace: cell
def: "Pyramidal neurons have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their  region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." []
synonym: "projection neuron" EXACT []
synonym: "pyramidal cell" EXACT []
synonym: "pyramidal neuron" EXACT []
xref: BTO:0003102
xref: FMA:67310
xref: FMA:86775
xref: NIFSTD:sao862606388
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000599
name: conidium
namespace: cell
def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." []
xref: BTO:0000283
xref: FAO:0000024
is_a: CL:0000605 ! fungal asexual spore

[Term]
id: CL:0000600
name: heterokaryon
namespace: cell
def: "A fungal cell with two or more genetically distinct nuclei." []
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000601
name: outer hair cell
namespace: cell
def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." []
synonym: "cochlear outer hair cell" EXACT []
xref: BTO:0003666
xref: FMA:62366
is_a: CL:0000202 ! auditory hair cell

[Term]
id: CL:0000602
name: pressoreceptor cell
namespace: cell
def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." []
is_a: CL:1000082 ! stretch receptor cell

[Term]
id: CL:0000603
name: dikaryon
namespace: cell
def: "A fungal cell with two genetically distinct haploid nuclei." []
is_a: CL:0000227 ! binucleate cell
is_a: CL:0000600 ! heterokaryon

[Term]
id: CL:0000604
name: retinal rod cell
namespace: cell
def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." []
xref: BTO:0001024
xref: CALOHA:TS-0870
xref: FMA:67747
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: develops_from CL:0002672 ! retinal progenitor cell

[Term]
id: CL:0000605
name: fungal asexual spore
namespace: cell
def: "A spore formed following mitosis or mitoses." []
xref: FAO:0000023
is_a: CL:0002369 ! fungal spore

[Term]
id: CL:0000606
name: macroconidium
namespace: cell
def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." []
xref: FAO:0000038
is_a: CL:0000599 ! conidium

[Term]
id: CL:0000607
name: ascospore
namespace: cell
def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." []
xref: BTO:0000097
xref: FAO:0000020
is_a: CL:0000596 ! sexual spore

[Term]
id: CL:0000608
name: zygospore
namespace: cell
def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." []
xref: FAO:0000040
is_a: CL:0000596 ! sexual spore

[Term]
id: CL:0000609
name: vestibular hair cell
namespace: cell
def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." []
synonym: "vestibular receptor cell" EXACT []
xref: FMA:62351
is_a: CL:0002374 ! ear hair cell

[Term]
id: CL:0000610
name: obsolete plant cell
namespace: cell
comment: This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO)
is_obsolete: true
consider: PO:0009002

[Term]
id: CL:0000611
name: eosinophil progenitor cell
namespace: cell
comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76).
synonym: "CFU-Eo" RELATED []
synonym: "colony forming unit eosinophil" RELATED []
synonym: "EoP" EXACT []
synonym: "eosinophil stem cell" RELATED []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
relationship: capable_of GO:0030222
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
relationship: has_part PR:000001003
relationship: has_part PR:000001408
relationship: has_part PR:000001865
relationship: has_part PR:000001867
relationship: has_part PR:000001944
relationship: has_part PR:000002065
relationship: has_part PR:000005307
relationship: has_part PR:000007857

[Term]
id: CL:0000612
name: eosinophilic myelocyte
namespace: cell
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." []
xref: BTO:0003454
xref: FMA:83542
is_a: CL:0000772 ! immature eosinophil
is_a: CL:0002087 ! nongranular leukocyte
is_a: CL:0002193 ! myelocyte
relationship: has_part GO:0042582
relationship: has_part PR:000001456
relationship: has_part PR:000001892
relationship: has_part PR:000001932
relationship: has_part PR:000002031

[Term]
id: CL:0000613
name: basophil progenitor cell
namespace: cell
def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." []
comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf).
synonym: "BaP" EXACT []
synonym: "basophilic stem cell" RELATED []
synonym: "CFU-Bas" RELATED []
synonym: "colony forming unit basophil" RELATED []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
relationship: capable_of GO:0030221
relationship: develops_from CL:0002028 ! basophil mast progenitor cell
relationship: has_part PR:000005307
relationship: has_part PR:000007431
relationship: has_part PR:000007857
relationship: has_part PR:000007858
relationship: has_part PR:000016401

[Term]
id: CL:0000614
name: basophilic myelocyte
namespace: cell
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." []
xref: BTO:0003456
xref: FMA:83543
is_a: CL:0000768 ! immature basophil
is_a: CL:0002087 ! nongranular leukocyte
relationship: has_part GO:0042582
relationship: has_part PR:000001456
relationship: has_part PR:000001892
relationship: has_part PR:000001932
relationship: has_part PR:000002031

[Term]
id: CL:0000615
name: basidiospore
namespace: cell
def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." []
xref: BTO:0002166
xref: FAO:0000021
is_a: CL:0000596 ! sexual spore

[Term]
id: CL:0000616
name: obsolete sporangiospore
namespace: cell
def: "OBSOLETE: A walled spore produced in a sporangium." []
is_obsolete: true

[Term]
id: CL:0000617
name: GABAergic neuron
namespace: cell
def: "A neuron that uses GABA as a vesicular neurotransmitter" []
synonym: "GABA-ergic neuron" EXACT []
xref: FMA:84788
xref: WBbt:0005190
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061534
relationship: capable_of GO:0061534

[Term]
id: CL:0000618
name: sheath cell
namespace: cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000619
name: support cell (sensu Nematoda)
namespace: cell
is_a: CL:0000124 ! glial cell (sensu Nematoda and Protostomia)
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000620
name: obsolete zoospore
namespace: cell
def: "OBSOLETE: A sporangiospore that is motile, having flagella." []
xref: FAO:0000039
is_obsolete: true

[Term]
id: CL:0000621
name: fusion competent myoblast
namespace: cell
def: "A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)." []
is_a: CL:0008018 ! somatic muscle myoblast

[Term]
id: CL:0000622
name: acinar cell
namespace: cell
def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." []
synonym: "acinic cell" EXACT []
synonym: "acinous cell" EXACT []
xref: FMA:83625
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000154 ! protein secreting cell
relationship: part_of UBERON:0009842 ! glandular acinus

[Term]
id: CL:0000623
name: natural killer cell
namespace: cell
def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." []
synonym: "large granular lymphocyte" BROAD []
synonym: "NK cell" EXACT []
synonym: "null cell" BROAD []
xref: BTO:0000914
xref: BTO:0004716
xref: CALOHA:TS-0664
xref: FMA:63147
xref: FMA:83601
xref: VHOG:0001697
is_a: CL:0001067 ! group 1 innate lymphoid cell
relationship: capable_of GO:0002228
relationship: capable_of GO:0050776 ! regulation of immune response
relationship: develops_from CL:0000825 ! pro-NK cell

[Term]
id: CL:0000624
name: CD4-positive, alpha-beta T cell
namespace: cell
def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." []
synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta T-cell" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell
relationship: has_part PR:000001004

[Term]
id: CL:0000625
name: CD8-positive, alpha-beta T cell
namespace: cell
def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." []
synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta T-cell" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
relationship: has_part PR:000025402

[Term]
id: CL:0000626
name: olfactory granule cell
namespace: cell
def: "Granule cell that is part of the olfactory bulb." []
is_a: CL:0000120 ! granule cell
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0002264 ! olfactory bulb
relationship: part_of UBERON:0002264 ! olfactory bulb

[Term]
id: CL:0000627
name: transporting cell
namespace: cell
def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." []
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000628
name: photosynthetic cell
namespace: cell
def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." []
comment: see PMID:21177950, The making of a photosynthetic animal.
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000629
name: storage cell
namespace: cell
def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." []
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000630
name: supportive cell
namespace: cell
def: "A cell whose primary function is to support other cell types." []
xref: BTO:0002315
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000631
name: labyrinth supporting cell
namespace: cell
def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." []
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000632
name: hepatic stellate cell
namespace: cell
def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." []
comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.
synonym: "fat-storing cell" RELATED []
synonym: "hepatic perisinusoidal cell" EXACT []
synonym: "Ito cell" EXACT []
synonym: "lipocyte" RELATED []
synonym: "perisinusoidal cell" EXACT []
synonym: "vitamin A-storing cells" RELATED []
xref: BTO:0002741
xref: CALOHA:TS-0452
xref: FMA:67763
is_a: CL:0000057 ! fibroblast
is_a: CL:0000152 ! exocrine cell
is_a: CL:0000327 ! extracellular matrix secreting cell
relationship: has_part PR:000007939
relationship: part_of UBERON:0002107 ! liver

[Term]
id: CL:0000633
name: Hensen cell
namespace: cell
def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." []
synonym: "cell of Hensen" EXACT []
synonym: "external limiting cell of organ of Corti" EXACT []
synonym: "Hensen's cell" EXACT []
xref: FMA:79799
is_a: CL:0002490 ! organ of Corti supporting cell

[Term]
id: CL:0000634
name: Claudius cell
namespace: cell
def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." []
synonym: "cell of Claudius" EXACT []
synonym: "external supporting cell of Claudius" RELATED []
synonym: "external supporting cell of vestibular epithelium" EXACT []
xref: FMA:79802
is_a: CL:0002315 ! supporting cell of cochlea

[Term]
id: CL:0000635
name: Deiter's cell
namespace: cell
def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." []
synonym: "Deiters cell" EXACT []
synonym: "outer phalangeal cell" EXACT []
xref: FMA:75725
is_a: CL:0002165 ! phalangeal cell

[Term]
id: CL:0000636
name: Mueller cell
namespace: cell
xref: BTO:0003064
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000637
name: chromophil cell of anterior pituitary gland
namespace: cell
def: "A cell that stains readily in the anterior pituitary gland." []
xref: FMA:83089
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000166 ! chromaffin cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0002319 ! neural cell
is_a: CL:2000004 ! pituitary gland cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002196 ! adenohypophysis
relationship: part_of UBERON:0002196 ! adenohypophysis

[Term]
id: CL:0000638
name: acidophil cell of pars distalis of adenohypophysis
namespace: cell
def: "An acidophilic chromophil cell that of the anterior pituitary gland." []
synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT []
synonym: "acidophil of pars anterior of adenohypophysis" EXACT []
synonym: "acidophil of pars distalis of adenohypophysis" EXACT []
synonym: "pituitary alpha cell" EXACT []
xref: FMA:83093
is_a: CL:0000637 ! chromophil cell of anterior pituitary gland
relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis

[Term]
id: CL:0000639
name: basophil cell of pars distalis of adenohypophysis
namespace: cell
def: "A basophillic chromophil cell that of the anterior pituitary gland." []
synonym: "basophil cell of anterior lobe of hypophysis" EXACT []
synonym: "beta cell" RELATED []
synonym: "pituitary beta cell" RELATED []
xref: FMA:83094
is_a: CL:0000637 ! chromophil cell of anterior pituitary gland

[Term]
id: CL:0000641
name: chromophobe cell
namespace: cell
def: "A cell that is resistant to stains." []
synonym: "chromophobic cell" EXACT []
xref: FMA:83626
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000642
name: folliculostellate cell
namespace: cell
def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." []
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000644
name: Bergmann glial cell
namespace: cell
def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." []
synonym: "Bergmann astrocyte" EXACT []
synonym: "Bergmann glial cell of cerebellum" EXACT []
xref: FMA:54559
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000645
name: pituicyte
namespace: cell
def: "A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." []
xref: BTO:0003793
xref: FMA:83503
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000646
name: basal cell
namespace: cell
def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." []
xref: BTO:0000939
xref: FMA:62516
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000647
name: multinucleated giant cell
namespace: cell
def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." []
comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this.
synonym: "foreign body giant cell" EXACT []
synonym: "Langerhans giant cell" EXACT []
synonym: "macrophage polykaryon" EXACT []
synonym: "multinucleate giant cell" EXACT []
synonym: "syncytial giant cell" EXACT []
xref: BTO:0003107
xref: FMA:83035
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000235 ! macrophage

[Term]
id: CL:0000648
name: kidney granular cell
namespace: cell
alt_id: CL:0000461
def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." []
synonym: "JG cell" EXACT []
synonym: "juxtaglomerular cell" BROAD []
synonym: "renin secreting cell" EXACT []
xref: FMA:84138
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000192 ! smooth muscle cell
is_a: CL:1000618 ! juxtaglomerular complex cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0002001
intersection_of: part_of UBERON:0002113 ! kidney
relationship: capable_of GO:0002001

[Term]
id: CL:0000649
name: prickle cell
namespace: cell
alt_id: CL:0002186
def: "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin." []
synonym: "prickle cell of epidermis" EXACT []
xref: FMA:69059
is_a: CL:0000312 ! keratinocyte
relationship: part_of UBERON:0002026 ! stratum spinosum of epidermis

[Term]
id: CL:0000650
name: mesangial cell
namespace: cell
def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." []
comment: Do all of these cells really develop from some mesenchymal stem cell?
synonym: "kidney mesangial cell" EXACT []
xref: BTO:0000853
xref: CALOHA:TS-0617
xref: FMA:70972
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000669 ! pericyte cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000651
name: mucous neck cell
namespace: cell
def: "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" []
synonym: "neck cell" BROAD []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000319 ! mucus secreting cell

[Term]
id: CL:0000652
name: pinealocyte
namespace: cell
def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." []
xref: BTO:0001068
xref: FMA:83417
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0030187 ! melatonin biosynthetic process
relationship: part_of UBERON:0001905 ! pineal body

[Term]
id: CL:0000653
name: glomerular visceral epithelial cell
namespace: cell
def: "A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." []
comment: GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm].
synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD []
synonym: "glomerular podocyte" EXACT []
synonym: "podocyte" EXACT []
xref: BTO:0002295
is_a: CL:0002522 ! renal filtration cell
is_a: CL:1000451 ! epithelial cell of visceral layer of glomerular capsule

[Term]
id: CL:0000654
name: primary oocyte
namespace: cell
def: "A primary oocyte is an oocyte that has not completed female meosis I." []
synonym: "primary oogonium" RELATED []
xref: BTO:0000512
xref: FMA:18645
is_a: CARO:0000000
is_a: CL:0000023 ! oocyte
relationship: develops_from CL:0000024 ! oogonial cell

[Term]
id: CL:0000655
name: secondary oocyte
namespace: cell
def: "A secondary oocyte is an oocyte that has not completed meiosis II." []
synonym: "primary oogonium" RELATED []
xref: BTO:0003094
xref: FMA:18646
is_a: CARO:0000000
is_a: CL:0000023 ! oocyte
relationship: develops_from CL:0000654 ! primary oocyte

[Term]
id: CL:0000656
name: primary spermatocyte
namespace: cell
def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." []
xref: BTO:0001115
xref: CALOHA:TS-2194
xref: FMA:72292
is_a: CL:0000017 ! spermatocyte
relationship: capable_of GO:0007140 ! male meiotic nuclear division

[Term]
id: CL:0000657
name: secondary spermatocyte
namespace: cell
def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." []
xref: BTO:0000709
xref: CALOHA:TS-2195
xref: FBbt:00004941
xref: FMA:72293
is_a: CL:0000017 ! spermatocyte
is_a: CL:0000413 ! haploid cell
relationship: capable_of GO:0007142
relationship: develops_from CL:0000656 ! primary spermatocyte

[Term]
id: CL:0000658
name: cuticle secreting cell
namespace: cell
def: "An epithelial cell that secretes cuticle." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000659
name: eggshell secreting cell
namespace: cell
def: "An extracellular matrix secreting cell that secretes eggshell." []
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000500 ! follicular epithelial cell

[Term]
id: CL:0000660
name: glycocalyx secreting cell
namespace: cell
def: "An extracellular matrix secreting cell that secretes glycocalyx." []
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000661
name: distal tip cell (sensu Nematoda)
namespace: cell
is_a: CL:0000422 ! mitogenic signaling cell

[Term]
id: CL:0000662
name: neuroglioblast (sensu Nematoda)
namespace: cell
is_a: CL:0000468 ! neuroglioblast

[Term]
id: CL:0000663
name: valve cell
namespace: cell
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000664
name: closable valve cell
namespace: cell
is_a: CL:0000185 ! myoepithelial cell
is_a: CL:0000663 ! valve cell

[Term]
id: CL:0000665
name: permanently open valve cell
namespace: cell
is_a: CL:0000663 ! valve cell

[Term]
id: CL:0000666
name: fenestrated cell
namespace: cell
synonym: "window cell" EXACT []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000667
name: collagen secreting cell
namespace: cell
def: "An extracellular matrix secreting cell that secretes collagen." []
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000668
name: obsolete parenchymal cell
namespace: cell
def: "OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." []
comment: OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074.
xref: BTO:0002174
xref: FMA:84638
is_obsolete: true

[Term]
id: CL:0000669
name: pericyte cell
namespace: cell
alt_id: CL:0000184
def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." []
comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A.
synonym: "adventitial cell" RELATED []
synonym: "adventitial reticular cell" EXACT []
synonym: "ARC" EXACT []
synonym: "cell of Rouget" EXACT []
synonym: "pericyte" EXACT []
synonym: "pericyte of Rouget" EXACT []
xref: BTO:0002441
xref: FMA:63174
is_a: CL:0000183 ! contractile cell
is_a: CL:0000630 ! supportive cell
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000670
name: primordial germ cell
namespace: cell
def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." []
synonym: "gonocyte" EXACT []
synonym: "primitive germ cell" EXACT []
xref: FMA:70567
is_a: CL:0000039 ! germ line cell
is_a: CL:0000219 ! motile cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: capable_of GO:0048870 ! cell motility
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: CL:0000671
name: centripetally migrating follicle cell
namespace: cell
xref: FBbt:00004906
is_a: CL:0000477 ! follicle cell

[Term]
id: CL:0000672
name: obsolete tracheary element
namespace: cell
def: "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." []
comment: replaced_by: PO:0000290
is_obsolete: true

[Term]
id: CL:0000673
name: Kenyon cell
namespace: cell
is_a: CL:0000028 ! CNS neuron (sensu Nematoda and Protostomia)

[Term]
id: CL:0000674
name: interfollicle cell
namespace: cell
synonym: "fly stalk cell" EXACT []
xref: FBbt:00004910
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000675
name: female gamete
namespace: cell
def: "A mature sexual reproductive cell of the female germline." []
is_a: CL:0000021 ! female germ cell
is_a: CL:0000300 ! gamete

[Term]
id: CL:0000676
name: cap cell
namespace: cell
xref: BTO:0001033
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000677
name: gut absorptive cell
namespace: cell
def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." []
is_a: CL:0000212 ! absorptive cell

[Term]
id: CL:0000678
name: commissural neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000679
name: glutamatergic neuron
namespace: cell
xref: WBbt:0006829
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061535
relationship: capable_of GO:0061535

[Term]
id: CL:0000680
name: muscle precursor cell
namespace: cell
def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." []
is_a: CARO:0000000
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000681
name: radial glial cell
namespace: cell
def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." []
comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life.
synonym: "forebrain radial glial cell" NARROW []
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
relationship: develops_from CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000682
name: M cell of gut
namespace: cell
def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." []
comment: Should double check and see if M cells are particular to a specific region.
synonym: "M cell" BROAD []
synonym: "M-cell" EXACT []
synonym: "microfold cell" EXACT []
xref: BTO:0003600
xref: FMA:62929
is_a: CL:0000473 ! defensive cell
is_a: CL:0000627 ! transporting cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
relationship: part_of UBERON:0003929 ! digestive tract epithelium

[Term]
id: CL:0000683
name: ependymoglial cell
namespace: cell
def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." []
synonym: "ependymal astrocyte" EXACT []
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000684
name: littoral cell of liver
namespace: cell
is_a: CL:0000077 ! mesothelial cell
relationship: part_of UBERON:0002107 ! liver

[Term]
id: CL:0000685
name: obsolete meristematic cell
namespace: cell
def: "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." []
comment: replaced_by: PO:0004010
is_obsolete: true

[Term]
id: CL:0000686
name: cerebrospinal fluid secreting cell
namespace: cell
def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." []
is_a: CL:0000151 ! secretory cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0033326
relationship: capable_of GO:0033326
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000687
name: R1 photoreceptor cell
namespace: cell
synonym: "R1 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000688
name: perijunctional fibroblast
namespace: cell
def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." []
is_a: CL:0000057 ! fibroblast
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000689
name: myoendocrine cell
namespace: cell
def: "A cell with both myofibrils and secretory granules." []
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000690
name: R2 photoreceptor cell
namespace: cell
synonym: "R2 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000691
name: stellate interneuron
namespace: cell
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000692
name: terminal Schwann cell
namespace: cell
def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." []
synonym: "Schwann cell" BROAD []
is_a: CL:0000630 ! supportive cell
is_a: CL:0002376 ! non-myelinating Schwann cell

[Term]
id: CL:0000693
name: neuroglioform cell
namespace: cell
def: "A stellate interneuron having 7-10 dendrites that may branch." []
synonym: "spiderweb cell" EXACT []
is_a: CL:0000691 ! stellate interneuron

[Term]
id: CL:0000694
name: R3 photoreceptor cell
namespace: cell
synonym: "R3 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000695
name: Cajal-Retzius cell
namespace: cell
def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000696
name: PP cell
namespace: cell
def: "A cell that stores and secretes pancreatic polypeptide hormone." []
synonym: "type F enteroendocrine cell" EXACT []
xref: FMA:62938
xref: FMA:83409
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000697
name: R4 photoreceptor cell
namespace: cell
synonym: "R4 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000698
name: obsolete paraganglial cell
namespace: cell
is_obsolete: true

[Term]
id: CL:0000699
name: paraganglial type 1 cell
namespace: cell
def: "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." []
is_a: CL:0000165 ! neuroendocrine cell

[Term]
id: CL:0000700
name: dopaminergic neuron
namespace: cell
def: "A neuron that releases dopamine as a neurotransmitter." []
synonym: "dopaminergic cell" EXACT []
xref: BTO:0004032
xref: FMA:84787
xref: WBbt:0006746
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061527
relationship: capable_of GO:0061527

[Term]
id: CL:0000701
name: paraganglia type 2 cell
namespace: cell
def: "Supports paraganglial type 1 cell." []
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000702
name: R5 photoreceptor cell
namespace: cell
synonym: "R5 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000703
name: sustentacular cell
namespace: cell
def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." []
xref: BTO:0002315
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000704
name: endothelial tip cell
namespace: cell
def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." []
is_a: CL:0000071 ! blood vessel endothelial cell

[Term]
id: CL:0000705
name: R6 photoreceptor cell
namespace: cell
synonym: "R6 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000706
name: choroid plexus epithelial cell
namespace: cell
alt_id: CL:1000430
def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." []
synonym: "epithelial cell of choroid plexus" EXACT []
xref: FMA:70549
is_a: CL:0000065 ! ependymal cell
is_a: CL:0000627 ! transporting cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000065 ! ependymal cell
intersection_of: part_of UBERON:0001886 ! choroid plexus
relationship: part_of UBERON:0001886 ! choroid plexus

[Term]
id: CL:0000707
name: R7 photoreceptor cell
namespace: cell
synonym: "R7 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000494 ! UV sensitive photoreceptor cell

[Term]
id: CL:0000708
name: leptomeningeal cell
namespace: cell
def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." []
synonym: "leptomemingeal cell" RELATED []
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000327 ! extracellular matrix secreting cell
intersection_of: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier
relationship: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier

[Term]
id: CL:0000709
name: R8 photoreceptor cell
namespace: cell
synonym: "R8 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000710
name: neurecto-epithelial cell
namespace: cell
def: "Epithelial cells derived from neural plate and neural crest." []
comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
xref: FMA:70557
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002077 ! ecto-epithelial cell
intersection_of: CL:0002077 ! ecto-epithelial cell
intersection_of: develops_from CL:0000133 ! neurectodermal cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000711
name: cumulus cell
namespace: cell
def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." []
xref: BTO:0002236
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0002174 ! follicular cell of ovary
relationship: develops_from CL:0000501 ! granulosa cell

[Term]
id: CL:0000712
name: stratum granulosum cell
namespace: cell
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000362 ! epidermal cell
intersection_of: part_of UBERON:0002069 ! stratum granulosum of epidermis
relationship: part_of UBERON:0002069 ! stratum granulosum of epidermis

[Term]
id: CL:0000713
name: corona radiata cell
namespace: cell
is_a: CL:0000711 ! cumulus cell

[Term]
id: CL:0000715
name: embryonic crystal cell
namespace: cell
is_a: CL:0000392 ! crystal cell
is_a: CL:0000736 ! embryonic gland hemocyte

[Term]
id: CL:0000716
name: lymph gland crystal cell
namespace: cell
is_a: CL:0000392 ! crystal cell
is_a: CL:0000735 ! lymph gland hemocyte

[Term]
id: CL:0000717
name: fusimotor neuron
namespace: cell
def: "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." []
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:0000718
name: compound eye cone cell
namespace: cell
synonym: "cone cell (sensu Endopterygota)" RELATED []
is_a: BFO:0000002
is_a: CL:0000306 ! crystallin accumulating cell
relationship: part_of UBERON:0000018 ! compound eye

[Term]
id: CL:0000719
name: posterior cone cell (sensu Endopterygota)
namespace: cell
is_a: CL:0000718 ! compound eye cone cell

[Term]
id: CL:0000720
name: anterior cone cell (sensu Endopterygota)
namespace: cell
is_a: CL:0000718 ! compound eye cone cell

[Term]
id: CL:0000721
name: equatorial cone cell (sensu Endopterygota)
namespace: cell
is_a: CL:0000718 ! compound eye cone cell

[Term]
id: CL:0000722
name: cystoblast
namespace: cell
is_a: CL:0000586 ! germ cell

[Term]
id: CL:0000723
name: somatic stem cell
namespace: cell
def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." []
xref: CALOHA:TS-2086
xref: FMA:63368
is_a: CL:0000034 ! stem cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000034 ! stem cell
intersection_of: capable_of GO:0048103
relationship: capable_of GO:0048103

[Term]
id: CL:0000724
name: heterocyst
namespace: cell
def: "A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." []
xref: BTO:0000600
is_a: CL:0000520 ! prokaryotic cell
is_a: CL:0000725 ! nitrogen fixing cell

[Term]
id: CL:0000725
name: nitrogen fixing cell
namespace: cell
is_a: BFO:0000040 ! material entity
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0009399
relationship: capable_of GO:0009399

[Term]
id: CL:0000726
name: chlamydospore
namespace: cell
def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." []
comment: Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus.
is_a: CL:0000605 ! fungal asexual spore

[Term]
id: CL:0000727
name: primary pigment cell
namespace: cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000728
name: secondary pigment cell
namespace: cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000729
name: tertiary pigment cell
namespace: cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000730
name: leading edge cell
namespace: cell
def: "A cell at the front of a migrating epithelial sheet." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000731
name: urothelial cell
namespace: cell
def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." []
synonym: "bladder transitional cell" NARROW []
synonym: "transitional epithelial cell of urinary bladder" NARROW []
synonym: "urinary tract transitional epithelial cell" NARROW []
xref: FMA:84127
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000244 ! transitional epithelial cell
intersection_of: CL:0000244 ! transitional epithelial cell
intersection_of: part_of UBERON:0000365 ! urothelium
relationship: part_of UBERON:0000365 ! urothelium

[Term]
id: CL:0000732
name: amoeboid cell
namespace: cell
is_a: CL:0000219 ! motile cell

[Term]
id: CL:0000733
name: lymph gland plasmatocyte
namespace: cell
is_a: CL:0000394 ! plasmatocyte
is_a: CL:0000735 ! lymph gland hemocyte

[Term]
id: CL:0000734
name: embryonic gland plasmatocyte
namespace: cell
is_a: CL:0000394 ! plasmatocyte
is_a: CL:0000736 ! embryonic gland hemocyte

[Term]
id: CL:0000735
name: lymph gland hemocyte
namespace: cell
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000736
name: embryonic gland hemocyte
namespace: cell
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000737
name: striated muscle cell
namespace: cell
def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." []
xref: BTO:0002916
xref: CALOHA:TS-2157
xref: FMA:86936
is_a: CL:0000187 ! muscle cell
disjoint_from: CL:0008000 ! non-striated muscle cell
relationship: has_part GO:0030017

[Term]
id: CL:0000738
name: leukocyte
namespace: cell
def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." []
synonym: "immune cell" EXACT []
synonym: "leucocyte" EXACT []
synonym: "white blood cell" EXACT []
xref: BTO:0000751
xref: CALOHA:TS-0549
xref: FMA:62852
is_a: CARO:0000000
is_a: CL:0000219 ! motile cell
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration
relationship: capable_of GO:0001667 ! ameboidal-type cell migration
relationship: develops_from CL:0000037 ! hematopoietic stem cell
relationship: part_of UBERON:0002405 ! immune system

[Term]
id: CL:0000740
name: retinal ganglion cell
namespace: cell
def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." []
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
synonym: "RGC" EXACT []
xref: BTO:0001800
xref: FMA:67765
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0000966 ! retina

[Term]
id: CL:0000741
name: spinal accessory motor neuron
namespace: cell
def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." []
synonym: "SACMN" EXACT []
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:0000742
name: periarticular chondrocyte
namespace: cell
def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." []
is_a: CL:1001607 ! articular chondrocyte

[Term]
id: CL:0000743
name: hypertrophic chondrocyte
namespace: cell
def: "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." []
comment: is hypertrophic pathological or normal? and can it be described using a pato term?
is_a: CL:0000138 ! chondrocyte

[Term]
id: CL:0000744
name: columnar chondrocyte
namespace: cell
def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." []
is_a: CL:0000138 ! chondrocyte

[Term]
id: CL:0000745
name: retina horizontal cell
namespace: cell
def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." []
synonym: "horizontal cell" EXACT []
xref: BTO:0004120
is_a: CL:0000099 ! interneuron
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0003902 ! retinal neural layer

[Term]
id: CL:0000746
name: cardiac muscle cell
namespace: cell
alt_id: FMA:83808
def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." []
comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods.  The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein).  According to these refs, the cells participating in heart contraction in all cases are transversely striated.  Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.
synonym: "cardiac muscle fiber" EXACT []
synonym: "cardiac myocyte" EXACT []
synonym: "cardiocyte" BROAD []
synonym: "cardiomyocyte" EXACT []
synonym: "heart muscle cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:14067
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0002494 ! cardiocyte
relationship: develops_from CL:0000513 ! cardiac muscle myoblast

[Term]
id: CL:0000747
name: cyanophore
namespace: cell
def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." []
synonym: "blue chromatophore" RELATED []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005005 ! cyanoblast

[Term]
id: CL:0000748
name: retinal bipolar neuron
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." []
is_a: CL:0000103 ! bipolar neuron
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0008028 ! visual system neuron
is_a: CL:0008030 ! excitatory neuron
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000103 ! bipolar neuron
intersection_of: part_of UBERON:0000966 ! retina
relationship: part_of UBERON:0000966 ! retina

[Term]
id: CL:0000749
name: ON-bipolar cell
namespace: cell
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." []
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000750
name: OFF-bipolar cell
namespace: cell
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells depolatize in response to light to dark transition." []
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000751
name: rod bipolar cell
namespace: cell
def: "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells.  These neurons depolarize in response to light." []
xref: FMA:67750
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000752
name: cone retinal bipolar cell
namespace: cell
def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." []
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000753
name: type 1 cone bipolar cell (sensu Mus)
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." []
synonym: "DB1 cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000754
name: type 2 cone bipolar cell (sensu Mus)
namespace: cell
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1 (Ghosh et al., 2004).  It can be differentiated from other retinal bipolar neurons by its expression of marker genes: Neto1, Lhx3 and Irx-6 (Shekhar, 2016)." []
synonym: "FMB cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000755
name: type 3 cone bipolar cell (sensu Mus)
namespace: cell
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." []
synonym: "DB2 cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000756
name: type 4 cone bipolar cell (sensu Mus)
namespace: cell
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." []
synonym: "DB3 cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000757
name: type 5 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." []
synonym: "DB4 cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000758
name: type 6 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." []
synonym: "DB5 cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000759
name: type 7 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." []
synonym: "IMB cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000760
name: type 8 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." []
synonym: "DB6 cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000761
name: type 9 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." []
synonym: "BB cone bipolar cell" EXACT []
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000762
name: nucleated thrombocyte
namespace: cell
def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." []
comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals.
is_a: BFO:0000040 ! material entity
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000763 ! myeloid cell
relationship: capable_of GO:0007596 ! blood coagulation
relationship: develops_from CL:0000828 ! thromboblast

[Term]
id: CL:0000763
name: myeloid cell
namespace: cell
def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." []
xref: BTO:0001441
xref: CALOHA:TS-0647
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
relationship: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000764
name: erythroid lineage cell
namespace: cell
alt_id: CL:0002156
def: "A immature or mature cell in the lineage leading to and including erythrocytes." []
comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.
synonym: "erythropoietic cell" EXACT []
xref: CALOHA:TS-0290
xref: FMA:62845
xref: FMA:83516
is_a: CL:0000763 ! myeloid cell

[Term]
id: CL:0000765
name: erythroblast
namespace: cell
def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." []
synonym: "normoblast" EXACT []
xref: BTO:0001571
xref: CALOHA:TS-0289
xref: FMA:83504
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
is_a: CL:0011115 ! precursor cell
relationship: capable_of GO:0030218
relationship: develops_from CL:0000547 ! proerythroblast

[Term]
id: CL:0000766
name: myeloid leukocyte
namespace: cell
def: "A cell of the monocyte, granulocyte, or mast cell lineage." []
is_a: CL:0000738 ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000767
name: basophil
namespace: cell
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." []
comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive.
synonym: "basophilic leucocyte" EXACT []
synonym: "basophilic leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
xref: BTO:0000129
xref: CALOHA:TS-0073
xref: FMA:62862
is_a: CL:0000094 ! granulocyte
relationship: has_part PR:000001255
relationship: has_part PR:000001344
relationship: has_part PR:000001865
relationship: has_part PR:000001950
relationship: has_part PR:000007431

[Term]
id: CL:0000768
name: immature basophil
namespace: cell
def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." []
synonym: "immature basophilic leucocyte" EXACT []
synonym: "immature basophilic leukocyte" EXACT []
is_a: CL:0000767 ! basophil
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000767 ! basophil
intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33
relationship: develops_from CL:0000830 ! basophilic promyelocyte
relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33

[Term]
id: CL:0000769
name: basophilic metamyelocyte
namespace: cell
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." []
xref: FMA:84198
is_a: CL:0000768 ! immature basophil
is_a: CL:0002192 ! metamyelocyte
relationship: develops_from CL:0000614 ! basophilic myelocyte
relationship: has_part CP:0000040
relationship: has_part GO:0000792
relationship: has_part GO:0042582
relationship: has_part GO:0070820
relationship: has_part PR:000001456
relationship: has_part PR:000001483
relationship: has_part PR:000001892
relationship: has_part PR:000001932
relationship: has_part PR:000002031

[Term]
id: CL:0000770
name: band form basophil
namespace: cell
def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." []
is_a: CL:0000768 ! immature basophil
intersection_of: CL:0000768 ! immature basophil
intersection_of: has_part CP:0000039
relationship: develops_from CL:0000769 ! basophilic metamyelocyte
relationship: has_part CP:0000039

[Term]
id: CL:0000771
name: eosinophil
namespace: cell
def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." []
comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte.
synonym: "eosinocyte" EXACT []
synonym: "eosinophilic granulocyte" EXACT []
synonym: "eosinophilic leucocyte" EXACT []
synonym: "eosinophilic leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
xref: BTO:0000399
xref: CALOHA:TS-0279
xref: FMA:62861
is_a: CL:0000094 ! granulocyte
relationship: has_part PR:000001254
relationship: has_part PR:000001255
relationship: has_part PR:000001307
relationship: has_part PR:000001343
relationship: has_part PR:000005178

[Term]
id: CL:0000772
name: immature eosinophil
namespace: cell
def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." []
synonym: "immature eosinocyte" EXACT []
synonym: "immature eosinophilic leucocyte" EXACT []
synonym: "immature eosinophilic leukocyte" EXACT []
is_a: CL:0000771 ! eosinophil
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000771 ! eosinophil
intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33
relationship: develops_from CL:0000833 ! eosinophilic promyelocyte
relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33

[Term]
id: CL:0000773
name: eosinophilic metamyelocyte
namespace: cell
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." []
is_a: CL:0000772 ! immature eosinophil
is_a: CL:0002192 ! metamyelocyte
relationship: develops_from CL:0000612 ! eosinophilic myelocyte
relationship: has_part CP:0000027
relationship: has_part CP:0000040
relationship: has_part GO:0000792
relationship: has_part GO:0042582
relationship: has_part GO:0070820
relationship: has_part PR:000001456
relationship: has_part PR:000001483
relationship: has_part PR:000001892
relationship: has_part PR:000001932
relationship: has_part PR:000002031

[Term]
id: CL:0000774
name: band form eosinophil
namespace: cell
def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." []
is_a: CL:0000772 ! immature eosinophil
intersection_of: CL:0000772 ! immature eosinophil
intersection_of: has_part CP:0000039
relationship: develops_from CL:0000773 ! eosinophilic metamyelocyte
relationship: has_part CP:0000039

[Term]
id: CL:0000775
name: neutrophil
namespace: cell
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." []
synonym: "neutrocyte" EXACT []
synonym: "neutrophil leucocyte" EXACT []
synonym: "neutrophil leukocyte" EXACT []
synonym: "neutrophilic leucocyte" EXACT []
synonym: "neutrophilic leukocyte" EXACT []
synonym: "PMN" BROAD []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" BROAD []
synonym: "polynuclear neutrophilic leucocyte" BROAD []
synonym: "polynuclear neutrophilic leukocyte" BROAD []
xref: BTO:0000130
xref: CALOHA:TS-0688
xref: FMA:62860
is_a: CL:0000094 ! granulocyte
relationship: has_part PR:000001479
relationship: has_part PR:000001879

[Term]
id: CL:0000776
name: immature neutrophil
namespace: cell
def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." []
synonym: "immatuer neutrophilic leukocyte" EXACT []
synonym: "immature neutrocyte" EXACT []
synonym: "immature neutrophil leucocyte" EXACT []
synonym: "immature neutrophil leukocyte" EXACT []
synonym: "immature neutrophilic leucocyte" EXACT []
is_a: CL:0000775 ! neutrophil
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000775 ! neutrophil
intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33
relationship: develops_from CL:0000564 ! neutrophilic promyelocyte
relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33

[Term]
id: CL:0000777
name: mesangial phagocyte
namespace: cell
def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." []
synonym: "mesangial cell" BROAD []
is_a: CL:0000864 ! tissue-resident macrophage
relationship: capable_of GO:0019882
relationship: capable_of GO:0048771

[Term]
id: CL:0000778
name: mononuclear osteoclast
namespace: cell
def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." []
comment: Morphology: mononuclear, highly vesicular.
is_a: CL:0000092 ! osteoclast
is_a: CL:0000226 ! single nucleate cell

[Term]
id: CL:0000779
name: multinuclear osteoclast
namespace: cell
def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." []
comment: Morphology: multinucleated, highly vesicular.
synonym: "multinucleated osteoclast" EXACT []
is_a: CL:0000092 ! osteoclast
is_a: CL:0000228 ! multinucleate cell
relationship: develops_from CL:0000778 ! mononuclear osteoclast

[Term]
id: CL:0000780
name: multinuclear odontoclast
namespace: cell
def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." []
comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth.
synonym: "multinucleated odontoclast" EXACT []
is_a: CL:0000588 ! odontoclast
is_a: CL:0000779 ! multinuclear osteoclast
relationship: develops_from CL:0000781 ! mononuclear odontoclast

[Term]
id: CL:0000781
name: mononuclear odontoclast
namespace: cell
def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." []
comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth.
is_a: CL:0000588 ! odontoclast
is_a: CL:0000778 ! mononuclear osteoclast

[Term]
id: CL:0000782
name: myeloid dendritic cell
namespace: cell
def: "A dendritic cell of the myeloid lineage." []
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
synonym: "veiled cell" BROAD []
xref: BTO:0004721
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
relationship: develops_from CL:0000576 ! monocyte

[Term]
id: CL:0000783
name: multinucleated phagocyte
namespace: cell
def: "A phagocyte formed by the fusion of mononuclear phagocytes." []
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)

[Term]
id: CL:0000784
name: plasmacytoid dendritic cell
namespace: cell
def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." []
synonym: "DC2" EXACT []
synonym: "interferon-producing cell" EXACT []
synonym: "IPC" EXACT []
synonym: "lymphoid dendritic cell" EXACT []
synonym: "pDC" EXACT []
synonym: "plasmacytoid monocyte" EXACT []
synonym: "plasmacytoid T cell" EXACT []
synonym: "T-associated plasma cell" EXACT []
synonym: "type 2 DC" EXACT []
xref: BTO:0004625
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: capable_of GO:0032606
relationship: capable_of GO:0032606

[Term]
id: CL:0000785
name: mature B cell
namespace: cell
def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." []
comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive.
synonym: "mature B lymphocyte" EXACT []
synonym: "mature B-cell" EXACT []
synonym: "mature B-lymphocyte" EXACT []
is_a: CL:0000236 ! B cell
disjoint_from: CL:0000816 ! immature B cell
disjoint_from: CL:0000817 ! precursor B cell
disjoint_from: CL:0000818 ! transitional stage B cell
relationship: capable_of GO:0002504
relationship: capable_of GO:0042113 ! B cell activation
relationship: develops_from CL:0000818 ! transitional stage B cell

[Term]
id: CL:0000786
name: plasma cell
namespace: cell
def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." []
comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.
synonym: "effector B cell" RELATED []
synonym: "effector B-cell" RELATED []
synonym: "plasma B cell" EXACT []
synonym: "plasma B-cell" EXACT []
synonym: "plasmacyte" EXACT []
synonym: "plasmocyte" EXACT []
xref: BTO:0000392
xref: FMA:70574
is_a: CL:0000946 ! antibody secreting cell
relationship: develops_from CL:0000980 ! plasmablast
relationship: has_part CP:0000043
relationship: has_part GO:0005794
relationship: has_part PR:000001935

[Term]
id: CL:0000787
name: memory B cell
namespace: cell
def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." []
comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive.
synonym: "memory B lymphocyte" EXACT []
synonym: "memory B-cell" EXACT []
synonym: "memory B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
relationship: has_part GO:0042613
relationship: has_part PR:000001289
relationship: has_part PR:000001963

[Term]
id: CL:0000788
name: naive B cell
namespace: cell
def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive.
synonym: "naive B lymphocyte" EXACT []
synonym: "naive B-cell" EXACT []
synonym: "naive B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
relationship: has_part GO:0071738
relationship: has_part GO:0071753
relationship: has_part PR:000001289

[Term]
id: CL:0000789
name: alpha-beta T cell
namespace: cell
def: "A T cell that expresses an alpha-beta T cell receptor complex." []
synonym: "alpha-beta T lymphocyte" EXACT []
synonym: "alpha-beta T-cell" EXACT []
synonym: "alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000084 ! T cell
disjoint_from: CL:0000798 ! gamma-delta T cell
relationship: has_part GO:0042105

[Term]
id: CL:0000790
name: immature alpha-beta T cell
namespace: cell
def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." []
synonym: "immature alpha-beta T lymphocyte" EXACT []
synonym: "immature alpha-beta T-cell" EXACT []
synonym: "immature alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000789 ! alpha-beta T cell
is_a: CL:0002420 ! immature T cell

[Term]
id: CL:0000791
name: mature alpha-beta T cell
namespace: cell
def: "A alpha-beta T cell that has a mature phenotype." []
synonym: "mature alpha-beta T lymphocyte" EXACT []
synonym: "mature alpha-beta T-cell" EXACT []
synonym: "mature alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000789 ! alpha-beta T cell
is_a: CL:0002419 ! mature T cell
relationship: develops_from CL:0000790 ! immature alpha-beta T cell

[Term]
id: CL:0000792
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Treg'.  The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype.
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
synonym: "Treg" BROAD []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000815 ! regulatory T cell
relationship: has_part PR:000001380
relationship: has_part PR:000001869

[Term]
id: CL:0000793
name: CD4-positive, alpha-beta intraepithelial T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." []
synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte

[Term]
id: CL:0000794
name: CD8-positive, alpha-beta cytotoxic T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." []
comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo.
synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT []
synonym: "cytotoxic T cell" BROAD []
synonym: "cytotoxic T lymphocyte" BROAD []
synonym: "cytotoxic T-cell" BROAD []
synonym: "cytotoxic T-lymphocyte" BROAD []
synonym: "killer T cell" BROAD []
synonym: "killer T lymphocyte" BROAD []
synonym: "killer T-cell" BROAD []
synonym: "killer T-lymphocyte" BROAD []
xref: CALOHA:TS-0190
xref: FMA:70573
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000910 ! cytotoxic T cell
relationship: capable_of GO:0033380
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_part PR:000003466
relationship: has_part PR:000003499

[Term]
id: CL:0000795
name: CD8-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." []
synonym: "CD8+ regulatory T cell" EXACT []
synonym: "CD8+ T(reg)" EXACT []
synonym: "CD8+ Treg" EXACT []
synonym: "CD8-positive T(reg)" EXACT []
synonym: "CD8-positive Treg" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta Treg" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000815 ! regulatory T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: capable_of GO:0050777 ! negative regulation of immune response

[Term]
id: CL:0000796
name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell
namespace: cell
def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." []
synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
relationship: has_part PR:000025402

[Term]
id: CL:0000797
name: alpha-beta intraepithelial T cell
namespace: cell
def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." []
synonym: "alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "alpha-beta intraepithelial T-cell" EXACT []
synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000791 ! mature alpha-beta T cell
is_a: CL:0002496 ! intraepithelial lymphocyte

[Term]
id: CL:0000798
name: gamma-delta T cell
namespace: cell
def: "A T cell that expresses a gamma-delta T cell receptor complex." []
comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways.
synonym: "gamma-delta T lymphocyte" EXACT []
synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
synonym: "gammadelta T cell" EXACT []
synonym: "gd T cell" RELATED []
is_a: CL:0000084 ! T cell
relationship: has_part GO:0042106

[Term]
id: CL:0000799
name: immature gamma-delta T cell
namespace: cell
def: "A gamma-delta T cell that has an immature phenotype." []
comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways.
synonym: "immature gamma-delta T lymphocyte" EXACT []
synonym: "immature gamma-delta T-cell" EXACT []
synonym: "immature gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000798 ! gamma-delta T cell
is_a: CL:0002420 ! immature T cell
relationship: develops_from CL:0000807 ! DN3 thymocyte

[Term]
id: CL:0000800
name: mature gamma-delta T cell
namespace: cell
def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." []
synonym: "mature gamma-delta T lymphocyte" EXACT []
synonym: "mature gamma-delta T-cell" EXACT []
synonym: "mature gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000798 ! gamma-delta T cell
is_a: CL:0002419 ! mature T cell
relationship: develops_from CL:0000799 ! immature gamma-delta T cell

[Term]
id: CL:0000801
name: gamma-delta intraepithelial T cell
namespace: cell
def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." []
synonym: "gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "gamma-delta intraepithelial T-cell" EXACT []
synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000800 ! mature gamma-delta T cell
is_a: CL:0002496 ! intraepithelial lymphocyte

[Term]
id: CL:0000802
name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell
namespace: cell
def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." []
synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000801 ! gamma-delta intraepithelial T cell
relationship: has_part PR:000001084

[Term]
id: CL:0000803
name: CD4-negative CD8-negative gamma-delta intraepithelial T cell
namespace: cell
def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." []
synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000801 ! gamma-delta intraepithelial T cell

[Term]
id: CL:0000805
name: immature single positive thymocyte
namespace: cell
def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." []
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages.
synonym: "immature single positive T cell" EXACT []
synonym: "immature single positive T lymphocyte" EXACT []
synonym: "immature single positive T-lymphocyte" EXACT []
synonym: "ISP" EXACT []
synonym: "T.ISP.th" EXACT []
is_a: CL:0000893 ! thymocyte
relationship: develops_from CL:0000808 ! DN4 thymocyte
relationship: has_part GO:0043384
relationship: has_part PR:000001932
relationship: has_part PR:000025402

[Term]
id: CL:0000806
name: DN2 thymocyte
namespace: cell
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." []
comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains.
synonym: "DN2 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN2 alpha-beta immature T-cell" EXACT []
synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN2 cell" EXACT []
synonym: "DN2 immature T cell" EXACT []
synonym: "double negative 2" EXACT []
synonym: "preT.DN2.Th" EXACT []
synonym: "TN2 cell" EXACT []
synonym: "TN2 thymocyte" EXACT []
is_a: CL:0002489 ! double negative thymocyte
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell
relationship: has_part PR:000001307
relationship: has_part PR:000001380

[Term]
id: CL:0000807
name: DN3 thymocyte
namespace: cell
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." []
synonym: "DN3 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN3 alpha-beta immature T-cell" EXACT []
synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN3 cell" EXACT []
synonym: "DN3 immature T cell" EXACT []
synonym: "double negative 3" EXACT []
synonym: "early cortical thymocyte" BROAD []
synonym: "preT.DN3.Th" EXACT []
synonym: "TN3 cell" EXACT []
synonym: "TN3 thymocyte" EXACT []
is_a: CL:0002489 ! double negative thymocyte
relationship: develops_from CL:0000806 ! DN2 thymocyte
relationship: has_part GO:0043384
relationship: has_part PR:000001380

[Term]
id: CL:0000808
name: DN4 thymocyte
namespace: cell
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." []
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain.
synonym: "DN4 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN4 cell" EXACT []
synonym: "DN4 immature T cell" EXACT []
synonym: "DN4 immature T-cell" EXACT []
synonym: "double negative 4" EXACT []
synonym: "early cortical thymocyte" BROAD []
synonym: "T.DN4.th" EXACT []
is_a: CL:0002489 ! double negative thymocyte
relationship: develops_from CL:0000807 ! DN3 thymocyte
relationship: has_part GO:0043384

[Term]
id: CL:0000809
name: double-positive, alpha-beta thymocyte
namespace: cell
def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." []
comment: Thymocytes of this stage are undergoing positive and negative selection.
synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "DP cell" EXACT []
synonym: "DP thymocyte" EXACT []
synonym: "late cortical thymocyte" BROAD []
is_a: CL:0000790 ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
relationship: develops_from CL:0000805 ! immature single positive thymocyte
relationship: has_part PR:000001004
relationship: has_part PR:000025402

[Term]
id: CL:0000810
name: CD4-positive, alpha-beta thymocyte
namespace: cell
def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." []
synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta immature T-cell" EXACT []
synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT []
synonym: "SP CD4 cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_part PR:000001004

[Term]
id: CL:0000811
name: CD8-positive, alpha-beta thymocyte
namespace: cell
def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." []
synonym: "CD8-positive, alpha-beta immature T cell" RELATED []
synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta immature T-cell" EXACT []
synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT []
synonym: "SP CD8 cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_part PR:000025402

[Term]
id: CL:0000813
name: memory T cell
namespace: cell
def: "A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." []
synonym: "memory T lymphocyte" EXACT []
synonym: "memory T-cell" EXACT []
synonym: "memory T-lymphocyte" EXACT []
xref: BTO:0003435
is_a: CL:0002419 ! mature T cell
disjoint_from: CL:0000898 ! naive T cell
relationship: has_part PR:000001017
relationship: has_part PR:000001869

[Term]
id: CL:0000814
name: mature NK T cell
namespace: cell
def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." []
synonym: "mature natural killer T cell" EXACT []
synonym: "mature natural killer T lymphocyte" EXACT []
synonym: "mature natural killer T-cell" EXACT []
synonym: "mature natural killer T-lymphocyte" EXACT []
synonym: "mature NK T lymphocyte" EXACT []
synonym: "mature NK T-cell" EXACT []
synonym: "mature NK T-lymphocyte" EXACT []
synonym: "mature NKT cell" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
is_a: CL:0002127 ! innate effector T cell
relationship: capable_of GO:0032394
relationship: develops_from CL:0002042 ! immature NK T cell stage IV
relationship: has_part PR:000001874

[Term]
id: CL:0000815
name: regulatory T cell
namespace: cell
def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." []
comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.
synonym: "regulatory T lymphocyte" EXACT []
synonym: "regulatory T-cell" EXACT []
synonym: "regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
xref: BTO:0004520
xref: FMA:84070
is_a: CL:0002419 ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
relationship: capable_of GO:0050777 ! negative regulation of immune response

[Term]
id: CL:0000816
name: immature B cell
namespace: cell
def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." []
comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive.
synonym: "immature B lymphocyte" EXACT []
synonym: "immature B-cell" EXACT []
synonym: "immature B-lymphocyte" EXACT []
synonym: "newly formed B cell" EXACT []
is_a: CL:0000236 ! B cell
relationship: develops_from CL:0000954 ! small pre-B-II cell
relationship: has_part GO:0071753
relationship: has_part PR:000001289

[Term]
id: CL:0000817
name: precursor B cell
namespace: cell
def: "A precursor B cell is a B cell with the phenotype CD10-positive." []
synonym: "pre-B cell" RELATED []
xref: BTO:0001133
xref: CALOHA:TS-0819
is_a: CL:0000236 ! B cell
disjoint_from: CL:0000826 ! pro-B cell
relationship: has_part PR:000001898

[Term]
id: CL:0000818
name: transitional stage B cell
namespace: cell
def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'.
synonym: "T1 B cell" NARROW []
synonym: "T2 B cell" NARROW []
synonym: "T3 B cell" NARROW []
synonym: "transitional B cell" EXACT []
synonym: "transitional stage B lymphocyte" EXACT []
synonym: "transitional stage B-cell" EXACT []
synonym: "transitional stage B-lymphocyte" EXACT []
is_a: CL:0000236 ! B cell
relationship: develops_from CL:0000816 ! immature B cell
relationship: has_part GO:0071753
relationship: has_part PR:000001289
relationship: has_part PR:000001408
relationship: has_part PR:000001932

[Term]
id: CL:0000819
name: B-1 B cell
namespace: cell
def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." []
comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low.
synonym: "B-1 B lymphocyte" EXACT []
synonym: "B-1 B-cell" EXACT []
synonym: "B-1 B-lymphocyte" EXACT []
synonym: "B-1 cell" EXACT []
synonym: "B1 B cell" EXACT []
synonym: "B1 B lymphocyte" EXACT []
synonym: "B1 B-cell" EXACT []
synonym: "B1 B-lymphocyte" EXACT []
synonym: "B1 cell" EXACT []
is_a: CL:0000785 ! mature B cell
relationship: capable_of GO:0045087
relationship: has_part GO:0071753
relationship: has_part PR:000001014
relationship: has_part PR:000001289
relationship: has_part PR:000001879

[Term]
id: CL:0000820
name: B-1a B cell
namespace: cell
def: "A B-1 B cell that has the phenotype CD5-positive." []
synonym: "B-1a B lymphocyte" EXACT []
synonym: "B-1a B-cell" EXACT []
synonym: "B-1a B-lymphocyte" EXACT []
synonym: "B1a B cell" EXACT []
synonym: "B1a B lymphocyte" EXACT []
synonym: "B1a B-cell" EXACT []
synonym: "B1a B-lymphocyte" EXACT []
synonym: "B1a cell" EXACT []
synonym: "CD5(+) B1 cell" EXACT []
synonym: "CD5+ B1 cell" EXACT []
synonym: "CD5-positive B1 cell" EXACT []
is_a: CL:0000819 ! B-1 B cell
relationship: has_part PR:000001839

[Term]
id: CL:0000821
name: B-1b B cell
namespace: cell
def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." []
synonym: "B-1b B lymphocyte" EXACT []
synonym: "B-1b B-cell" EXACT []
synonym: "B-1b B-lymphocyte" EXACT []
synonym: "B1b B cell" EXACT []
synonym: "B1b B lymphocyte" EXACT []
synonym: "B1b B-cell" EXACT []
synonym: "B1b B-lymphocyte" EXACT []
synonym: "B1b cell" EXACT []
is_a: CL:0000819 ! B-1 B cell

[Term]
id: CL:0000822
name: B-2 B cell
namespace: cell
def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." []
comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive.
synonym: "B-0 B cell" RELATED []
synonym: "B-2 B lymphocyte" EXACT []
synonym: "B-2 B-cell" EXACT []
synonym: "B-2 B-lymphocyte" EXACT []
synonym: "B2 B cell" EXACT []
synonym: "B2 B lymphocyte" EXACT []
synonym: "B2 B-cell" EXACT []
synonym: "B2 B-lymphocyte" EXACT []
synonym: "B2 cell" EXACT []
is_a: CL:0000785 ! mature B cell
relationship: has_part PR:000001289

[Term]
id: CL:0000823
name: immature natural killer cell
namespace: cell
def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." []
comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules.
synonym: "immature NK cell" EXACT []
synonym: "p-NK" RELATED []
is_a: CL:0000623 ! natural killer cell
disjoint_from: CL:0000824 ! mature natural killer cell
disjoint_from: CL:0000937 ! pre-natural killer cell
relationship: develops_from CL:0000937 ! pre-natural killer cell

[Term]
id: CL:0000824
name: mature natural killer cell
namespace: cell
def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." []
synonym: "LAK cell" BROAD []
synonym: "lymphokine activated killer cell" BROAD []
synonym: "mature NK cell" EXACT []
is_a: CL:0000623 ! natural killer cell
disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell
disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell
relationship: develops_from CL:0000823 ! immature natural killer cell

[Term]
id: CL:0000825
name: pro-NK cell
namespace: cell
def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." []
comment: Most markers only described for human pro NK cells.
synonym: "natural killer cell progenitor" EXACT []
synonym: "NKP" EXACT []
synonym: "null cell" RELATED []
synonym: "preNK cell" RELATED []
synonym: "pro-natural killer cell" EXACT []
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_part PR:000001003
relationship: has_part PR:000001015
relationship: has_part PR:000001381
relationship: has_part PR:000001898

[Term]
id: CL:0000826
name: pro-B cell
namespace: cell
def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." []
comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
synonym: "pre-B cell (Philadelphia nomenclature)" RELATED []
synonym: "pre-pro B cell" BROAD []
synonym: "pro-B lymphocyte" EXACT []
synonym: "pro-B-cell" EXACT []
synonym: "pro-B-lymphocyte" EXACT []
synonym: "progenitor B cell" EXACT []
synonym: "progenitor B lymphocyte" EXACT []
synonym: "progenitor B-cell" EXACT []
synonym: "progenitor B-lymphocyte" EXACT []
xref: BTO:0003104
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_part PR:000001903
relationship: has_part PR:000006611

[Term]
id: CL:0000827
name: pro-T cell
namespace: cell
def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." []
synonym: "DN1 cell" NARROW []
synonym: "DN1 thymocyte" NARROW []
synonym: "pro-T lymphocyte" EXACT []
synonym: "progenitor T cell" EXACT []
synonym: "TN1 cell" NARROW []
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: capable_of GO:0030217 ! T cell differentiation
relationship: capable_of GO:0030217 ! T cell differentiation
relationship: develops_from CL:0000051 ! common lymphoid progenitor

[Term]
id: CL:0000828
name: thromboblast
namespace: cell
def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." []
comment: Note that this is a non-mammalian cell type.
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: capable_of GO:0002574
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell

[Term]
id: CL:0000829
name: basophilic myeloblast
namespace: cell
def: "A myeloblast committed to the basophil lineage." []
is_a: CL:0000835 ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: capable_of GO:0030221
relationship: capable_of GO:0030221
relationship: develops_from CL:0000613 ! basophil progenitor cell

[Term]
id: CL:0000830
name: basophilic promyelocyte
namespace: cell
def: "A promyelocyte committed to the basophil lineage." []
xref: FMA:84208
is_a: CL:0000836 ! promyelocyte
intersection_of: CL:0000836 ! promyelocyte
intersection_of: capable_of GO:0030221
relationship: capable_of GO:0030221
relationship: develops_from CL:0000829 ! basophilic myeloblast

[Term]
id: CL:0000831
name: mast cell progenitor
namespace: cell
def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." []
comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa.
synonym: "CFU-Mast" RELATED []
synonym: "CFU-MC" RELATED []
synonym: "colony forming unit mast cell" RELATED []
synonym: "MCP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: capable_of GO:0060374
relationship: develops_from CL:0002028 ! basophil mast progenitor cell
relationship: has_part PR:000002065
relationship: has_part PR:000005178
relationship: has_part PR:000007431
relationship: has_part PR:000007857
relationship: has_part PR:000007858
relationship: has_part PR:000009143
relationship: has_part PR:000016401

[Term]
id: CL:0000832
name: eosinophilic myeloblast
namespace: cell
def: "A myeloblast committed to the eosinophil lineage." []
is_a: CL:0000835 ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: capable_of GO:0030222
relationship: capable_of GO:0030222
relationship: develops_from CL:0000611 ! eosinophil progenitor cell

[Term]
id: CL:0000833
name: eosinophilic promyelocyte
namespace: cell
def: "A promyelocyte committed to the eosinophil lineage." []
xref: FMA:84199
is_a: CL:0000836 ! promyelocyte
intersection_of: CL:0000836 ! promyelocyte
intersection_of: capable_of GO:0030222
relationship: capable_of GO:0030222
relationship: develops_from CL:0000832 ! eosinophilic myeloblast

[Term]
id: CL:0000834
name: neutrophil progenitor cell
namespace: cell
def: "A progenitor cell of the neutrophil lineage." []
synonym: "neutrophil stem cell" RELATED []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: capable_of GO:0030223
relationship: capable_of GO:0030223
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000835
name: myeloblast
namespace: cell
def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." []
xref: BTO:0000187
xref: FMA:83524
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
is_a: CL:0002242 ! nucleate cell
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
relationship: has_part CP:0000028
relationship: has_part CP:0000037
relationship: has_part GO:0000791

[Term]
id: CL:0000836
name: promyelocyte
namespace: cell
def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." []
xref: CALOHA:TS-0825
xref: FMA:83530
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
is_a: CL:0002242 ! nucleate cell
relationship: develops_from CL:0000835 ! myeloblast
relationship: has_part CP:0000028
relationship: has_part CP:0000037
relationship: has_part GO:0005730
relationship: has_part GO:0042582
relationship: has_part PR:000001456
relationship: has_part PR:000001892

[Term]
id: CL:0000837
name: hematopoietic multipotent progenitor cell
namespace: cell
def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." []
comment: Markers differ between mouse and human.
synonym: "hemopoietic progenitor cell" EXACT []
synonym: "MPP" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0008001 ! hematopoietic precursor cell
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: develops_from CL:0000037 ! hematopoietic stem cell
relationship: has_part PR:000001003

[Term]
id: CL:0000838
name: lymphoid lineage restricted progenitor cell
namespace: cell
def: "A progenitor cell restricted to the lymphoid lineage." []
comment: Note that this is a class of cell types, not an identified single cell type.
synonym: "lymphoid progenitor cell" BROAD []
xref: BTO:0004731
xref: CALOHA:TS-2025
xref: FMA:70338
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: capable_of GO:0030098 ! lymphocyte differentiation

[Term]
id: CL:0000839
name: myeloid lineage restricted progenitor cell
namespace: cell
def: "A progenitor cell restricted to the myeloid lineage." []
comment: Note that this is a class of cell types, not an identified single cell type.
synonym: "myeloid progenitor cell" BROAD []
xref: BTO:0004730
xref: CALOHA:TS-2099
xref: FMA:70339
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: capable_of GO:0030099
relationship: capable_of GO:0030099

[Term]
id: CL:0000840
name: immature conventional dendritic cell
namespace: cell
def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." []
synonym: "immature myeloid dendritic cell" NARROW []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
relationship: develops_from CL:0001029 ! common dendritic progenitor
relationship: has_part GO:0042613
relationship: has_part PR:000001412
relationship: has_part PR:000001438

[Term]
id: CL:0000841
name: mature conventional dendritic cell
namespace: cell
def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." []
synonym: "mature dendritic cell" BROAD []
synonym: "mature myeloid dendritic cell" NARROW []
xref: FMA:83038
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
relationship: develops_from CL:0000840 ! immature conventional dendritic cell
relationship: has_part GO:0042613
relationship: has_part PR:000001310
relationship: has_part PR:000001412
relationship: has_part PR:000001438

[Term]
id: CL:0000842
name: mononuclear cell
namespace: cell
def: "A leukocyte with a single non-segmented nucleus in the mature form." []
synonym: "mononuclear leukocyte" EXACT []
synonym: "peripheral blood mononuclear cell" NARROW []
xref: BTO:0000878
xref: CALOHA:TS-0768
xref: FMA:86713
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0002087 ! nongranular leukocyte

[Term]
id: CL:0000843
name: follicular B cell
namespace: cell
def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." []
comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive.
synonym: "Fo B cell" EXACT []
synonym: "Fo B-cell" EXACT []
synonym: "follicular B lymphocyte" EXACT []
synonym: "follicular B-cell" EXACT []
synonym: "follicular B-lymphocyte" EXACT []
is_a: CL:0000822 ! B-2 B cell
relationship: has_part GO:0071738
relationship: has_part GO:0071753
relationship: has_part PR:000001014
relationship: has_part PR:000001338

[Term]
id: CL:0000844
name: germinal center B cell
namespace: cell
def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." []
comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive.
synonym: "GC B cell" EXACT []
synonym: "GC B lymphocyte" EXACT []
synonym: "GC B-cell" EXACT []
synonym: "GC B-lymphocyte" EXACT []
synonym: "germinal center B lymphocyte" EXACT []
synonym: "germinal center B-cell" EXACT []
synonym: "germinal center B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
relationship: develops_from CL:0000843 ! follicular B cell
relationship: has_part PR:000001289
relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue

[Term]
id: CL:0000845
name: marginal zone B cell
namespace: cell
def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." []
comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive.
synonym: "marginal zone B lymphocyte" EXACT []
synonym: "marginal zone B-cell" EXACT []
synonym: "marginal zone B-lymphocyte" EXACT []
synonym: "MZ B cell" EXACT []
synonym: "MZ B lymphocyte" EXACT []
synonym: "MZ B-cell" EXACT []
synonym: "MZ B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
is_a: CL:2000074 ! splenocyte
relationship: capable_of GO:0042742
relationship: has_part GO:0071753
relationship: has_part PR:000001289
relationship: has_part PR:000001338
relationship: part_of UBERON:0001251 ! marginal zone of spleen

[Term]
id: CL:0000846
name: vestibular dark cell
namespace: cell
def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000847
name: ciliated olfactory receptor neuron
namespace: cell
def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." []
synonym: "ciliated olfactory sensory neuron" EXACT []
synonym: "ciliated sensory neuron" EXACT []
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000207 ! olfactory receptor cell

[Term]
id: CL:0000848
name: microvillous olfactory receptor neuron
namespace: cell
def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." []
synonym: "microvillous olfactory sensory neuron" EXACT []
synonym: "microvillous sensory neuron" RELATED []
is_a: CL:0000207 ! olfactory receptor cell

[Term]
id: CL:0000849
name: crypt olfactory receptor neuron
namespace: cell
def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." []
synonym: "crypt cell" EXACT []
synonym: "crypt olfactory sensory neuron" EXACT []
synonym: "crypt sensory neuron" EXACT []
is_a: CL:0000207 ! olfactory receptor cell

[Term]
id: CL:0000850
name: serotonergic neuron
namespace: cell
alt_id: CL:0000403
def: "A neuron that releases serotonin as a neurotransmitter." []
synonym: "5-HT neuron" EXACT []
synonym: "5-hydroxytryptamine neuron" EXACT []
synonym: "serotinergic neuron" RELATED []
xref: FBbt:00005133
xref: WBbt:0006837
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0060096
relationship: capable_of GO:0060096

[Term]
id: CL:0000851
name: neuromast mantle cell
namespace: cell
def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." []
is_a: CARO:0000000
is_a: CL:0000151 ! secretory cell
disjoint_from: CL:0000855 ! sensory hair cell
relationship: part_of UBERON:0008904 ! neuromast

[Term]
id: CL:0000852
name: neuromast support cell
namespace: cell
def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000630 ! supportive cell
disjoint_from: CL:0000855 ! sensory hair cell
relationship: part_of UBERON:0008904 ! neuromast

[Term]
id: CL:0000853
name: olfactory epithelial support cell
namespace: cell
def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." []
synonym: "olfactory sustentacular cell" EXACT []
synonym: "supporting cell of olfactory epithelium" EXACT []
synonym: "sustentaculocyte of olfactory epithelium" EXACT []
xref: FMA:62302
is_a: CL:0000630 ! supportive cell
is_a: CL:0002169 ! basal cell of olfactory epithelium
intersection_of: CL:0000630 ! supportive cell
intersection_of: part_of UBERON:0001997 ! olfactory epithelium

[Term]
id: CL:0000854
name: interneuromast cell
namespace: cell
def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." []
is_a: CL:0000133 ! neurectodermal cell
relationship: develops_from CL:0000032 ! neuroplacodal cell

[Term]
id: CL:0000855
name: sensory hair cell
namespace: cell
def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." []
synonym: "hair cell" BROAD []
xref: BTO:0004744
is_a: CL:0000199 ! mechanoreceptor cell

[Term]
id: CL:0000856
name: neuromast hair cell
namespace: cell
def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." []
is_a: CL:0000855 ! sensory hair cell
intersection_of: CL:0000855 ! sensory hair cell
intersection_of: part_of UBERON:0008904 ! neuromast
relationship: part_of UBERON:0008904 ! neuromast

[Term]
id: CL:0000857
name: slow muscle myoblast
namespace: cell
def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." []
is_a: CL:0000515 ! skeletal muscle myoblast

[Term]
id: CL:0000858
name: fast muscle myoblast
namespace: cell
def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." []
is_a: CL:0000515 ! skeletal muscle myoblast

[Term]
id: CL:0000860
name: classical monocyte
namespace: cell
def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." []
comment: Markers: CCR2+CXCCR1<low> (human, mouse, rat).
synonym: "inflammatory monocyte" EXACT []
is_a: CL:0000234 ! phagocyte
is_a: CL:0000576 ! monocyte
relationship: capable_of GO:0002548
relationship: capable_of GO:0006954 ! inflammatory response
relationship: has_part PR:000001199
relationship: has_part PR:000001206

[Term]
id: CL:0000861
name: elicited macrophage
namespace: cell
def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." []
comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response).
synonym: "free macrophage" EXACT []
synonym: "wandering histiocyte" EXACT []
xref: FMA:84643
xref: FMA:84645
is_a: CL:0000235 ! macrophage
relationship: develops_from CL:0000860 ! classical monocyte
relationship: has_part PR:000001012
relationship: has_part PR:000001813
relationship: has_part PR:000002064

[Term]
id: CL:0000862
name: suppressor macrophage
namespace: cell
def: "A macrophage that suppresses immune responses." []
comment: Markers: May express: IL10, TGFbeta.
is_a: CL:0000861 ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
relationship: capable_of GO:0050777 ! negative regulation of immune response

[Term]
id: CL:0000863
name: inflammatory macrophage
namespace: cell
def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." []
comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).
synonym: "classically activated macrophage" EXACT []
synonym: "M1 macrophage" RELATED []
is_a: CL:0000861 ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: capable_of GO:0032611
intersection_of: capable_of GO:0032635
intersection_of: capable_of GO:0032640
intersection_of: capable_of GO:0042554
intersection_of: capable_of GO:0042742
intersection_of: capable_of GO:0051767
relationship: capable_of GO:0032611
relationship: capable_of GO:0032635
relationship: capable_of GO:0032640
relationship: capable_of GO:0042554
relationship: capable_of GO:0042742
relationship: capable_of GO:0051767

[Term]
id: CL:0000864
name: tissue-resident macrophage
namespace: cell
def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." []
synonym: "fixed macrophage" EXACT []
synonym: "resting histiocyte" EXACT []
xref: FMA:84642
xref: FMA:84644
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0000479 ! tissue
relationship: part_of UBERON:0000479 ! tissue

[Term]
id: CL:0000865
name: gastrointestinal tract (lamina propria) macrophage
namespace: cell
def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." []
is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage
intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage
intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine
relationship: part_of UBERON:0001238 ! lamina propria of small intestine

[Term]
id: CL:0000866
name: thymic macrophage
namespace: cell
def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." []
comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation.
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: capable_of GO:0043277
intersection_of: part_of UBERON:0002370 ! thymus
relationship: capable_of GO:0043277
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000867
name: secondary lymphoid organ macrophage
namespace: cell
def: "A tissue-resident macrophage found in a secondary lymphoid organ." []
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000868
name: lymph node macrophage
namespace: cell
def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." []
comment: Marker was observed on rat cells.
synonym: "MF.LN" EXACT []
is_a: CL:0000867 ! secondary lymphoid organ macrophage
relationship: has_part PR:000001012
relationship: has_part PR:000001813
relationship: has_part PR:000001931
relationship: part_of UBERON:0000029 ! lymph node

[Term]
id: CL:0000869
name: tonsillar macrophage
namespace: cell
def: "A gut-associated lymphoid tissue macrophage found in tonsils." []
is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage
intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage
intersection_of: capable_of GO:0002395
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: capable_of GO:0002395
relationship: part_of UBERON:0002372 ! tonsil

[Term]
id: CL:0000870
name: Peyer's patch macrophage
namespace: cell
def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." []
is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage
intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage
intersection_of: part_of UBERON:0001211 ! Peyer's patch
relationship: part_of UBERON:0001211 ! Peyer's patch

[Term]
id: CL:0000871
name: splenic macrophage
namespace: cell
def: "A secondary lymphoid organ macrophage found in the spleen." []
comment: Role or process: immune, clearance of apoptotic and senescent cells.
xref: FMA:83026
is_a: CL:0000867 ! secondary lymphoid organ macrophage
is_a: CL:2000074 ! splenocyte
intersection_of: CL:0000867 ! secondary lymphoid organ macrophage
intersection_of: capable_of GO:0034102
intersection_of: part_of UBERON:0002106 ! spleen
relationship: capable_of GO:0034102

[Term]
id: CL:0000872
name: splenic marginal zone macrophage
namespace: cell
def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." []
comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+.
is_a: CL:0000871 ! splenic macrophage
relationship: has_part PR:000001806
relationship: has_part PR:000001884
relationship: has_part PR:000001885
relationship: has_part PR:000006172
relationship: part_of UBERON:0001251 ! marginal zone of spleen

[Term]
id: CL:0000873
name: splenic metallophillic macrophage
namespace: cell
def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." []
comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+.
is_a: CL:0000871 ! splenic macrophage
relationship: has_part PR:000001806
relationship: has_part PR:000001931
relationship: part_of UBERON:0001251 ! marginal zone of spleen

[Term]
id: CL:0000874
name: splenic red pulp macrophage
namespace: cell
def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." []
comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes.
is_a: CL:0000871 ! splenic macrophage
relationship: capable_of GO:0006955 ! immune response
relationship: has_part PR:000001012
relationship: has_part PR:000001806
relationship: has_part PR:000001813
relationship: has_part PR:000001931
relationship: has_part PR:000002064
relationship: has_part PR:000002972
relationship: part_of UBERON:0001250 ! red pulp of spleen

[Term]
id: CL:0000875
name: non-classical monocyte
namespace: cell
def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." []
comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-.
synonym: "patrolling monocyte" EXACT []
synonym: "resident monocyte" EXACT []
is_a: CL:0000576 ! monocyte
relationship: capable_of GO:0031294
relationship: develops_from CL:0002393 ! intermediate monocyte
relationship: has_part PR:000001206

[Term]
id: CL:0000876
name: splenic white pulp macrophage
namespace: cell
def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." []
comment: Markers: Mouse: F4/80-, CD68+, macrosialin+.
is_a: CL:0000871 ! splenic macrophage
relationship: has_part PR:000002064
relationship: part_of UBERON:0001959 ! white pulp of spleen

[Term]
id: CL:0000877
name: splenic tingible body macrophage
namespace: cell
def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." []
is_a: CL:0000876 ! splenic white pulp macrophage
relationship: capable_of GO:0043277
relationship: has_part PR:000010329
relationship: part_of UBERON:0001249 ! spleen lymphoid follicle

[Term]
id: CL:0000878
name: central nervous system macrophage
namespace: cell
def: "A tissue-resident macrophage found in the central nervous system." []
synonym: "CNS macrophage" EXACT []
is_a: CL:0000864 ! tissue-resident macrophage
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000879
name: meningeal macrophage
namespace: cell
def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors." []
is_a: CL:0000878 ! central nervous system macrophage
intersection_of: CL:0000878 ! central nervous system macrophage
intersection_of: capable_of GO:0005044
intersection_of: part_of UBERON:0002360 ! meninx
relationship: capable_of GO:0005044
relationship: part_of UBERON:0002360 ! meninx

[Term]
id: CL:0000880
name: choroid-plexus macrophage
namespace: cell
def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." []
is_a: CL:0000878 ! central nervous system macrophage
relationship: capable_of GO:0005044

[Term]
id: CL:0000881
name: perivascular macrophage
namespace: cell
def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." []
comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+.
is_a: CL:0000878 ! central nervous system macrophage
relationship: has_part PR:000001483
relationship: has_part PR:000001889
relationship: has_part PR:000001925
relationship: part_of UBERON:0001981 ! blood vessel

[Term]
id: CL:0000882
name: thymic medullary macrophage
namespace: cell
def: "A thymic macrophage found in the thymic medulla." []
is_a: CL:0000866 ! thymic macrophage
intersection_of: CL:0000866 ! thymic macrophage
intersection_of: part_of UBERON:0002124 ! medulla of thymus
relationship: part_of UBERON:0002124 ! medulla of thymus

[Term]
id: CL:0000883
name: thymic cortical macrophage
namespace: cell
def: "A thymic macrophage found in the thymic cortex." []
is_a: CL:0000866 ! thymic macrophage
intersection_of: CL:0000866 ! thymic macrophage
intersection_of: part_of UBERON:0002123 ! cortex of thymus
relationship: part_of UBERON:0002123 ! cortex of thymus

[Term]
id: CL:0000884
name: mucosa-associated lymphoid tissue macrophage
namespace: cell
def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." []
is_a: CL:0000867 ! secondary lymphoid organ macrophage
intersection_of: CL:0000867 ! secondary lymphoid organ macrophage
intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue
relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue

[Term]
id: CL:0000885
name: gut-associated lymphoid tissue macrophage
namespace: cell
def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." []
is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage
intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage
intersection_of: capable_of GO:0002387
intersection_of: part_of UBERON:0001962 ! gut-associated lymphoid tissue
relationship: capable_of GO:0002387
relationship: part_of UBERON:0001962 ! gut-associated lymphoid tissue

[Term]
id: CL:0000886
name: nasal and broncial associated lymphoid tissue macrophage
namespace: cell
def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." []
is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage
intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage
intersection_of: capable_of GO:0002395
intersection_of: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue
relationship: capable_of GO:0002395
relationship: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue

[Term]
id: CL:0000887
name: lymph node subcapsular sinus macrophage
namespace: cell
def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." []
is_a: CL:0000868 ! lymph node macrophage
relationship: capable_of GO:0032816
relationship: has_part PR:000001931

[Term]
id: CL:0000888
name: lymph node tingible body macrophage
namespace: cell
def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." []
is_a: CL:0000868 ! lymph node macrophage
intersection_of: CL:0000868 ! lymph node macrophage
intersection_of: capable_of GO:0002905
intersection_of: capable_of GO:0043277
intersection_of: part_of UBERON:0002006 ! cortex of lymph node
relationship: capable_of GO:0002905
relationship: capable_of GO:0043277
relationship: part_of UBERON:0002006 ! cortex of lymph node

[Term]
id: CL:0000889
name: myeloid suppressor cell
namespace: cell
def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." []
comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.
is_a: CL:0000766 ! myeloid leukocyte
relationship: capable_of GO:0050777 ! negative regulation of immune response
relationship: has_part PR:000001006
relationship: has_part PR:000001012

[Term]
id: CL:0000890
name: alternatively activated macrophage
namespace: cell
def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." []
comment: Role or process: tissue remodeling.
synonym: "M2 macrophage" RELATED []
is_a: CL:0000861 ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: capable_of GO:0048771
intersection_of: has_part PR:000001844
relationship: capable_of GO:0048771
relationship: has_part PR:000001844

[Term]
id: CL:0000891
name: foam cell
namespace: cell
def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." []
xref: BTO:0003872
xref: FMA:83586
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000892
name: smooth muscle cell derived foam cell
namespace: cell
def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000891 ! foam cell
relationship: develops_from CL:0000192 ! smooth muscle cell

[Term]
id: CL:0000893
name: thymocyte
namespace: cell
def: "An immature T cell located in the thymus." []
synonym: "immature T cell" BROAD []
synonym: "immature T lymphocyte" BROAD []
synonym: "immature T-cell" BROAD []
synonym: "immature T-lymphocyte" BROAD []
synonym: "thymic lymphocyte" EXACT []
xref: BTO:0001372
xref: CALOHA:TS-1042
xref: FMA:72202
xref: XAO:0003159
is_a: CL:0002420 ! immature T cell
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000894
name: DN1 thymic pro-T cell
namespace: cell
def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." []
synonym: "DN1 thymic pro-T lymphocyte" EXACT []
synonym: "DN1 thymic pro-T-cell" EXACT []
synonym: "DN1 thymic pro-T-lymphocyte" EXACT []
synonym: "DN1 thymic progenitor T cell" EXACT []
synonym: "DN1 thymocyte" EXACT []
synonym: "double negative 1" EXACT []
synonym: "preT.DN1.Th" EXACT []
is_a: CL:0000827 ! pro-T cell
relationship: develops_from CL:0002425 ! early T lineage precursor
relationship: has_part PR:000001307
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000895
name: naive thymus-derived CD4-positive, alpha-beta T cell
namespace: cell
def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." []
comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells.
synonym: "naive CD4+ T cell" BROAD []
synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT []
synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT []
synonym: "T.4Nve.Sp" EXACT []
synonym: "Th0" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000898 ! naive T cell
relationship: develops_from CL:0002436 ! mature CD4 single-positive thymocyte

[Term]
id: CL:0000896
name: activated CD4-positive, alpha-beta T cell
namespace: cell
def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." []
synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "activated CD4-positive, alpha-beta T-cell" EXACT []
synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell
relationship: has_part PR:000001343
relationship: has_part PR:000001380

[Term]
id: CL:0000897
name: CD4-positive, alpha-beta memory T cell
namespace: cell
def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." []
synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "T4.Mem.Sp" RELATED []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000813 ! memory T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_part PR:000001307
relationship: has_part PR:000001381

[Term]
id: CL:0000898
name: naive T cell
namespace: cell
def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." []
synonym: "naive T lymphocyte" EXACT []
synonym: "naive T-cell" EXACT []
synonym: "naive T-lymphocyte" EXACT []
is_a: CL:0002419 ! mature T cell
relationship: has_part PR:000001015
relationship: has_part PR:000001203
relationship: has_part PR:000001307
relationship: has_part PR:000001318
relationship: has_part PR:000001869

[Term]
id: CL:0000899
name: T-helper 17 cell
namespace: cell
def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells.
synonym: "helper T cell type 17" EXACT []
synonym: "IL-17-producing CD4+ T helper" EXACT []
synonym: "T helper cells type 17" EXACT []
synonym: "T(H)-17 cell" EXACT []
synonym: "Th17 CD4+ T cell" EXACT []
synonym: "Th17 cell" EXACT []
synonym: "Th17 T cell" EXACT []
synonym: "Th17 T lymphocyte" EXACT []
synonym: "Th17 T-cell" EXACT []
synonym: "Th17 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
relationship: capable_of GO:0032620
relationship: has_part PR:000001202
relationship: has_part PR:000003455

[Term]
id: CL:0000900
name: naive thymus-derived CD8-positive, alpha-beta T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." []
comment: This cell traffics in secondary lymphoid organs and blood.  This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells.
synonym: "naive CD8+ T cell" BROAD []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT []
synonym: "T.8Nve.Sp" NARROW []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000898 ! naive T cell
relationship: develops_from CL:0002437 ! mature CD8 single-positive thymocyte

[Term]
id: CL:0000901
name: Tr1 cell
namespace: cell
def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." []
comment: These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.)
synonym: "T-regulatory T cell type 1" EXACT []
synonym: "Tr1 T cell" EXACT []
synonym: "Tr1 T lymphocyte" EXACT []
synonym: "Tr1 T-cell" EXACT []
synonym: "Tr1 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
is_a: CL:0000815 ! regulatory T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: capable_of GO:0032613
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
relationship: capable_of GO:0032613

[Term]
id: CL:0000902
name: induced T-regulatory cell
namespace: cell
def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." []
synonym: "adaptive Treg" RELATED []
synonym: "aTreg" RELATED []
synonym: "induced regulatory T cell" EXACT []
synonym: "induced regulatory T lymphocyte" EXACT []
synonym: "induced regulatory T-cell" EXACT []
synonym: "induced regulatory T-lymphocyte" EXACT []
synonym: "induced Treg" EXACT []
synonym: "iTreg" EXACT []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_part PR:000001350
relationship: has_part PR:000001852

[Term]
id: CL:0000903
name: natural T-regulatory cell
namespace: cell
def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." []
synonym: "natural regulatory T cell" EXACT []
synonym: "natural regulatory T lymphocyte" EXACT []
synonym: "natural regulatory T-cell" EXACT []
synonym: "natural regulatory T-lymphocyte" EXACT []
synonym: "natural Treg" EXACT []
synonym: "nTreg" EXACT []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_part PR:000001318
relationship: has_part PR:000001350
relationship: has_part PR:000001852

[Term]
id: CL:0000904
name: central memory CD4-positive, alpha-beta T cell
namespace: cell
def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells.
synonym: "central CD4-positive, alpha-beta memory T cell" EXACT []
synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "central memory CD4+ T cell" BROAD []
synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT []
synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell
relationship: has_part PR:000001203

[Term]
id: CL:0000905
name: effector memory CD4-positive, alpha-beta T cell
namespace: cell
def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells.
synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "effector memory CD4+ T cell" BROAD []
synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT []
synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell

[Term]
id: CL:0000906
name: activated CD8-positive, alpha-beta T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." []
synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "activated CD8-positive, alpha-beta T-cell" EXACT []
synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell
relationship: has_part PR:000001343
relationship: has_part PR:000001380

[Term]
id: CL:0000907
name: central memory CD8-positive, alpha-beta T cell
namespace: cell
def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells.
synonym: "central CD8-positive, alpha-beta memory T cell" EXACT []
synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "central memory CD8+ T cell" BROAD []
synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT []
synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell
relationship: has_part PR:000001203

[Term]
id: CL:0000908
name: CD8-positive, alpha-beta cytokine secreting effector T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000912 ! helper T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_part PR:000001343
relationship: has_part PR:000001380

[Term]
id: CL:0000909
name: CD8-positive, alpha-beta memory T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." []
synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "T.8Mem.Sp" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000813 ! memory T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_part PR:000001307
relationship: has_part PR:000001381

[Term]
id: CL:0000910
name: cytotoxic T cell
namespace: cell
def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." []
synonym: "cytotoxic T lymphocyte" EXACT []
synonym: "cytotoxic T-cell" EXACT []
synonym: "cytotoxic T-lymphocyte" EXACT []
xref: BTO:0000289
xref: CALOHA:TS-0190
xref: FMA:70573
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: capable_of GO:0001913
relationship: capable_of GO:0001913

[Term]
id: CL:0000911
name: effector T cell
namespace: cell
def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." []
synonym: "effector T lymphocyte" EXACT []
synonym: "effector T-cell" EXACT []
synonym: "effector T-lymphocyte" EXACT []
is_a: CL:0002419 ! mature T cell

[Term]
id: CL:0000912
name: helper T cell
namespace: cell
def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." []
synonym: "helper T lymphocyte" EXACT []
synonym: "helper T-cell" EXACT []
synonym: "helper T-lymphocyte" EXACT []
synonym: "T-helper cell" EXACT []
xref: BTO:0002417
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: capable_of GO:0001816
relationship: capable_of GO:0001816

[Term]
id: CL:0000913
name: effector memory CD8-positive, alpha-beta T cell
namespace: cell
def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells.
synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "effector memory CD8+ T cell" BROAD []
synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT []
synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell

[Term]
id: CL:0000914
name: immature NK T cell
namespace: cell
def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." []
synonym: "immature NK T lymphocyte" EXACT []
synonym: "immature NK T-cell" EXACT []
synonym: "immature NK T-lymphocyte" EXACT []
synonym: "immature NKT cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: has_part PR:000003469
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_part PR:000003469

[Term]
id: CL:0000915
name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell
namespace: cell
def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte
relationship: has_part PR:000001084

[Term]
id: CL:0000916
name: dendritic epidermal T cell
namespace: cell
def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." []
comment: In mice, DETC have an invariant T cell receptor.
synonym: "dendritic epidermal T lymphocyte" EXACT []
synonym: "dendritic epidermal T-cell" EXACT []
synonym: "dendritic epidermal T-lymphocyte" EXACT []
synonym: "DETC" EXACT []
is_a: CL:0000800 ! mature gamma-delta T cell
relationship: capable_of GO:0060054 ! positive regulation of epithelial cell proliferation involved in wound healing
relationship: develops_from CL:0002401 ! mature dendritic epithelial T cell precursor

[Term]
id: CL:0000917
name: Tc1 cell
namespace: cell
def: "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells.
synonym: "T-cytotoxic T cell type 1" EXACT []
synonym: "Tc1 CD8+ T cell" EXACT []
synonym: "Tc1 T cell" EXACT []
synonym: "Tc1 T lymphocyte" EXACT []
synonym: "Tc1 T-cell" EXACT []
synonym: "Tc1 T-lymphocyte" EXACT []
xref: BTO:0004793
xref: BTO:0004888
xref: FMA:84793
is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell
relationship: capable_of GO:0032609
relationship: has_part PR:000001207
relationship: has_part PR:000001835
relationship: has_part PR:000003463

[Term]
id: CL:0000918
name: Tc2 cell
namespace: cell
def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell.
synonym: "T-cytotoxic T cell type 2" EXACT []
synonym: "Tc2 T cell" EXACT []
synonym: "Tc2 T lymphocyte" EXACT []
synonym: "Tc2 T-cell" EXACT []
synonym: "Tc2 T-lymphocyte" EXACT []
xref: BTO:0004794
xref: FMA:84794
is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell
is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
relationship: capable_of GO:0032633
relationship: has_part PR:000001941

[Term]
id: CL:0000919
name: CD8-positive, CD25-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." []
synonym: "CD8+CD25+ T cell" EXACT []
synonym: "CD8+CD25+ T lymphocyte" EXACT []
synonym: "CD8+CD25+ T(reg)" EXACT []
synonym: "CD8+CD25+ T-cell" EXACT []
synonym: "CD8+CD25+ T-lymphocyte" EXACT []
synonym: "CD8+CD25+ Treg" EXACT []
synonym: "CD8-positive, CD25-positive Treg" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_part PR:000001350
relationship: has_part PR:000001380

[Term]
id: CL:0000920
name: CD8-positive, CD28-negative, alpha-beta regulatory T cell
namespace: cell
def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." []
synonym: "CD8+CD28- T cell" EXACT []
synonym: "CD8+CD28- T lymphocyte" EXACT []
synonym: "CD8+CD28- T(reg)" EXACT []
synonym: "CD8+CD28- T-cell" EXACT []
synonym: "CD8+CD28- T-lymphocyte" EXACT []
synonym: "CD8+CD28- Treg" EXACT []
synonym: "CD8-positive, CD28-negative T(reg)" EXACT []
synonym: "CD8-positive, CD28-negative Treg" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_part PR:000001350

[Term]
id: CL:0000921
name: type I NK T cell
namespace: cell
def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." []
comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24.
synonym: "classical NK T cell" EXACT []
synonym: "invariant NK T cell" RELATED []
synonym: "type I NK T lymphocyte" EXACT []
synonym: "type I NK T-cell" EXACT []
synonym: "type I NK T-lymphocyte" EXACT []
synonym: "type I NKT cell" EXACT []
is_a: CL:0000814 ! mature NK T cell
intersection_of: CL:0000814 ! mature NK T cell
intersection_of: capable_of GO:0043208
relationship: capable_of GO:0043208

[Term]
id: CL:0000922
name: type II NK T cell
namespace: cell
def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." []
synonym: "type II NK T lymphocyte" EXACT []
synonym: "type II NK T-cell" EXACT []
synonym: "type II NK T-lymphocyte" EXACT []
synonym: "type II NKT cell" EXACT []
is_a: CL:0000814 ! mature NK T cell
intersection_of: CL:0000814 ! mature NK T cell
intersection_of: capable_of GO:0002288
relationship: capable_of GO:0002288

[Term]
id: CL:0000923
name: CD4-positive type I NK T cell
namespace: cell
def: "A type I NK T cell that has the phenotype CD4-positive." []
synonym: "CD4-positive type I NK T lymphocyte" EXACT []
synonym: "CD4-positive type I NK T-cell" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte" EXACT []
synonym: "CD4-positive type I NKT cell" EXACT []
synonym: "NKT.4+.SP" NARROW []
is_a: CL:0000921 ! type I NK T cell
relationship: has_part PR:000001004

[Term]
id: CL:0000924
name: CD4-negative, CD8-negative type I NK T cell
namespace: cell
def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT []
synonym: "NKT.4-.Sp" NARROW []
is_a: CL:0000921 ! type I NK T cell

[Term]
id: CL:0000925
name: activated CD4-positive type I NK T cell
namespace: cell
def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." []
synonym: "activated CD4-positive type I NK T lymphocyte" EXACT []
synonym: "activated CD4-positive type I NK T-cell" EXACT []
synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT []
synonym: "activated CD4-positive type I NKT cell" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000923 ! CD4-positive type I NK T cell
relationship: capable_of GO:0032609
relationship: capable_of GO:0032633
relationship: develops_from CL:0000923 ! CD4-positive type I NK T cell
relationship: has_part PR:000001343

[Term]
id: CL:0000926
name: CD4-positive type I NK T cell secreting interferon-gamma
namespace: cell
def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." []
synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT []
synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000923 ! CD4-positive type I NK T cell
relationship: capable_of GO:0002827
relationship: capable_of GO:0032609
relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell

[Term]
id: CL:0000927
name: CD4-positive type I NK T cell secreting interleukin-4
namespace: cell
def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." []
synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT []
synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000923 ! CD4-positive type I NK T cell
relationship: capable_of GO:0002830
relationship: capable_of GO:0032616
relationship: capable_of GO:0032633
relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell

[Term]
id: CL:0000928
name: activated CD4-negative, CD8-negative type I NK T cell
namespace: cell
def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." []
synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
relationship: capable_of GO:0002369
relationship: develops_from CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
relationship: has_part PR:000001343

[Term]
id: CL:0000929
name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma
namespace: cell
def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." []
synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
relationship: capable_of GO:0002827
relationship: capable_of GO:0032609
relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell

[Term]
id: CL:0000930
name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4
namespace: cell
def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." []
synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
relationship: capable_of GO:0002830
relationship: capable_of GO:0032633
relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell

[Term]
id: CL:0000931
name: activated type II NK T cell
namespace: cell
def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." []
synonym: "activated type II NK T lymphocyte" EXACT []
synonym: "activated type II NK T-cell" EXACT []
synonym: "activated type II NK T-lymphocyte" EXACT []
synonym: "activated type II NKT cell" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000922 ! type II NK T cell
relationship: capable_of GO:0002369
relationship: has_part PR:000001343

[Term]
id: CL:0000932
name: type II NK T cell secreting interferon-gamma
namespace: cell
def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." []
synonym: "type II NK T cell secreting IFN-gamma" EXACT []
synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "type II NK T-cell secreting interferon-gamma" EXACT []
synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "type II NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000922 ! type II NK T cell
relationship: capable_of GO:0032609
relationship: develops_from CL:0000931 ! activated type II NK T cell
relationship: has_part PR:000001343

[Term]
id: CL:0000933
name: type II NK T cell secreting interleukin-4
namespace: cell
def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." []
synonym: "type II NK T cell secreting IL-4" EXACT []
synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "type II NK T-cell secreting interleukin-4" EXACT []
synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "type II NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000922 ! type II NK T cell
relationship: capable_of GO:0032633
relationship: develops_from CL:0000931 ! activated type II NK T cell
relationship: has_part PR:000001343

[Term]
id: CL:0000934
name: CD4-positive, alpha-beta cytotoxic T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." []
synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT []
synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000910 ! cytotoxic T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000935
name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell
namespace: cell
def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." []
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT []
is_a: CL:0000797 ! alpha-beta intraepithelial T cell

[Term]
id: CL:0000936
name: early lymphoid progenitor
namespace: cell
def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." []
comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative.
synonym: "ELP" EXACT []
synonym: "GMLP" RELATED []
synonym: "LMPP" EXACT []
synonym: "lymphoid-primed multipotent progenitor" EXACT []
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
is_a: CL:0011115 ! precursor cell
relationship: capable_of GO:0030098 ! lymphocyte differentiation
relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell
relationship: has_part PR:000002001
relationship: has_part PR:000002065
relationship: has_part PR:000002979

[Term]
id: CL:0000937
name: pre-natural killer cell
namespace: cell
def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." []
comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high.
synonym: "pre-NK cell" EXACT []
is_a: CL:0000623 ! natural killer cell
disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell
disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell
relationship: has_part PR:000001003
relationship: has_part PR:000001381
relationship: has_part PR:000002065

[Term]
id: CL:0000938
name: CD16-negative, CD56-bright natural killer cell
namespace: cell
def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types.
synonym: "CD16-CD56bright NK cell" EXACT []
synonym: "CD16-negative, CD56-bright NK cell" EXACT []
synonym: "CD56-bright cytokine secreting natural killer cell" EXACT []
synonym: "CD56-bright cytokine secreting NK cell" EXACT []
is_a: CL:0000824 ! mature natural killer cell
disjoint_from: CL:0000939 ! CD16-positive, CD56-dim natural killer cell
relationship: has_part PR:000001024
relationship: has_part PR:000001319

[Term]
id: CL:0000939
name: CD16-positive, CD56-dim natural killer cell
namespace: cell
def: "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types.
synonym: "CD16+CD56+ NK cell" EXACT []
synonym: "CD16-positive, CD56-dim NK cell" EXACT []
synonym: "CD16-positive, CD56-low natural killer cell" EXACT []
synonym: "CD16-positive, CD56-low NK cell" EXACT []
synonym: "CD16-positive, CD56-positive natural killer cell" EXACT []
synonym: "CD16-positive, CD56-positive NK cell" EXACT []
synonym: "cytotoxic CD56-dim natural killer cell" EXACT []
synonym: "cytotoxic CD56-dim NK cell" EXACT []
is_a: CL:0000824 ! mature natural killer cell
relationship: capable_of GO:0042267
relationship: has_part PR:000001024
relationship: has_part PR:000001483

[Term]
id: CL:0000940
name: mucosal invariant T cell
namespace: cell
def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." []
synonym: "mucosal invariant T lymphocyte" EXACT []
synonym: "mucosal invariant T-cell" EXACT []
synonym: "mucosal invariant T-lymphocyte" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
is_a: CL:0002127 ! innate effector T cell
relationship: capable_of GO:0002227
relationship: capable_of GO:0032394

[Term]
id: CL:0000941
name: thymic conventional dendritic cell
namespace: cell
def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." []
comment: In the mouse this cell expresses CD8-alpha-alpha.
is_a: CL:0000990 ! conventional dendritic cell
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell
relationship: has_part PR:000001013
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000942
name: thymic plasmacytoid dendritic cell
namespace: cell
def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." []
is_a: CL:0000784 ! plasmacytoid dendritic cell
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell
relationship: has_part PR:000001015
relationship: has_part PR:000001865

[Term]
id: CL:0000943
name: Be1 Cell
namespace: cell
def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." []
comment: Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive.
synonym: "B effector 1 cell" EXACT []
synonym: "B effector cell type 1" RELATED []
is_a: CL:0000968 ! Be cell
intersection_of: CL:0000968 ! Be cell
intersection_of: capable_of GO:0032609
intersection_of: capable_of GO:0032623
intersection_of: capable_of GO:0032640
intersection_of: capable_of GO:0045627
relationship: capable_of GO:0032609
relationship: capable_of GO:0032623
relationship: capable_of GO:0032640
relationship: capable_of GO:0045627

[Term]
id: CL:0000944
name: Be2 cell
namespace: cell
def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." []
comment: Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive.
synonym: "B effector 2 cell" EXACT []
synonym: "B effector cell type 2" RELATED []
is_a: CL:0000968 ! Be cell
intersection_of: CL:0000968 ! Be cell
intersection_of: capable_of GO:0032613
intersection_of: capable_of GO:0032623
intersection_of: capable_of GO:0032633
intersection_of: capable_of GO:0032635
intersection_of: capable_of GO:0045630
relationship: capable_of GO:0032613
relationship: capable_of GO:0032623
relationship: capable_of GO:0032633
relationship: capable_of GO:0032635
relationship: capable_of GO:0045630

[Term]
id: CL:0000945
name: lymphocyte of B lineage
namespace: cell
def: "A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex." []
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells).  Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).
is_a: CL:0000542 ! lymphocyte
relationship: develops_from CL:0000826 ! pro-B cell
relationship: has_part PR:000001002

[Term]
id: CL:0000946
name: antibody secreting cell
namespace: cell
def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." []
is_a: CL:0000945 ! lymphocyte of B lineage

[Term]
id: CL:0000947
name: IgE plasma cell
namespace: cell
def: "A long lived plasma cell that secretes IgE." []
is_a: CL:0000974 ! long lived plasma cell

[Term]
id: CL:0000948
name: IgE memory B cell
namespace: cell
def: "A class switched memory B cell that expresses IgE on the cell surface." []
synonym: "IgE memory B lymphocyte" EXACT []
synonym: "IgE memory B-cell" EXACT []
synonym: "IgE memory B-lymphocyte" EXACT []
synonym: "memory IgE B cell" EXACT []
synonym: "memory IgE B lymphocyte" EXACT []
synonym: "memory IgE B-cell" EXACT []
synonym: "memory IgE B-lymphocyte" EXACT []
is_a: CL:0000972 ! class switched memory B cell
relationship: has_part GO:0071742

[Term]
id: CL:0000949
name: IgD plasmablast
namespace: cell
def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." []
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000950
name: IgE plasmablast
namespace: cell
def: "A plasmablast that secretes IgE." []
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000951
name: IgE short lived plasma cell
namespace: cell
def: "A short lived plasma cell that secretes IgE." []
is_a: CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000952
name: preBCR-positive large pre-B-II cell
namespace: cell
def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." []
is_a: CL:0000957 ! large pre-B-II cell
relationship: has_part GO:0035369
relationship: has_part PR:000001858
relationship: has_part PR:000001859

[Term]
id: CL:0000953
name: preBCR-negative large pre-B-II cell
namespace: cell
def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." []
is_a: CL:0000957 ! large pre-B-II cell

[Term]
id: CL:0000954
name: small pre-B-II cell
namespace: cell
def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." []
comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
synonym: "small pre-BII cell" EXACT []
is_a: CL:0000955 ! pre-B-II cell
relationship: has_part PR:000003457
relationship: has_part PR:000003460

[Term]
id: CL:0000955
name: pre-B-II cell
namespace: cell
def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." []
comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive.
synonym: "pre-B-lymphocyte" EXACT []
synonym: "pre-BII cell" EXACT []
xref: BTO:0001133
xref: CALOHA:TS-0819
is_a: CL:0000817 ! precursor B cell
disjoint_from: CL:0000956 ! pre-B-I cell

[Term]
id: CL:0000956
name: pre-B-I cell
namespace: cell
def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." []
comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive.
synonym: "pre-BI cell" EXACT []
synonym: "pro-B cell (Philadelphia nomenclature)" RELATED []
is_a: CL:0000817 ! precursor B cell
relationship: has_part PR:000001003
relationship: has_part PR:000001858
relationship: has_part PR:000001859
relationship: has_part PR:000003457
relationship: has_part PR:000003460
relationship: has_part PR:000006611

[Term]
id: CL:0000957
name: large pre-B-II cell
namespace: cell
def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." []
comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
synonym: "large pre-B cell" BROAD []
synonym: "large pre-BII cell" EXACT []
is_a: CL:0000955 ! pre-B-II cell

[Term]
id: CL:0000958
name: T1 B cell
namespace: cell
def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." []
comment: T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive.
synonym: "T1 B lymphocyte" EXACT []
synonym: "T1 B-cell" EXACT []
synonym: "T1 B-lymphocyte" EXACT []
synonym: "transitional stage 1 B cell" EXACT []
is_a: CL:0000818 ! transitional stage B cell
relationship: has_part PR:000002037

[Term]
id: CL:0000959
name: T2 B cell
namespace: cell
def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." []
comment: T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive.
synonym: "T2 B lymphocyte" EXACT []
synonym: "T2 B-cell" EXACT []
synonym: "T2 B-lymphocyte" EXACT []
synonym: "transitional stage 2 B cell" EXACT []
is_a: CL:0000818 ! transitional stage B cell
relationship: develops_from CL:0000958 ! T1 B cell
relationship: has_part GO:0071738
relationship: has_part PR:000001338
relationship: has_part PR:000001880
relationship: has_part PR:000002037

[Term]
id: CL:0000960
name: T3 B cell
namespace: cell
def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." []
synonym: "An1 B cell" EXACT []
synonym: "T3 B lymphocyte" EXACT []
synonym: "T3 B-cell" EXACT []
synonym: "T3 B-lymphocyte" EXACT []
synonym: "transitional stage 3 B cell" EXACT []
is_a: CL:0000818 ! transitional stage B cell
relationship: develops_from CL:0000959 ! T2 B cell
relationship: has_part GO:0071738
relationship: has_part PR:000001318
relationship: has_part PR:000001338
relationship: has_part PR:000001880

[Term]
id: CL:0000961
name: Bm1 B cell
namespace: cell
def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." []
comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm1 B lymphocyte" EXACT []
synonym: "Bm1 B-cell" EXACT []
synonym: "Bm1 B-lymphocyte" EXACT []
is_a: CL:0000843 ! follicular B cell
is_a: CL:0002056 ! Fraction F mature B cell

[Term]
id: CL:0000962
name: Bm2 B cell
namespace: cell
def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." []
comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm2 B lymphocyte" EXACT []
synonym: "Bm2 B-cell" EXACT []
synonym: "Bm2 B-lymphocyte" EXACT []
is_a: CL:0000843 ! follicular B cell
relationship: develops_from CL:0000961 ! Bm1 B cell
relationship: has_part PR:000001408
relationship: has_part PR:000001880

[Term]
id: CL:0000963
name: Bm3-delta B cell
namespace: cell
def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." []
synonym: "Bm3-delta B lymphocyte" EXACT []
synonym: "Bm3-delta B-cell" EXACT []
synonym: "Bm3-delta B-lymphocyte" EXACT []
is_a: CL:0000844 ! germinal center B cell
relationship: develops_from CL:0000965 ! Bm3 B cell
relationship: has_part GO:0071738
relationship: has_part PR:000001408

[Term]
id: CL:0000964
name: Bm2' B cell
namespace: cell
def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." []
comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm2' B lymphocyte" EXACT []
synonym: "Bm2' B-cell" EXACT []
synonym: "Bm2-prime B cell" EXACT []
synonym: "Bm2-prime B-lymphocyte" EXACT []
synonym: "germinal center founder cell" RELATED []
is_a: CL:0000844 ! germinal center B cell
relationship: capable_of GO:0002634
relationship: develops_from CL:0000962 ! Bm2 B cell
relationship: has_part GO:0071738
relationship: has_part PR:000001408

[Term]
id: CL:0000965
name: Bm3 B cell
namespace: cell
def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." []
comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive.
synonym: "Bm3 B lymphocyte" EXACT []
synonym: "Bm3 B-cell" EXACT []
synonym: "Bm3 B-lymphocyte" EXACT []
synonym: "centroblast" RELATED []
is_a: CL:0000844 ! germinal center B cell
relationship: capable_of GO:0016446
relationship: develops_from CL:0000964 ! Bm2' B cell
relationship: has_part PR:000001408
relationship: has_part PR:000003516

[Term]
id: CL:0000966
name: Bm4 B cell
namespace: cell
def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." []
comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive.
synonym: "Bm4 B lymphocyte" EXACT []
synonym: "Bm4 B-cell" EXACT []
synonym: "Bm4 B-lymphocyte" EXACT []
synonym: "centrocyte" RELATED []
is_a: CL:0000844 ! germinal center B cell
relationship: develops_from CL:0000963 ! Bm3-delta B cell
relationship: has_part PR:000001408

[Term]
id: CL:0000967
name: Bm5 B cell
namespace: cell
def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." []
comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative.
synonym: "Bm5 B lymphocyte" EXACT []
synonym: "Bm5 B-cell" EXACT []
synonym: "Bm5 B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
relationship: develops_from CL:0000966 ! Bm4 B cell

[Term]
id: CL:0000968
name: Be cell
namespace: cell
def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." []
synonym: "B effector cell" EXACT []
synonym: "effector B cell" EXACT []
synonym: "effector B lymphocyte" EXACT []
synonym: "effector B-cell" EXACT []
synonym: "effector B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
relationship: capable_of GO:0001816
relationship: capable_of GO:0043370
relationship: has_part PR:000001289

[Term]
id: CL:0000969
name: regulatory B cell
namespace: cell
def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." []
comment: Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive.
synonym: "B(reg)" EXACT []
synonym: "B10 cell" EXACT []
synonym: "Breg" EXACT []
synonym: "regulatory B lymphocyte" EXACT []
synonym: "regulatory B-cell" EXACT []
synonym: "regulatory B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
relationship: capable_of GO:0032613
relationship: capable_of GO:0050777 ! negative regulation of immune response
relationship: has_part PR:000001289
relationship: has_part PR:000002028

[Term]
id: CL:0000970
name: unswitched memory B cell
namespace: cell
def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive.
synonym: "IgD+ memory B cell" BROAD []
synonym: "unswitched memory B lymphocyte" EXACT []
synonym: "unswitched memory B-cell" EXACT []
synonym: "unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000787 ! memory B cell
relationship: develops_from CL:0000980 ! plasmablast
relationship: has_part GO:0071738
relationship: has_part GO:0071753

[Term]
id: CL:0000971
name: IgM memory B cell
namespace: cell
def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." []
comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive.
synonym: "IgM memory B lymphocyte" EXACT []
synonym: "IgM memory B-cell" EXACT []
synonym: "IgM memory B-lymphocyte" EXACT []
synonym: "memory IgM B cell" EXACT []
synonym: "memory IgM B lymphocyte" EXACT []
synonym: "memory IgM B-cell" EXACT []
synonym: "memory IgM B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
relationship: has_part GO:0071753

[Term]
id: CL:0000972
name: class switched memory B cell
namespace: cell
def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." []
comment: Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive.
synonym: "class switched memory B lymphocyte" EXACT []
synonym: "class switched memory B-cell" EXACT []
synonym: "class switched memory B-lymphocyte" EXACT []
is_a: CL:0000787 ! memory B cell
relationship: develops_from CL:0000970 ! unswitched memory B cell

[Term]
id: CL:0000973
name: IgA memory B cell
namespace: cell
def: "A class switched memory B cell that expresses IgA." []
comment: IgA memory B cell are also reportedly RORalpha-positive.
synonym: "IgA memory B lymphocyte" EXACT []
synonym: "IgA memory B-cell" EXACT []
synonym: "IgA memory B-lymphocyte" EXACT []
synonym: "memory IgA B cell" EXACT []
synonym: "memory IgA B lymphocyte" EXACT []
synonym: "memory IgA B-cell" EXACT []
synonym: "memory IgA B-lymphocyte" EXACT []
is_a: CL:0000972 ! class switched memory B cell
relationship: has_part GO:0071745

[Term]
id: CL:0000974
name: long lived plasma cell
namespace: cell
def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." []
is_a: CL:0000786 ! plasma cell
relationship: develops_from CL:0000975 ! short lived plasma cell
relationship: has_part PR:000001002
relationship: has_part PR:000001208
relationship: has_part PR:000001935

[Term]
id: CL:0000975
name: short lived plasma cell
namespace: cell
def: "A fully differentiated plasma cell that lives for months." []
is_a: CL:0000786 ! plasma cell

[Term]
id: CL:0000976
name: IgA short lived plasma cell
namespace: cell
def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." []
is_a: CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000977
name: IgG short lived plasma cell
namespace: cell
def: "A short lived plasma cell that secretes IgG." []
is_a: CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000978
name: IgM short lived plasma cell
namespace: cell
def: "A short lived plasma cell that secretes IgM." []
is_a: CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000979
name: IgG memory B cell
namespace: cell
def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." []
synonym: "IgG memory B lymphocyte" EXACT []
synonym: "IgG memory B-cell" EXACT []
synonym: "IgG memory B-lymphocyte" EXACT []
synonym: "memory IgG B cell" EXACT []
synonym: "memory IgG B lymphocyte" EXACT []
synonym: "memory IgG B-cell" EXACT []
synonym: "memory IgG B-lymphocyte" EXACT []
is_a: CL:0000972 ! class switched memory B cell
relationship: has_part GO:0071735

[Term]
id: CL:0000980
name: plasmablast
namespace: cell
def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative.
xref: FMA:84371
is_a: CL:0000785 ! mature B cell
is_a: CL:0000946 ! antibody secreting cell
relationship: develops_from CL:0000785 ! mature B cell
relationship: has_part PR:000001408
relationship: has_part PR:000001963

[Term]
id: CL:0000981
name: double negative memory B cell
namespace: cell
def: "A memory B cell with the phenotype IgD-negative and CD27-negative." []
synonym: "dn memory B cell" EXACT []
synonym: "dn memory B lymphocyte" EXACT []
synonym: "dn memory B-cell" EXACT []
synonym: "dn memory B-lymphocyte" EXACT []
synonym: "double negative memory B lymphocyte" EXACT []
synonym: "double negative memory B-cell" EXACT []
synonym: "double negative memory B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell

[Term]
id: CL:0000982
name: IgG plasmablast
namespace: cell
def: "A plasmablast that secretes IgG." []
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000983
name: IgM plasmablast
namespace: cell
def: "A plasmablast that secretes IgM." []
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000984
name: IgA plasmablast
namespace: cell
def: "A plasmablast that secretes IgA." []
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000985
name: IgG plasma cell
namespace: cell
def: "A fully differentiated plasma cell that secretes IgG." []
is_a: CL:0000974 ! long lived plasma cell

[Term]
id: CL:0000986
name: IgM plasma cell
namespace: cell
def: "A fully differentiated plasma cell that secretes IgM." []
is_a: CL:0000974 ! long lived plasma cell

[Term]
id: CL:0000987
name: IgA plasma cell
namespace: cell
def: "A fully differentiated plasma cell that secretes IgA." []
is_a: CL:0000974 ! long lived plasma cell

[Term]
id: CL:0000988
name: hematopoietic cell
namespace: cell
def: "A cell of a hematopoietic lineage." []
synonym: "haematopoietic cell" EXACT []
synonym: "haemopoietic cell" EXACT []
synonym: "hemopoietic cell" EXACT []
xref: BTO:0000574
xref: CALOHA:TS-2017
xref: FMA:70366
xref: FMA:83598
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000989
name: CD11c-low plasmacytoid dendritic cell
namespace: cell
def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8).
is_a: CL:0000784 ! plasmacytoid dendritic cell
relationship: has_part PR:000001013
relationship: has_part PR:000001014
relationship: has_part PR:000002978

[Term]
id: CL:0000990
name: conventional dendritic cell
namespace: cell
def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive.
synonym: "cDC" EXACT []
synonym: "DC1" EXACT []
synonym: "dendritic reticular cell" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "type 1 DC" EXACT []
synonym: "veiled cell" BROAD []
xref: FMA:84191
is_a: CL:0000451 ! dendritic cell
relationship: has_part PR:000001013

[Term]
id: CL:0000991
name: CD11c-negative plasmacytoid dendritic cell
namespace: cell
def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10).
synonym: "CD303-positive dendritic cell" EXACT []
is_a: CL:0000784 ! plasmacytoid dendritic cell
relationship: has_part PR:000001014
relationship: has_part PR:000001292
relationship: has_part PR:000001398
relationship: has_part PR:000001865

[Term]
id: CL:0000992
name: immature CD11c-low plasmacytoid dendritic cell
namespace: cell
def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617).
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
relationship: develops_from CL:0001029 ! common dendritic progenitor
relationship: has_part PR:000001412
relationship: has_part PR:000001438

[Term]
id: CL:0000993
name: mature CD11c-low plasmacytoid dendritic cell
namespace: cell
def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617).
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
relationship: develops_from CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell
relationship: has_part GO:0042613
relationship: has_part PR:000001310
relationship: has_part PR:000001412
relationship: has_part PR:000001438

[Term]
id: CL:0000994
name: immature CD11c-negative plasmacytoid dendritic cell
namespace: cell
def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617).
is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell
relationship: develops_from CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
relationship: has_part GO:0042613
relationship: has_part PR:000001412

[Term]
id: CL:0000995
name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617).
synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD []
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor

[Term]
id: CL:0000996
name: mature CD11c-negative plasmacytoid dendritic cell
namespace: cell
def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617).
is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell
relationship: develops_from CL:0000994 ! immature CD11c-negative plasmacytoid dendritic cell
relationship: has_part GO:0042613
relationship: has_part PR:000001310
relationship: has_part PR:000001412
relationship: has_part PR:000001438

[Term]
id: CL:0000997
name: immature CD8_alpha-negative CD11b-positive dendritic cell
namespace: cell
def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0000999 ! CD4-positive CD11b-positive dendritic cell

[Term]
id: CL:0000998
name: CD8_alpha-negative CD11b-negative dendritic cell
namespace: cell
def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." []
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617).
synonym: "DC.8-4-11b-" EXACT []
synonym: "triple negative dendritic cell" EXACT []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
relationship: capable_of GO:0002474
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_part PR:000001026

[Term]
id: CL:0000999
name: CD4-positive CD11b-positive dendritic cell
namespace: cell
def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative." []
comment: Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617).
synonym: "DC.4+" EXACT []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0002465 ! CD11b-positive dendritic cell
relationship: capable_of GO:0050728 ! negative regulation of inflammatory response
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_part PR:000001004

[Term]
id: CL:0001000
name: CD8_alpha-positive CD11b-negative dendritic cell
namespace: cell
def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive." []
comment: Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617).
synonym: "DC.8+" EXACT []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
relationship: capable_of GO:0042590
relationship: capable_of GO:0050729 ! positive regulation of inflammatory response
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_part PR:000001026
relationship: has_part PR:000001084

[Term]
id: CL:0001001
name: immature CD8_alpha-negative CD11b-negative dendritic cell
namespace: cell
def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." []
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell

[Term]
id: CL:0001002
name: mature CD8_alpha-negative CD11b-negative dendritic cell
namespace: cell
def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." []
comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell
relationship: develops_from CL:0001001 ! immature CD8_alpha-negative CD11b-negative dendritic cell

[Term]
id: CL:0001003
name: mature CD8_alpha-negative CD11b-positive dendritic cell
namespace: cell
def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0000999 ! CD4-positive CD11b-positive dendritic cell
relationship: develops_from CL:0000997 ! immature CD8_alpha-negative CD11b-positive dendritic cell

[Term]
id: CL:0001004
name: immature CD8_alpha-positive CD11b-negative dendritic cell
namespace: cell
def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell

[Term]
id: CL:0001005
name: mature CD8_alpha-positive CD11b-negative dendritic cell
namespace: cell
def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell
relationship: develops_from CL:0001004 ! immature CD8_alpha-positive CD11b-negative dendritic cell

[Term]
id: CL:0001006
name: dermal dendritic cell
namespace: cell
def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9).
xref: BTO:0004812
is_a: CL:0002465 ! CD11b-positive dendritic cell
relationship: has_part PR:000001026
relationship: has_part PR:000001084
relationship: part_of UBERON:0002067 ! dermis

[Term]
id: CL:0001007
name: interstitial dendritic cell
namespace: cell
def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10).
is_a: CL:0002465 ! CD11b-positive dendritic cell
relationship: has_part PR:000001300
relationship: has_part PR:000001905
relationship: has_part PR:000002025
relationship: has_part PR:000002972

[Term]
id: CL:0001008
name: Kit and Sca1-positive hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." []
comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617).
synonym: "LSK stem cell" EXACT []
synonym: "Sca1-positive hematopoietic stem cell" EXACT []
is_a: CL:0000037 ! hematopoietic stem cell
disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell
relationship: has_part PR:000001833
relationship: has_part PR:000002065
relationship: has_part PR:000002979

[Term]
id: CL:0001009
name: immature dermal dendritic cell
namespace: cell
def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001006 ! dermal dendritic cell

[Term]
id: CL:0001010
name: mature dermal dendritic cell
namespace: cell
def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001006 ! dermal dendritic cell
relationship: develops_from CL:0001009 ! immature dermal dendritic cell

[Term]
id: CL:0001011
name: immature interstitial dendritic cell
namespace: cell
def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001007 ! interstitial dendritic cell

[Term]
id: CL:0001012
name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617).
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0000557 ! granulocyte monocyte progenitor cell
union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell

[Term]
id: CL:0001013
name: mature interstitial dendritic cell
namespace: cell
def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001007 ! interstitial dendritic cell
relationship: develops_from CL:0001011 ! immature interstitial dendritic cell

[Term]
id: CL:0001014
name: CD1a-positive Langerhans cell
namespace: cell
def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." []
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15.
synonym: "CD1a-LC" EXACT []
is_a: CL:0000453 ! Langerhans cell
relationship: has_part PR:000001447
relationship: has_part PR:000002025

[Term]
id: CL:0001015
name: CD8_alpha-low Langerhans cell
namespace: cell
def: "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low." []
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9).
is_a: CL:0000453 ! Langerhans cell
relationship: has_part PR:000001026
relationship: has_part PR:000001084

[Term]
id: CL:0001016
name: immature CD1a-positive Langerhans cell
namespace: cell
def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001014 ! CD1a-positive Langerhans cell

[Term]
id: CL:0001017
name: mature CD1a-positive Langerhans cell
namespace: cell
def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." []
comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15.
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001014 ! CD1a-positive Langerhans cell
relationship: develops_from CL:0001016 ! immature CD1a-positive Langerhans cell

[Term]
id: CL:0001018
name: immature CD8_alpha-low Langerhans cell
namespace: cell
def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." []
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001015 ! CD8_alpha-low Langerhans cell

[Term]
id: CL:0001019
name: CD115-positive monocyte OR common dendritic progenitor
namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617).
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
union_of: CL:0001022 ! CD115-positive monocyte
union_of: CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0001020
name: mature CD8_alpha-low Langerhans cell
namespace: cell
def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." []
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001015 ! CD8_alpha-low Langerhans cell
relationship: develops_from CL:0001018 ! immature CD8_alpha-low Langerhans cell

[Term]
id: CL:0001021
name: CD34-positive, CD38-positive common lymphoid progenitor
namespace: cell
def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." []
comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617).
synonym: "CD10-positive common lymphocyte precursor" EXACT []
synonym: "CD10-positive common lymphocyte progenitor" EXACT []
synonym: "CD10-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor
relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: has_part PR:000001003
relationship: has_part PR:000001015
relationship: has_part PR:000001408
relationship: has_part PR:000001898

[Term]
id: CL:0001022
name: CD115-positive monocyte
namespace: cell
def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." []
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617).
is_a: CL:0000576 ! monocyte
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor
relationship: has_part PR:000001012
relationship: has_part PR:000002062

[Term]
id: CL:0001023
name: Kit-positive, CD34-positive common myeloid progenitor
namespace: cell
def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." []
comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617).
synonym: "CD117-positive common myeloid precursor" BROAD []
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
is_a: CL:0001059 ! common myeloid progenitor, CD34-positive
disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell
relationship: has_part GO:0033001
relationship: has_part PR:000001481
relationship: has_part PR:000002065

[Term]
id: CL:0001024
name: CD34-positive, CD38-negative hematopoietic stem cell
namespace: cell
def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." []
comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617).
synonym: "CD133-positive hematopoietic stem cell" EXACT []
xref: CALOHA:TS-0448
xref: FMA:86475
is_a: CL:0000037 ! hematopoietic stem cell
relationship: has_part PR:000001003
relationship: has_part PR:000001786
relationship: has_part PR:000001809
relationship: has_part PR:000001843

[Term]
id: CL:0001025
name: Kit-positive, Sca1-positive common lymphoid progenitor
namespace: cell
def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." []
comment: Markers are associated with mouse cells.
synonym: "CD217-positive common lymphocyte precursor" EXACT []
synonym: "CD217-positive common lymphocyte progenitor" EXACT []
synonym: "CD217-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
relationship: develops_from CL:0000936 ! early lymphoid progenitor
relationship: has_part PR:000001869
relationship: has_part PR:000001963
relationship: has_part PR:000002001
relationship: has_part PR:000002037
relationship: has_part PR:000002065
relationship: has_part PR:000002979

[Term]
id: CL:0001026
name: CD34-positive, CD38-positive common myeloid progenitor
namespace: cell
def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." []
comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617).
synonym: "CD71-positive common myeloid precursor" NARROW []
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
is_a: CL:0001059 ! common myeloid progenitor, CD34-positive
relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: has_part PR:000001408
relationship: has_part PR:000001865

[Term]
id: CL:0001027
name: CD7-negative lymphoid progenitor cell
namespace: cell
def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." []
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).
synonym: "CD7-negative lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
relationship: develops_from CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
relationship: has_part PR:000001003

[Term]
id: CL:0001028
name: CD7-positive lymphoid progenitor cell
namespace: cell
def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." []
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617).
synonym: "CD7-positive lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
relationship: develops_from CL:0001027 ! CD7-negative lymphoid progenitor cell
relationship: has_part PR:000001003
relationship: has_part PR:000001836

[Term]
id: CL:0001029
name: common dendritic progenitor
namespace: cell
def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." []
comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617).
synonym: "CDP" EXACT []
synonym: "common dendritic precursor" EXACT []
synonym: "pro-DCs" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor
relationship: has_part PR:000002001
relationship: has_part PR:000002062
relationship: has_part PR:000002065

[Term]
id: CL:0001030
name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617).
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor
union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor

[Term]
id: CL:0001031
name: cerebellar granule cell
namespace: cell
def: "Granule cell that is part of the cerebellum." []
xref: BTO:0004278
is_a: CL:0000120 ! granule cell
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0002037 ! cerebellum

[Term]
id: CL:0001032
name: cortical granule cell
namespace: cell
def: "Granule cell that is part of the cerebral cortex." []
is_a: CL:0000120 ! granule cell
is_a: CL:0002609 ! neuron of cerebral cortex
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0000956 ! cerebral cortex

[Term]
id: CL:0001033
name: hippocampal granule cell
namespace: cell
def: "Granule cell that is part of the hippocampus." []
is_a: CL:0001032 ! cortical granule cell
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0001954 ! Ammon's horn

[Term]
id: CL:0001034
name: cell in vitro
namespace: cell
def: "A cell that is maintained or propagated in a controlled artificial environment for use in an investigation." []
comment: 'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells.
is_a: CL:0000000 ! cell
is_a: GO:0005623 ! cell
created_by: haendel
creation_date: 2012-01-12T09:58:38Z

[Term]
id: CL:0001035
name: bone cell
namespace: cell
def: "A connective tissue cell found in bone." []
is_a: BFO:0000002
is_a: CL:0000548 ! animal cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0001474 ! bone element
created_by: adiehl
creation_date: 2011-11-16T04:28:16Z

[Term]
id: CL:0001039
name: terminally differentiated osteoblast
namespace: cl
def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." []
xref: VSAO:0000116
is_a: CL:0000062 ! osteoblast

[Term]
id: CL:0001040
name: non-terminally differentiated osteoblast
namespace: cl
def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." []
comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118
xref: VSAO:0000117
is_a: CL:0000062 ! osteoblast
is_a: CL:0001035 ! bone cell
relationship: part_of UBERON:0002481 ! bone tissue

[Term]
id: CL:0001041
name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." []
comment: These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction.
synonym: "CD8+CXCR3+ T cell" EXACT []
synonym: "CD8+CXCR3+ T lymphocyte" EXACT []
synonym: "CD8+CXCR3+ T(reg)" EXACT []
synonym: "CD8+CXCR3+ T-cell" EXACT []
synonym: "CD8+CXCR3+ Treg" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT []
synonym: "CD8-positive, CXCR3-positive, Treg" EXACT []
is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
intersection_of: capable_of GO:0032613
intersection_of: capable_of GO:0032689
intersection_of: capable_of GO:0042130
intersection_of: has_part PR:000001207
relationship: capable_of GO:0032613
relationship: capable_of GO:0032689
relationship: capable_of GO:0042130
relationship: has_part PR:000001207

[Term]
id: CL:0001042
name: T-helper 22 cell
namespace: cell
def: "CD4-positive, alpha-beta T cell that produces IL-22." []
comment: TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13.
synonym: "helper T cell type 22" EXACT []
synonym: "T(H)-22 cell" EXACT []
synonym: "Th22 cell" EXACT []
synonym: "Th22 T cell" EXACT []
synonym: "Th22 T lymphocyte" EXACT []
synonym: "Th22 T-cell" EXACT []
synonym: "Th22 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: capable_of GO:0032626
relationship: capable_of GO:0032626

[Term]
id: CL:0001043
name: activated CD4-positive, alpha-beta T cell, human
namespace: cell
def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells.  The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II.
synonym: "activated CD4+ T cell" BROAD []
synonym: "activated CD4-positive, alpha-beta T lymphocyte, human" EXACT []
synonym: "activated CD4-positive, alpha-beta T-cell, human" EXACT []
synonym: "activated CD4-positive, alpha-beta T-lymphocyte, human" EXACT []
is_a: CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_part PR:000001408
relationship: has_part PR:000002015

[Term]
id: CL:0001044
name: effector CD4-positive, alpha-beta T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'.  The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy.
synonym: "effector CD4+ T cell" BROAD []
synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector CD4-positive, alpha-beta T-cell" EXACT []
synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000911 ! effector T cell
relationship: has_part PR:000001015

[Term]
id: CL:0001045
name: naive CCR4-positive regulatory T cell
namespace: cell
def: "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'.  The definition is valid for human; its applicability for mouse and other species is unknown.
synonym: "naive CCR4+ Treg" EXACT []
synonym: "naive CCR4-positive regulatory T lymphocyte" EXACT []
synonym: "naive CCR4-positive regulatory T-cell" EXACT []
synonym: "naive CCR4-positive regulatory T-lymphocyte" EXACT []
is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
is_a: CL:0002677 ! naive regulatory T cell

[Term]
id: CL:0001046
name: memory CCR4-positive regulatory T cell
namespace: cell
def: "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'.  The definition is valid for human; its applicability for mouse and other species is unknown.
synonym: "memory CCR4+ Treg" EXACT []
synonym: "memory CCR4-positive regulatory T lymphocyte" EXACT []
synonym: "memory CCR4-positive regulatory T-cell" EXACT []
synonym: "memory CCR4-positive regulatory T-lymphocyte" EXACT []
is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
is_a: CL:0002678 ! memory regulatory T cell

[Term]
id: CL:0001047
name: CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'.  The definition is valid for human; its applicability for mouse and other species is unknown.
synonym: "CCR+ Treg" EXACT []
synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
relationship: has_part PR:000001200

[Term]
id: CL:0001048
name: activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human
namespace: cell
def: "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'.  The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II.
synonym: "activated CCR4+ Treg" EXACT []
synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
relationship: has_part PR:000002015

[Term]
id: CL:0001049
name: activated CD8-positive, alpha-beta T cell, human
namespace: cell
def: "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells.  The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II.
synonym: "activated CD8+ T cell" BROAD []
synonym: "activated CD8-positive, alpha-beta T lymphocyte, human" EXACT []
synonym: "activated CD8-positive, alpha-beta T-cell, human" EXACT []
synonym: "activated CD8-positive, alpha-beta T-lymphocyte, human" EXACT []
is_a: CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_part PR:000001408
relationship: has_part PR:000002015

[Term]
id: CL:0001050
name: effector CD8-positive, alpha-beta T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'.  The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy.
synonym: "effector CD8+ T cell" BROAD []
synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector CD8-positive, alpha-beta T-cell" EXACT []
synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000911 ! effector T cell
relationship: has_part PR:000001015

[Term]
id: CL:0001051
name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'.  Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells.
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT []
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT []
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT []
synonym: "non-Th1/Th17 CD4+ T cell" BROAD []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell

[Term]
id: CL:0001052
name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'.  Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells.
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT []
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT []
synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell

[Term]
id: CL:0001053
name: IgD-negative memory B cell
namespace: cell
def: "A memory B cell that lacks expression of surface IgD." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'.  The majority of these cells are class-switched, though some are IgM-positive.
synonym: "IgD- memory B cell" EXACT []
is_a: CL:0000787 ! memory B cell

[Term]
id: CL:0001054
name: CD14-positive monocyte
namespace: cell
def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes.
synonym: "monocyte" NARROW []
is_a: CL:0000576 ! monocyte
relationship: has_part PR:000001889

[Term]
id: CL:0001055
name: CD14-positive, CD16-low monocyte
namespace: cell
def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." []
comment: Definition is valid for human intermediate monocytes.
synonym: "intermediate monocyte, human" EXACT []
is_a: CL:0002393 ! intermediate monocyte
is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte
relationship: has_part PR:000001483

[Term]
id: CL:0001056
name: dendritic cell, human
namespace: cell
def: "A dendritic cell with the phenotype HLA-DRA-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells.
synonym: "dendritic cell" BROAD []
is_a: CL:0000451 ! dendritic cell
relationship: has_part PR:000002015

[Term]
id: CL:0001057
name: myeloid dendritic cell, human
namespace: cell
def: "A myeloid dendritic cell with the phenotype HLA-DRA-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells.
synonym: "myeloid dendritic cell" BROAD []
is_a: CL:0000782 ! myeloid dendritic cell
is_a: CL:0001056 ! dendritic cell, human

[Term]
id: CL:0001058
name: plasmacytoid dendritic cell, human
namespace: cell
def: "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells.
synonym: "plasmacytoid dendritic cell" BROAD []
is_a: CL:0000784 ! plasmacytoid dendritic cell
is_a: CL:0001056 ! dendritic cell, human
relationship: has_part PR:000001865

[Term]
id: CL:0001059
name: common myeloid progenitor, CD34-positive
namespace: cell
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." []
comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
synonym: "CFU-GEMM" RELATED []
synonym: "CFU-S" RELATED []
synonym: "CMP" BROAD []
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED []
synonym: "common myeloid precursor, CD34-positive" EXACT []
synonym: "multipotential myeloid stem cell" RELATED []
synonym: "myeloid stem cell" RELATED []
synonym: "pluripotent stem cell (bone marrow)" RELATED []
is_a: CL:0000049 ! common myeloid progenitor
is_a: CL:0011115 ! precursor cell
relationship: capable_of GO:0043011
relationship: has_part PR:000001003
relationship: has_part PR:000001944
relationship: has_part PR:000005307
relationship: has_part PR:000007857
relationship: has_part PR:000007858

[Term]
id: CL:0001060
name: hematopoietic oligopotent progenitor cell, lineage-negative
namespace: cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." []
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
created_by: tmeehan
creation_date: 2010-01-06T03:43:27Z

[Term]
id: CL:0001061
name: abnormal cell
namespace: cell
def: "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." []
comment: https://github.com/obophenotype/cell-ontology/issues/448
xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913
is_a: CL:0000000 ! cell
is_a: GO:0005623 ! cell
relationship: dc-creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T18:53:32Z xsd:dateTime

[Term]
id: CL:0001062
name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated
namespace: cell
def: "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." []
comment: This cell type is seen human but not found in the mouse.
synonym: "TEMRA" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
relationship: develops_from CL:0000913 ! effector memory CD8-positive, alpha-beta T cell
relationship: has_part PR:000001015

[Term]
id: CL:0001063
name: neoplastic cell
namespace: cell
def: "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." []
comment: https://github.com/obophenotype/cell-ontology/issues/448
synonym: "tumor cell" RELATED []
synonym: "tumour cell" RELATED []
xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922
is_a: CL:0001061 ! abnormal cell
relationship: dc-creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T19:16:26Z xsd:dateTime

[Term]
id: CL:0001064
name: malignant cell
namespace: cell
def: "A neoplastic cell that is capable of entering a surrounding tissue" []
comment: https://github.com/obophenotype/cell-ontology/issues/448
synonym: "cancer cell" RELATED []
xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917
is_a: CL:0001063 ! neoplastic cell
relationship: dc-creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T19:39:12Z xsd:dateTime

[Term]
id: CL:0001065
name: innate lymphoid cell
namespace: cell
def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." []
is_a: CL:0000542 ! lymphocyte
relationship: capable_of GO:0001816
relationship: capable_of GO:0045087
relationship: dc-creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:20:48Z xsd:dateTime

[Term]
id: CL:0001066
name: erythroid progenitor cell, mammalian
namespace: cell
def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." []
synonym: "BFU-E" RELATED []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000038 ! erythroid progenitor cell
relationship: capable_of GO:0030218
relationship: has_part PR:000001945

[Term]
id: CL:0001067
name: group 1 innate lymphoid cell
namespace: cell
def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: capable_of GO:0032609
relationship: capable_of GO:0032609
relationship: dc-creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:42:44Z xsd:dateTime

[Term]
id: CL:0001068
name: ILC1
namespace: cell
def: "A group 1 innate lymphoid cell that is non-cytotoxic." []
is_a: CL:0001067 ! group 1 innate lymphoid cell
relationship: dc-creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:54:12Z xsd:dateTime

[Term]
id: CL:0001069
name: group 2 innate lymphoid cell
namespace: cell
def: "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." []
synonym: "ILC2" EXACT []
synonym: "nuocyte" EXACT []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: capable_of GO:0032634
relationship: capable_of GO:0032634
relationship: dc-creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T21:20:08Z xsd:dateTime

[Term]
id: CL:0001070
name: beige adipocyte
namespace: cell
def: "A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." []
synonym: "beige brown adipocyte" EXACT []
synonym: "beige fat cell" EXACT []
synonym: "beige/brite adipocyte" EXACT []
synonym: "brite adipocyte" EXACT []
synonym: "brite cell" EXACT []
synonym: "brite fat cell" EXACT []
is_a: CL:0000136 ! fat cell
relationship: part_of UBERON:0001347 ! white adipose tissue

[Term]
id: CL:0001071
name: group 3 innate lymphoid cell
namespace: cell
def: "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." []
synonym: "ILC3" EXACT []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: has_part PR:000003455
relationship: dc-creator http://orcid.org/0000-0001-9990-8331
relationship: has_part PR:000003455
property_value: http://purl.org/dc/elements/1.1/date 2017-01-31T20:21:26Z xsd:dateTime

[Term]
id: CL:0001658
name: visual pigment cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004230
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0002000
name: Kit-positive erythroid progenitor cell
namespace: cell
def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." []
comment: Markers found on mouse cells.
synonym: "c- Kit-positive erythroid progenitor cell" EXACT []
is_a: CL:0001066 ! erythroid progenitor cell, mammalian
relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
relationship: has_part PR:000001345
relationship: has_part PR:000002065
created_by: tmeehan
creation_date: 2010-04-26T10:14:16Z

[Term]
id: CL:0002001
name: CD34-positive, CD38-positive granulocyte monocyte progenitor
namespace: cell
def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." []
comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population.
is_a: CL:0000557 ! granulocyte monocyte progenitor cell
relationship: develops_from CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
relationship: has_part PR:000001003
relationship: has_part PR:000001408
created_by: tmeehan
creation_date: 2010-01-13T03:19:22Z

[Term]
id: CL:0002002
name: Kit-positive granulocyte monocyte progenitor
namespace: cell
def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." []
comment: Markers are found on mouse cells.
is_a: CL:0000557 ! granulocyte monocyte progenitor cell
relationship: develops_from CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor
relationship: has_part GO:0033001
relationship: has_part PR:000001003
relationship: has_part PR:000001479
relationship: has_part PR:000002065
created_by: tmeehan
creation_date: 2010-01-13T03:19:28Z

[Term]
id: CL:0002003
name: CD34-positive, GlyA-negative erythroid progenitor cell
namespace: cell
def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." []
comment: Cell markers associated with human cells.
xref: FMA:83517
is_a: CL:0001066 ! erythroid progenitor cell, mammalian
relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
relationship: has_part PR:000001003
created_by: tmeehan
creation_date: 2010-04-26T10:14:30Z

[Term]
id: CL:0002004
name: CD34-negative, GlyA-negative proerythroblast
namespace: cell
def: "A proerythoblast that is CD34-negative and GlyA-negative." []
comment: Cell surface markers are associated with human cells.
is_a: CL:0000547 ! proerythroblast
relationship: develops_from CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell
created_by: tmeehan
creation_date: 2010-04-26T10:31:50Z

[Term]
id: CL:0002005
name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
namespace: cell
def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." []
comment: Markers are associated with human cell type.
is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell
relationship: has_part PR:000001003
relationship: has_part PR:000001408
created_by: tmeehan
creation_date: 2010-01-13T03:43:10Z

[Term]
id: CL:0002006
name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
namespace: cell
def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." []
comment: Markers are associated with mouse cells.
is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell
relationship: has_part GO:0033001
relationship: has_part PR:000002065
created_by: tmeehan
creation_date: 2010-01-13T03:43:12Z

[Term]
id: CL:0002007
name: Kit-low, CD34-positive eosinophil progenitor cell
namespace: cell
def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." []
comment: Markers are found on mouse cells.
is_a: CL:0000611 ! eosinophil progenitor cell
relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor
relationship: has_part PR:000002065
created_by: tmeehan
creation_date: 2010-01-14T03:25:15Z

[Term]
id: CL:0002008
name: CD34-positive, CD38-positive eosinophil progenitor cell
namespace: cell
def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." []
comment: Markers are associated with human cells.
is_a: CL:0000611 ! eosinophil progenitor cell
relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor
relationship: has_part PR:000001015
created_by: tmeehan
creation_date: 2010-01-14T03:25:17Z

[Term]
id: CL:0002009
name: macrophage dendritic cell progenitor
namespace: cell
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." []
synonym: "MDP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030224
intersection_of: capable_of GO:0043011
relationship: capable_of GO:0030224
relationship: capable_of GO:0043011
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
created_by: tmeehan
creation_date: 2010-01-19T02:51:58Z

[Term]
id: CL:0002010
name: pre-conventional dendritic cell
namespace: cell
def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
relationship: develops_from CL:0001029 ! common dendritic progenitor
relationship: has_part PR:000001013
relationship: has_part PR:000001968
relationship: has_part PR:000002001
created_by: tmeehan
creation_date: 2010-01-19T03:39:30Z

[Term]
id: CL:0002011
name: Kit-positive macrophage dendritic cell progenitor
namespace: cell
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." []
comment: Markers are associated with mouse cells.
synonym: "murine MDP" EXACT []
is_a: CL:0002009 ! macrophage dendritic cell progenitor
relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor
relationship: has_part PR:000001206
relationship: has_part PR:000002001
relationship: has_part PR:000002062
relationship: has_part PR:000002065
created_by: tmeehan
creation_date: 2010-01-26T02:43:40Z

[Term]
id: CL:0002012
name: Kit-low proerythroblast
namespace: cell
def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." []
comment: Markers are associated with mouse cells.
is_a: CL:0000547 ! proerythroblast
relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell
relationship: has_part PR:000001945
relationship: has_part PR:000002065
relationship: has_part PR:000002981
created_by: tmeehan
creation_date: 2010-04-26T10:31:56Z

[Term]
id: CL:0002013
name: GlyA-positive basophillic erythroblast
namespace: cell
def: "A basophilic erythroblast that is GlyA-positive." []
comment: Markers are associated with human cells.
is_a: CL:0000549 ! basophilic erythroblast
relationship: develops_from CL:0002004 ! CD34-negative, GlyA-negative proerythroblast
relationship: has_part PR:000001460
created_by: tmeehan
creation_date: 2010-04-26T10:41:15Z

[Term]
id: CL:0002014
name: Kit-negative, Ly-76 high basophilic erythroblast
namespace: cell
def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." []
comment: Cell surface markers are associated with mouse cells.
is_a: CL:0000549 ! basophilic erythroblast
relationship: develops_from CL:0002012 ! Kit-low proerythroblast
relationship: has_part PR:000002981
created_by: tmeehan
creation_date: 2010-04-26T10:41:22Z

[Term]
id: CL:0002015
name: Kit-negative, Ly-76 high polychromatophilic erythroblast
namespace: cell
def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." []
synonym: "late basophilic and polychromatophilic erythroblast" BROAD []
is_a: CL:0000550 ! polychromatophilic erythroblast
relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast
relationship: has_part PR:000002981
created_by: tmeehan
creation_date: 2010-04-26T10:53:11Z

[Term]
id: CL:0002016
name: CD71-low, GlyA-positive polychromatic erythroblast
namespace: cell
def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." []
comment: Cell surface markers are associated with human cells.
is_a: CL:0000550 ! polychromatophilic erythroblast
relationship: develops_from CL:0002013 ! GlyA-positive basophillic erythroblast
relationship: has_part PR:000001460
relationship: has_part PR:000001945
created_by: tmeehan
creation_date: 2010-04-26T10:53:16Z

[Term]
id: CL:0002017
name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts
namespace: cell
def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." []
comment: Cell surface markers associated with mouse cells.
is_a: CL:0000552 ! orthochromatic erythroblast
relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast
relationship: has_part PR:000001945
relationship: has_part PR:000002981
created_by: tmeehan
creation_date: 2010-04-26T11:04:15Z

[Term]
id: CL:0002018
name: CD71-negative, GlyA-positive orthochromatic erythroblast
namespace: cell
def: "An erythroblast that is GlyA-positive and CD71-negative." []
comment: Markers associated with human cells.
is_a: CL:0000552 ! orthochromatic erythroblast
relationship: develops_from CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast
relationship: has_part PR:000001460
created_by: tmeehan
creation_date: 2010-04-26T11:04:21Z

[Term]
id: CL:0002019
name: Ly-76 high reticulocyte
namespace: cell
def: "A reticulocyte that is Ly76-high and is Kit-negative." []
comment: Marker associated with mouse cells.
is_a: CL:0002422 ! enucleated reticulocyte
relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts
relationship: has_part PR:000002981
created_by: tmeehan
creation_date: 2010-04-26T11:37:00Z

[Term]
id: CL:0002020
name: GlyA-positive reticulocytes
namespace: cell
def: "A reticulocyte that is GlyA-positive." []
comment: Markers is associated with human cells.
is_a: CL:0002422 ! enucleated reticulocyte
relationship: develops_from CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast
relationship: has_part PR:000001460
created_by: tmeehan
creation_date: 2010-04-26T11:48:25Z

[Term]
id: CL:0002021
name: GlyA-positive erythrocyte
namespace: cell
def: "An enucleate erythrocyte that is GlyA-positive." []
comment: Marker is associated with human cell types.
is_a: CL:0000595 ! enucleate erythrocyte
relationship: develops_from CL:0002020 ! GlyA-positive reticulocytes
relationship: has_part PR:000001460
created_by: tmeehan
creation_date: 2010-04-26T11:51:22Z

[Term]
id: CL:0002022
name: Ly-76 high positive erythrocyte
namespace: cell
def: "An enucleate erythrocyte that is Lyg-76-high." []
comment: Marker is associated with mouse cell types.
is_a: CL:0000595 ! enucleate erythrocyte
relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte
relationship: has_part PR:000002981
created_by: tmeehan
creation_date: 2010-04-26T11:51:27Z

[Term]
id: CL:0002023
name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell
namespace: cell
def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." []
comment: Markers are associated with human cell type.
is_a: CL:0000553 ! megakaryocyte progenitor cell
relationship: develops_from CL:0002025 ! CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell
relationship: has_part PR:000001003
relationship: has_part PR:000001907
relationship: has_part PR:000009127
created_by: tmeehan
creation_date: 2010-04-26T02:39:09Z

[Term]
id: CL:0002024
name: Kit-positive megakaryocyte progenitor cell
namespace: cell
def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." []
comment: Markers are associated with mouse cells.
is_a: CL:0000553 ! megakaryocyte progenitor cell
relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
relationship: has_part PR:000001479
relationship: has_part PR:000001483
relationship: has_part PR:000002065
relationship: has_part PR:000005178
created_by: tmeehan
creation_date: 2010-04-26T02:39:15Z

[Term]
id: CL:0002025
name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell
namespace: cell
def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." []
comment: Markers are commonly associated with human cells.
is_a: CL:0000553 ! megakaryocyte progenitor cell
relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
relationship: has_part PR:000001003
relationship: has_part PR:000009127
created_by: tmeehan
creation_date: 2010-04-26T03:52:47Z

[Term]
id: CL:0002026
name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell
namespace: cell
def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." []
comment: Markers are commonly associated with human cells.
is_a: CL:0000556 ! megakaryocyte
relationship: develops_from CL:0002023 ! CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell
relationship: has_part PR:000001907
relationship: has_part PR:000009127
created_by: tmeehan
creation_date: 2010-04-26T03:59:22Z

[Term]
id: CL:0002027
name: CD9-positive, CD41-positive megakaryocyte cell
namespace: cell
def: "A megakaryocyte cell with is CD9-positive and CD41-positive." []
comment: Markers are commonly associated with mouse cells.
is_a: CL:0000556 ! megakaryocyte
relationship: develops_from CL:0002024 ! Kit-positive megakaryocyte progenitor cell
relationship: has_part PR:000005178
relationship: has_part PR:000009127
created_by: tmeehan
creation_date: 2010-04-27T10:39:07Z

[Term]
id: CL:0002028
name: basophil mast progenitor cell
namespace: cell
def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" []
comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low.
synonym: "BMCP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
relationship: capable_of GO:0030221
relationship: capable_of GO:0060374
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
relationship: has_part PR:000001867
relationship: has_part PR:000002065
relationship: has_part PR:000005307
relationship: has_part PR:000007857
relationship: has_part PR:000007858
created_by: tmeehan
creation_date: 2010-04-27T12:46:33Z

[Term]
id: CL:0002029
name: Fc-epsilon RIalpha-low mast cell progenitor
namespace: cell
def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." []
is_a: CL:0000831 ! mast cell progenitor
relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell
relationship: has_part PR:000001006
relationship: has_part PR:000002065
relationship: has_part PR:000009143
created_by: tmeehan
creation_date: 2010-04-27T01:22:19Z

[Term]
id: CL:0002030
name: Fc-epsilon RIalpha-high basophil progenitor cell
namespace: cell
def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." []
comment: Markers are associated with mouse cells.
is_a: CL:0000613 ! basophil progenitor cell
relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell
relationship: has_part PR:000001003
created_by: tmeehan
creation_date: 2010-04-27T01:22:32Z

[Term]
id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
namespace: cell
def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." []
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0008001 ! hematopoietic precursor cell
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell
created_by: tmeehan
creation_date: 2010-01-06T03:43:20Z

[Term]
id: CL:0002032
name: hematopoietic oligopotent progenitor cell
namespace: cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." []
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell.  For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0008001 ! hematopoietic precursor cell
relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell
created_by: tmeehan
creation_date: 2010-01-06T03:43:27Z

[Term]
id: CL:0002033
name: short term hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." []
comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low.
synonym: "ST stem cell" EXACT []
synonym: "ST-HSC" EXACT []
is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
relationship: develops_from CL:0002034 ! long term hematopoietic stem cell
relationship: has_part PR:000001003
created_by: tmeehan
creation_date: 2010-01-08T09:19:25Z

[Term]
id: CL:0002034
name: long term hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." []
comment: Markers are associated with mouse cells.
synonym: "LT stem cell" EXACT []
synonym: "LT-HSC" EXACT []
is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
relationship: has_part PR:000001843
created_by: tmeehan
creation_date: 2010-01-08T09:19:28Z

[Term]
id: CL:0002035
name: Slamf1-negative multipotent progenitor cell
namespace: cell
def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." []
comment: Markers are associated with mouse cells.
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
relationship: develops_from CL:0002036 ! Slamf1-positive multipotent progenitor cell
relationship: has_part PR:000002065
relationship: has_part PR:000002979
created_by: tmeehan
creation_date: 2010-01-08T11:16:33Z

[Term]
id: CL:0002036
name: Slamf1-positive multipotent progenitor cell
namespace: cell
def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." []
comment: Markers are associated with mouse cells.
synonym: "KSL cell" EXACT []
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: develops_from CL:0002033 ! short term hematopoietic stem cell
relationship: has_part PR:000001833
relationship: has_part PR:000002065
relationship: has_part PR:000002979
created_by: tmeehan
creation_date: 2010-01-08T11:16:35Z

[Term]
id: CL:0002037
name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell
namespace: cell
def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." []
synonym: "memory alpha beta IEL" EXACT []
is_a: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell
relationship: has_part PR:000001083
relationship: has_part PR:000001307
relationship: has_part PR:000001839
created_by: tmeehan
creation_date: 2009-10-20T02:20:43Z

[Term]
id: CL:0002038
name: T follicular helper cell
namespace: cell
def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." []
synonym: "follicular B helper T cell" RELATED []
synonym: "follicular helper T cell" RELATED []
synonym: "follicular helper T-cell" RELATED []
synonym: "follicular T cell" RELATED []
synonym: "follicular T-cell" RELATED []
synonym: "follicular T-helper cell" RELATED []
synonym: "T(FH)" EXACT []
synonym: "Tfh" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
relationship: capable_of GO:0045830
relationship: capable_of GO:0051024
relationship: has_part PR:000001209
relationship: has_part PR:000001860
relationship: has_part PR:000001919
relationship: has_part PR:000003450
created_by: tmeehan
creation_date: 2009-10-29T04:01:27Z

[Term]
id: CL:0002039
name: immature NK T cell stage I
namespace: cell
def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." []
is_a: CL:0000914 ! immature NK T cell
relationship: has_part PR:000001004
relationship: has_part PR:000001932
relationship: has_part PR:000025402
created_by: tmeehan
creation_date: 2009-10-29T04:09:16Z

[Term]
id: CL:0002040
name: immature NK T cell stage II
namespace: cell
def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." []
comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org.
synonym: "NKT.44-NK1.1-.Th" EXACT []
is_a: CL:0000914 ! immature NK T cell
relationship: develops_from CL:0002039 ! immature NK T cell stage I
relationship: has_part PR:000001932
created_by: tmeehan
creation_date: 2009-10-29T04:13:43Z

[Term]
id: CL:0002041
name: immature NK T cell stage III
namespace: cell
def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." []
synonym: "NKT.44+.NK1.1-.Th" BROAD []
is_a: CL:0000914 ! immature NK T cell
relationship: develops_from CL:0002040 ! immature NK T cell stage II
relationship: has_part PR:000001008
relationship: has_part PR:000001307
relationship: has_part PR:000001932
created_by: tmeehan
creation_date: 2009-10-29T04:14:48Z

[Term]
id: CL:0002042
name: immature NK T cell stage IV
namespace: cell
def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." []
synonym: "NKT.44+.NK1.1-.Th" BROAD []
is_a: CL:0000914 ! immature NK T cell
relationship: develops_from CL:0002041 ! immature NK T cell stage III
relationship: has_part PR:000001008
relationship: has_part PR:000001307
relationship: has_part PR:000001932
created_by: tmeehan
creation_date: 2009-10-29T04:17:38Z

[Term]
id: CL:0002043
name: CD34-positive, CD38-negative multipotent progenitor cell
namespace: cell
def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." []
comment: Cell markers are associated with human hematopoietic multipotent progenitor cells.
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
relationship: develops_from CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell
created_by: tmeehan
creation_date: 2010-01-12T11:14:15Z

[Term]
id: CL:0002044
name: Kit-positive, integrin beta7-high basophil mast progenitor cell
namespace: cell
def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." []
comment: Markers are associated with mouse cells.
is_a: CL:0002028 ! basophil mast progenitor cell
relationship: has_part PR:000001479
relationship: has_part PR:000001483
relationship: has_part PR:000009143
created_by: tmeehan
creation_date: 2010-04-27T01:22:38Z

[Term]
id: CL:0002045
name: Fraction A pre-pro B cell
namespace: cell
def: "A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." []
comment: Markers associated with mouse cells.
synonym: "fraction A" EXACT []
synonym: "pre pro B cell" RELATED []
is_a: CL:0000826 ! pro-B cell
relationship: has_part PR:000001015
relationship: has_part PR:000001879
relationship: has_part PR:000001932
relationship: has_part PR:000002037
relationship: has_part PR:000002065
created_by: tmeehan
creation_date: 2010-04-28T10:50:07Z

[Term]
id: CL:0002046
name: early pro-B cell
namespace: cell
def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." []
comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
is_a: CL:0000826 ! pro-B cell
relationship: has_part GO:0035369
relationship: has_part PR:000001003
relationship: has_part PR:000001288
relationship: has_part PR:000001408
relationship: has_part PR:000001898
created_by: tmeehan
creation_date: 2010-04-28T11:19:11Z

[Term]
id: CL:0002047
name: Fraction B precursor B cell
namespace: cell
def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." []
comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive.
synonym: "Fr. B" EXACT []
synonym: "Fraction B" EXACT []
is_a: CL:0002400 ! Fraction B/C precursor B cell
relationship: develops_from CL:0002045 ! Fraction A pre-pro B cell
relationship: has_part PR:000001014
created_by: tmeehan
creation_date: 2010-04-28T11:56:21Z

[Term]
id: CL:0002048
name: late pro-B cell
namespace: cell
def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." []
comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
is_a: CL:0000817 ! precursor B cell
relationship: develops_from CL:0002046 ! early pro-B cell
relationship: has_part PR:000001002
relationship: has_part PR:000001003
relationship: has_part PR:000001288
relationship: has_part PR:000001408
created_by: tmeehan
creation_date: 2010-04-28T12:06:06Z

[Term]
id: CL:0002049
name: Fraction C precursor B cell
namespace: cell
def: "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." []
synonym: "Fraction C" RELATED []
is_a: CL:0002400 ! Fraction B/C precursor B cell
relationship: develops_from CL:0002047 ! Fraction B precursor B cell
relationship: has_part PR:000001014
relationship: has_part PR:000001858
relationship: has_part PR:000001859
relationship: has_part PR:000002039
relationship: has_part PR:000003457
relationship: has_part PR:000003460
created_by: tmeehan
creation_date: 2010-04-28T02:04:01Z

[Term]
id: CL:0002050
name: Fraction C' precursor B cell
namespace: cell
def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." []
synonym: "Fr. C'" EXACT []
synonym: "Fraction C-prime" EXACT []
is_a: CL:0000817 ! precursor B cell
relationship: develops_from CL:0002049 ! Fraction C precursor B cell
relationship: has_part GO:0035369
relationship: has_part PR:000001014
relationship: has_part PR:000001380
relationship: has_part PR:000001879
relationship: has_part PR:000001932
relationship: has_part PR:000002039
created_by: tmeehan
creation_date: 2010-04-28T02:13:46Z

[Term]
id: CL:0002051
name: CD38-high pre-BCR positive cell
namespace: cell
def: "A pre-BCR positive T cell that is CD38-high." []
comment: Markers are associated with human cells.
synonym: "large pre-B cell type I" RELATED []
is_a: CL:0000952 ! preBCR-positive large pre-B-II cell
relationship: develops_from CL:0002048 ! late pro-B cell
relationship: has_part PR:000001288
relationship: has_part PR:000001408
created_by: tmeehan
creation_date: 2010-04-28T02:27:47Z

[Term]
id: CL:0002052
name: Fraction D precursor B cell
namespace: cell
def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." []
comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative.
synonym: "Fr. D" EXACT []
synonym: "Fraction D pre-B cell" EXACT []
is_a: CL:0002400 ! Fraction B/C precursor B cell
relationship: develops_from CL:0002050 ! Fraction C' precursor B cell
relationship: has_part PR:000001014
relationship: has_part PR:000001380
relationship: has_part PR:000001879
relationship: has_part PR:000002039
created_by: tmeehan
creation_date: 2010-04-28T02:55:16Z

[Term]
id: CL:0002053
name: CD22-positive, CD38-low small pre-B cell
namespace: cell
def: "A small pre-B cell that is CD22-positive and CD38-low." []
comment: Markers are associated with human cell. RAG expression maybe diminishing.
synonym: "small pre-B cell" EXACT []
is_a: CL:0000954 ! small pre-B-II cell
relationship: develops_from CL:0002051 ! CD38-high pre-BCR positive cell
relationship: has_part PR:000001288
relationship: has_part PR:000001408
created_by: tmeehan
creation_date: 2010-04-28T03:04:48Z

[Term]
id: CL:0002054
name: Fraction E immature B cell
namespace: cell
def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." []
comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative.
is_a: CL:0000816 ! immature B cell
relationship: develops_from CL:0002052 ! Fraction D precursor B cell
relationship: has_part PR:000001879
relationship: has_part PR:000001932
relationship: has_part PR:000002037
created_by: tmeehan
creation_date: 2010-04-28T03:13:47Z

[Term]
id: CL:0002055
name: CD38-negative immature B cell
namespace: cell
def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." []
comment: Markers are associated with human cell type.
is_a: CL:0000816 ! immature B cell
relationship: develops_from CL:0002053 ! CD22-positive, CD38-low small pre-B cell
relationship: has_part PR:000001288
relationship: has_part PR:000001338
relationship: has_part PR:000001898
created_by: tmeehan
creation_date: 2010-04-28T03:19:14Z

[Term]
id: CL:0002056
name: Fraction F mature B cell
namespace: cell
def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." []
is_a: CL:0000822 ! B-2 B cell
relationship: develops_from CL:0002054 ! Fraction E immature B cell
relationship: has_part GO:0071738
relationship: has_part GO:0071753
relationship: has_part PR:000001014
relationship: has_part PR:000001338
created_by: tmeehan
creation_date: 2010-04-30T03:01:48Z

[Term]
id: CL:0002057
name: CD14-positive, CD16-negative classical monocyte
namespace: cell
def: "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." []
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes.
synonym: "CD16- monocyte" EXACT []
synonym: "CD16-negative monocyte" EXACT []
is_a: CL:0000860 ! classical monocyte
is_a: CL:0001054 ! CD14-positive monocyte
relationship: has_part PR:000001465
relationship: has_part PR:000001925
created_by: tmeehan
creation_date: 2010-06-05T08:25:41Z

[Term]
id: CL:0002058
name: Gr1-low non-classical monocyte
namespace: cell
def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." []
comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative.
is_a: CL:0000875 ! non-classical monocyte
is_a: CL:0002398 ! Gr1-positive, CD43-positive monocyte
relationship: develops_from CL:0002398 ! Gr1-positive, CD43-positive monocyte
relationship: has_part PR:000001199
relationship: has_part PR:000001206
relationship: has_part PR:000002980
created_by: tmeehan
creation_date: 2010-06-05T08:25:44Z

[Term]
id: CL:0002059
name: CD8alpha-positive thymic conventional dendritic cell
namespace: cell
def: "A conventional thymic dendritic cell that is CD8alpha-positive." []
synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT []
synonym: "DC.8+.Th" EXACT []
is_a: CL:0000941 ! thymic conventional dendritic cell
relationship: has_part PR:000001084
created_by: tmeehan
creation_date: 2010-06-07T02:48:36Z

[Term]
id: CL:0002060
name: melanophage
namespace: cell
def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." []
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: has_part CHEBI:25179
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: has_part CHEBI:25179
relationship: part_of UBERON:0002097 ! skin of body
created_by: tmeehan
creation_date: 2010-06-22T10:46:12Z

[Term]
id: CL:0002061
name: T-helper 9 cell
namespace: cell
def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." []
synonym: "T helper cells type 9" EXACT []
synonym: "T(H)-9 cell" EXACT []
synonym: "Th9" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
relationship: capable_of GO:0002215
relationship: capable_of GO:0032638
relationship: has_part PR:000008982
created_by: tmeehan
creation_date: 2010-06-22T11:18:44Z

[Term]
id: CL:0002062
name: type I pneumocyte
namespace: cell
def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." []
synonym: "AT1" EXACT []
synonym: "ATI" EXACT []
synonym: "lung type 1 cells" EXACT []
synonym: "membranous pneumocytes" EXACT []
synonym: "pulmonary alveolar type I cell" EXACT []
synonym: "small alveolar cells" EXACT []
synonym: "squamous alveolar cell" EXACT []
synonym: "squamous alveolar lining cell" EXACT []
synonym: "type 1 alveolar epithelial cells" EXACT []
synonym: "type 1 pneumocyte" EXACT []
synonym: "type I alveolar cells" EXACT []
synonym: "type I alveolar epithelial cells" EXACT []
xref: BTO:0000780
xref: FMA:62500
is_a: BFO:0000040 ! material entity
is_a: CL:0000322 ! pneumocyte
intersection_of: CL:0000322 ! pneumocyte
intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system
created_by: tmeehan
creation_date: 2010-06-23T04:37:54Z

[Term]
id: CL:0002063
name: type II pneumocyte
namespace: cell
def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." []
synonym: "AT2" EXACT []
synonym: "ATII" EXACT []
synonym: "cuboidal type II cell" EXACT []
synonym: "granular pneumocyte" EXACT []
synonym: "great alveolar cell" EXACT []
synonym: "lung type 2 cell" EXACT []
synonym: "lung type II cell" RELATED []
synonym: "TII" EXACT []
synonym: "type 2 alveolar epithelial cell" EXACT []
synonym: "type 2 alveolocyte" EXACT []
synonym: "type 2 pneumocyte" EXACT []
synonym: "type II alveolar cell" EXACT []
synonym: "type II alveolar epithelial cell" EXACT []
synonym: "type II alveolocyte" EXACT []
xref: BTO:0000538
xref: FMA:62501
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0000322 ! pneumocyte
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000322 ! pneumocyte
intersection_of: capable_of GO:0032940 ! secretion by cell
intersection_of: capable_of GO:0043129
created_by: tmeehan
creation_date: 2010-06-24T12:04:13Z

[Term]
id: CL:0002064
name: pancreatic acinar cell
namespace: cell
def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." []
synonym: "acinar cell of pancreas" EXACT []
xref: BTO:0000028
xref: CALOHA:TS-0737
xref: FMA:63032
is_a: CL:0000622 ! acinar cell
is_a: CL:1001599 ! pancreas exocrine glandular cell
intersection_of: CL:0000622 ! acinar cell
intersection_of: part_of UBERON:0001263 ! pancreatic acinus
relationship: has_part GO:0042589
relationship: part_of UBERON:0001263 ! pancreatic acinus
created_by: tmeehan
creation_date: 2010-06-24T03:16:29Z

[Term]
id: CL:0002066
name: Feyrter cell
namespace: cell
def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." []
synonym: "bronchiolar Kulchitsky cell" EXACT []
synonym: "Kultschitzky cell of bronchiole" EXACT []
synonym: "P cell" BROAD []
synonym: "respiratory enterochromaffin cell" EXACT []
xref: FMA:14118
is_a: CL:0000165 ! neuroendocrine cell
created_by: tmeehan
creation_date: 2010-06-28T08:24:30Z

[Term]
id: CL:0002067
name: type A enterocrine cell
namespace: cell
def: "An enterocrine cell that produces glucagon." []
xref: FMA:62939
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000170 ! glucagon secreting cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: capable_of GO:0070091 ! glucagon secretion
created_by: tmeehan
creation_date: 2010-09-10T10:48:54Z

[Term]
id: CL:0002068
name: Purkinje myocyte
namespace: cell
def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." []
synonym: "myocytus conducens cardiacus" EXACT []
synonym: "Purkinje cell fiber" EXACT []
synonym: "Purkinje muscle cell" EXACT []
xref: BTO:0001032
xref: FMA:14146
is_a: CL:0002086 ! specialized cardiac myocyte
created_by: tmeehan
creation_date: 2010-06-28T08:36:15Z

[Term]
id: CL:0002069
name: type II vestibular sensory cell
namespace: cell
def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." []
synonym: "type 2 vestibular hair cell" EXACT []
synonym: "type 2 vestibular sensory cell" EXACT []
synonym: "type II hair cell" EXACT []
xref: FMA:67909
is_a: CL:0000609 ! vestibular hair cell
created_by: tmeehan
creation_date: 2010-06-29T09:58:13Z

[Term]
id: CL:0002070
name: type I vestibular sensory cell
namespace: cell
def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." []
synonym: "type 1 vestibular hair cell" EXACT []
synonym: "type 1 vestibular sensory cell" EXACT []
synonym: "type I hair cell" EXACT []
xref: FMA:62352
is_a: CL:0000609 ! vestibular hair cell
created_by: tmeehan
creation_date: 2010-06-29T09:58:19Z

[Term]
id: CL:0002071
name: enterocyte of epithelium of large intestine
namespace: cell
def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." []
synonym: "columnar cell" BROAD []
synonym: "columnar cell of the colon" EXACT []
synonym: "vacuolar absorptive cell" EXACT []
xref: BTO:0002484
xref: FMA:63638
xref: FMA:66771
is_a: CL:0000584 ! enterocyte
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000584 ! enterocyte
intersection_of: part_of UBERON:0001278 ! epithelium of large intestine
relationship: part_of UBERON:0001278 ! epithelium of large intestine
created_by: tmeehan
creation_date: 2010-06-29T11:07:25Z

[Term]
id: CL:0002072
name: nodal myocyte
namespace: cell
def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." []
synonym: "cardiac pacemaker cell" EXACT []
synonym: "myocytus nodalis" EXACT []
synonym: "P cell" EXACT []
synonym: "pacemaker cell" BROAD []
xref: BTO:0004190
xref: FMA:67101
is_a: CL:0002086 ! specialized cardiac myocyte
created_by: tmeehan
creation_date: 2010-06-29T11:41:37Z

[Term]
id: CL:0002073
name: transitional myocyte
namespace: cell
def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." []
xref: FMA:67142
is_a: CL:0002086 ! specialized cardiac myocyte
created_by: tmeehan
creation_date: 2010-06-29T02:39:32Z

[Term]
id: CL:0002074
name: myocardial endocrine cell
namespace: cell
def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." []
xref: FMA:67111
is_a: CL:0000163 ! endocrine cell
is_a: CL:0002086 ! specialized cardiac myocyte
created_by: tmeehan
creation_date: 2010-06-29T11:50:47Z

[Term]
id: CL:0002075
name: brush cell of trachebronchial tree
namespace: cell
def: "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known." []
synonym: "pulmonary brush cell" RELATED []
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0002204 ! brush cell
intersection_of: CL:0002204 ! brush cell
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
created_by: tmeehan
creation_date: 2010-06-29T03:22:46Z

[Term]
id: CL:0002076
name: endo-epithelial cell
namespace: cell
def: "An epithelial cell derived from endoderm." []
xref: FMA:69075
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000223 ! endodermal cell
created_by: tmeehan
creation_date: 2010-06-29T03:38:14Z

[Term]
id: CL:0002077
name: ecto-epithelial cell
namespace: cell
def: "An epithelial cell derived from ectoderm." []
xref: FMA:69074
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000221 ! ectodermal cell
relationship: develops_from CL:0000221 ! ectodermal cell
created_by: tmeehan
creation_date: 2010-06-29T03:38:22Z

[Term]
id: CL:0002078
name: meso-epithelial cell
namespace: cell
def: "Epithelial cell derived from mesoderm or mesenchyme." []
synonym: "epithelial mesenchymal cell" EXACT []
xref: FMA:69076
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000222 ! mesodermal cell
relationship: develops_from CL:0000222 ! mesodermal cell
created_by: tmeehan
creation_date: 2010-06-29T03:49:14Z

[Term]
id: CL:0002079
name: pancreatic ductal cell
namespace: cell
def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." []
xref: FMA:63099
is_a: BFO:0000040 ! material entity
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000083 ! epithelial cell of pancreas
intersection_of: capable_of GO:0015106
intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct
relationship: capable_of GO:0015106
relationship: part_of UBERON:0001064 ! ventral pancreatic duct
created_by: tmeehan
creation_date: 2010-06-30T08:49:43Z

[Term]
id: CL:0002080
name: pancreatic centro-acinar cell
namespace: cell
def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." []
synonym: "centroacinar cell of Langerhans" EXACT []
synonym: "pancreatic centroacinar cell" EXACT []
xref: FMA:62455
is_a: BFO:0000040 ! material entity
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000083 ! epithelial cell of pancreas
intersection_of: capable_of GO:0015106
intersection_of: part_of UBERON:0001263 ! pancreatic acinus
relationship: capable_of GO:0015106
relationship: part_of UBERON:0001263 ! pancreatic acinus
created_by: tmeehan
creation_date: 2010-06-30T08:49:52Z

[Term]
id: CL:0002081
name: type II cell of carotid body
namespace: cell
def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." []
synonym: "sheath cell of carotid body" EXACT []
xref: FMA:84187
is_a: CL:0000703 ! sustentacular cell
is_a: CL:0002256 ! supporting cell of carotid body
created_by: tmeehan
creation_date: 2010-06-30T04:23:42Z

[Term]
id: CL:0002082
name: type II cell of adrenal medulla
namespace: cell
def: "A chromaffin cell of the adrenal medulla that produces epinephrine." []
synonym: "adremergic chromaffin cell" EXACT []
synonym: "adrenal secreting cell of the adrenal medulla" EXACT []
synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT []
xref: FMA:69322
is_a: CL:0000336 ! adrenal medulla chromaffin cell
is_a: CL:0000454 ! epinephrine secreting cell
intersection_of: CL:0000336 ! adrenal medulla chromaffin cell
intersection_of: capable_of GO:0048242
intersection_of: part_of UBERON:0001236 ! adrenal medulla
created_by: tmeehan
creation_date: 2010-07-14T09:41:42Z

[Term]
id: CL:0002083
name: type I cell of adrenal medulla
namespace: cell
def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." []
synonym: "noradrenergic chromaffin cell" EXACT []
xref: FMA:69321
is_a: CL:0000336 ! adrenal medulla chromaffin cell
is_a: CL:0000459 ! noradrenergic cell
intersection_of: CL:0000336 ! adrenal medulla chromaffin cell
intersection_of: capable_of GO:0048243 ! norepinephrine secretion
intersection_of: part_of UBERON:0001236 ! adrenal medulla
created_by: tmeehan
creation_date: 2010-07-14T10:12:24Z

[Term]
id: CL:0002084
name: Boettcher cell
namespace: cell
def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." []
synonym: "Boettcher's cell" EXACT []
synonym: "Bottcher cell" EXACT []
synonym: "Bottcher's cell" EXACT []
is_a: CL:0002315 ! supporting cell of cochlea
created_by: tmeehan
creation_date: 2010-07-14T03:22:02Z

[Term]
id: CL:0002085
name: tanycyte
namespace: cell
alt_id: CL:0000643
def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." []
synonym: "stretch cell" EXACT []
xref: BTO:0001953
xref: FMA:54560
is_a: CL:0000683 ! ependymoglial cell
created_by: tmeehan
creation_date: 2010-07-15T11:21:11Z

[Term]
id: CL:0002086
name: specialized cardiac myocyte
namespace: cell
def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." []
xref: FMA:67968
is_a: CL:0000746 ! cardiac muscle cell
created_by: tmeehan
creation_date: 2010-07-21T01:33:38Z

[Term]
id: CL:0002087
name: nongranular leukocyte
namespace: cell
def: "A leukocyte that lacks granules." []
synonym: "agranular leukocyte" EXACT []
xref: FMA:62855
is_a: CL:0000738 ! leukocyte
created_by: tmeehan
creation_date: 2010-07-22T11:30:33Z

[Term]
id: CL:0002088
name: interstitial cell of Cajal
namespace: cell
def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." []
comment: Some argue this cell type is of mesenchymal origin.
synonym: "ICC" EXACT []
synonym: "intestinal pacemaker cell" EXACT []
xref: BTO:0003914
xref: FMA:86573
is_a: BFO:0000040 ! material entity
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000710 ! neurecto-epithelial cell
intersection_of: capable_of GO:0043134
relationship: capable_of GO:0043134
created_by: tmeehan
creation_date: 2010-07-22T03:26:00Z

[Term]
id: CL:0002089
name: group 2 innate lymphoid cell, mouse
namespace: cell
def: "A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." []
synonym: "nuocyte" BROAD []
is_a: CL:0001069 ! group 2 innate lymphoid cell
relationship: capable_of GO:0002830
relationship: capable_of GO:0032616
relationship: has_part PR:000001860
relationship: has_part PR:000001869
relationship: has_part PR:000008982
relationship: has_part PR:000008994
created_by: tmeehan
creation_date: 2010-08-12T02:22:19Z

[Term]
id: CL:0002090
name: polar body
namespace: cell
def: "One of two small cells formed by the first and second meiotic division of oocytes." []
xref: EHDAA2:0004716
xref: FMA:85543
xref: WBbt:0008429
xref: XAO:0000262
is_a: CL:0000021 ! female germ cell
created_by: tmeehan
creation_date: 2010-08-23T09:49:53Z

[Term]
id: CL:0002091
name: primary polar body
namespace: cell
def: "A small cell formed by the first meiotic division of oocytes." []
synonym: "first polar body" EXACT []
synonym: "polocytus primarius" EXACT []
xref: EHDAA2:0000541
xref: EMAPA:16032
xref: FMA:18650
xref: VHOG:0000464
is_a: CL:0002090 ! polar body
created_by: tmeehan
creation_date: 2010-08-23T09:49:58Z

[Term]
id: CL:0002092
name: bone marrow cell
namespace: cell
def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." []
comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.
xref: BTO:0004850
xref: FMA:83621
is_a: BFO:0000004
is_a: CARO:0000000
is_a: CL:0001035 ! bone cell
intersection_of: CL:0001035 ! bone cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
created_by: tmeehan
creation_date: 2010-07-22T04:48:15Z

[Term]
id: CL:0002093
name: secondary polar body
namespace: cell
def: "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." []
synonym: "polocytus secundarius" EXACT []
synonym: "second polar body" EXACT []
xref: EHDAA2:0001820
xref: EMAPA:16034
xref: EMAPA:16045
xref: FMA:18651
is_a: CL:0002090 ! polar body
created_by: tmeehan
creation_date: 2010-08-23T09:50:01Z

[Term]
id: CL:0002094
name: interstitial cell of ovary
namespace: cell
def: "A cell that makes up the loose connective tissue of the ovary." []
xref: FMA:18709
is_a: CL:0002132 ! stromal cell of ovary
created_by: tmeehan
creation_date: 2010-08-23T11:11:34Z

[Term]
id: CL:0002095
name: hilus cell of ovary
namespace: cell
def: "A cell in the hilum of the ovary that produces androgens." []
synonym: "hilar cell of ovary" EXACT []
xref: FMA:18710
is_a: CL:0000593 ! androgen secreting cell
is_a: CL:0002132 ! stromal cell of ovary
created_by: tmeehan
creation_date: 2010-08-23T11:18:18Z

[Term]
id: CL:0002096
name: internodal tract myocyte
namespace: cell
def: "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." []
xref: FMA:223275
is_a: CL:0002086 ! specialized cardiac myocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0009966 ! internodal tract
relationship: part_of UBERON:0009966 ! internodal tract
created_by: tmeehan
creation_date: 2010-08-23T11:24:11Z

[Term]
id: CL:0002097
name: cortical cell of adrenal gland
namespace: cell
def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." []
synonym: "adrenal cortex cell" EXACT []
synonym: "adrenocortical cell" EXACT []
xref: FMA:69545
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1001601 ! adrenal gland glandular cell
intersection_of: CL:0002078 ! meso-epithelial cell
intersection_of: part_of UBERON:0001235 ! adrenal cortex
created_by: tmeehan
creation_date: 2010-08-24T01:37:44Z

[Term]
id: CL:0002098
name: regular cardiac myocyte
namespace: cell
def: "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." []
synonym: "regular cardiac muscle cell" EXACT []
synonym: "regular cardiac muscle fiber" EXACT []
xref: FMA:67967
is_a: CL:0000746 ! cardiac muscle cell
created_by: tmeehan
creation_date: 2010-08-23T11:33:10Z

[Term]
id: CL:0002099
name: type I cell of adrenal cortex
namespace: cell
alt_id: CL:1000423
def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." []
synonym: "epithelial cell of zona glomerulosa of adrenal gland" EXACT []
xref: FMA:69273
is_a: CL:0000456 ! mineralocorticoid secreting cell
is_a: CL:0002097 ! cortical cell of adrenal gland
intersection_of: CL:0002097 ! cortical cell of adrenal gland
intersection_of: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland
relationship: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland
created_by: tmeehan
creation_date: 2010-08-24T01:42:02Z

[Term]
id: CL:0002100
name: regular interventricular cardiac myocyte
namespace: cell
def: "A regular cardiac myocyte of the interventricular region of the heart." []
xref: FMA:228792
is_a: CL:0002098 ! regular cardiac myocyte
created_by: tmeehan
creation_date: 2010-08-23T11:40:52Z

[Term]
id: CL:0002101
name: CD38-positive naive B cell
namespace: cell
def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." []
synonym: "CD38+ naive B cell" EXACT []
synonym: "CD38+ naive B lymphocyte" EXACT []
synonym: "CD38+ naive B-cell" EXACT []
synonym: "CD38+ naive B-lymphocyte" EXACT []
synonym: "CD38-positive naive B lymphocyte" EXACT []
synonym: "CD38-positive naive B-cell" EXACT []
synonym: "CD38-positive naive B-lymphocyte" EXACT []
is_a: CL:0000788 ! naive B cell
relationship: has_part PR:000001408

[Term]
id: CL:0002102
name: CD38-negative naive B cell
namespace: cell
def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." []
synonym: "CD38- naive B cell" EXACT []
synonym: "CD38- naive B lymphocyte" EXACT []
synonym: "CD38- naive B-cell" EXACT []
synonym: "CD38- naive B-lymphocyte" EXACT []
synonym: "CD38-negative naive B lymphocyte" EXACT []
synonym: "CD38-negative naive B-cell" EXACT []
synonym: "CD38-negative naive B-lymphocyte" EXACT []
is_a: CL:0000788 ! naive B cell

[Term]
id: CL:0002103
name: IgG-positive double negative memory B cell
namespace: cell
def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." []
synonym: "IgG+ dn memory B cell" EXACT []
synonym: "IgG+ dn memory B lymphocyte" EXACT []
synonym: "IgG+ dn memory B-cell" EXACT []
synonym: "IgG+ dn memory B-lymphocyte" EXACT []
synonym: "IgG+ double negative memory B cell" EXACT []
synonym: "IgG+ double negative memory B lymphocyte" EXACT []
synonym: "IgG+ double negative memory B-cell" EXACT []
synonym: "IgG+ double negative memory B-lymphocyte" EXACT []
synonym: "IgG-positive dn memory B cell" EXACT []
synonym: "IgG-positive dn memory B lymphocyte" EXACT []
synonym: "IgG-positive dn memory B-cell" EXACT []
synonym: "IgG-positive dn memory B-lymphocyte" EXACT []
synonym: "IgG-positive double negative memory B lymphocyte" EXACT []
synonym: "IgG-positive double negative memory B-cell" EXACT []
synonym: "IgG-positive double negative memory B-lymphocyte" EXACT []
is_a: CL:0000981 ! double negative memory B cell
relationship: has_part GO:0071735

[Term]
id: CL:0002104
name: IgG-negative double negative memory B cell
namespace: cell
def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." []
synonym: "IgG- dn memory B cell" EXACT []
synonym: "IgG- dn memory B lymphocyte" EXACT []
synonym: "IgG- dn memory B-cell" EXACT []
synonym: "IgG- dn memory B-lymphocyte" EXACT []
synonym: "IgG- double negative memory B cell" EXACT []
synonym: "IgG- double negative memory B lymphocyte" EXACT []
synonym: "IgG- double negative memory B-cell" EXACT []
synonym: "IgG- double negative memory B-lymphocyte" EXACT []
synonym: "IgG-negative dn memory B cell" EXACT []
synonym: "IgG-negative dn memory B lymphocyte" EXACT []
synonym: "IgG-negative dn memory B-cell" EXACT []
synonym: "IgG-negative dn memory B-lymphocyte" EXACT []
synonym: "IgG-negative double negative memory B lymphocyte" EXACT []
synonym: "IgG-negative double negative memory B-cell" EXACT []
synonym: "IgG-negative double negative memory B-lymphocyte" EXACT []
is_a: CL:0000981 ! double negative memory B cell

[Term]
id: CL:0002105
name: CD38-positive IgG memory B cell
namespace: cell
def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." []
synonym: "CD38+ IgG memory B cell" EXACT []
synonym: "CD38+ IgG memory B lymphocyte" EXACT []
synonym: "CD38+ IgG memory B-cell" EXACT []
synonym: "CD38+ IgG memory B-lymphocyte" EXACT []
synonym: "CD38-positive IgG memory B lymphocyte" EXACT []
synonym: "CD38-positive IgG memory B-cell" EXACT []
synonym: "CD38-positive IgG memory B-lymphocyte" EXACT []
is_a: CL:0000979 ! IgG memory B cell
relationship: has_part PR:000001408

[Term]
id: CL:0002106
name: IgD-positive CD38-positive IgG memory B cell
namespace: cell
def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." []
is_a: CL:0002105 ! CD38-positive IgG memory B cell
relationship: has_part GO:0071738

[Term]
id: CL:0002107
name: IgD-negative CD38-positive IgG memory B cell
namespace: cell
def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." []
is_a: CL:0001053 ! IgD-negative memory B cell
is_a: CL:0002105 ! CD38-positive IgG memory B cell

[Term]
id: CL:0002108
name: CD38-negative IgG memory B cell
namespace: cell
def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." []
is_a: CL:0000979 ! IgG memory B cell
is_a: CL:0001053 ! IgD-negative memory B cell

[Term]
id: CL:0002109
name: B220-positive CD38-positive naive B cell
namespace: cell
def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." []
synonym: "B220+CD38+ naive B cell" EXACT []
synonym: "B220+CD38+ naive B lymphocyte" EXACT []
synonym: "B220+CD38+ naive B-cell" EXACT []
synonym: "B220+CD38+ naive B-lymphocyte" EXACT []
synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT []
synonym: "B220-positive CD38-positive naive B-cell" EXACT []
synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT []
synonym: "CD38+B220+ naive B cell" EXACT []
synonym: "CD38+B220+ naive B lymphocyte" EXACT []
synonym: "CD38+B220+ naive B-cell" EXACT []
synonym: "CD38+B220+ naive B-lymphocyte" EXACT []
is_a: CL:0002101 ! CD38-positive naive B cell
relationship: has_part PR:000001014

[Term]
id: CL:0002110
name: B220-low CD38-positive naive B cell
namespace: cell
def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." []
is_a: CL:0002109 ! B220-positive CD38-positive naive B cell
relationship: has_part PR:000001014

[Term]
id: CL:0002111
name: CD38-negative unswitched memory B cell
namespace: cell
def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." []
synonym: "CD38- unswitched memory B cell" EXACT []
synonym: "CD38- unswitched memory B lymphocyte" EXACT []
synonym: "CD38- unswitched memory B-cell" EXACT []
synonym: "CD38- unswitched memory B-lymphocyte" EXACT []
synonym: "CD38-negative unswitched memory B lymphocyte" EXACT []
synonym: "CD38-negative unswitched memory B-cell" EXACT []
synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000970 ! unswitched memory B cell

[Term]
id: CL:0002112
name: B220-positive CD38-negative unswitched memory B cell
namespace: cell
def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." []
is_a: CL:0002111 ! CD38-negative unswitched memory B cell
relationship: has_part PR:000001014

[Term]
id: CL:0002113
name: B220-low CD38-negative unswitched memory B cell
namespace: cell
def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." []
is_a: CL:0002112 ! B220-positive CD38-negative unswitched memory B cell
relationship: has_part PR:000001014

[Term]
id: CL:0002114
name: CD38-positive unswitched memory B cell
namespace: cell
def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." []
synonym: "CD38+ unswitched memory B cell" EXACT []
synonym: "CD38+ unswitched memory B lymphocyte" EXACT []
synonym: "CD38+ unswitched memory B-cell" EXACT []
synonym: "CD38+ unswitched memory B-lymphocyte" EXACT []
synonym: "CD38-positive unswitched memory B lymphocyte" EXACT []
synonym: "CD38-positive unswitched memory B-cell" EXACT []
synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000970 ! unswitched memory B cell
relationship: has_part PR:000001408

[Term]
id: CL:0002115
name: B220-positive CD38-positive unswitched memory B cell
namespace: cell
def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." []
is_a: CL:0002114 ! CD38-positive unswitched memory B cell
relationship: has_part PR:000001014

[Term]
id: CL:0002116
name: B220-low CD38-positive unswitched memory B cell
namespace: cell
def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." []
is_a: CL:0002115 ! B220-positive CD38-positive unswitched memory B cell
relationship: has_part PR:000001014

[Term]
id: CL:0002117
name: IgG-negative class switched memory B cell
namespace: cell
def: "A class switched memory B cell that lacks IgG on the cell surface." []
synonym: "IgG- class switched memory B cell" EXACT []
synonym: "IgG- class switched memory B lymphocyte" EXACT []
synonym: "IgG- class switched memory B-cell" EXACT []
synonym: "IgG- class switched memory B-lymphocyte" EXACT []
synonym: "IgG-negative class switched memory B lymphocyte" EXACT []
synonym: "IgG-negative class switched memory B-cell" EXACT []
synonym: "IgG-negative class switched memory B-lymphocyte" EXACT []
is_a: CL:0000972 ! class switched memory B cell

[Term]
id: CL:0002118
name: CD38-negative IgG-negative class switched memory B cell
namespace: cell
def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." []
is_a: CL:0002117 ! IgG-negative class switched memory B cell

[Term]
id: CL:0002119
name: CD38-positive IgG-negative class switched memory B cell
namespace: cell
def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." []
is_a: CL:0002117 ! IgG-negative class switched memory B cell
relationship: has_part PR:000001408

[Term]
id: CL:0002120
name: CD24-positive CD38-negative IgG-negative class switched memory B cell
namespace: cell
def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." []
is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
relationship: has_part PR:000001932

[Term]
id: CL:0002121
name: CD24-negative CD38-negative IgG-negative class switched memory B cell
namespace: cell
def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." []
is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell

[Term]
id: CL:0002122
name: B220-positive CD38-positive IgG-negative class switched memory B cell
namespace: cell
def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." []
is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
relationship: has_part PR:000001014

[Term]
id: CL:0002123
name: B220-low CD38-positive IgG-negative class switched memory B cell
namespace: cell
def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." []
is_a: CL:0002122 ! B220-positive CD38-positive IgG-negative class switched memory B cell
relationship: has_part PR:000001014

[Term]
id: CL:0002124
name: CD27-positive gamma-delta T cell
namespace: cell
def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." []
synonym: "gammadelta27-positive" EXACT []
synonym: "gd27-positive"